angiotensin ii has been researched along with Cirrhosis in 983 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.10) | 18.7374 |
| 1990's | 59 (6.00) | 18.2507 |
| 2000's | 219 (22.28) | 29.6817 |
| 2010's | 486 (49.44) | 24.3611 |
| 2020's | 218 (22.18) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, H; Gao, F; Li, C; Wang, Y; Xue, K | 1 |
| Liu, A; Shang, Z; Zhang, Y | 1 |
| Can, J; Hao, S; Ning, Z; Qiang, X; Wu, Y | 1 |
| Cheng, C; Cheng, J; Hao, P; Sui, W; Wang, X; Xing, Y; Xue, F; Zhang, C; Zhang, J; Zhang, M; Zhang, Y | 1 |
| Billoff, S; Bode-Böger, SM; Bornstein, SR; Deussen, A; Jarzebska, N; Kolouschek, A; Kopaliani, I; Mangoni, AA; Martens-Lobenhoffer, J; Ragavan, VN; Rodionov, RN; Weiss, N | 1 |
| Chen, Y; Huang, D; Shao, W; Wang, S; Yao, L | 1 |
| Li, X; Li, Y; Liu, L; Liu, X; Shi, Q | 1 |
| Guo, X; Kong, X; Miao, J; Sun, W; Tu, J; Weng, L; Wu, T; Wu, X; Xu, T; Yang, C; Zhang, D; Zhang, J; Zhao, K; Zhou, B | 1 |
| Chen, W; Cong, C; Hu, Y; Tao, L; Wang, Y; Yuan, X | 1 |
| Chen, Y; He, D; Huang, M; Yan, Y | 1 |
| Deng, HY; Dong, ZC; Han, X; He, ZY; Li, HH; Zhang, YL | 1 |
| Cao, L; Chen, Y; Fan, J; Liu, Y; Lu, L; Yin, Y | 1 |
| Carletti, R; Castoldi, G; di Gioia, CRT; Ippolito, S; Pelucchi, S; Stella, A; Zatti, G; Zerbini, G | 1 |
| Chen, D; Cheng, Y; Gong, Y; Han, W; Liu, Z; Song, B; Zhang, R; Zhang, Z | 1 |
| Al-Hasani, J; Friede, PAP; Ghosh, S; Hecker, M; Nahar, T; Reil, JC; Sens-Albert, C; Trogisch, FA | 1 |
| Chen, Y; Dong, Z; Li, X; Liu, X; Liu, Y; Shi, H; Song, J; Tang, J; Xie, M; Zhang, M; Zhang, Z; Zhong, J | 1 |
| Chen, H; Qiao, H; Wei, F; Zhao, Q | 1 |
| Abderrahim, N; Adriani, W; Ahmed, F; Algarra, M; Amor, HB; Andreasi, V; Bailey, RL; Bettinardi, V; Bezzi, C; Bithe, SA; Boumnijel, I; Burr, SE; Cadmus, P; Calcaprina, B; Canevari, C; Catalfamo, B; Chen, J; Chen, X; Chen, Y; Clements, WH; Cornick, J; Cotton, SJ; De Cobelli, F; Djellabi, R; Falconi, M; Ghezzo, S; Gianolli, L; Guarnaccia, A; Guo, X; Hart, JD; Hasan, MM; Head-Gordon, M; Iwasaki, Y; Kalua, K; Kong, X; Laviola, G; Li, L; Li, M; Liu, M; Mao, Y; Mapelli, P; Meleke, H; Messina, A; Miller, WH; Muffatti, F; Neher, B; Palumbo, D; Partelli, S; Peláez, D; Pepe, M; Picchio, M; Presotto, L; Ranville, J; Samanes Gajate, AM; Samikwa, L; Schiavo Lena, M; Scifo, P; Shu, H; Soto, J; Sun, W; Talbot, JJ; Tu, J; Vaquer, F; Weng, L; Wu, J; Xu, T; Zhang, D; Zhao, B; Zhao, K; Zhao, Y | 1 |
| Chen, Y; Dong, Z; Guo, Y; Jin, H; Li, X; Liu, X; Liu, Y; Song, J; Wang, N; Xu, Y; Zhang, M; Zhang, Z; Zhong, J | 1 |
| Chai, SB; Han, L; Hou, YL; Jia, MZ; Lin, F; Liu, XY; Lu, WW; Ni, XQ; Qi, YF; Tang, CS; Wang, XJ; Yu, YR; Zhang, JS; Zhang, LS | 1 |
| Hu, G; Ji, M; Xu, Z; Zhang, M; Zuo, Z | 1 |
| Ning, Z; Song, X; Song, Z; Wu, J; Zhong, X | 1 |
| Chen, X; Gu, Y; Li, Y; Liu, Y; Zhang, S | 1 |
| Arjmand, MH; Ferns, GA; Khazaie, M; Shabanian, S | 1 |
| Bae, E; Han, SW; Kim, JE; Kim, YS; Lee, S; Moon, JJ; Park, DJ; Yang, SH; Yu, MY | 1 |
| Lin, L; Liu, A; Mei, Y; Xun, S; Zhang, Y; Zhou, G | 1 |
| Li, Y; Zhang, J; Zhang, S; Zou, F | 1 |
| Hua, D; Li, P; Li, Y; Mao, Y; Wu, X; Yong, Y; Zhao, K; Zhou, Z | 1 |
| Hu, J; Liu, Y; Wang, Q; Wang, W | 1 |
| Assa, C; Barrera, V; Bhetariya, P; Chen, J; Cheng, HS; Feinberg, MW; Jamaiyar, A; Khyrul Wara, A; Liu, Z; Mitchell, RN; Pandey, AK; Pérez-Cremades, D; Plutzky, J; Tzani, A; Zhang, B; Zhuang, R | 1 |
| Cantrell, AC; Chen, JX; He, X; Williams, QA; Zeng, H | 1 |
| Chen, H; Cheng, L; Maboh, RN; Mao, GW; Wang, H; Wu, XY | 1 |
| Ji, L; Liu, D; Liu, G; Liu, M; Ono, K; Wang, L; Wei, M; Yin, Y; Zhan, Y; Zheng, M; Zhou, X | 1 |
| Li, Y; Mao, B; Xu, F; Zhao, Y | 1 |
| Ji, Y; Kong, X; Li, L; Lu, Y; Qiu, M; Shen, Y; Shu, H; Sun, W; Tian, Y | 1 |
| Bai, Y; Chen, C; Gao, Z; Jiang, X; Meng, Y; Zhang, X; Zheng, C | 1 |
| Gan, L; Hu, X; Li, H; Li, X; Lu, Y; Meng, T; Peng, L; Tang, R; Wang, W; Xiao, C; Xiao, P; Zhou, Q | 1 |
| Idrees, M; Khalid, M; Manzoor, S | 1 |
| Han, X; Hao, H; Li, C; Li, W; Li, Y; Liang, C; Liu, HE; Liu, S; Liu, Y; Luo, Y; Pan, Z; Su, M; Sun, LI; Wei, Y; Yan, S; Yuan, Y; Zhang, R; Zhao, X | 1 |
| Bai, F; Banks, TE; Rajapaksha, M; Wang, NP; Zhang, LH; Zhao, ZQ | 1 |
| Han, X; Li, G; Liang, G; Liang, S; Long, X; Luo, W; Sun, J; Wang, M; Yu, T; Zhang, Y | 1 |
| Dong, R; Du, T; Ferrucci, L; Hu, X; Jin, Y; Liu, H; Pang, H; Sun, L; Tanaka, T; Tang, X; Tian, R; Tian, Z; Wang, H; Wang, L; Xiao, S; Xiao, Y; Yang, X; Ye, Y; Zhang, S; Zhang, Y | 1 |
| Chattipakorn, N; Chen, R; Chen, Y; Dai, C; Huang, W; Liang, G; Luo, W; Shen, S; Wang, J; Wang, Z | 1 |
| Chen, L; Liang, Q; Liu, M; Qian, L; Xu, H; Yan, J; Yang, G | 1 |
| An, Y; Cheng, L; Deng, B; Guo, X; Li, J; Wang, D; Xie, J; Yan, T; Yue, X; Zhang, B; Zhang, J | 1 |
| Guo, R; Li, C; Ma, X; Wang, J; Wang, Y; Zhang, J; Zhang, Q; Zheng, N | 1 |
| Cheng, G; Li, X; Liao, S; Lu, W; Wu, J; Zhu, H | 1 |
| Gaspari, TA; Hossain, MA; Samuel, CS; Tapia Cáceres, F | 1 |
| Ge, C; He, Y; Liang, Y; Zhao, Y | 1 |
| Chen, L; Guan, X; Khan, ZA; Li, X; Liang, G; Luo, W; Qian, J; Wang, Y; Xu, Z; Yang, D; Zhuang, Z | 1 |
| Cooper, STE; Haines, ZHR; Malone, GO; Meijles, DN; Sheppard, MN; Westaby, JD | 1 |
| Carvalho, FB; Fernandes, RS; Netto, MRT; Rigatto, K | 1 |
| Algara-Suarez, P; Amissi, S; Auger, C; Belcastro, E; Bruckert, C; Chaker, AB; Houngue, U; Jesel, L; Matsushita, K; Morel, O; Mroueh, A; Ohlmann, P; Park, SH; Remila, L; Schini-Kerth, VB | 1 |
| Betazza, MC; Cianciulli, TF; Fontana Estevez, FS; Gironacci, M; González, GE; Goren, N; Medina, V; Miksztowicz, V; Morales, C; Penas, F; Selser, C; Seropian, IM; Silva, MG; Touceda, V; Villaverde, A | 1 |
| Han, P; Jensen, DM; Kriegel, AJ; Liang, M; Liu, J; Lopez-Berestein, G; Mangala, LS; Sood, AK; Usa, K; Widlansky, ME | 1 |
| Juan, Z; Liu, J; Sun, Q; Sun, X; Wang, D; Wang, Q; Zhang, D; Zhang, R; Zhuang, B; Zou, G | 1 |
| Hada, Y; Uchida, HA; Umebayashi, R; Wada, J; Yoshida, M | 1 |
| Li, G; Liang, G; Liang, S; Luo, W; Sun, J; Wang, M; Yu, T; Zou, C | 1 |
| Asgharzadeh, F; Askarnia-Faal, MM; Avan, A; Daghiani, M; Hassanian, SM; Khazaei, M; Naimi, H; Nazari, SE; Sayyed-Hosseinian, SH; Vahedi, E | 1 |
| Ji, M; Li, Y; Liu, Y; Ma, G | 1 |
| Dong, Z; Guo, Y; Lu, J; Luo, Y; Wang, L; Wang, Z; Wu, G | 1 |
| Huang, C; Luo, H; Luo, Y; Wu, H; Zhang, Y | 1 |
| Chen, L; Li, Y; Liu, X; Wang, Y; Xing, Y; Zhang, G | 1 |
| Hu, X; Huang, W; Khan, ZA; Liang, G; Lin, K; Luo, W; Su, L; Wang, Y; Wu, G; Yang, N; Zhou, H | 1 |
| Apte, SS; Bhutada, S; Chen, J; DeAngelo, LP; Gojanovich, GS; Hara, A; Heckl, JR; Hokutan, K; Jahansooz, JR; Kuwabara, JT; Lee, AY; Shettigar, V; Tacdol, DK; Tallquist, MD; Ziolo, MT | 1 |
| Ding, Y; Gu, Y; Li, Y; Shang, Z; Zhang, X | 1 |
| Liang, G; Luo, W; Shan, P; Wang, M; Wang, Y; Wu, G; Xu, D; Yang, N; Zou, C | 1 |
| Chen, W; Han, L; Ji, H; Yu, L; Zhu, H | 1 |
| Abe, E; Azushima, K; Hirota, K; Suzuki, T; Taguchi, S; Takahashi, H; Tamura, K; Tanaka, S; Tsukamoto, S; Uehara, T; Urate, S; Wakui, H; Yamaji, T; Yamashita, A | 1 |
| Duan, Y; Gu, H; Jiang, M; Li, S; Wang, C; Wang, Q; Yin, S; Zhen, W | 1 |
| Dai, C; Huang, W; Li, W; Li, X; Liang, G; Luo, W; Shen, S; Wu, G | 1 |
| Chen, YH; Li, XT; Liang, LR; Liu, XY; Liu, Y; Miao, R; Song, JW; Zhang, MW; Zhang, ZZ; Zhong, JC | 1 |
| Briones, AM; Dalli, J; de Benito-Bueno, A; Díaz Del Campo, LS; Duro-Sánchez, S; García-Redondo, AB; Palmas, F; Peraza, DA; Rodrigues-Díez, R; Rodríguez, C; Salaices, M; Socuéllamos, PG; Valenzuela, C; Zaragoza, C | 1 |
| Du, C; He, MC; Poon, CC; Wang, NN; Wong, MS; Zhang, JL; Zhang, Y | 1 |
| Feng, N; Gao, W; Wang, Y; Xiao, H; Yu, H; Zhang, Y | 1 |
| Kong, Y; Li, L; Li, W; Lou, Q; Yang, W; Zhang, L; Zhang, W; Zhao, H | 1 |
| Cui, Y; Song, X; Zhu, T | 1 |
| Cicalese, SM; Coffman, TM; Eguchi, S; Hashimoto, T; Okuno, K; Preston, K; Rizzo, V; Sparks, MA; Torimoto, K | 1 |
| Aras, O; Brown, S; Campbell, A; Gardenier, J; Hespe, GE; Kataru, RP; Kuonqui, K; Li, C; Ly, C; Mehrara, BJ; Nores, GDG; Park, HJ; Sarker, A; Shin, J | 1 |
| Guo, SB; Han, X; Li, HH; Yin, WP; Zhang, YL; Zhao, YX | 1 |
| Fu, G; Gong, Y; Han, X; Huang, H; Huang, W; Liang, G; Long, X; Luo, W; Wang, Y; Wu, L; Ye, S; Ye, Y; Zhao, X | 1 |
| Kopkan, L; Kratky, V; Sykora, M; Szeiffova Bacova, B; Tribulova, N | 1 |
| Bayne, A; Blaney, J; Bouazza, C; Bourque, K; Clarke, PBS; Gora, S; Hébert, TE; Jones-Tabah, J; Khan, SM; Lau, J; MacKinnon, S; Martin, RD; Martins-Cannavino, K; Pétrin, D; Tanny, JC; Trempe, JF; Trieu, P; Zhang, A | 1 |
| Ouyang, J; Pi, D; Wang, R; Xi, T; Yang, J | 1 |
| Du, Z; Hao, Y; Li, W; Liang, Z; Liu, Y; Tao, Y; Wang, J; Yan, X; Yang, Y; Yu, J; Yuan, Y; Zhao, X | 1 |
| Ferder, L; García Menéndez, S; Inserra, F; Manucha, W; Mazzei, L; Sanz, RL | 1 |
| Chen, X; Chen, Y; Fan, S; Li, Z; Liang, G; Lin, Y; Su, X; Wang, X; Zhao, Y | 1 |
| Du, CX; Huang, CW; Ku, HC; Kuo, YH; Lee, SY | 1 |
| An, J; Bai, HM; He, SY; Li, CH; Li, J; Liu, MJ; Wang, PP; Wang, XP; Xia, ZQ; Zhang, W; Zhang, X; Zhou, JH | 1 |
| Chen, L; Han, W; Mou, Z; Zhu, X | 1 |
| Chen, B; Chen, X; Cui, C; Hall, DD; Hong, J; Huang, J; Li, D; Li, F; Lu, M; Pan, Z; Shi, L; Song, L; Song, LS; Wang, B; Wang, J; Wang, Y; Yang, K; Zhang, L; Zhao, S | 1 |
| Kokkonen-Simon, K; Kovacs, A; Li, T; Matkovich, SJ; Matsiukevich, D; Oladipupo, SS; Ornitz, DM | 1 |
| Chen, K; Fu, H; Ma, J; Song, W; Wang, X; Zang, X; Zhao, Y; Zhao, Z | 1 |
| Abeßer, M; Baba, HA; Denton, CP; Krebes, L; Kuhn, M; Michel, K; Möllmann, D; Potapenko, T; Prentki Santos, E; Schlattjan, M; Schmidt, H; Schrader, H; Schuh, K; Skryabin, BV; Špiranec Spes, K; Völker, K; Werner, F | 1 |
| Chen, L; Ge, F; Guo, J; He, Y; Hu, K; Jia, M; Jiang, L; Jin, J; Li, L; Li, Q; Lv, X; Ma, S; Meng, D; Osto, E; Wang, X; Wei, X; Wu, H; Wu, J; Yang, Z; Zhang, J; Zhi, X | 1 |
| Adamson, A; Ahmed, FZ; Binder, P; Butterworth, S; Cartwright, EJ; Fitzgerald, EM; Guan, K; Hille, SS; Liu, W; Luo, X; Müller, OJ; Nguyen, BY; Wang, X; Zhang, H; Zhou, F; Zi, M | 1 |
| Chen, J; Fu, G; Han, X; Huang, H; Huang, W; Lai, D; Liang, G; Luo, W; Shi, F; Wang, Y; Xiao, Y; Ye, S; Ye, Y; Zhao, X | 1 |
| Cai, L; Chen, S; Chen, X; Ding, Y; Li, J; Li, X; Li, Y; Liu, S; Lu, X; Wei, Y; Wu, X; Xu, J; Zhou, G | 1 |
| Bizé, A; Boucher, P; Brehat, J; Chiaroni, PM; Corboz, D; Dai, J; de Pommereau, A; Denormandie, P; Gallet, R; Germain, S; Ghaleh, B; Lacampagne, A; Marbán, E; Mouri, N; Pallot, G; Panel, M; Sambin, L; Su, JB; Teiger, E; Thery, G | 1 |
| Li, L; Lu, Z; Yang, J; Zheng, X; Zhou, H | 1 |
| Carletti, R; Castoldi, G; Colzani, M; di Gioia, CRT; Ippolito, S; Pelucchi, S; Perseghin, G; Zatti, G; Zerbini, G | 1 |
| Gan, PXL; Liao, W; Linke, KM; Mei, D; Wong, WSF; Wu, XD | 1 |
| Cho, S; Jeong, D; Lee, C | 1 |
| Alcalai, R; Arad, M; Guetta, T; Hochhauser, E; Kornowski, R; Ofek, E; Petrover, Z; Seidman, CE; Seidman, J; Yadin, D | 1 |
| Chen, X; Dai, J; Fang, R; Feng, M; Shen, C; Shu, T; Wang, J; Wang, S; Wu, N | 1 |
| Cai, X; Li, M; Liang, Z; Yang, W; Zhong, Y | 1 |
| Bourke, JE; Widdop, RE; Young, ON | 1 |
| Chen, L; He, Z; Huang, Y; Li, Y; Lu, F; Lyu, F; Lyu, X; Mo, Q; Qin, Q; Xu, H | 1 |
| Cao, W; Chen, L; Fang, G; Gu, Y; Li, Y; Liu, L; Mo, B; Song, S; Wan, Y; Wang, Q; Wang, Y; Yu, Y; Zhang, R | 1 |
| Aubdool, A; Baliga, RS; Bedi, KC; D'Amico, G; Dukinfield, M; Hobbs, A; Hodivala-Dilke, K; Maiques, O; Maniati, E; Margulies, KB; Reynolds, LE; Sanz-Moreno, V; Wang, J | 1 |
| Changying, Z; Min, Z; Yangchun, L; Yuquan, W | 1 |
| Hao, L; Li, X; Lyu, H; Wu, Q | 1 |
| Atala, A | 1 |
| Cui, X; Ding, DZ; Guan, CM; Jia, YN; Li, X; Zhang, B; Zhou, S | 1 |
