angiotensinogen has been researched along with Hemangiosarcoma* in 3 studies
3 other study(ies) available for angiotensinogen and Hemangiosarcoma
| Article | Year |
|---|---|
Erythropoietin in capillary hemangioblastoma. An immunohistochemical study.
Capillary hemangioblastoma is a tumor known to be associated with secondary polycythemia. Therefore, specimens from ten hemangioblastomas were studied by immunohistochemistry for the presence of erythropoietin, renin substrate, and for various endothelial, histiocytic and glial markers. In all tumors scattered cells among the stromal cells showed a positive-staining reaction with both anti-erythropoietin and anti-renin substrate. The same cells also stained positively for alpha-1-anti-trypsin. It is concluded that, in addition to the capillary endothelial cells, pericytes and stromal cells, capillary hemangioblastomas harbor cells containing and perhaps producing renin substrate and/or erythropoietin or a substance with similar antigenic determinants. Topics: Angiotensinogen; Brain Neoplasms; Cerebellar Neoplasms; Erythropoietin; Hemangiosarcoma; Humans; Immunologic Techniques; Medulla Oblongata | 1987 |
Renin substrate (angiotensinogen) as a possible erythropoietin precursor.
Topics: Angiotensinogen; Antibodies; Brain Neoplasms; Cross Reactions; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Female; Fluorescent Antibody Technique; Hemangiosarcoma; Humans; Molecular Weight; Radioimmunoassay | 1986 |
Evidence that renin substrate (angiotensinogen) may be a precursor of erythropoietin.
We suggested a role for renin substrate (RS, angiotensinogen) in the biogenesis of erythropoietin (EP) (Nature 308:649-652, 1984). Purified RS was prepared from pooled plasma of healthy adult subjects, or from plasma of pregnant, healthy females. Antisera against human RS were shown to cross-react with purified human urinary EP, using a haemagglutination technique. On the other hand, antisera generated against highly purified human urinary EP showed strong cross-reaction with purified human plasma RS, by agglutinating erythrocytes covered with glutaraldehyde-coupled human RS. Moreover, using antisera generated against RS or EP, we have demonstrated monocytoid cells staining positive for both EP and RS in cerebellar haemangioblastoma tumors from 8 patients. Taken together, these observations point to a close relation between RS and EP. One interesting explanation is that renin substrate may be a precursor of erythropoietin. Topics: Adult; Angiotensinogen; Angiotensins; Cerebellar Neoplasms; Cross Reactions; Erythropoietin; Female; Fluorescent Antibody Technique; Hemangiosarcoma; Humans; Immunoenzyme Techniques; Pregnancy | 1985 |