angiotensinogen and Anuria

angiotensinogen has been researched along with Anuria* in 2 studies

Other Studies

2 other study(ies) available for angiotensinogen and Anuria

ArticleYear
[Renal tubular dysgenesis and mutation in the renin gene].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007, Volume: 14, Issue:9

    Renal tubular dysgenesis is a severe and rare disorder of the renal development characterized by fetal anuria, oligohydramnios and early death from pulmonary hypoplasia and refractory arterial hypotension. We report on a female patient who presented with anuria in the neonatal period, requiring peritoneal dialysis until 5 months of age with unexpected diuresis recovery at 2 months of age. Clinical, histological and pathophysiological issues are discussed for this disease related to a mutation in the renin gene.

    Topics: Angiotensinogen; Anuria; Diuresis; Female; Humans; Infant; Kidney Tubules; Mutation; Recovery of Function; Renal Insufficiency; Renin

2007
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
    Nature genetics, 2005, Volume: 37, Issue:9

    Autosomal recessive renal tubular dysgenesis is a severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (Potter phenotype). Absence or paucity of differentiated proximal tubules is the histopathological hallmark of the disease and may be associated with skull ossification defects. We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1. We propose that renal lesions and early anuria result from chronic low perfusion pressure of the fetal kidney, a consequence of renin-angiotensin system inactivity. This is the first identification to our knowledge of a renal mendelian disorder linked to genetic defects in the renin-angiotensin system, highlighting the crucial role of the renin-angiotensin system in human kidney development.

    Topics: Adolescent; Angiotensinogen; Anuria; Family; Female; Genes, Recessive; Heterozygote; Homozygote; Humans; Infant, Newborn; Kidney Tubules; Male; Mutation; Peptidyl-Dipeptidase A; Pregnancy; Receptor, Angiotensin, Type 1; Renin

2005