| Chiasson, V; Guleria, RS; Gupta, S; Takano, APC | 1 |
| Che, H; Ge, S; Gong, W; Guo, Z; Shen, Z; Shi, Y; Sun, F; Zhang, C | 1 |
| Cha, RH; Choi, JW; Han, SS; Kim, DK; Kim, JE; Kim, YC; Kim, YS; Lee, H; Lee, JP; Lee, JW; Lee, S; Yang, SH; Yu, MY | 1 |
| Huang, H; Liu, YM; Lv, YG; Wu, RD; Xu, JQ; Zhu, W | 1 |
| Gu, L; Li, Y; Shi, H; Sun, J; Wang, H; Wang, L; Wang, Q; Wang, S; Wang, Z; Wei, T | 1 |
| Bishop, E; Bordas, M; Chowdhury, SR; Cossette, SM; Gupta, A; Harmann, LM; Kumar, SN; Lu, Q; Pan, AY; Ramchandran, R; Simpson, PM; Sonin, DL; Spearman, AD; Strande, JL; Thirugnanam, K; Zou, MH | 1 |
| Bai, F; Bose, HS; James, EA; Sturdivant, K; Wang, NP; Zhang, WW; Zhao, ZQ; Zheng, RH | 1 |
| Hill, JA | 1 |
| Furgeson, SB; Jolly, AJ; Lu, S; Moulton, KS; Mutryn, MF; Nemenoff, RA; Strand, KA; Tucker, RM; Weiser-Evans, MCM | 1 |
| Dang, Z; Ge, R; Jin, G; Li, Z; Lu, D; Ma, L; Nan, X; Su, S | 1 |
| Barzaghi, F; Carletti, R; Castoldi, G; Colzani, M; di Gioia, CRT; Ippolito, S; Perseghin, G; Stella, A; Zerbini, G | 1 |
| Abraham, NG; Arad, M; Aravot, D; Arow, M; Freimark, D; Hochhauser, E; Kornowski, R; Nudelman, V; Shainberg, A; Waldman, M; Yadin, D | 1 |
| Ahmed, MS; Attramadal, H; Aukrust, P; Holt, MF; Lien, E; Louwe, MC; Mollnes, TE; Nilsson, PH; Schjalm, C; Shahini, N; Yndestad, A; Øgaard, JDS | 1 |
| Chen, Y; Ge, Z; Wang, B; Xie, Y; Yan, Y; Zhang, X; Zhang, Y; Zhou, L | 1 |
| Alonso, J; Ballester-Servera, C; Cañes, L; Galán, M; Herraiz-Martínez, A; Hove-Madsen, L; Martí-Pàmies, I; Martínez-González, J; Muniesa, P; Nistal, JF; Osada, J; Rodríguez, C | 1 |
| Guo, D; Liu, H; Zhao, Z | 1 |
| Song, W; Su, L; Yao, Y | 1 |
| Chen, P; Cheng, Q; Huo, C; Li, J; Liu, J; Lu, L; Miao, N; Ni, J; Xie, H; Xu, D; Yin, F; Yu, C; Zhang, W; Zhang, Y; Zheng, P; Zhou, L; Zhou, Z | 1 |
| Aono, T; Arimoto, T; Goto, J; Kato, S; Kutsuzawa, D; Narumi, T; Nishiyama, S; Otaki, Y; Shishido, T; Sugai, T; Takahashi, H; Takahashi, T; Tamura, H; Toshima, T; Wanezaki, M; Watanabe, K; Watanabe, M; Watanabe, T | 1 |
| Jurado Acosta, A; Moilanen, AM; Ruskoaho, H; Rysä, J; Serpi, R; Szabo, Z | 1 |
| Gotoh, T; Hoshizaki, M; Imai, Y; Inagaki, T; Koyota, S; Kuba, K; Minato, T; Motoyama, S; Nakahara, K; Nakaoka, Y; Natsui, M; Nirasawa, S; Ozawa, R; Penninger, JM; Sato, T; Takahashi, S; Watanabe, H; Yamaguchi, T; Yokota, S; Yoshihashi, T; Yoshiya, T; Yoshizawa-Kumagaye, K | 1 |
| Chen, W; Wang, Y; Zhang, Y | 1 |
| Jiang, C; Lu, Y; Zhang, S | 1 |
| Cui, H; Li, G; Li, X; Lv, J; Ye, F; Zhong, L; Zhu, Y | 1 |
| He, X; Ou, C | 1 |
| Guo, H; Lu, T; Wang, C; Wang, H; Xing, D; Yang, J; Zhong, S | 1 |
| Cao, W; Chen, Y; Ge, Z; Hu, Q; Huang, S; Li, Y; Weng, Y; Zhai, C; Zhou, L | 1 |
| Deng, M; Ji, Y; Kong, X; Lu, Y; Qiu, M; Sheng, Y; Sun, W; Yang, S | 1 |
| Cicogna, AC; Corrêa, CR; da Silva-Bertani, DCT; de Oliveira, EM; de Souza, SLB; de Tomasi, LC; Fernandes, T; Freire, PP; Mota, GAF; Padovani, CR; Sant'Ana, PG; Vileigas, DF | 1 |
| Fukushima, A; Furihata, T; Kakutani, N; Kinugawa, S; Matsumoto, J; Nambu, H; Takada, S; Yokota, T | 1 |
| An, X; Tan, A; Wang, L; Xia, Y; Xie, Y | 1 |
| Han, F; Jin, D | 1 |
| An, C; Hu, Z; Mitch, WE; Wang, Y; Wen, J | 1 |
| Chen, Y; Du, J; Jia, MZ; Liu, Y; Ning, ZP; Qi, YF; Ren, JL; Tang, CS; Yu, YR; Zhang, LS; Zhang, YR | 1 |
| Cong, W; Dong, E; Feng, Y; Hu, G; Li, M; Song, Y; Wang, S; Xiao, H; Zhang, Y | 1 |
| Ding, Y; Fu, X; Liu, F; Lou, Y; Wen, H; Yang, L; Yang, Q; Zhang, J; Zhang, L | 1 |
| Adami, E; Chen, X; Cook, SA; Corden, B; Ko, NSJ; Lim, WW; Schafer, S; Song, W; Su, L; Tee, NGZ | 1 |
| Bumdelger, B; Ishida, M; Karasaki, K; Kokubo, H; Otani, M; Sakai, C; Yoshizumi, M | 1 |
| Hayashi, H; Morishita, R; Nakagami, H; Nakamaru, R; Rakugi, H; Shimamura, M; Sun, J; Tenma, A; Yamamoto, K | 1 |
| Bao, Y; Dai, Y; Jia, K; Jin, Q; Li, X; Liu, A; Lu, L; Wu, L | 1 |
| Abe, I; Arakane, M; Daa, T; Ishii, Y; Kira, S; Kondo, H; Miyoshi, M; Nakagawa, M; Oniki, T; Takahashi, N; Teshima, Y; Yufu, K; Zhan, Y | 1 |
| Guo, J; Kong, X; Li, Z; Xu, Y; Yu, L; Zhang, Y | 1 |
| Kong, X; Li, P; Liu, C; Shen, Y; Wu, X; Yang, C | 1 |
| Chen, JX; He, X; Liu, B; Zeng, H; Zhao, Y | 1 |
| Dong, Z; Ge, J; Hu, K; Li, W; Sun, A; Sun, X; Wu, J; Yin, L | 1 |
| Chen, F; Geng, J; Li, X; Xie, J; Xu, B; Zhao, J | 1 |
| Baker, AH; Borthwick, G; Boswell, L; Dweck, MR; Gray, GA; Jansen, MA; Kwiecinski, J; Lennen, RJ; Newby, DE | 1 |
| Chen, Z; He, X; Liu, X; Lu, Y; Miao, R; Wang, J | 1 |
| Bi, XY; Ding, YQ; Wang, PX; Ye, JT; Yu, YH; Yuan, J; Zhang, LL; Zhang, YH; Zhou, H | 1 |
| Boogerd, CJ; de Boer, RA; Dokter, MM; Lam, CSP; Markousis-Mavrogenis, G; Meems, LMG; Schouten, EM; Silljé, HHW; Voors, AA; Westenbrink, BD; Withaar, C | 1 |
| Cui, J; Lin, Y; Liu, J | 1 |
| Cha, TJ; Choi, EK; Hajjar, RJ; Jang, SP; Jeong, D; Kook, H; Kwak, TH; Lee, M; Lee, MA; Park, WJ; Raad, N; Song, MH; Yoo, J | 1 |
| Li, Y; Liu, L; Ruan, Z; Wang, G; Wang, R; Zhu, L | 1 |
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| Ratajska, A; Sun, Y; Weber, KT | 1 |
| Appay, MD; Bariety, J; Heudes, D; Hinglais, N; Michel, JB; Nicoletti, A; Philippe, M; Sassy-Prigent, C | 1 |
| Ishidoya, S; Klahr, S; Morrissey, J | 1 |
| Fogo, A; Hunley, TE; Kon, V | 1 |
| Janicki, JS; Reddy, HK; Sigusch, H; Tyagi, SC; Weber, KT; Zhou, G | 1 |
| Cleutjens, JP; Katwa, LC; Sun, Y; Weber, KT; Zhou, G | 1 |
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| Alpers, CE; Clozel, JP; Eng, E; Fingerle, J; Floege, J; Johnson, RJ; Menard, J; Veniant, M | 1 |
| Ratajska, A; Sun, Y; Weber, KT; Zhou, G | 1 |
| Fukunami, M; Hori, M; Houki, N; Sato, H | 1 |
| Battle, T; Bunkenburg, B; Heudes, D; Ménard, J; Schnell, C; Wood, JM | 1 |
| Brilla, CG; Matsubara, LS; Weber, KT | 2 |
| Campbell, SE; Janicki, JS; Weber, KT | 1 |
| Campbell, SE; Sigusch, HH; Weber, KT | 1 |
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| Ganjam, VK; Ou, R; Sun, Y; Weber, KT | 1 |
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| Fogo, A; Freeman, M; Lo, W; Oikawa, T; Vaughan, DE | 1 |
| De Carvalho Frimm, C; Sun, Y; Weber, KT | 1 |
| Noble, NA; Peters, H | 1 |
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| Fukuda, R; Imura, Y; Matsuo, T; Nagano, H; Nishikawa, K; Noda, M; Ohta, M; Shibouta, Y | 1 |
| Akagi, Y; Ando, A; Hori, M; Horio, M; Imai, E; Kawada, N; Moriyama, T; Nagata, K; Yamauchi, A | 1 |
| Egido, J; Ruiz-Ortega, M | 1 |
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| Aupetit-Faisant, B; Carayon, A; Delcayre, C; Heymes, C; Oubénaïssa, A; Robert, V; Silvestre, JS; Swynghedauw, B | 1 |
| Cerullo, G; Colucci, M; Gesualdo, L; Grandaliano, G; Monno, R; Ranieri, E; Rossiello, MR; Schena, FP; Semeraro, N; Ursi, M | 1 |
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| Guo, G; Klahr, S; McCracken, R; Morrissey, J; Tolley, T | 1 |
| Al-Nimri, MA; Anderson, S; Chapman, JG; Kelly, FJ; Kennefick, TM; Oyama, TT; Thompson, MM | 1 |
| Joshi, I; Pardo, A; Ramos, C; Selman, M; Uhal, BD; Wang, R; Zagariya, A | 1 |
| Ang, E; Ibarra-Sunga, O; Uhal, BD; Wang, R; Zagariya, A | 1 |
| Capogrossi, MC; Emanueli, C; Madeddu, P; Maestri, R; Minasi, A; Olivetti, G; Salis, MB | 1 |
| Barr, M; Do, YS; Hsueh, WA; Kawano, H; Kawano, Y; Law, RE; Starnes, V | 1 |
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| Doyle, S; Kurtzberg, L; Ledbetter, S; Pratt, BM | 1 |
| Basso, N; González Bosc, L; Kurnjek, ML; Müller, A | 1 |
| Cowley, AW; Dickhout, JG; Dumas, P; Greene, AS; Jacob, HJ; Kaldunski, ML; Roman, RJ | 1 |
| Pathak, M; Sarkar, S; Sen, S; Vellaichamy, E | 1 |
| Carretero, OA; Harding, P; LaPointe, MC; Peng, H; Rhaleb, NE; Tayeh, M | 1 |
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| Egido, J; Mezzano, SA; Ruiz-Ortega, M | 1 |
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| Border, WA; Gaedeke, J; Noble, NA; Peters, H | 1 |
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| Egido, J; Esteban, V; Lorenzo, O; Mezzano, S; Plaza, JJ; Ruiz-Ortega, M; Rupérez, M; Suzuki, Y | 1 |
| Huang, X; Li, D; Lu, H; Wang, Z; Wei, H; Zhan, Y | 1 |
| Fujihara, CK; Noronha, IL; Zatz, R | 1 |
| Griffiths, NM; Naftalin, RJ; Pedley, KC; Thiagarajah, JR | 1 |
| Border, WA; Noble, NA; Yu, L | 1 |
| Aoki, M; Hashiya, N; Hiraoka, K; Kaneda, Y; Matsumoto, K; Morishita, R; Nakamura, T; Ogihara, T; Taniyama, Y; Yamasaki, K | 1 |
| Brilla, CG; Weber, KT | 1 |
| Brilla, CG; Janicki, JS; Pick, R; Tan, LB; Weber, KT | 1 |
| Jalil, JE; Janicki, JS; Pick, R; Tan, LB; Weber, KT | 1 |
| Emoto, R; Fukuzaki, H; Kubo, M; Kurozumi, H; Maehashi, N; Masuda, J; Miki, T; Nakanishi, O; Takarada, A; Yokota, Y | 1 |
86 review(s) available for angiotensin ii and Cirrhosis
| Article | Year |
|---|---|
Local renin-angiotensin system molecular mechanisms in intrauterine adhesions formation following gynecological operations, new strategy for novel treatment.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cicatrix; Female; Fibrosis; Gynecologic Surgical Procedures; Humans; Hypoxia; Renin; Renin-Angiotensin System; Tissue Adhesions; Transforming Growth Factor beta1; Uterine Diseases | 2022 |
Alamandine: A promising treatment for fibrosis.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Antioxidants; Collagen; COVID-19 Drug Treatment; Fibrosis; Humans; Mice; Oligopeptides; Peptidyl-Dipeptidase A; Rats; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Vasodilator Agents | 2022 |
Metabolic Syndrome and Cardiac Remodeling Due to Mitochondrial Oxidative Stress Involving Gliflozins and Sirtuins.
Topics: Angiotensin II; Cardiovascular Diseases; Diabetes Mellitus; Fibrosis; Humans; Hypertension; Metabolic Syndrome; Oxidative Stress; Sirtuins; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Remodeling | 2023 |
Catch your breath: The protective role of the angiotensin AT
Topics: Angiotensin II; Fibroblasts; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Lung; Receptors, Angiotensin | 2023 |
Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Atrial Fibrillation; Blood Coagulation; Capillary Permeability; Cardiomyopathies; COVID-19; Cytokine Release Syndrome; Cytokines; Endothelium, Vascular; Fibroblasts; Fibrosis; Humans; Liver Cirrhosis; Myocarditis; Receptors, Coronavirus; Renin-Angiotensin System; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Thrombosis; Virus Internalization | 2020 |
RAS inhibition in resident fibroblast biology.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Epigenesis, Genetic; Fibroblasts; Fibrosis; Humans; Renin-Angiotensin System; Signal Transduction; Transforming Growth Factor beta | 2021 |
Renin angiotensin system in liver diseases: Friend or foe?
Topics: Angiotensin II; Animals; Cell Proliferation; Fibrosis; Hemodynamics; Hepatorenal Syndrome; Humans; Inflammation; Liver; Liver Cirrhosis; Liver Diseases; Mice; Peptidyl-Dipeptidase A; Renin-Angiotensin System | 2017 |
Angiotensin-converting enzyme 2 and renal disease.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Diabetes Mellitus; Fibrosis; Humans; Inflammation; Kidney; Kidney Diseases; Peptidyl-Dipeptidase A; Renin-Angiotensin System | 2018 |
Retarding progression of chronic kidney disease: use of modalities that counter acid retention.
Topics: Acid-Base Imbalance; Aldosterone; Angiotensin II; Animals; Buffers; Citrates; Dietary Proteins; Disease Progression; Endothelins; Fibrosis; Fruit; Humans; Kidney; Renal Insufficiency, Chronic; Sodium Bicarbonate; Sodium Citrate; Vegetables | 2018 |
Angiotensin peptides in the non-gravid uterus: Paracrine actions beyond circulation.
