angiotensinogen and Fabry-Disease

angiotensinogen has been researched along with Fabry-Disease* in 1 studies

Other Studies

1 other study(ies) available for angiotensinogen and Fabry-Disease

Article	Year
Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2013, Volume: 18, Issue:7 Stroke and/or white matter lesions (WMLs) are significant in Fabry disease. Polymorphisms of angiotensinogen (AGT), AGT Promoter and angiotensinogen II receptor type 1 (AGTR1) are correlated with WMLs.. We compared AGT. AGT Promoter and AGTR1 genotypes to stroke incidence, Fabry-specific [Mainz Severity Score Index (MSSI)] severity score, and neurologic sub-score (n-MSSI).. Sixty-three Fabry patients and 49 matched controls plus historic controls were genotyped. Institutional Review Board approval was received. Results. C and/or CC alleles of AGT Promoter and AGTR1 were significantly correlated with stroke and n-MSSI.. Findings are suggestive of role of AGT Promoter and AGTR1 genotypes in Fabry phenotypes. Topics: Adolescent; Adult; Angiotensinogen; Brain Ischemia; Case-Control Studies; Fabry Disease; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Incidence; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Prevalence; Promoter Regions, Genetic; Receptor, Angiotensin, Type 1; Severity of Illness Index; Young Adult	2013

Article

Year

Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2013, Volume: 18, Issue:7

Stroke and/or white matter lesions (WMLs) are significant in Fabry disease. Polymorphisms of angiotensinogen (AGT), AGT Promoter and angiotensinogen II receptor type 1 (AGTR1) are correlated with WMLs.. We compared AGT. AGT Promoter and AGTR1 genotypes to stroke incidence, Fabry-specific [Mainz Severity Score Index (MSSI)] severity score, and neurologic sub-score (n-MSSI).. Sixty-three Fabry patients and 49 matched controls plus historic controls were genotyped. Institutional Review Board approval was received. Results. C and/or CC alleles of AGT Promoter and AGTR1 were significantly correlated with stroke and n-MSSI.. Findings are suggestive of role of AGT Promoter and AGTR1 genotypes in Fabry phenotypes.

Topics: Adolescent; Adult; Angiotensinogen; Brain Ischemia; Case-Control Studies; Fabry Disease; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Incidence; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Prevalence; Promoter Regions, Genetic; Receptor, Angiotensin, Type 1; Severity of Illness Index; Young Adult

2013