angiotensinogen and Non-alcoholic-Fatty-Liver-Disease

Topics: Angiotensinogen; Case-Control Studies; China; Coronary Disease; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Non-alcoholic Fatty Liver Disease; Polymorphism, Single Nucleotide; Risk Factors

To investigate the relationship between angiotensin (. Polymerase chain reaction was performed to determine. The

Topics: Angiotensinogen; Angiotensins; Asian People; China; Coronary Artery Disease; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Non-alcoholic Fatty Liver Disease; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors

Nonalcoholic fatty liver disease (NAFLD) can develop in prenatal stages and can be exacerbated by exposure to a postnatal high-fat (HF) diet. We investigated the protective effects of resveratrol on prenatal and postnatal HF diet-induced NAFLD.. Male Sprague-Dawley rat offspring were placed in five experimental groups (n = 10-12 per group): normal diet (VNF), maternal HF diet (ONF), postnatal HF diet (VHF), and maternal HF diet/postnatal HF diet (OHF). A therapeutic group with resveratrol for maternal HF diet/postnatal HF diet (OHFR) was used for comparison. Resveratrol (50 mg/kg/day) was dissolved in drinking water for offspring from post-weaning to postnatal day (PND) 120.. We found that HF/HF-induced NAFLD was prevented in adult offspring by the administration of resveratrol. Resveratrol administration mediated a protective effect on rats on HF/HF by regulating lipid metabolism, reducing oxidative stress and apoptosis, restoring nutrient-sensing pathways by increasing Sirt1 and leptin expression, and mediating the renin-angiotensin system (RAS) to decrease angiotensinogen, renin, ACE1, and AT1R levels and increased ACE2, AT2R and MAS1 levels compared to those in the OHF group.. Our results suggest that a maternal and post-weaning HF diet increases liver steatosis and apoptosis via the RAS. Resveratrol might serve as a therapeutic target by mediating protective actions against NAFLD in offspring exposed to a combination of maternal and postnatal HF diet.

Topics: Angiotensin-Converting Enzyme 2; Angiotensinogen; Animals; Animals, Newborn; Diet, High-Fat; Female; Gene Expression Regulation; Hypolipidemic Agents; Leptin; Lipid Metabolism; Male; Maternal Nutritional Physiological Phenomena; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Renin; Renin-Angiotensin System; Resveratrol; Sirtuin 1; Stilbenes; Weaning

Topics: Administration, Oral; Angiotensin II; Angiotensinogen; Animals; Atherosclerosis; Chlorogenic Acid; Commiphora; Curcumin; Diet, High-Fat; Dietary Supplements; Fatty Acid-Binding Proteins; Gene Expression Regulation; Inulin; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Non-alcoholic Fatty Liver Disease; Plant Extracts; Plant Gums; RNA, Messenger; Silymarin; Suppressor of Cytokine Signaling 3 Protein