Topics: Angiotensin II; Animals; Cell Transdifferentiation; Endometrium; Female; Fibrosis; Humans; Myofibroblasts; Paracrine Communication; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2018 |
Molecular and Cellular Mechanisms of Atrial Fibrosis in Atrial Fibrillation.
Topics: Angiotensin II; Atrial Fibrillation; Collagen; Connective Tissue Growth Factor; Extracellular Matrix; Fibroblasts; Fibrosis; Heart Atria; Humans; Ion Channels; MicroRNAs; Myocytes, Cardiac; Platelet-Derived Growth Factor; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
Muscle wasting: A review of exercise, classical and non-classical RAS axes.
Topics: Angiotensin I; Angiotensin II; Apoptosis; Exercise; Fibrosis; Humans; Mitochondria; Muscle, Skeletal; Muscular Atrophy; NADPH Oxidases; Peptide Fragments; Protein Biosynthesis; Reactive Oxygen Species; Renin-Angiotensin System; Ubiquitin-Protein Ligases | 2019 |
The Key Role of Epithelial to Mesenchymal Transition (EMT) in Hypertensive Kidney Disease.
Topics: Angiotensin II; Animals; Biomarkers; Disease Susceptibility; Endothelins; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Hypertension; Hypertension, Renal; Nephritis | 2019 |
Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease.
Topics: Aging; Aldosterone; Angiotensin II; Animals; Atherosclerosis; Blood Pressure; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Carotid Arteries; Fibrosis; Gene Expression Regulation; Humans; Hypertension; Mice; Muscle, Smooth, Vascular; Placenta Growth Factor; Pregnancy Proteins; Receptors, Mineralocorticoid; Signal Transduction | 2013 |
Aldosterone mediates cardiac fibrosis in the setting of hypertension.
Topics: Aldosterone; Angiotensin II; Animals; Cytochrome P-450 CYP11B2; Fibrosis; Heart Diseases; Humans; Hypertension | 2013 |
Myofibroblasts: trust your heart and let fate decide.
Topics: Actins; Angiotensin II; Cell Differentiation; Endothelin-1; Extracellular Matrix; Fibrosis; Gene Expression Regulation; Heart; Humans; Mechanotransduction, Cellular; Mitogen-Activated Protein Kinases; Myofibroblasts; Serum Response Factor; Transforming Growth Factor beta | 2014 |
Molecular mechanism of aggravation of hypertensive organ damages by short-term blood pressure variability.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Disease Models, Animal; Fibrosis; Humans; Hypertension; Myocarditis; Myocardium; Rats; Receptors, Mineralocorticoid; Renin-Angiotensin System; Risk Factors; Signal Transduction; Time Factors; Ventricular Dysfunction | 2014 |
Getting to the heart of the matter: new insights into cardiac fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Arrhythmias, Cardiac; Atrophy; Cicatrix; Connective Tissue Growth Factor; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Humans; Hypoxia; Models, Cardiovascular; Molecular Targeted Therapy; Myocardium; Myofibroblasts; Platelet-Derived Growth Factor; Pyridones; Rats; Signal Transduction; Transforming Growth Factor beta | 2015 |
Integrins and integrin-related proteins in cardiac fibrosis.
Topics: Age Factors; Aging; Angiotensin II; Animals; Blood Pressure; Carrier Proteins; Cytokines; Diabetic Cardiomyopathies; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Integrins; Molecular Targeted Therapy; Myocardial Infarction; Myocardium; Protein Binding; Stress, Mechanical | 2016 |
Myofibroblast secretome and its auto-/paracrine signaling.
Topics: Angiotensin II; Collagen; Fibroblasts; Fibrosis; Humans; Myofibroblasts; Paracrine Communication; Wound Healing | 2016 |
Vascular Fibrosis in Aging and Hypertension: Molecular Mechanisms and Clinical Implications.
Topics: Aging; Angiotensin II; Endothelin-1; Endothelium, Vascular; Fibrosis; Humans; Hypertension; Matrix Metalloproteinases; Risk Factors; Smad Proteins; Transforming Growth Factor beta1; Vascular Stiffness | 2016 |
Molecular mechanisms of atrial fibrosis: implications for the clinic.
Topics: Angiotensin II; Atrial Fibrillation; Fibrosis; Heart Atria; Humans; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
Myocardial repair/remodelling following infarction: roles of local factors.
Topics: Angiotensin II; Animals; Cell Death; Fibrosis; Heart Failure; Humans; Inflammation; Myocardial Infarction; Myocardium; Oxidative Stress; Prognosis; Reactive Oxygen Species; Signal Transduction; Ventricular Remodeling | 2009 |
Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy.
Topics: 14-3-3 Proteins; Angiotensin II; Animals; Apoptosis; Cardiomegaly; Cardiomyopathies; Diabetes Complications; Fibrosis; Humans; Myocardium; Oxidative Stress; Signal Transduction | 2009 |
Large blood pressure variability and hypertensive cardiac remodeling--role of cardiac inflammation.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Fibrosis; Humans; Hypertension; Macrophages; Myocarditis; Myocardium; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Sympathectomy; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2009 |
The role of inflammatory and fibrogenic pathways in heart failure associated with aging.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Angiotensin II; Fibroblasts; Fibrosis; Heart Failure, Diastolic; Humans; Inflammation; Muscle Cells; Phagocytes; Reactive Oxygen Species; Risk Factors; Transforming Growth Factor beta; United States; Ventricular Remodeling | 2010 |
Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation.
Topics: Angiotensin II; Animals; Cardiovascular Agents; Connective Tissue Growth Factor; Drug Design; Endothelin-1; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Heart Diseases; Humans; Myocardium; Platelet-Derived Growth Factor; Signal Transduction; Transforming Growth Factor beta | 2010 |
Stimulation of reactive oxygen species and collagen synthesis by angiotensin II in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Collagen; Fibroblasts; Fibrosis; Free Radical Scavengers; Heart Diseases; Humans; Hypertension; Myocardium; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species; Superoxides | 2012 |
Targets of chymase inhibitors.
Topics: Angiotensin II; Animals; Cardiovascular Diseases; Chymases; Digestive System Diseases; Enzyme Inhibitors; Fibrosis; Humans; Intestinal Diseases; Matrix Metalloproteinase 9; Molecular Targeted Therapy; Transforming Growth Factor beta | 2011 |
This is not Dr. Conn's aldosterone anymore.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cytochrome P-450 CYP11B2; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; Humans; Hyperaldosteronism; Inflammation Mediators; Kidney; Ligands; Mice; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Receptors, Mineralocorticoid; Signal Transduction; Time Factors | 2011 |
Renal oxidative stress, oxygenation, and hypertension.
Topics: Angiotensin II; Animals; Antioxidants; Disease Progression; Fibrosis; Humans; Hypertension; Hypoxia; Kidney; Kidney Diseases; Oxidative Stress; Oxygen; Oxygen Consumption; Reactive Oxygen Species | 2011 |
NADPH oxidases in heart failure: poachers or gamekeepers?
Topics: Aldosterone; Angiotensin II; Animals; Apoptosis; Arrhythmias, Cardiac; Enzyme Activation; Fibroblasts; Fibrosis; Heart Failure; Humans; Hydrogen Peroxide; Hypertrophy, Left Ventricular; Leukocytes; Membrane Glycoproteins; Mice; Models, Cardiovascular; Molecular Targeted Therapy; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Neovascularization, Pathologic; Oxidative Stress; Protein Isoforms; Reactive Oxygen Species; Subcellular Fractions | 2013 |
Vascular actions of aldosterone.
Topics: Adipocytes; Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Blood Vessels; Cardiovascular Diseases; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Fibrosis; Gene Expression Regulation; Humans; Hypertension; Hypertrophy; Metabolic Syndrome; Mineralocorticoid Receptor Antagonists; Mineralocorticoids; Muscle, Smooth, Vascular; Oxidative Stress; Receptor, Endothelin A; Receptors, Mineralocorticoid; Renin-Angiotensin System; Signal Transduction; Sodium; Vasculitis; Vasoconstriction | 2013 |
Androgen modulates cardiac fibrosis contributing to gender differences on heart failure.
Topics: Androgens; Angiotensin II; Female; Fibrosis; Heart Failure; Humans; Male; Myocardium; Oxidative Stress; Sex Factors; Taiwan; Transforming Growth Factor beta; Young Adult | 2013 |
Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Cardiomegaly; Fibrosis; Heart; Hypertension; Mice; Mice, Knockout; Mice, Transgenic; Models, Biological; Myocardial Infarction; Myocardium; Organ Specificity; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Stress, Mechanical; Ventricular Remodeling | 2002 |
Regulation of myocardial fibrillar collagen by angiotensin II. A role in hypertensive heart disease?
Topics: Angiotensin II; Antihypertensive Agents; Fibrillar Collagens; Fibrosis; Humans; Hypertension; Myocardium | 2002 |
Molecular mechanisms of angiotensin II-induced vascular injury.
Topics: Angiotensin II; Animals; Arteries; Cell Division; Extracellular Matrix; Fibrosis; Growth Substances; Humans; Inflammation Mediators; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; NF-kappa B; Signal Transduction | 2003 |
The role of angiotensin II in regulating vascular structural and functional changes in hypertension.
Topics: Angiotensin II; Animals; Apoptosis; Arteries; Cell Division; Fibrosis; Humans; Hypertension; Inflammation; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; Oxidation-Reduction; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vascular Resistance; Vasomotor System | 2003 |
[Vasoactive peptides and the development of renal sclerosis: contribution of transgenes].
Topics: Angiotensin II; Animals; Collagen Type II; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Fibrosis; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Humans; Kidney; Luciferases; MAP Kinase Signaling System; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Renin-Angiotensin System; Sclerosis; Transforming Growth Factor beta; Transgenes | 2002 |
[Pathophysiology and clinical implication of obstructive nephropathy].
Topics: Angiotensin II; Animals; Fibrosis; Humans; Hydronephrosis; Kidney Diseases; Kidney Tubules; Mice; Rats; Receptors, Angiotensin; Renal Circulation; Renin-Angiotensin System; Ureteral Obstruction | 2003 |
Fibrosis in hypertensive heart disease: role of the renin-angiotensin-aldosterone system.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Collagen; Fibrosis; Humans; Hypertension; Renin-Angiotensin System | 2004 |
The role of angiotensin II in kidney embryogenesis and kidney abnormalities.
Topics: Angiotensin II; Animals; Fibrosis; Hematopoiesis; Humans; Kidney; Nephrons; Renal Circulation | 2004 |
[Renin-angiotensin system and vascular remodelling].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Arteriosclerosis; Blood Pressure; Blood Vessels; Fibrosis; Humans; Hypertension, Renovascular; Hypertrophy; Inflammation; Models, Biological; NADPH Oxidases; Reactive Oxygen Species; Receptors, Angiotensin; Renin-Angiotensin System; Transforming Growth Factor beta | 2004 |
[Involvement of Aldosterone and mineralocorticoid receptor in pathogenesis of cardiovascular diseases].
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Angiotensin II; Cardiovascular Diseases; Fibrosis; Humans; Hydrocortisone; Mineralocorticoid Receptor Antagonists; Myocardium; Plasminogen Activator Inhibitor 1; Receptor, Angiotensin, Type 1; Receptors, Mineralocorticoid; Spironolactone | 2004 |
Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomyopathies; Fibrosis; Humans; Mice; Mice, Transgenic; Receptors, Mineralocorticoid; Renin-Angiotensin System; Sodium Chloride, Dietary; Sodium-Hydrogen Exchangers; Vasculitis | 2004 |
Heart failure: how important is cellular sequestration? The role of the renin-angiotensin-aldosterone system.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Arrhythmias, Cardiac; Cardiac Output, Low; Cell Communication; Fibroblasts; Fibrosis; Humans; Renin-Angiotensin System; Signal Transduction; Sympathetic Nervous System | 2004 |
Mediators of fibrosis and apoptosis in obstructive uropathies.
Topics: Angiotensin II; Apoptosis; Biomarkers; Female; Fibrosis; Humans; Kidney Diseases; Male; Prognosis; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Ureteral Obstruction | 2005 |
[Pulmonary fibrosis and apoptosis].
Topics: Angiotensin II; Animals; Apoptosis; Caspases; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Endothelial Cells; Epithelial Cells; Fas Ligand Protein; Fibroblasts; Fibrosis; Humans; Lung; Membrane Glycoproteins; Pulmonary Fibrosis; Reactive Oxygen Species; Regeneration; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2005 |
Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes.
Topics: Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fibrosis; Humans; Hyperglycemia; Hypoglycemia; Islets of Langerhans; Pancreas; Peptidyl-Dipeptidase A; PPAR gamma; Receptors, Angiotensin; Renin; Renin-Angiotensin System | 2006 |
Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases.
Topics: Angiotensin II; Cytokines; Female; Fibrosis; Humans; Inflammation Mediators; Kidney Diseases; Kidney Function Tests; Male; NF-kappa B; Prognosis; Receptor, Angiotensin, Type 2; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Signal Transduction | 2006 |
Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Fibrosis; Glomerulosclerosis, Focal Segmental; Hypertension; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Diseases; Microcirculation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Vasoconstrictor Agents | 2006 |
Pharmacological management of renal fibrotic disease.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Calcium Channel Blockers; Disease Progression; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fibrosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Diseases; Practice Guidelines as Topic; Protein Kinase Inhibitors; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Transforming Growth Factor beta | 2006 |
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.
Topics: Angiogenesis Inhibitors; Angiotensin II; Animals; Aortic Aneurysm; Chymases; Fibrosis; Heart Diseases; Humans; Hypertension; Mast Cells; Myocardial Infarction; Neovascularization, Pathologic; Serine Proteinase Inhibitors | 2006 |
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.
Topics: Angiotensin II; Cell Proliferation; Chronic Disease; Embryonic Stem Cells; Fibroblasts; Fibrosis; Humans; Infections; Neovascularization, Pathologic; Transforming Growth Factor beta1; Wound Healing | 2007 |
Reversal of renal disease: is it enough to inhibit the action of angiotensin II?
Topics: Angiotensin II; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Extracellular Matrix Proteins; Fibrosis; Hepatocyte Growth Factor; Humans; Kidney; Kidney Diseases; Kidney Glomerulus; Transforming Growth Factor beta | 2007 |
[Cardiac fibrosis].
Topics: Angiotensin II; Fibroblasts; Fibrosis; Humans; Myocardium; Transforming Growth Factor beta | 2007 |
Cellular and molecular mechanisms of fibrosis.
Topics: Angiotensin II; Chemokines; Chemotaxis; Cytokines; Disease Progression; Fibroblasts; Fibrosis; Humans; Immunity, Innate; Interleukins; Th1 Cells; Th2 Cells; Transforming Growth Factor beta | 2008 |
The intracellular renin-angiotensin system: implications in cardiovascular remodeling.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiovascular Agents; Extracellular Fluid; Fibrosis; Humans; Intracellular Fluid; Myocardium; Renin-Angiotensin System; Signal Transduction; Ventricular Remodeling | 2008 |
Targeting tissue angiotensin-converting enzyme for imaging cardiopulmonary fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antibiotics, Antineoplastic; Bleomycin; Carboxypeptidases; Chymases; Fibrosis; Gene Expression Regulation, Enzymologic; Heart; Humans; Molecular Diagnostic Techniques; Myocardium; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Pulmonary Fibrosis; Renin-Angiotensin System | 2008 |
Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Collagen; Enalapril; Extracellular Matrix Proteins; Fibrosis; Kidney; Kidney Diseases; Kidney Tubules; Macrophages; Monocytes; Rats; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta; Triazoles; Ureteral Obstruction | 1995 |
Connective tissue and repair in the heart. Potential regulatory mechanisms.
Topics: Angiotensin I; Angiotensin II; Animals; Bradykinin; Connective Tissue; Fibrosis; Heart; Hormones; Humans; Models, Cardiovascular; Myocardium; Prostaglandins; Wound Healing | 1995 |
Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Collagen; Collagenases; Endothelium, Vascular; Extracellular Matrix; Fibroblasts; Fibrosis; Muscle Proteins; Myocardium; Peptidyl-Dipeptidase A; Rats; Receptors, Angiotensin; Receptors, Bradykinin; Receptors, Mineralocorticoid; Renin-Angiotensin System | 1994 |
[Pathophysiology of cytoskeleton and extracellular matrix in failing myocardium].
Topics: Angiotensin II; Calcium; Collagen; Cytoskeleton; Extracellular Matrix; Fibroblasts; Fibrosis; Heart Failure; Humans; Myocardial Contraction; Myocardium; Norepinephrine | 1993 |
Structural remodeling of the infarcted rat heart.
Topics: Aldosterone; Angiotensin II; Animals; Collagen; Fibrosis; Humans; Metalloendopeptidases; Myocardial Infarction; Myocardial Ischemia; Myocardium; Rats; Renin-Angiotensin System; Wound Healing | 1996 |
Growth factors and apoptosis in neonatal ureteral obstruction.
Topics: Adult; Age Factors; Angiotensin II; Animals; Animals, Newborn; Apoptosis; Clusterin; Epidermal Growth Factor; Fibrosis; Gene Expression Regulation; Glycoproteins; Growth Substances; Hemodynamics; Humans; Infant; Infant, Newborn; Kidney; Kidney Diseases, Cystic; Mice; Mice, Knockout; Models, Biological; Molecular Chaperones; Proto-Oncogene Proteins c-bcl-2; Rats; Renin-Angiotensin System; Transforming Growth Factor beta; Ureteral Obstruction | 1996 |
Angiotensin II and L-arginine in tissue fibrosis: more than blood pressure.
Topics: Angiotensin II; Animals; Arginine; Blood Pressure; Dietary Proteins; Fibrinolysin; Fibrosis; Humans; Transforming Growth Factor beta | 1997 |
Angiotensin II in renal fibrosis: should TGF-beta rather than blood pressure be the therapeutic target?
Topics: Angiotensin II; Animals; Disease Models, Animal; Fibrosis; Humans; Hypertension, Renal; Kidney Diseases; Transforming Growth Factor beta | 1997 |
Fibrosis, a common pathway to organ failure: angiotensin II and tissue repair.
Topics: Angiotensin II; Animals; Culture Techniques; Fibrosis; Humans; Kidney; Liver; Lung; Multiple Organ Failure; Myocardium; Wound Healing | 1997 |
Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation.
Topics: Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Collagen; Female; Fibrosis; Heart Failure; Humans; Myocardial Infarction; Myofibrils; Peptidyl-Dipeptidase A; Ventricular Dysfunction, Left | 1997 |
Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis.
Topics: Angiotensin II; Animals; Fibrinolysin; Fibrosis; Gene Transfer Techniques; Humans; Integrins; Kidney; Kidney Diseases; Transforming Growth Factor beta | 1998 |
The role of growth factors, cytokines, and vasoactive compounds in obstructive nephropathy.
Topics: Angiotensin II; Animals; Decorin; Extracellular Matrix Proteins; Fibrosis; Humans; Kidney Tubules; NF-kappa B; Nitric Oxide; Proteoglycans; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Ureteral Obstruction; Vasoconstriction | 1998 |
Biology and functions of renal receptors for angiotensin II and its active fragments.
Topics: Angiotensin II; Animals; Cell Division; Extracellular Matrix; Fibrosis; Humans; Kidney; Peptide Fragments; Receptors, Angiotensin; Renin-Angiotensin System | 1998 |
Aldosterone and the heart: towards a physiological function?
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Animals; Cytochrome P-450 CYP11B2; Fibrosis; Gene Expression; Humans; Hypertension; Ion Transport; Myocardium; Receptors, Angiotensin; Receptors, Mineralocorticoid | 1999 |
Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis.
Topics: Angiotensin II; Animals; Collagenases; Extracellular Matrix; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Humans; Insulin-Like Growth Factor I; Integrins; Myocardium; Signal Transduction; Stress, Mechanical; Transforming Growth Factor beta; Ventricular Remodeling | 2000 |
Angiotensin II, adhesion, and cardiac fibrosis.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Adhesion; Extracellular Matrix; Fibrosis; Humans; Integrins; Myocardium; Osteopontin; Sialoglycoproteins | 2000 |
Mechanism of cardiac fibrosis by angiotensin. New insight revealed by genetic engineering.
Topics: Angiotensin II; Animals; Chimera; Fibrosis; Heart; Humans; Mice; Mice, Mutant Strains; Mice, Transgenic; Myocardium; Receptors, Angiotensin | 1999 |
Renal tubulointerstitial fibrosis. New thoughts on its development and progression.
Topics: Angiotensin II; Epithelium; Fibrosis; Humans; Kidney Failure, Chronic; Kidney Tubules; Transforming Growth Factor beta | 2000 |
Urinary tract obstruction.
Topics: Angiotensin II; Animals; Apoptosis; Fibrosis; Humans; NF-kappa B; Oxidative Stress; Signal Transduction; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Up-Regulation; Ureteral Obstruction | 2001 |
Aldosterone as a determinant of cardiovascular and renal dysfunction.
Topics: Aldosterone; Angiotensin II; Animals; Cardiovascular Diseases; Endothelium, Vascular; Fibrosis; Humans; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Nitric Oxide; Potassium; Randomized Controlled Trials as Topic; Sodium; Spironolactone | 2001 |
Angiotensin II and renal fibrosis.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Fibrosis; Humans; Kidney; Kidney Diseases | 2001 |
Molecular mechanisms of renal allograft fibrosis.
Topics: Angiotensin II; Cytokines; Extracellular Matrix; Fibrosis; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Matrix Metalloproteinases; Transplantation, Homologous | 2001 |
Angiotensin II, TGF-beta and renal fibrosis.
Topics: Angiotensin II; Animals; Disease Models, Animal; Fibrosis; Humans; Kidney; Kidney Diseases; Rats; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Transforming Growth Factor beta | 2001 |
Maximizing hemodynamic-independent effects of angiotensin II antagonists in fibrotic diseases.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Fibrosis; Humans; Kidney Diseases; Liver Cirrhosis; Pulmonary Fibrosis; Renin-Angiotensin System; Transforming Growth Factor beta | 2001 |
Role of the renin-angiotensin system in vascular diseases: expanding the field.
Topics: Angiotensin II; Angiotensin III; Animals; Apoptosis; Fibrosis; Humans; Kidney; Oxidative Stress; Renin-Angiotensin System; Vascular Diseases | 2001 |
The inflammatory component in progressive renal disease--are interventions possible?
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Fibrosis; Humans; Inflammation; Inflammation Mediators; Kidney Diseases; Models, Biological; Mycophenolic Acid; Nephritis; Renin-Angiotensin System; Transforming Growth Factor beta | 2002 |
Therapeutic strategies to halt renal fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Enzyme Inhibitors; Fibrosis; Humans; Kidney; Kidney Diseases; Receptor, Angiotensin, Type 1 | 2002 |
5 trial(s) available for angiotensin ii and Cirrhosis
| Article | Year |
|---|---|
Topics: Acoustics; Adsorption; Angiotensin II; Animals; Anti-Bacterial Agents; Azithromycin; Calcium; Carbon; Charcoal; Child; Chlorides; Copper; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Resistance, Bacterial; Ecosystem; Epigenesis, Genetic; Female; Fibroblasts; Fibrosis; Gallium Radioisotopes; Heterozygote; Hot Temperature; Humans; Hydrogen-Ion Concentration; Inflammasomes; Inflammation; Kinetics; Macrolides; Magnetic Resonance Imaging; Malawi; Male; Mass Drug Administration; Methylene Blue; Mice; Neuroendocrine Tumors; NLR Family, Pyrin Domain-Containing 3 Protein; Octreotide; Organometallic Compounds; Oxidative Stress; Phenotype; Positron-Emission Tomography; Prevalence; Prognosis; Rats; Receptors, Somatostatin; Retrospective Studies; Rivers; Streptococcus pneumoniae; Trachoma; Water Pollutants, Chemical; Zinc Compounds | 2022 |
Three-vessel coronary infusion of cardiosphere-derived cells for the treatment of heart failure with preserved ejection fraction in a pre-clinical pig model.
Topics: Angiotensin II; Animals; Fibrosis; Heart Failure; Hypertrophy, Left Ventricular; Stroke Volume; Swine; Ventricular Function, Left | 2023 |
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection | 2013 |
Angiotensin II blockade in kidney transplant recipients.
Topics: Adult; Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Double-Blind Method; Female; Fibrosis; Glomerular Filtration Rate; Humans; Kidney; Kidney Transplantation; Losartan; Male; Middle Aged; Postoperative Complications; Transplantation, Homologous; Treatment Outcome | 2013 |
Losartan decreases plasma levels of TGF-beta1 in transplant patients with chronic allograft nephropathy.
Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; Chronic Disease; Endothelins; Female; Fibrosis; Follow-Up Studies; Graft Rejection; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Losartan; Male; Middle Aged; Pilot Projects; Proteinuria; Transforming Growth Factor beta; Transplantation, Homologous; Vasoconstrictor Agents | 1999 |
892 other study(ies) available for angiotensin ii and Cirrhosis
| Article | Year |
|---|---|
Elevated reactivity of Apelin inhibited renal fibrosis induced by chronic intermittent hypoxia.
Topics: Angiotensin II; Animals; Apelin; Apelin Receptors; Cell Line; Fibrosis; Humans; Hypoxia; Inflammation; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Diseases; Male; Nitrobenzoates; Oxidative Stress; Pyrans; Rats, Wistar | 2021 |
Angiotensin-(3-7) alleviates isoprenaline-induced cardiac remodeling via attenuating cAMP-PKA and PI3K/Akt signaling pathways.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Fibrosis; Isoproterenol; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Peptide Fragments; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Ventricular Remodeling | 2021 |
LOXL2 Inhibitor Attenuates Angiotensin II-Induced Atrial Fibrosis and Vulnerability to Atrial Fibrillation through Inhibition of Transforming Growth Factor Beta-1 Smad2/3 Pathway.
Topics: Amino Acid Oxidoreductases; Angiotensin II; Animals; Atrial Fibrillation; Fibrosis; Humans; Male; Mice; Mice, Inbred C57BL; Smad2 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2022 |
Angiotensin IV attenuates diabetic cardiomyopathy
Topics: Angiotensin II; Animals; Apoptosis; Autophagy; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Forkhead Box Protein O1; Glucose; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Quinolones; Signal Transduction; Streptozocin; Ventricular Dysfunction, Left | 2021 |
Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodeling.
Topics: Amidohydrolases; Angiotensin II; Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Induction; Fibrosis; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Inflammation Mediators; Male; Mice, Inbred C57BL; Mice, Transgenic; Time Factors; Vascular Remodeling; Vasodilation; Ventricular Function, Left; Ventricular Remodeling | 2021 |
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways.
Topics: ADAM Proteins; Angiotensin II; Animals; Antigens, CD; Endothelial Cells; Fibrosis; Membrane Proteins; Mice; Mice, Inbred C57BL; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2022 |
Attenuation of Myocardial Fibrosis Using Molecular Hydrogen by Inhibiting the TGF-β Signaling Pathway in Spontaneous Hypertensive Rats.
Topics: Angiotensin II; Animals; Cardiomyopathies; Collagen Type I; Fibrosis; Hydrogen; Myocardium; Procollagen; Rats; Rats, Inbred SHR; Signal Transduction; Superoxide Dismutase; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2022 |
Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway.
Topics: Angiotensin II; Animals; Cardiomegaly; Caveolin 1; Cells, Cultured; Fibrosis; Inflammation; Male; Mice; Mice, Inbred C57BL; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Ultrasonic Waves | 2021 |
Catalpol Alleviates Ang II-Induced Renal Injury Through NF-κB Pathway and TGF-β1/Smads Pathway.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Fibrosis; Humans; Inflammation Mediators; Iridoid Glucosides; Kidney; Male; Mice; Mice, Inbred C57BL; Nephritis; NF-kappa B; Rats; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2022 |
Tranilast inhibits angiotensin II-induced myocardial fibrosis through S100A11/ transforming growth factor-β (TGF-β1)/Smad axis.
Topics: Angiotensin II; Cardiomyopathies; Cell Movement; Cell Survival; Cells, Cultured; Fibrosis; Humans; ortho-Aminobenzoates; S100 Proteins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2021 |
MicroRNA-451a attenuates angiotensin II-induced cardiac fibrosis and inflammation by directly targeting T-box1.
Topics: Angiotensin II; Animals; Fibrosis; Inflammation; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardium; Myocytes, Cardiac | 2022 |
Angiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis through regulating the interaction of proto-oncogene tyrosine-protein kinase Src (c-Src) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)).
Topics: Angiotensin I; Angiotensin II; Animals; Fibrosis; Matrix Metalloproteinase 2; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; Signal Transduction; src Homology Domains; Transforming Growth Factor beta | 2021 |
Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Inflammatory Cell Infiltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension.
Topics: Angiotensin I; Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Hypertension; Imidazoles; Injections, Intraperitoneal; Losartan; Male; Peptide Fragments; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiophenes; Tyrosine 3-Monooxygenase | 2021 |
Stromal cell-derived factor-1 exerts opposing roles through CXCR4 and CXCR7 in angiotensin II-induced adventitial remodeling.
Topics: Adventitia; Angiotensin II; Animals; Benzylamines; Cell Movement; Cell Proliferation; Chemokine CXCL12; Collagen; Cyclams; Disease Models, Animal; Fibroblasts; Fibrosis; Hypertension; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Receptors, CXCR; Receptors, CXCR4; Signal Transduction; Wound Healing | 2022 |
Zyxin protects from hypertension-induced cardiac dysfunction.
Topics: Angiotensin II; Animals; Apoptosis; Blood Pressure; Cardiomegaly; Fibrosis; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Zyxin | 2022 |
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling.
Topics: Angiotensin II; Animals; Endothelial Cells; Ferroptosis; Fibrosis; Glutathione Peroxidase; Hypertension; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Signal Transduction | 2022 |
Topics: Angiotensin II; Animals; Carrier Proteins; Fibrosis; Hypertension; Inflammasomes; Inflammation; Mice; MicroRNAs; NLR Family, Pyrin Domain-Containing 3 Protein; Thioredoxins | 2022 |
MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Apelin; Cardiomyopathies; Fibrosis; Growth Differentiation Factor 15; Hypertension; Inflammation; MicroRNAs; Rats | 2022 |
Intermedin
Topics: Adrenomedullin; Angiotensin II; Animals; Cells, Cultured; Endoribonucleases; Fibrosis; Inflammasomes; Multienzyme Complexes; Neuropeptides; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Serine-Threonine Kinases; Rats | 2022 |
Osteocrin alleviates cardiac hypertrophy via attenuating oxidative stress.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Mice; Muscle Proteins; Myocytes, Cardiac; Oxidative Stress; Rats; Transcription Factors | 2022 |
Inhibition of Src improves cardiac fibrosis in AngII-induced hypertrophy by regulating the expression of galectin-3.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Galectin 3; Mice; Mice, Knockout; Myocytes, Cardiac; src-Family Kinases | 2022 |
LongShengZhi alleviated cardiac remodeling via upregulation microRNA-150-5p with matrix metalloproteinase 14 as the target.
Topics: Angiotensin II; Animals; Cardiomegaly; Drugs, Chinese Herbal; Fibrosis; Matrix Metalloproteinase 14; MicroRNAs; Myocytes, Cardiac; Rats; Up-Regulation; Ventricular Remodeling | 2022 |
Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy.
Topics: Angiotensin II; Animals; Atherosclerosis; Endothelial Cells; Fibrosis; Humans; Hypertension, Renal; Interleukin-18; Kruppel-Like Transcription Factors; Mice; Nephritis; RNA, Messenger; Simvastatin; Transcription Factors | 2022 |
Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress.
Topics: Angiotensin II; Animals; Collagen; Fibroblast Growth Factors; Fibronectins; Fibrosis; Heart Failure; Mice; Myocardial Infarction; Myocardium; Oxidative Stress; Ventricular Remodeling | 2022 |
DP1 (Prostaglandin D
Topics: Angiotensin II; Animals; Cells, Cultured; Fibronectins; Fibrosis; Guanine Nucleotide Exchange Factors; Hypertension; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myofibroblasts; Receptors, Immunologic; Receptors, Prostaglandin; Transcription Factors; Vascular Remodeling | 2022 |
Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction via binding to matrix metalloproteinase-9 to attenuate inflammation.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cardiotonic Agents; Fibronectins; Fibrosis; Ginkgolides; Heart Diseases; Inflammation; Lactones; Matrix Metalloproteinase 9; Mice; Myocardial Infarction; Myocytes, Cardiac; Rats; Ventricular Remodeling | 2022 |
MircroRNA-145 Attenuates Cardiac Fibrosis Via Regulating Mitogen-Activated Protein Kinase Kinase Kinase 3.
Topics: Angiotensin II; Animals; Collagen; Fibrosis; Heart Failure; MAP Kinase Kinase Kinase 3; Mice; MicroRNAs; Myocardial Infarction; Myocardium; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2023 |
Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells.
Topics: Angiotensin II; Animals; CD4-Positive T-Lymphocytes; Early Growth Response Transcription Factors; Fibrosis; Humans; Hypertension; Interleukin-9; Kruppel-Like Transcription Factors; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA | 2022 |
TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.
Topics: Angiotensin II; Animals; Apoptosis Regulatory Proteins; Blood Pressure; Female; Fibrosis; Glycolysis; Humans; Hypertension; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoric Monoester Hydrolases | 2022 |
Naoxintong Capsule Activates the Nrf2/HO-1 Signaling Pathway and Suppresses the p38α Signaling Pathway Via Estrogen Receptors to Ameliorate Heart Remodeling in Female Mice With Postmenopausal Hypertension.
Topics: Angiotensin II; Animals; Body Weight; Drugs, Chinese Herbal; Female; Fibrosis; Heme Oxygenase-1; Hypertension; Membrane Proteins; Mice; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Postmenopause; Receptors, Estrogen; Signal Transduction; Ventricular Remodeling | 2022 |
Pharmacological activation of estrogenic receptor G protein-coupled receptor 30 attenuates angiotensin II-induced atrial fibrosis in ovariectomized mice by modulating TGF-β1/smad pathway.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cardiomyopathies; Female; Fibroblasts; Fibrosis; Heart Atria; Mice; Mice, Inbred C57BL; Receptors, Estrogen; Receptors, G-Protein-Coupled; Smad Proteins; Transforming Growth Factor beta1 | 2022 |
Knockdown of HIPK2 Attenuates Angiotensin II-Induced Cardiac Fibrosis in Cardiac Fibroblasts.
Topics: Angiotensin II; Carrier Proteins; Cell Proliferation; Cells, Cultured; Fibroblasts; Fibrosis; Humans; Myocardium; Protein Serine-Threonine Kinases; Transforming Growth Factor beta1 | 2022 |
Interleukin 10 Attenuates Angiotensin II-Induced Aortic Remodelling by Inhibiting Oxidative Stress-Induced Activation of the Vascular p38 and NF-
Topics: Angiotensin II; Animals; Cells, Cultured; Fibrosis; Humans; Hypertension; Interleukin-10; Matrix Metalloproteinase 2; Mice; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Signal Transduction | 2022 |
Sulfasalazine exacerbates angiotensin II-induced cardiac remodelling by activating Akt signal pathway.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Hypertrophy; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfasalazine; Ventricular Remodeling | 2022 |
Interleukin-22 exacerbates angiotensin II-induced hypertensive renal injury.
Topics: Angiotensin II; Animals; Fibrosis; Humans; Hypertension; Inflammation; Interleukin-22; Interleukins; Kidney; Kidney Diseases; Mice; Mice, Inbred C57BL | 2022 |
P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis.
Topics: Angiotensin II; Animals; Antioxidants; Carcinoma, Hepatocellular; Cytokines; Elastin; Fibrosis; Hepacivirus; Hepatitis C; Humans; Laminin; Liver Neoplasms; Rats; Receptors, Purinergic P2X4; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2022 |
Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner.
Topics: Adipose Tissue, White; Angiotensin II; Animals; Cardiomyopathies; Exosomes; Fibrosis; Mice; Mice, Inbred C57BL; MicroRNAs | 2022 |
Suppression of angiotensin II-activated NOX4/NADPH oxidase and mitochondrial dysfunction by preserving glucagon-like peptide-1 attenuates myocardial fibrosis and hypertension.
Topics: Angiotensin II; Animals; Cardiomyopathies; Fibrosis; Glucagon-Like Peptide 1; Hypertension; Linagliptin; Liraglutide; Mitochondria; NADPH Oxidase 4; Rats; Rats, Sprague-Dawley | 2022 |
Corynoline protects ang II-induced hypertensive heart failure by increasing PPARα and Inhibiting NF-κB pathway.
Topics: Angiotensin II; Animals; Berberine Alkaloids; Fibrosis; Heart Failure; Hypertension; Inflammation; Mice; Mice, Inbred C57BL; NF-kappa B; PPAR alpha; RNA | 2022 |
CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure.
Topics: Angiotensin II; Animals; Cardiomegaly; Chemokine CCL17; Chemokines; Fibrosis; Heart Failure; Humans; Ligands; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Proteomics | 2022 |
Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Heart Failure; Indole Alkaloids; Inflammation; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Quinolines; Rats; Signal Transduction; Ventricular Remodeling | 2022 |
Postnatal Deletion of Bmal1 in Cardiomyocyte Promotes Pressure Overload Induced Cardiac Remodeling in Mice.
Topics: Angiotensin II; Animals; ARNTL Transcription Factors; Cardiomegaly; Disease Models, Animal; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Ventricular Remodeling | 2022 |
DR7dA, a Novel Antioxidant Peptide Analog, Demonstrates Antifibrotic Activity in Pulmonary Fibrosis
Topics: Alanine; Angiotensin II; Animals; Antioxidants; Bleomycin; Fibrosis; Isoleucine; Lung; Mice; Mitogen-Activated Protein Kinases; Peptides; Pulmonary Fibrosis; Transforming Growth Factor beta1 | 2022 |
Liraglutide inhibits AngII-induced cardiac fibroblast proliferation and ECM deposition through regulating miR-21/PTEN/PI3K pathway.
Topics: Angiotensin II; Animals; Cell Movement; Cell Proliferation; Extracellular Matrix; Fibroblasts; Fibrosis; Liraglutide; Mice; Mice, Inbred C57BL; MicroRNAs; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt | 2023 |
Rhein attenuates angiotensin II-induced cardiac remodeling by modulating AMPK-FGF23 signaling.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Anthraquinones; Fibroblast Growth Factor-23; Fibrosis; Heart Failure; Hypertrophy; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Rats; Ventricular Remodeling | 2022 |
Relaxin Inhibits the Cardiac Myofibroblast NLRP3 Inflammasome as Part of Its Anti-Fibrotic Actions via the Angiotensin Type 2 and ATP (P2X7) Receptors.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Caspase 1; Fibrosis; Inflammasomes; Interleukin-18; Interleukin-1beta; Mice; Myofibroblasts; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Receptors, Purinergic P2X7; Relaxin; Toll-Like Receptor 4 | 2022 |
Silencing of TLR4 Inhibits Atrial Fibrosis and Susceptibility to Atrial Fibrillation via Downregulation of NLRP3-TGF-
Topics: Angiotensin II; Animals; Atrial Fibrillation; Collagen Type I; Down-Regulation; Fibrosis; Heart Atria; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Inbred SHR; RNA, Small Interfering; Toll-Like Receptor 4; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2022 |
Ang II (Angiotensin II)-Induced FGFR1 (Fibroblast Growth Factor Receptor 1) Activation in Tubular Epithelial Cells Promotes Hypertensive Kidney Fibrosis and Injury.
Topics: Angiotensin II; Animals; Epithelial Cells; Fibrosis; Humans; Hypertension; Hypertension, Renal; Kidney; Mice; Mice, Inbred C57BL; Nephritis; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Angiotensin | 2022 |
Of Mouse and Man: Cross-Species Characterization of Hypertensive Cardiac Remodeling.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Fibrosis; Heart; Humans; Hypertension; Mice; Myocardium; Myocytes, Cardiac; Ventricular Remodeling | 2022 |
Empagliflozin prevents angiotensin II-induced hypertension related micro and macrovascular endothelial cell activation and diastolic dysfunction in rats despite persistent hypertension: Role of endothelial SGLT1 and 2.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Blood Pressure; Collagen; Endothelial Cells; Fibrosis; Glucosides; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats; Rats, Wistar; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Vascular Cell Adhesion Molecule-1 | 2022 |
Genetic Deletion of Galectin-3 Exacerbates Age-Related Myocardial Hypertrophy and Fibrosis in Mice.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Galectin 3; Gene Deletion; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Sirtuin 1; Transforming Growth Factor beta; Ventricular Remodeling | 2022 |
Broad-acting therapeutic effects of miR-29b-chitosan on hypertension and diabetic complications.
Topics: Angiotensin II; Animals; Chitosan; Diabetes Complications; Diabetes Mellitus; Disease Models, Animal; Fibrosis; Humans; Hypertension; Mice; Mice, Inbred Strains; Mice, Knockout, ApoE; MicroRNAs; Thiolester Hydrolases | 2022 |
Therapeutic Effects of Salvianolic Acid B on Angiotensin II-Induced Atrial Fibrosis by Regulating Atrium Metabolism via Targeting AMPK/FoxO1/miR-148a-3p Axis.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Fibrosis; Forkhead Box Protein O1; Humans; MicroRNAs | 2023 |
Cilostazol Attenuates AngII-Induced Cardiac Fibrosis in apoE Deficient Mice.
Topics: Angiotensin II; Animals; Cilostazol; Fibrosis; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Myocardium; Osteopontin; RNA, Messenger | 2022 |
Diacerein alleviates Ang II-induced cardiac inflammation and remodeling by inhibiting the MAPKs/c-Myc pathway.
Topics: Angiotensin II; Animals; Anthraquinones; Cardiomegaly; Cardiomyopathies; Fibrosis; Heart Failure; Hypertension; Inflammation; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; RNA; Ventricular Remodeling | 2022 |
Effect of angiotensin II pathway inhibitors on post-surgical adhesion band formation: a potential repurposing of old drugs.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Drug Repositioning; Enalapril; Eosine Yellowish-(YS); Fibrosis; Hematoxylin; Inflammation; Pharmaceutical Preparations; Rats; Rats, Wistar; Sulfhydryl Compounds; Superoxide Dismutase; Telmisartan; Tissue Adhesions | 2022 |
Vaspin Ameliorates Cardiac Remodeling by Suppressing Phosphoinositide 3-Kinase/Protein Kinase B Pathway to Improve Oxidative Stress in Heart Failure Rats.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Collagen; Fibrosis; Heart Failure; Myocardial Infarction; Myocytes, Cardiac; NADPH Oxidases; Natriuretic Peptide, Brain; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Ventricular Remodeling | 2022 |
Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts.
Topics: Angiotensin II; Animals; Catechin; Fibroblasts; Fibrosis; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Myofibroblasts; Proto-Oncogene Proteins c-akt; Sirtuin 1; Ubiquitin | 2022 |
Activating transcription factor 3 inhibits angiotensin II‑induced cardiomyocyte viability and fibrosis by activating the transcription of cysteine‑rich angiogenic protein 61.
Topics: Activating Transcription Factor 3; Angiogenic Proteins; Angiotensin II; Cyclic AMP Response Element-Binding Protein; Cysteine; Cysteine-Rich Protein 61; Fibrosis; Humans; Myocytes, Cardiac; RNA, Messenger; Transforming Growth Factor beta | 2022 |
G-protein coupled receptor 30 attenuates myocardial hypertrophy by reducing oxidative stress and apoptosis in Ang II-treated mice.
Topics: Angiotensin II; Animals; Apoptosis; Atrial Natriuretic Factor; Cardiomegaly; Female; Fibrosis; GTP-Binding Proteins; Mice; Myocytes, Cardiac; Myosin Heavy Chains; Natriuretic Peptide, Brain; Oxidative Stress; Peptide Hormones; Rats; Receptors, Estrogen; Receptors, G-Protein-Coupled | 2022 |
Inhibition of MyD88 attenuates angiotensin II-induced hypertensive kidney disease via regulating renal inflammation.
Topics: Angiotensin II; Animals; Cytokines; Fibrosis; Hypertension; Hypertension, Renal; Inflammation; Kidney; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; RNA, Small Interfering; Signal Transduction; Toll-Like Receptor 4 | 2022 |
Consequences of PDGFRα
Topics: Angiotensin II; Animals; Calcium; Collagen; Fibroblasts; Fibrosis; Mice; Myocardial Infarction; Myocardium; Phenylephrine; Proteome; Receptor, Platelet-Derived Growth Factor alpha | 2022 |
Secreted frizzled-related protein 3 alleviated cardiac remodeling induced by angiotensin II via inhibiting oxidative stress and apoptosis in mice.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Fibrosis; Hypertrophy; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Rats; Ventricular Remodeling | 2022 |
Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling.
Topics: Angiotensin II; Animals; Fibrosis; Heart Failure; Hypertension; Inflammation; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardium; Myocytes, Cardiac; Ventricular Remodeling | 2023 |
Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis.
Topics: Angiotensin II; Animals; Cardiomyopathies; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Integrins; Losartan; Mice; Myocardium; RNA, Small Interfering; Transforming Growth Factor beta1 | 2022 |
Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Fibrosis; Iron; Mice; Receptor, Angiotensin, Type 1; Receptors, Transferrin | 2022 |
miR-409-3p Regulated by GATA2 Promotes Cardiac Fibrosis through Targeting Gpd1.
Topics: Angiotensin II; Animals; Antagomirs; Fibrosis; GATA2 Transcription Factor; Mice; MicroRNAs; Myocardial Infarction; Myocardium; Rats; RNA, Small Interfering; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factors | 2022 |
Leonurine attenuates angiotensin II-induced cardiac injury and dysfunction via inhibiting MAPK and NF-κB pathway.
Topics: Angiotensin II; Animals; Fibrosis; Heart Failure; Mice; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; NF-kappa B; Rats | 2023 |
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Topics: Angiotensin II; Animals; Ferroptosis; Fibrosis; Hypertension; Kidney; Kidney Diseases; Kruppel-Like Transcription Factors; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Sirtuins | 2022 |
Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension.
Topics: Angiotensin II; Animals; Fibrosis; Hypertension; Mice; Mice, Inbred C57BL | 2023 |
Structural characterization and protective effect against renal fibrosis of polysaccharide from Ligustrum lucidum Ait.
Topics: Angiotensin II; Animals; Chemokine CCL5; Fibrosis; Kidney; Kidney Diseases; Ligustrum; Male; Mice; Polysaccharides; Ureteral Obstruction | 2023 |
Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Fibrosis; Mice; Mice, Inbred C57BL; Myocardium; Transcription Factors | 2023 |
CircCAMTA1 facilitates atrial fibrosis by regulating the miR-214-3p/TGFBR1 axis in atrial fibrillation.
Topics: Angiotensin II; Atrial Fibrillation; Collagen; Fibroblasts; Fibrosis; Humans; MicroRNAs; Receptor, Transforming Growth Factor-beta Type I | 2023 |
MicroRNA-19 upregulation attenuates cardiac fibrosis via targeting connective tissue growth factor.
Topics: Angiotensin II; Animals; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Heart Failure; MicroRNAs; Myocardial Infarction; Myocardium; Rats; Transforming Growth Factor beta1; Up-Regulation | 2023 |
Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; Receptor, Angiotensin, Type 1; Vascular Remodeling | 2023 |
Topical captopril: a promising treatment for secondary lymphedema.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Fibrosis; Lymphedema; Mice; Transforming Growth Factor beta1 | 2023 |
Adipose Triglyceride Lipase Deficiency Aggravates Angiotensin II-Induced Atrial Fibrillation by Reducing Peroxisome Proliferator-Activated Receptor α Activation in Mice.
Topics: Acyltransferases; Angiotensin II; Animals; Atrial Fibrillation; Fibrosis; Lipase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR alpha | 2023 |
Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling.
Topics: Angiotensin II; Animals; Fibrosis; Heart Failure; Hypertension; Lectins, C-Type; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NF-kappa B; Ventricular Remodeling | 2023 |
Anti-Fibrotic Potential of Angiotensin (1-7) in Hemodynamically Overloaded Rat Heart.
Topics: Angiotensin II; Animals; Connexin 43; Fibrosis; Heart; Heart Failure; Hypertension; Male; Rats; Rats, Transgenic | 2023 |
Gβγ subunits colocalize with RNA polymerase II and regulate transcription in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Cell Nucleus; Fibroblasts; Fibrosis; Gene Expression Regulation; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Myocardium; Rats; RNA Polymerase II; Signal Transduction; Transcription, Genetic | 2023 |
The p53/miR-29a-3p axis mediates the antifibrotic effect of leonurine on angiotensin II-stimulated rat cardiac fibroblasts.
Topics: Angiotensin II; Animals; Collagen Type I; Fibroblasts; Fibrosis; MicroRNAs; Rats; Tumor Suppressor Protein p53 | 2023 |
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Topics: Aloe; Angiotensin II; Animals; Cardiomyopathies; Emodin; Fibrosis; Hypertrophy; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Rats; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta1; Ventricular Remodeling | 2023 |
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Topics: Angiotensin II; Animals; Deubiquitinating Enzymes; Fibrosis; Humans; Hypertension; Hypertension, Renal; Mice; Signal Transduction; Transforming Growth Factor beta; Ubiquitin Thiolesterase | 2023 |
A novel caffeic acid derivative prevents angiotensin II-induced cardiac remodeling.
Topics: Angiotensin II; Animals; Caffeic Acids; Cardiomyopathies; Collagen; Fibroblasts; Fibrosis; Myocardium; Transforming Growth Factor beta; Ventricular Remodeling | 2023 |
[Inhibition of glutaminolysis alleviates myocardial fibrosis induced by angiotensin II].
Topics: Angiotensin II; Animals; Collagen; Collagen Type I; Fibroblasts; Fibrosis; Mice; Mice, Inbred C57BL; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2023 |
All-trans retinoic acid inhibits oxidative stress via ACE2/Ang (1-7)/MasR pathway in renal tubular epithelial cells stimulated with high glucose.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Epithelial Cells; Fibrosis; Glucose; Humans; NADPH Oxidases; Oxidative Stress; Peptide Fragments; Peptidyl-Dipeptidase A; Tretinoin | 2023 |
CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Atrial Remodeling; Fibrosis; Heart Atria; Mice; RNA | 2023 |
Characterization of a robust mouse model of heart failure with preserved ejection fraction.
Topics: Angiotensin II; Animals; Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart Failure; Mice; Phenylephrine; Stroke Volume; Ventricular Function, Left | 2023 |
SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Fibrosis; Heart Atria; Humans; Mice; Reactive Oxygen Species; STAT3 Transcription Factor; Transforming Growth Factor beta1 | 2023 |
Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice.
Topics: Angiotensin II; Animals; Female; Fibroblasts; Fibrosis; Humans; Male; Mice; Natriuretic Peptide, C-Type; Vasodilator Agents; Ventricular Remodeling | 2023 |
Cardiac-specific BACH1 ablation attenuates pathological cardiac hypertrophy by inhibiting the Ang II type 1 receptor expression and the Ca2+/CaMKII pathway.
Topics: Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Fibrosis; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myocytes, Cardiac | 2023 |
Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II.
Topics: Angiotensin II; Animals; Fibrosis; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocytes, Cardiac; Ventricular Remodeling | 2023 |
Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Topics: Angiotensin II; Animals; Fibrosis; Hypertension, Renal; Kidney; Macrophages; Mice; Neutrophils; Transforming Growth Factor beta1 | 2023 |
Integrin beta-like 1 mediates fibroblast-cardiomyocyte crosstalk to promote cardiac fibrosis and hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibroblasts; Fibrosis; Heart Failure; Integrins; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Rats; Ventricular Remodeling | 2023 |
Dapagliflozin attenuates myocardial hypertrophy via activating the SIRT1/HIF-1α signaling pathway.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Mice; Myocytes, Cardiac; Signal Transduction; Sirtuin 1; Stroke Volume; Ventricular Function, Left | 2023 |
Cardioprotective Effects of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension Are Mediated by the Local Reduction of Sympathetic Activity and Inflammation.
Topics: Angiotensin II; Animals; Blood Glucose; Blood Pressure; Cardiomegaly; Fibrosis; Hypertension; Inflammation; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Tyrosine 3-Monooxygenase | 2023 |
Targeting the renin angiotensin system for respiratory diseases.
Topics: Angiotensin I; Angiotensin II; Angiotensins; Fibrosis; Humans; Peptide Fragments; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Respiratory Tract Diseases; Signal Transduction | 2023 |
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.
Topics: Angiotensin II; Animals; Calcium; Cardiomegaly; Cardiomyopathies; Fibrosis; Hypertension; Kruppel-Like Factor 4; Mice; Mice, Inbred C57BL; MicroRNAs; Myocytes, Cardiac | 2023 |
Effect of pharmacological heart failure drugs and gene therapy on Danon's cardiomyopathy.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Genetic Therapy; Glycogen Storage Disease Type IIb; Heart Failure; Humans; Mice; Ramipril; Reactive Oxygen Species; Spironolactone | 2023 |
Visfatin aggravates transverse aortic constriction-induced cardiac remodelling by enhancing macrophage-mediated oxidative stress in mice.
Topics: Angiotensin II; Animals; Aortic Valve Stenosis; Cardiomegaly; Constriction; Fibrosis; Macrophages; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Ventricular Remodeling | 2023 |
COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-β Signaling Pathway.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cartilage Oligomeric Matrix Protein; Fibrosis; Mice; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2023 |
[mRNA Expression Profile Changes in Angiotensin-Ⅱ-Induced Atrial Myocardial Fibrosis in Rats].
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cardiomyopathies; Collagen; Fibrosis; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2023 |
EZH2 as a novel therapeutic target for atrial fibrosis and atrial fibrillation.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Disease Models, Animal; Dogs; Enhancer of Zeste Homolog 2 Protein; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart Atria; Humans; Indoles; Male; Mice; Middle Aged; Pyridones | 2019 |
Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiovascular Agents; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Drug Repositioning; Fibrosis; Gene Expression Regulation; Heart Failure; Humans; Integrin alphaVbeta3; Male; Mice; Myocytes, Cardiac; Neovascularization, Physiologic; Recovery of Function; Signal Transduction; Snake Venoms; Transcriptome | 2019 |
Quercetin inhibition of myocardial fibrosis through regulating MAPK signaling pathway via ROS.
Topics: Angiotensin II; Animals; Cardiotonic Agents; Cell Proliferation; Cells, Cultured; Fibroblasts; Fibrosis; Heart; MAP Kinase Kinase 4; MAP Kinase Signaling System; Myocardium; Quercetin; Rats, Wistar; Reactive Oxygen Species | 2019 |
Overexpression of microRNA-21 mediates Ang II-induced renal fibrosis by activating the TGF-β1/Smad3 pathway via suppressing PPARα.
Topics: Angiotensin II; Cells, Cultured; Fibrosis; Fused Kidney; Gene Expression; Humans; Kidney; Kidney Diseases; MicroRNAs; Molecular Targeted Therapy; PPAR alpha; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2019 |
Re: Circulating miR-103a-3p Contributes to Angiotensin II-Induced Renal Inflammation and Fibrosis via a SNRK/NF-κB/p65 Regulatory Axis.
Topics: Angiotensin II; Fibrosis; Humans; Inflammation; MicroRNAs; Protein Serine-Threonine Kinases | 2020 |
C‑type natriuretic peptide prevents angiotensin II‑induced atrial connexin 40 and 43 dysregulation by activating AMP‑activated kinase signaling.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Biomarkers; Connexin 43; Connexins; Female; Fibroblasts; Fibrosis; Gap Junction alpha-5 Protein; Gene Expression Regulation; Heart Atria; Male; Natriuretic Peptide, C-Type; Rats; Signal Transduction; Transforming Growth Factor beta1 | 2019 |
Deficiency of MicroRNA miR-1954 Promotes Cardiac Remodeling and Fibrosis.
Topics: Actins; Angiotensin II; Animals; bcl-2 Homologous Antagonist-Killer Protein; Cardiomegaly; Caspase 3; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Collagen Type IV; Connective Tissue Growth Factor; Disease Models, Animal; Fibrosis; High-Throughput Nucleotide Sequencing; Interleukin-6; Mice, Transgenic; MicroRNAs; Myocardium; Organ Size; S100 Calcium-Binding Protein A4; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thrombospondin 1; Transforming Growth Factor beta1; Up-Regulation; Ventricular Remodeling | 2019 |
LncRNA NRON alleviates atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cells, Cultured; Collagen Type I; Culture Media, Conditioned; Fibroblasts; Fibrosis; Heart Atria; Macrophage Activation; Macrophages; Mice; Myocytes, Cardiac; RAW 264.7 Cells; RNA, Long Noncoding | 2019 |
Krüppel-like factor 15 is a key suppressor of podocyte fibrosis under rotational force-driven pressure.
Topics: Adult; Angiotensin II; Animals; Cells, Cultured; Female; Fibrosis; Humans; Hypertension, Renal; Kruppel-Like Transcription Factors; Male; Mice; Nephritis; Podocytes; Pressure; Primary Cell Culture; Rotation; Tight Junction Proteins | 2020 |
BRD4 blockage alleviates pathological cardiac hypertrophy through the suppression of fibrosis and inflammation via reducing ROS generation.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Line; Fibrosis; Heart; Heme Oxygenase-1; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; NF-kappa B; Nuclear Proteins; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Signal Transduction; Transcription Factors; Transforming Growth Factor beta1; Up-Regulation | 2020 |
LncRNA FAF inhibits fibrosis induced by angiotensinogen II via the TGFβ1-P-Smad2/3 signalling by targeting FGF9 in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Cell Proliferation; Fibroblast Growth Factor 9; Fibroblasts; Fibrosis; Heart Diseases; Myocardium; Rats, Sprague-Dawley; RNA, Long Noncoding; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Up-Regulation | 2020 |
Cardiomyocyte-Specific
Topics: Angiotensin II; Animals; Cell Line; Endothelial Cells; Fibrosis; Heart; Heart Failure; In Vitro Techniques; Inflammation; Macrophages; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; NF-kappa B; Protein Serine-Threonine Kinases; Vasoconstrictor Agents; Ventricular Dysfunction, Left | 2019 |
Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy.
Topics: Adrenal Glands; Angiotensin II; Animals; Biomarkers; Biopsy; Cardiomegaly; Cardiomyopathies; Collagen; Cytochrome P-450 CYP11B2; Disease Models, Animal; Disease Susceptibility; Fibrosis; Immunohistochemistry; Macrophages; Male; Models, Biological; Myocardium; Myofibroblasts; Phosphoproteins; Rats; Receptor, Angiotensin, Type 1; Signal Transduction; Smad2 Protein; Smad3 Protein | 2020 |
When the CAR Targets Scar.
Topics: Angiotensin II; Animals; Cardiomyopathies; Disease Models, Animal; Fibrosis; Immunotherapy, Adoptive; Mice; Mice, Mutant Strains; Myocardium; Phenylephrine; Receptors, Chimeric Antigen | 2019 |
PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report.
Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Fibrosis; Flow Cytometry; Gene Expression Regulation; Male; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; PTEN Phosphohydrolase; Rats; RNA; Vascular Diseases; Vascular Remodeling | 2020 |
Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R/ACE2-Ang1-7-Mas axis in rat.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Hypertrophy, Right Ventricular; Hypoxia; Male; Medicine, Tibetan Traditional; Peptide Fragments; Peptidyl-Dipeptidase A; Plant Preparations; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Ventricular Remodeling | 2020 |
Renal Anti-Fibrotic Effect of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Fibrosis; Glucosides; Hypertension; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
Sodium-glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Biomarkers; Blood Glucose; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Diabetes Mellitus; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Glucosides; Inflammation Mediators; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Sodium-Glucose Transporter 2 Inhibitors; Sodium-Hydrogen Exchanger 1; Ventricular Function, Left | 2020 |
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling.
Topics: Angiotensin II; Animals; Biomarkers; Blood Pressure; Cardiomegaly; Complement C3; Fibrosis; Hypertrophy; Interleukin-6; Lipopolysaccharide Receptors; Mice; Myocardium; Myocytes, Cardiac; Organ Size; RNA, Messenger; Systole; Toll-Like Receptors; Ventricular Remodeling | 2020 |
MFGE8 attenuates Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation through inhibition of TGF-β1/Smad2/3 pathway.
Topics: Angiotensin II; Animals; Antigens, Surface; Atrial Fibrillation; Cell Movement; Cell Proliferation; Cells, Cultured; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart Atria; Humans; Integrin beta3; Male; Milk Proteins; Models, Biological; Protein Binding; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2020 |
Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy.
Topics: Angiotensin II; Animals; Biomarkers; Cardiomegaly; Collagen; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Disease Progression; Electrocardiography; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Inflammation; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Nuclear Receptor Subfamily 4, Group A, Member 3; Transcription, Genetic; Ventricular Remodeling | 2020 |
Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways.
Topics: Amides; Angiotensin II; Animals; Apoptosis; Blotting, Western; Cardiomegaly; Disease Models, Animal; Fibrosis; Flow Cytometry; Fumarates; Isoproterenol; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Downregulation of miR-96 suppresses the profibrogenic functions of cardiac fibroblasts induced by angiotensin II and attenuates atrial fibrosis by upregulating KLF13.
Topics: Angiotensin II; Animals; Cell Cycle Proteins; Disease Models, Animal; Down-Regulation; Fibroblasts; Fibrosis; Gene Expression; Heart Atria; Humans; Kruppel-Like Transcription Factors; Mice; MicroRNAs; Myocardium; Repressor Proteins; Up-Regulation | 2020 |
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Topics: Angiotensin II; Animals; Biomarkers; Biopsy; Cytokines; DEAD Box Protein 58; Disease Susceptibility; Fibroblasts; Fibrosis; Gene Silencing; Immunohistochemistry; Inflammation Mediators; Interleukin-1beta; Male; Mice; Proto-Oncogene Proteins c-myc; Renal Insufficiency, Chronic; Smad Proteins; Transforming Growth Factor beta; Ureteral Obstruction | 2020 |
The association between microRNA-21 and hypertension-induced cardiac remodeling.
Topics: Aged; Angiotensin II; Animals; Animals, Newborn; Apoptosis Regulatory Proteins; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; Humans; Hypertension; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Signal Transduction; Transcription Factor AP-1; Transforming Growth Factor beta1 | 2020 |
Phosphorylation of GATA4 at serine 105 is required for left ventricular remodelling process in angiotensin II-induced hypertension in rats.
Topics: Angiotensin II; Animals; Apoptosis; Cell Proliferation; Echocardiography; Fibroblasts; Fibrosis; GATA4 Transcription Factor; Hypertension; Male; Myocardial Infarction; Myocytes, Cardiac; Phosphorylation; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2020 |
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Carboxypeptidases; Cardiomegaly; Disease Models, Animal; Fibrosis; Heart Failure; Hypertension; Male; Mice; Mice, Inbred C57BL; Paenibacillus; Peptidyl-Dipeptidase A; Recombinant Proteins | 2020 |
STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress.
Topics: Angiotensin II; Animals; Biomarkers; Cardiomegaly; Disease Models, Animal; Disease Susceptibility; Echocardiography; Endoplasmic Reticulum Stress; Fibrosis; Gene Expression; Gene Knockdown Techniques; Immunohistochemistry; Inflammation; Male; Membrane Proteins; Mice; Myocytes, Cardiac; Rats; Signal Transduction | 2020 |
Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II.
Topics: Aminopyridines; Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart; Humans; Hydrazones; Jumonji Domain-Containing Histone Demethylases; Myocardium; Myocytes, Cardiac; Oxidoreductases, N-Demethylating; Rats; RNA, Small Interfering; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1 | 2020 |
Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells.
Topics: Angiotensin II; Animals; Cell Line; Fas Ligand Protein; fas Receptor; Fibrosis; Humans; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; Necroptosis; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction | 2020 |
CircRNA circHIPK3: A novel therapeutic target for angiotensin II-induced cardiac fibrosis.
Topics: Angiotensin II; Fibrosis; Humans; Intracellular Signaling Peptides and Proteins; MicroRNAs; RNA, Circular | 2020 |
Apelin-13 alleviated cardiac fibrosis via inhibiting the PI3K/Akt pathway to attenuate oxidative stress in rats with myocardial infarction-induced heart failure.
Topics: Angiotensin II; Animals; Disease Models, Animal; Echocardiography; Fibroblasts; Fibrosis; Heart; Heart Failure; Humans; Injections, Intraperitoneal; Intercellular Signaling Peptides and Proteins; Male; Myocardial Infarction; Myocardium; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2020 |
Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Anthocyanins; Cardiomegaly; Fibrosis; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; NADPH Oxidases; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Reactive Oxygen Species; Signal Transduction | 2020 |
Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
Topics: Acetylation; Angiotensin II; Animals; Animals, Newborn; Cell Proliferation; Collagen Type I; Fibroblasts; Fibrosis; Histone Deacetylase 1; Histones; Male; Mice, Transgenic; Myocardium; Phosphorylation; Proteinase Inhibitory Proteins, Secretory; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 2020 |
Increased angiotensin II from adipose tissue modulates myocardial collagen I and III in obese rats.
Topics: Adipose Tissue; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Collagen Type I; Collagen Type III; Diet, High-Fat; Fibrosis; Losartan; Male; Myocardium; Obesity; Rats; Rats, Wistar; Renin-Angiotensin System | 2020 |
Angiotensin-converting-enzyme inhibitor prevents skeletal muscle fibrosis in myocardial infarction mice.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Collagen; Fibrosis; Lisinopril; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Muscular Diseases; Myocardial Infarction; Smad Proteins; Transforming Growth Factor beta | 2020 |
Quercetin Dihydrate inhibition of cardiac fibrosis induced by angiotensin II in vivo and in vitro.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiomyopathies; Collagen Type I; Collagen Type III; Disease Models, Animal; Disease Progression; Fibroblasts; Fibrosis; Male; Mice; Mice, Inbred C57BL; Myocardium; Quercetin; Rats | 2020 |
FOXF1 ameliorates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts through inhibiting the TGF-β1/Smad3 signaling pathway.
Topics: Angiotensin II; Animals; Cell Proliferation; Fibrosis; Forkhead Transcription Factors; Heart Diseases; Male; Myofibroblasts; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Vasoconstrictor Agents | 2020 |
Phosphoinositide 3-kinase γ deficiency attenuates kidney injury and fibrosis in angiotensin II-induced hypertension.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Fibroblasts; Fibrosis; Hypertension; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; T-Lymphocytes; Vasoconstrictor Agents | 2020 |
Intermedin alleviates pathological cardiac remodeling by upregulating klotho.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Constriction; Disease Models, Animal; Fibrosis; Glucuronidase; Hypertrophy, Left Ventricular; Klotho Proteins; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Neuropeptides; Peptide Hormones; Phosphorylation; PPAR gamma; Rats, Sprague-Dawley; Signal Transduction; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Paired box 6 inhibits cardiac fibroblast differentiation.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Differentiation; Chemokine CXCL10; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Introns; Male; Mice; Mice, Inbred C57BL; Myocardium; PAX6 Transcription Factor; Promoter Regions, Genetic; Protein Binding; Receptors, Interleukin-1 Type II; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor beta1 | 2020 |
Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro.
Topics: Angiotensin II; Animals; Cells, Cultured; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Hesperidin; Hypertrophy, Left Ventricular; Inflammation Mediators; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Therapeutic Targeting of Interleukin-11 Signalling Reduces Pressure Overload-Induced Cardiac Fibrosis in Mice.
Topics: Angiotensin II; Animals; Antibodies, Neutralizing; Aorta; Arterial Pressure; Cardiomyopathies; Collagen; Constriction; Disease Models, Animal; Fibronectins; Fibrosis; Hydroxyproline; Interleukin-11; Male; Mice, Inbred C57BL; Myocardium; Signal Transduction | 2021 |
Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation.
Topics: Adventitia; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cholesterol; Collagen Type I; Disease Models, Animal; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Osteoprotegerin; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2020 |
A novel angiotensin II peptide vaccine without an adjuvant in mice.
Topics: Adjuvants, Immunologic; Angiotensin II; Animals; Cells, Cultured; Epitopes, T-Lymphocyte; Fibrosis; Heart; Mice; Myocytes, Smooth Muscle; Vaccines, Subunit | 2021 |
Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice.
Topics: Angiotensin II; Aniline Compounds; Animals; Apoptosis; Cardiac Pacing, Artificial; Cardiomegaly; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Fibrosis; Heart Failure; Inflammation Mediators; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Rats, Sprague-Dawley; Stroke Volume; Sulfonamides; Tachycardia, Ventricular; Ventricular Function, Left; Ventricular Remodeling | 2020 |
A traditional herbal medicine rikkunshito prevents angiotensin II-Induced atrial fibrosis and fibrillation.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cardiotonic Agents; Drugs, Chinese Herbal; Fibrosis; Heart Atria; Male; Mice, Inbred C57BL | 2020 |
Dual roles of chromatin remodeling protein BRG1 in angiotensin II-induced endothelial-mesenchymal transition.
Topics: Angiotensin II; Animals; Cell Line; Chromatin Assembly and Disassembly; Collagen Type I; DNA Helicases; Endothelial Cells; Fibrosis; Histones; Humans; Mesoderm; Mice, Knockout; Myocardium; Nuclear Proteins; Protein Binding; Serum Response Factor; Snail Family Transcription Factors; Sp1 Transcription Factor; Transcription Factors; Transcription, Genetic | 2020 |
Alamandine attenuates angiotensin II-induced vascular fibrosis via inhibiting p38 MAPK pathway.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Arterial Pressure; Cells, Cultured; Disease Models, Animal; Fibrosis; Hypertension; Male; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nerve Tissue Proteins; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling | 2020 |
Endothelial prolyl hydroxylase 2 is necessary for angiotensin II-mediated renal fibrosis and injury.
Topics: Angiotensin II; Animals; Endothelial Cells; Endothelium; Fibrosis; Hypoxia-Inducible Factor-Proline Dioxygenases; Kidney; Kidney Diseases; Mice; Mice, Knockout; Procollagen-Proline Dioxygenase; RNA, Small Interfering | 2020 |
Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Angiotensin II; Animals; Animals, Newborn; Aorta; Apoptosis; Base Sequence; Cardiotonic Agents; Constriction, Pathologic; Disease Models, Animal; Fibrosis; Heart Failure; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Membrane Proteins; Mice, Inbred C57BL; Mitochondria; Mitochondrial Proteins; Myocytes, Cardiac; Nuclear Respiratory Factor 1; Pressure; Rats; Signal Transduction; Thioctic Acid | 2020 |
Bone marrow mesenchymal stem cell-derived exosomes attenuate cardiac hypertrophy and fibrosis in pressure overload induced remodeling.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Exosomes; Fibrosis; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Myocytes, Cardiac; Myofibroblasts; Pressure; Ventricular Remodeling | 2020 |
Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging, Cine; Male; Mice, Inbred C57BL; Myocardium; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2020 |
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Topics: Angiotensin II; Animals; Animals, Newborn; Aortic Valve Stenosis; Cardiomegaly; CRISPR-Cas Systems; Disease Models, Animal; Endopeptidases; Fibrosis; Inflammation; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phenylephrine; Pressure; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Ubiquitin-Protein Ligases; Ventricular Remodeling | 2020 |
MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3β.
Topics: 3' Untranslated Regions; Angiotensin II; Animals; Antagomirs; Cardiovascular Diseases; Fibroblasts; Fibrosis; Glycogen Synthase Kinase 3 beta; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; Rats, Sprague-Dawley; Up-Regulation | 2021 |
The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of heart failure with preserved ejection fraction.
Topics: Angiotensin II; Animals; Benzhydryl Compounds; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Female; Fibrosis; Gene Expression Regulation; Glucagon-Like Peptide-1 Receptor; Glucosides; Heart Failure, Diastolic; Hypertrophy, Left Ventricular; Incretins; Liraglutide; Mice, Inbred C57BL; Myocardium; Signal Transduction; Sodium-Glucose Transporter 2 Inhibitors; Ventricular Function, Left; Ventricular Remodeling | 2021 |
CircRNA circHIPK3: A novel, potential therapeutic target in the treatment of angiotensin II-induced cardiac fibrosis?
Topics: Angiotensin II; Fibrosis; Humans; Intracellular Signaling Peptides and Proteins; MicroRNAs; RNA, Circular | 2021 |
The matricellular protein CCN5 prevents adverse atrial structural and electrical remodelling.
Topics: Angiotensin II; Animals; Arrhythmias, Cardiac; Atrial Remodeling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cell Transdifferentiation; Dependovirus; Electrophysiological Phenomena; Fibrosis; Heart Atria; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Myofibroblasts | 2020 |
MicroRNA-132 attenuated cardiac fibrosis in myocardial infarction-induced heart failure rats.
Topics: Angiotensin II; Animals; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Echocardiography; Fibroblasts; Fibrosis; Heart; Heart Failure; Humans; Male; MicroRNAs; Myocardial Infarction; Myocardium; Primary Cell Culture; Rats; Signal Transduction | 2020 |
Characterization of the Renin-Angiotensin System in Aged Cavernosal Tissue and its Role in Penile Fibrosis.
Topics: Aged; Angiotensin I; Angiotensin II; Animals; Fibrosis; Humans; Male; Mice; Penile Erection; Penile Induration; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Renin-Angiotensin System | 2020 |
Long non-coding RNA LICPAR regulates atrial fibrosis via TGF-β/Smad pathway in atrial fibrillation.
Topics: Angiotensin II; Atrial Fibrillation; Biomarkers; Cell Proliferation; Cell Survival; Fibroblasts; Fibrosis; Heart Atria; Humans; Middle Aged; RNA, Long Noncoding; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Up-Regulation | 2020 |
Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Fibrosis; Gene Deletion; Hypertension, Renal; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephritis; Proteinuria; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Signal Transduction | 2020 |
N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial-mesenchymal transition in silicotic mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Epithelial-Mesenchymal Transition; Fibrosis; Losartan; Lung; Male; Mice, Inbred C57BL; Oligopeptides; Peptide Fragments; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Silicosis | 2020 |
Clofibrate improves myocardial ischemia-induced damage through regulation of renin-angiotensin system and favours a pro-vasodilator profile in left ventricle.
Topics: Angiotensin II; Animals; Clofibrate; Fibrosis; Heart Ventricles; Male; Myocardial Ischemia; Myocardium; Nitric Oxide; Oxidative Stress; Peptidyl-Dipeptidase A; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Time Factors | 2020 |
Sirtuin 3 governs autophagy-dependent glycolysis during Angiotensin II-induced endothelial-to-mesenchymal transition.
Topics: Angiotensin II; Animals; Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Endothelial Cells; Fibrosis; Glycolysis; Hypertension; Mesenchymal Stem Cells; Mice, Knockout; Mice, Transgenic; Mitochondria; Myocytes, Smooth Muscle; Pyruvate Kinase; Sirtuin 3 | 2020 |
Angiotensin II-Induced Cardiovascular Fibrosis Is Attenuated by NO-Sensitive Guanylyl Cyclase1.
Topics: Angiotensin II; Animals; Aorta; Cardiovascular System; Fibrosis; Guanylate Cyclase; Male; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger | 2020 |
SIRT3 Deficiency Sensitizes Angiotensin-II-Induced Renal Fibrosis.
Topics: Angiotensin II; Animals; Disease Models, Animal; Fibrosis; Humans; Hypertension; Kidney; Kidney Diseases; Mice; Sirtuin 3 | 2020 |
Leonurine Attenuates Myocardial Fibrosis Through Upregulation of miR-29a-3p in Mice Post-myocardial Infarction.
Topics: Angiotensin II; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Gallic Acid; Male; Mice, Inbred C57BL; MicroRNAs; Myocardial Infarction; Myocardium; Transforming Growth Factor beta; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2021 |
Deficit of glucocorticoid-induced leucine zipper amplifies angiotensin-induced cardiomyocyte hypertrophy and diastolic dysfunction.
Topics: Angiotensin II; Animals; Blood Pressure; Capillaries; Cell Death; Diastole; Extracellular Matrix; Fibrosis; Hypertrophy; Hypertrophy, Left Ventricular; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Transcription Factors | 2021 |
Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
Topics: Angiotensin II; Animals; Cardiomegaly; Cytokines; Fibrosis; Inflammation; Macrophages; Male; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction; Ventricular Remodeling | 2021 |
TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-κB signaling.
Topics: Angiotensin II; Animals; Aorta; Endothelial Cells; Fibrosis; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; NF-kappa B; Signal Transduction; Toll-Like Receptor 2; Vascular Remodeling | 2020 |
SIRT3 (Sirtuin-3) Prevents Ang II (Angiotensin II)-Induced Macrophage Metabolic Switch Improving Perivascular Adipose Tissue Function.
Topics: Acetylation; Adipose Tissue, Brown; Angiotensin II; Animals; Cell Plasticity; Disease Models, Animal; Energy Metabolism; Fibrosis; HEK293 Cells; Humans; Hypertension; Inflammasomes; Interleukin-1beta; Lactic Acid; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Panniculitis; Phenotype; Pyruvate Dehydrogenase (Lipoamide); Signal Transduction; Sirtuin 3 | 2021 |
Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD.
Topics: Angiotensin II; Animals; Biomarkers; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Fibrosis; Intracellular Signaling Peptides and Proteins; Kidney; Low Density Lipoprotein Receptor-Related Protein-2; Male; Membrane Proteins; Proteinuria; Rats, Wistar; Renal Insufficiency, Chronic; Retinol-Binding Proteins, Plasma; Signal Transduction; Sitagliptin Phosphate | 2021 |
The Histamine 3 Receptor Is Expressed in the Heart and Its Activation Opposes Adverse Cardiac Remodeling in the Angiotensin II Mouse Model.
Topics: Angiotensin II; Animals; Disease Models, Animal; Fibrosis; Inflammation; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Ventricular Remodeling | 2020 |
Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats.
Topics: Angiotensin II; Animals; Antioxidants; Cardiomegaly; Doxorubicin; Fibrosis; Heart Diseases; Male; Mast Cells; Myocardium; ortho-Aminobenzoates; Oxidative Stress; Rats; Rats, Wistar | 2021 |
Involvement of circHIPK3 in the pathogenesis of diabetic cardiomyopathy in mice.
Topics: Angiotensin II; Animals; Cell Proliferation; Cells, Cultured; Collagen Type I, alpha 1 Chain; Collagen Type III; Diabetic Cardiomyopathies; Disease Models, Animal; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; RNA, Circular; Signal Transduction | 2021 |
FoxM1 promotes Wnt/β-catenin pathway activation and renal fibrosis via transcriptionally regulating multi-Wnts expressions.
Topics: Angiotensin II; Animals; Biomarkers; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Epithelial Cells; Fibrosis; Forkhead Box Protein M1; Gene Expression Regulation; Humans; Immunohistochemistry; Kidney Diseases; Kidney Tubules; Male; Mice; Wnt Proteins; Wnt Signaling Pathway | 2021 |
Gastrin, via activation of PPARα, protects the kidney against hypertensive injury.
Topics: Angiotensin II; Animals; Apoptosis; Fibrosis; Gastrins; Humans; Hypertension; Hypertension, Renal; Jurkat Cells; Kidney Tubules, Proximal; Mice; Mice, Knockout; Nephritis; Phagocytosis; PPAR alpha; Receptors, Cholecystokinin; RNA, Small Interfering; Signal Transduction; Ureteral Obstruction | 2021 |
Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis by inhibiting Akt-FoxO1 signalling.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Cardiomyopathies; Dioxolanes; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Failure; Kruppel-Like Factor 4; Myocytes, Cardiac; Nerve Tissue Proteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2021 |
GRK5 is a regulator of fibroblast activation and cardiac fibrosis.
Topics: Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cell Transdifferentiation; Fibroblasts; Fibrosis; G-Protein-Coupled Receptor Kinase 5; Mice, Knockout; Models, Biological; Myocardial Ischemia; Myocardium; Myofibroblasts; Rats | 2021 |
Endothelial NADPH oxidase 4 protects against angiotensin II-induced cardiac fibrosis and inflammation.
Topics: Angiotensin II; Animals; Endothelial Cells; Fibrosis; Inflammation; Mice; Mice, Transgenic; Myocardium; NADPH Oxidase 4 | 2021 |
Epigenetics and expression of key genes associated with cardiac fibrosis:
Topics: Aged; Aged, 80 and over; Angiotensin II; Aorta; Connective Tissue Growth Factor; DNA Methylation; Enhancer Elements, Genetic; Epigenesis, Genetic; Female; Fibrosis; Gene Expression; Humans; Liver; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; MicroRNAs; Monocytes; Myocardium; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein | 2021 |
Angiotensin II receptor 1 controls profibrotic Wnt/β-catenin signalling in experimental autoimmune myocarditis.
Topics: Angiotensin II; Animals; Autoimmune Diseases; Autoimmunity; beta Catenin; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Fibrosis; Inflammation Mediators; Lymphocyte Activation; Mice, Inbred BALB C; Mice, Knockout; Myocarditis; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; Wnt Proteins; Wnt Signaling Pathway; Wnt1 Protein | 2022 |
Nlrp3 Deficiency Alleviates Angiotensin II-Induced Cardiomyopathy by Inhibiting Mitochondrial Dysfunction.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomyopathies; Cytokines; Electrocardiography; Fibrosis; Gene Deletion; Inflammasomes; Inflammation Mediators; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress | 2021 |
Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis.
Topics: Angiotensin II; Animals; Apoptosis; Cell Movement; Cell Survival; Cells, Cultured; Fibrosis; Heart; Matrix Metalloproteinase 3; Myocardium; Rats; Signal Transduction | 2021 |
The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Connexin 43; Connexins; Down-Regulation; Fibrosis; Gap Junction alpha-5 Protein; Gap Junctions; Ginsenosides; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor AP-1; Transforming Growth Factor beta1; Up-Regulation | 2021 |
Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Cardiomyopathies; Female; Fibrosis; Gene Expression; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Smad3 Protein | 2021 |
UCHL1 inhibition attenuates cardiac fibrosis via modulation of nuclear factor-κB signaling in fibroblasts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Cell Proliferation; Collagen Type I; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Mice; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Ubiquitin Thiolesterase | 2021 |
Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Dibenzocycloheptenes; Fibroblasts; Fibrosis; MAP Kinase Signaling System; Myocardium; Rats; Rats, Wistar; Reactive Oxygen Species; Schizophrenia; Transforming Growth Factor beta1 | 2021 |
Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.
Topics: Angiotensin II; Animals; Antifibrotic Agents; Cardiomegaly; Cell Survival; Disease Models, Animal; Extracellular Matrix; Fibrosis; Gene Expression; Heart Failure; Humans; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Myofibroblasts; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Pyrans; rho-Associated Kinases; Ventricular Remodeling | 2021 |
Inhibition of YAP activation attenuates renal injury and fibrosis in angiotensin II hypertensive mice.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Blood Pressure; Chemokine CCL2; Fibrosis; Hypertension; Hypertension, Renal; Male; Mice; Mice, Inbred C57BL; Nephritis; Photosensitizing Agents; Protein Serine-Threonine Kinases; Signal Transduction; Transforming Growth Factor beta; Vasoconstrictor Agents; Verteporfin; YAP-Signaling Proteins | 2021 |
Fus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-β1/Smad pathway.
Topics: Adult; Aged; Angiotensin II; Animals; Atrial Fibrillation; Cells, Cultured; Female; Fibroblasts; Fibrosis; Gene Knockdown Techniques; Humans; Male; Mice; Middle Aged; Myocardium; PAX3 Transcription Factor; RNA-Binding Protein FUS; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2021 |
Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency.
Topics: Angiotensin II; Animals; Cardiomegaly; Diastole; Endothelial Cells; Fibrosis; Gene Expression Regulation; Heart; Heart Rate; Kidney; Mice; Mice, Knockout; MicroRNAs; Myocardium; Neuregulin-1; Nitric Oxide; Nitric Oxide Synthase Type III; Random Allocation; Vasoconstrictor Agents | 2021 |
S-nitrosylation of c-Jun N-terminal kinase mediates pressure overload-induced cardiac dysfunction and fibrosis.
Topics: Angiotensin II; Animals; Aorta; Fibroblasts; Fibrosis; Heart Diseases; Humans; Imines; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Rats; Rats, Inbred SHR; Signal Transduction | 2022 |
Sacubitril/Valsartan Decreases Atrial Fibrillation Susceptibility by Inhibiting Angiotensin II-Induced Atrial Fibrosis Through p-Smad2/3, p-JNK, and p-p38 Signaling Pathways.
Topics: Aminobutyrates; Angiotensin II; Animals; Atrial Fibrillation; Biphenyl Compounds; Fibrosis; Rats; Signal Transduction; Valsartan | 2022 |
Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1/IL-11 signaling.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Interleukin-11; Lutein; Mice; Mice, Inbred C57BL; Myocardium; Rats; Transcription Factor AP-1; Ventricular Remodeling | 2021 |
Alarin alleviated cardiac fibrosis via attenuating oxidative stress in heart failure rats.
Topics: Angiotensin II; Animals; Fibrosis; Galanin-Like Peptide; Heart Failure; Male; Malondialdehyde; Myocardial Infarction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Vasoconstrictor Agents | 2021 |
Dapagliflozin: a sodium-glucose cotransporter 2 inhibitor, attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGFβ1/Smad signaling.
Topics: Angiotensin II; Animals; Antifibrotic Agents; Benzhydryl Compounds; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Glucosides; Hypertrophy, Left Ventricular; Male; Myocardium; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Sodium-Glucose Transporter 2 Inhibitors; Transforming Growth Factor beta1; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2021 |
PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II by reducing TGF-β1/Smads pathway activation.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cardiotonic Agents; Cells, Cultured; Fibrosis; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Myocardium; Myofibroblasts; Proto-Oncogene Proteins; Signal Transduction; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta | 2021 |
Inactivation of Interleukin-4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt-Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling.
Topics: Angiotensin II; Animals; Disease Models, Animal; Fibrosis; Hypertension; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Myocardium; Receptors, Cell Surface; Signal Transduction; Sodium Chloride, Dietary; Ventricular Remodeling | 2021 |
Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta; Cells, Cultured; Disease Models, Animal; Fibrosis; Ginsenosides; Humans; Hypertrophy; Immunomodulation; Inflammasomes; Myocardium; Myocytes, Cardiac; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Signal Transduction; Sirtuin 1 | 2021 |
An organ-on-a-chip model for pre-clinical drug evaluation in progressive non-genetic cardiomyopathy.
Topics: Angiotensin II; Animals; Cardiomyopathies; Cardiotonic Agents; Cell Line; Cell Survival; Coculture Techniques; Drug Evaluation, Preclinical; Fibroblasts; Fibrosis; Humans; Induced Pluripotent Stem Cells; Lab-On-A-Chip Devices; Losartan; Mice; Myocytes, Cardiac; Pilot Projects; Proteome; Proteomics; Recombinant Proteins; Relaxin; Ventricular Remodeling | 2021 |
Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Angiotensin II; Animals; Anti-Inflammatory Agents; Benzaldehydes; Cardiomegaly; Cardiotonic Agents; Enzyme Inhibitors; Fibrosis; Heart; Inflammasomes; Inflammation; Macrophages; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oximes | 2021 |
IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA.
Topics: Actins; Angiotensin II; Animals; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Infusions, Intravenous; Insulin-Like Growth Factor I; Male; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phenylephrine; Proto-Oncogene Proteins c-akt; Rats; Receptor, IGF Type 1; rho-Associated Kinases; Signal Transduction | 2021 |
Sex differences in angiotensin II-induced hypertension and kidney injury: role of AT1a receptors in the proximal tubule of the kidney.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterial Pressure; Disease Models, Animal; Female; Fibrosis; Hypertension; Kidney Diseases; Kidney Tubules, Proximal; Losartan; Male; Mice, Inbred C57BL; Mice, Knockout; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Sex Characteristics; Sex Factors; Signal Transduction | 2021 |
H
Topics: Angiotensin II; Atrial Fibrillation; Base Sequence; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Heart Atria; Humans; Hydrogen Sulfide; MicroRNAs | 2021 |
Fibroblast-specific IKK-β deficiency ameliorates angiotensin II-induced adverse cardiac remodeling in mice.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type I; Fibroblasts; Fibrosis; Gene Knockdown Techniques; Heart Rate; Hypertension; I-kappa B Kinase; Inflammation; Macrophages; Male; Mice; Myocarditis; Myocardium; Organ Size; Protective Factors; Signal Transduction; Ventricular Remodeling | 2021 |
Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosis in mice through the TGF‑β1/Smad2 and AKT/ERK signaling pathways.
Topics: Angiotensin II; Animals; Apoptosis; Cell Line; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Flavanones; Heart Diseases; Heart Function Tests; Isoproterenol; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2021 |
Long Noncoding RNA
Topics: Angiotensin II; Cell Line; Fibrosis; Gene Expression Regulation; Humans; Kidney; Kidney Diseases; MicroRNAs; Receptors, Mineralocorticoid; RNA, Long Noncoding | 2021 |
Krüppel-Like Factor 15/Interleukin 11 Axis-Mediated Adventitial Remodeling Depends on Extracellular Signal-Regulated Kinases 1 and 2 Activation in Angiotensin II-Induced Hypertension.
Topics: Adventitia; Angiotensin II; Animals; Aorta, Thoracic; Disease Models, Animal; Fibroblasts; Fibrosis; HEK293 Cells; Humans; Hypertension; Inflammation Mediators; Interleukin-11; Kruppel-Like Transcription Factors; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats, Sprague-Dawley; Signal Transduction; Vascular Remodeling | 2021 |
MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibroblast Growth Factor 1; Fibrosis; Mice; Mice, Knockout; MicroRNAs; Myocytes, Cardiac; Ventricular Remodeling | 2022 |
MFAP4 deletion attenuates the progression of angiotensin II-induced atrial fibrosis and atrial fibrillation.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Fibrosis; Heart Atria; Humans; Mice; Phosphatidylinositol 3-Kinases | 2022 |
EHP-101 alleviates angiotensin II-induced fibrosis and inflammation in mice.
Topics: Administration, Oral; Angiotensin II; Animals; Anti-Inflammatory Agents; Cannabidiol; Fibroblasts; Fibrosis; Gene Expression Regulation; Inflammation; Losartan; Male; Mice; Mice, Inbred C57BL; Myocardium; Myofibroblasts | 2021 |
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury.
Topics: Angiotensin II; Animals; Antibodies; Blood Pressure; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Humans; Hypertension; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Kidney; Kidney Diseases; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction | 2021 |
rAAV9-mediated supplementation of miR-29b improve angiotensin-II induced renal fibrosis in mice.
Topics: Angiotensin II; Animals; Cell Line; Dependovirus; Disease Models, Animal; Fibrosis; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Immunohistochemistry; Kidney Diseases; Male; Mice; MicroRNAs; Transduction, Genetic | 2021 |
Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Fibrosis; Genomics; Humans; Mice; Mice, Inbred C57BL; Pancreatic Elastase; Swine | 2021 |
Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 1; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Signal Transduction; Ventricular Remodeling; Vinca Alkaloids | 2017 |
Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2).
Topics: Angiotensin II; Animals; Biopsy; Cytokines; Disease Models, Animal; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Inflammation Mediators; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Lymphocyte Antigen 96; Mice; Mice, Knockout; NF-kappa B; Protein Binding; Signal Transduction; Toll-Like Receptor 4 | 2017 |
Role of the MAPKs/TGF-β1/TRAF6 signaling pathway in postoperative atrial fibrillation.
Topics: Angiotensin II; Atrial Appendage; Atrial Fibrillation; Connective Tissue Growth Factor; Extracellular Signal-Regulated MAP Kinases; Female; Fibrosis; Humans; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Middle Aged; Postoperative Complications; Prognosis; Rheumatic Heart Disease; RNA, Messenger; Severity of Illness Index; TNF Receptor-Associated Factor 6; Transforming Growth Factor beta1 | 2017 |
Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways.
Topics: Alkaloids; Angiotensin II; Anilides; Animals; Benzodioxoles; Cell Differentiation; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Fibroblasts; Fibrosis; Glycogen Synthase Kinase 3 beta; Heart; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardium; Myofibroblasts; Piperidines; Polyunsaturated Alkamides; PPAR gamma; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta | 2017 |
ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.
Topics: Angiotensin II; Animals; Aorta; Apelin Receptors; Arterial Pressure; Cardiotonic Agents; Constriction; Disease Models, Animal; Fibrosis; Forkhead Box Protein M1; Gene Expression Regulation; Heart Failure; HEK293 Cells; Humans; Hypertension; Hypertrophy, Left Ventricular; Infusions, Subcutaneous; Ligands; Male; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardium; Peptide Hormones; Peptidyl-Dipeptidase A; Signal Transduction; Transfection; Ventricular Dysfunction, Left; Ventricular Function, Left | 2017 |
Angiotensin-(1-7) attenuates angiotensin II-induced cardiac hypertrophy via a Sirt3-dependent mechanism.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cardiomegaly; Cardiotonic Agents; Cell Size; Fibrosis; Male; Myocytes, Cardiac; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Sirtuins; Superoxide Dismutase | 2017 |
β-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis.
Topics: Aminoisobutyric Acids; Angiotensin II; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Extracellular Matrix; Fibroblasts; Fibrosis; Interleukin-17; Kidney; Male; Rats, Sprague-Dawley; Reactive Oxygen Species; Renal Insufficiency, Chronic; Signal Transduction | 2017 |
[AMP-activated kinase activation inhibits transforming growth factor-β1 production in cardiac fibroblasts via targeting C/EBPβ].
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Animals; Binding Sites; CCAAT-Enhancer-Binding Protein-beta; Cells, Cultured; Fibroblasts; Fibrosis; Heart; Mice; Myocardium; Phosphorylation; Ribonucleotides; Transfection; Transforming Growth Factor beta1 | 2017 |
SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension.
Topics: Acetylation; Angiotensin II; Animals; Biphenyl Compounds; Disease Models, Animal; Fibrosis; Gene Expression; Gene Expression Regulation; Hypertension, Renal; Kidney; Kruppel-Like Transcription Factors; Lignans; Mice; Mice, Knockout; Models, Biological; Nephritis; Nuclear Proteins; Podocytes; Protein Binding; Signal Transduction; Sirtuin 3 | 2017 |
Inhibition of Angiotensin II-Induced Cardiac Fibrosis by Atorvastatin in Adiponectin Knockout Mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Angiotensin II; Animals; Atorvastatin; Collagen Type I; Collagen Type III; Fibrosis; Gene Expression Regulation; Gene Knockout Techniques; Heart Diseases; Injections, Subcutaneous; Male; Mice; Phosphorylation; Treatment Outcome | 2017 |
c-Myc promotes renal fibrosis by inducing integrin αv-mediated transforming growth factor-β signaling.
Topics: Angiotensin II; Animals; Extracellular Matrix; Fibroblasts; Fibrosis; Folic Acid; Integrin alphaV; Kidney; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-myc; Renal Insufficiency, Chronic; Signal Transduction; Thiazoles; Transforming Growth Factor beta; Up-Regulation; Ureteral Obstruction | 2017 |
Colchicine attenuates renal fibrosis in a murine unilateral ureteral obstruction model.
Topics: Angiotensin II; Animals; Biomarkers; Cell Line; Cell Movement; Cell Survival; Colchicine; Disease Models, Animal; Fibroblasts; Fibrosis; Immunohistochemistry; Kidney Diseases; Male; Mice; Rats; rhoA GTP-Binding Protein; Ureteral Obstruction | 2017 |
Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis.
Topics: Actins; Angiotensin II; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cells, Cultured; Connective Tissue Growth Factor; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Scleroderma, Systemic; Skin | 2017 |
The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation.
Topics: Activin Receptors, Type I; Activins; Adult; Aged; Angiotensin II; Animals; Atrial Fibrillation; Female; Fibrosis; Heart Atria; Humans; Male; Mice; Mice, Knockout; Middle Aged | 2017 |
The loss of Krüppel-like factor 15 in Foxd1
Topics: Angiotensin II; Animals; beta Catenin; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Disease Progression; DNA-Binding Proteins; Fibrosis; Forkhead Transcription Factors; Gene Expression Regulation; Gene Knockdown Techniques; Kidney; Kidney Diseases; Kruppel-Like Transcription Factors; Male; Mice; Mice, Inbred C57BL; Myofibroblasts; Phosphorylation; RNA, Messenger; Stromal Cells; Transcription Factors; Wnt Signaling Pathway; Wnt1 Protein | 2017 |
The ACE2-Ang (1-7)-Mas receptor axis attenuates cardiac remodeling and fibrosis in post-myocardial infarction.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Collagen; Fibrosis; Heart Function Tests; Immunohistochemistry; Male; Myocardial Infarction; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger; Ventricular Dysfunction, Left; Ventricular Remodeling | 2017 |
Differential Effects of Myocardial Afadin on Pressure Overload-Induced Compensated Cardiac Hypertrophy.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Fibrosis; Humans; Mice; Mice, Knockout; Microfilament Proteins; Myocardium; Pressure; Stress, Mechanical | 2017 |
Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies.
Topics: Angiotensin II; Animals; Antioxidants; Cardiomegaly; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrosis; Heart; Lung Diseases; Male; Melatonin; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Primary Cell Culture; Transcriptional Activation | 2017 |
Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin.
Topics: Adaptor Proteins, Signal Transducing; Age Factors; Angiotensin II; Animals; Collagen; Fibrosis; Genotype; Kidney; Longevity; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Oxidative Stress; Phenotype; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Signal Transduction; Sirtuin 1; Time Factors; Transforming Growth Factor beta | 2017 |
Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.
Topics: Acetylation; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Collagen Type I; Collagen Type III; Disease Models, Animal; Disease Progression; Fibrosis; Genetic Predisposition to Disease; Hypertension; Mice, 129 Strain; Mice, Knockout; Mitochondria, Heart; Mitophagy; Myocardium; Neovascularization, Physiologic; Oxidative Stress; Phenotype; Protein Kinases; Signal Transduction; Sirtuin 3; Time Factors; Tissue Culture Techniques; Ubiquitin-Protein Ligases; Ventricular Remodeling | 2017 |
Inhibition of microRNA‑155 ameliorates cardiac fibrosis in the process of angiotensin II‑induced cardiac remodeling.
Topics: Angiotensin II; Animals; Antagomirs; Cells, Cultured; Fibroblasts; Fibrosis; Heart; Heart Ventricles; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardium; Smad3 Protein; Spleen; Suppressor of Cytokine Signaling 1 Protein; Transforming Growth Factor beta1; Ventricular Remodeling | 2017 |
Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.
Topics: Aging; Angiotensin II; Animals; Aortic Valve Stenosis; Cells, Cultured; Chemokine CCL2; Fibroblasts; Fibrosis; Humans; Hypertension; Intercellular Adhesion Molecule-1; Intercellular Signaling Peptides and Proteins; Interleukin-1beta; Macrophages; Mice; Myocardium | 2018 |
Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.
Topics: Adamantane; Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Aorta; Blood Pressure; Cardiomegaly; CD4-Positive T-Lymphocytes; CD8 Antigens; Diastole; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Echocardiography; Fibrosis; Gene Expression; Heart; Inflammation; Interleukin-17; Interleukin-18; Lymphocytes; Macrophages; Male; Mice; Proto-Oncogene Proteins c-jun; Signal Transduction; Vascular Stiffness; Vasoconstrictor Agents | 2017 |
The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation.
Topics: Angiotensin II; Animals; Benzamides; Cardiotonic Agents; Cells, Cultured; Cytoprotection; Fibrosis; Heart; Hydrazines; Inflammasomes; Inflammation; Mice; Mice, Inbred C57BL; Myocarditis; Myocardium; NLR Family, Pyrin Domain-Containing 3 Protein | 2018 |
Investigation of cardiac fibroblasts using myocardial slices.
Topics: Actins; Angiotensin II; Animals; Biomarkers; Cell Proliferation; Collagen; Dogs; Fibroblasts; Fibrosis; Humans; Mice, Transgenic; Myocardium; Phenotype; Physical Stimulation; Time Factors; Tissue Culture Techniques; Transforming Growth Factor beta; Vimentin | 2018 |
Differential Expression of Hypertensive Phenotypes in BXD Mouse Strains in Response to Angiotensin II.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Heart Diseases; Hypertension; Inflammation; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Phenotype; Species Specificity; Transforming Growth Factor beta; Vasoconstrictor Agents | 2017 |
Kaempferol Alleviates Angiotensin II-Induced Cardiac Dysfunction and Interstitial Fibrosis in Mice.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cell Survival; Cells, Cultured; Collagen Type I; Collagen Type II; Echocardiography; Fibroblasts; Fibrosis; Heart Ventricles; Human Umbilical Vein Endothelial Cells; Humans; Kaempferols; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Rats; Signal Transduction; Transforming Growth Factor beta1; Ventricular Remodeling | 2017 |
Inhibition of angiotensin II and calpain attenuates pleural fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bleomycin; Calpain; Carbon; Cell Line; Collagen Type I; Dipeptides; Disease Models, Animal; Fibrosis; Humans; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pleural Diseases | 2018 |
Nox4 genetic inhibition in experimental hypertension and metabolic syndrome.
Topics: Angiotensin II; Animals; Biomarkers; Blood Glucose; Blood Pressure; Cardiomegaly; Diet, High-Fat; Disease Models, Animal; Female; Fibrosis; Genetic Predisposition to Disease; Heart Rate; Hypertension; Male; Metabolic Syndrome; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NADPH Oxidase 4; Phenotype; Reactive Oxygen Species; Time Factors; Triglycerides; Ventricular Remodeling | 2018 |
MicroRNA-130a, a Potential Antifibrotic Target in Cardiac Fibrosis.
Topics: Angiotensin II; Animals; Blotting, Western; Cardiomyopathies; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; MicroRNAs; Myocardium; Reverse Transcriptase Polymerase Chain Reaction; RNA; Up-Regulation | 2017 |
Deletion of protein kinase B2 preserves cardiac function by blocking interleukin-6-mediated injury and restores blood pressure during angiotensin II/high-salt-diet-induced hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Cell Movement; Chemokine CCL2; Fibrosis; Gene Expression; Hypertension; Inflammation; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocytes, Cardiac; Oxidative Stress; Proto-Oncogene Proteins c-akt; Sodium Chloride, Dietary; Stroke Volume; Vasoconstrictor Agents; Ventricular Function, Left | 2018 |
Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway.
Topics: Angiotensin II; Animals; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Kidney Diseases; Mice; Phosphorylation; Podocytes; ras Proteins; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Smad2 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1; Triterpenes; Up-Regulation; Wolfiporia | 2017 |
KLF 15 Works as an Early Anti-Fibrotic Transcriptional Regulator in Ang II-Induced Renal Fibrosis via Down-Regulation of CTGF Expression.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Connective Tissue Growth Factor; DNA-Binding Proteins; Fibrosis; Gene Expression Regulation; Kruppel-Like Transcription Factors; Losartan; Mice; Promoter Regions, Genetic; Rats; Receptor, Angiotensin, Type 1; Transcription Factors | 2017 |
Upregulation of Cabin1 During Injury to Renal Tubular Epithelial Cells in Rats.
Topics: Angiotensin II; Animals; Apoptosis Regulatory Proteins; Cadherins; Cell Line; Disease Models, Animal; Epithelial Cells; Fibrosis; Kidney Diseases; Kidney Tubules; Mitochondria; Mitochondrial Swelling; Nephrectomy; Rats, Sprague-Dawley; Smad Proteins; Time Factors; Up-Regulation | 2017 |
DKK3 overexpression attenuates cardiac hypertrophy and fibrosis in an angiotensin-perfused animal model by regulating the ADAM17/ACE2 and GSK-3β/β-catenin pathways.
Topics: ADAM17 Protein; Adaptor Proteins, Signal Transducing; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Animals, Newborn; Apoptosis; beta Catenin; Cardiomegaly; Cell Proliferation; Disease Models, Animal; Fibroblasts; Fibrosis; Glycogen Synthase Kinase 3 beta; Inflammation; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinases; Mice, Inbred C57BL; Peptide Fragments; Peptidyl-Dipeptidase A; Perfusion; Phosphorylation; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2018 |
Loss of Vascular Myogenic Tone in miR-143/145 Knockout Mice Is Associated With Hypertension-Induced Vascular Lesions in Small Mesenteric Arteries.
Topics: Actin Cytoskeleton; Angiotensin II; Animals; Arterial Pressure; Calcium Signaling; Cells, Cultured; Disease Models, Animal; Elastic Tissue; Female; Fibrosis; Gene Knockout Techniques; Hyperplasia; Hypertension; Male; Mesenteric Arteries; Mice, Knockout; MicroRNAs; Muscle, Smooth, Vascular; Neointima; Vascular Remodeling; Vascular Resistance; Vasoconstriction | 2018 |
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.
Topics: Angiotensin II; Animals; Cytochrome P450 Family 4; Enzyme Induction; Fibrosis; Formamides; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Knockout; Morpholines | 2018 |
Epac is required for exogenous and endogenous stimulation of adenosine A
Topics: Actins; Angiotensin II; Animals; Cell Differentiation; Cells, Cultured; Collagen; Cyclic AMP; Fibrosis; Guanine Nucleotide Exchange Factors; Heart Diseases; Myofibroblasts; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B | 2018 |
Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway.
Topics: Angiotensin II; Animals; Cells, Cultured; Collagen; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Fibronectins; Fibrosis; Flavonoids; Heart Diseases; Myocardium; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2018 |
Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice.
Topics: Angiotensin II; Animals; Antibodies, Neutralizing; Cardiomegaly; Cells, Cultured; Cytokines; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Interleukin-22; Interleukins; Male; Mice; Mice, Inbred C57BL; Myocardium; RNA, Messenger; STAT3 Transcription Factor | 2017 |
Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Movement; Cell Proliferation; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Fibrosis; Hypertension; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Myofibroblasts; Receptor Cross-Talk; Receptors, Lysophosphatidic Acid; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Ventricular Remodeling | 2018 |
Activation of calcium-sensing receptor-mediated autophagy in angiotensinII-induced cardiac fibrosis in vitro.
Topics: Angiotensin II; Animals; Autophagy; Cells, Cultured; Collagen; Fibroblasts; Fibrosis; MAP Kinase Signaling System; Myocardium; Rats, Wistar; Receptors, Calcium-Sensing | 2018 |
CD44 Deficiency in Mice Protects the Heart Against Angiotensin Ii-Induced Cardiac Fibrosis.
Topics: Angiotensin II; Animals; Female; Fibrosis; Heart Diseases; Hyaluronan Receptors; Male; Mice; Mice, Knockout; Myocardium; NF-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Abnormal Downregulation of Caveolin-3 Mediates the Pro-Fibrotic Action of MicroRNA-22 in a Model of Myocardial Infarction.
Topics: Actins; Angiotensin II; Animals; Base Sequence; Caveolin 3; Cells, Cultured; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Disease Models, Animal; Down-Regulation; Fibroblasts; Fibrosis; Male; Mice; MicroRNAs; Myocardial Infarction; Myocardium; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; RNA Interference | 2018 |
TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Gene Expression Regulation; Immunohistochemistry; Male; Myocardium; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA; Sick Sinus Syndrome; Signal Transduction; Sinoatrial Node; Smad2 Protein; TRPM Cation Channels | 2018 |
CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Animals; Cardiomegaly; Cell Movement; Chemokine CXCL1; Female; Fibrosis; Heart Failure; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocytes; Myocardium; Receptors, Interleukin-8B; Signal Transduction; Up-Regulation | 2018 |
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
Topics: Actins; Angiotensin II; Animals; Aspirin; beta Catenin; Cell Line; Collagen Type I; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Failure; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Serpin E2; Signal Transduction | 2018 |
Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation.
Topics: Alisma; Angiotensin II; Animals; Cell Line; Epithelial-Mesenchymal Transition; Fibrosis; Kidney; Kidney Diseases; Phosphatidylinositol 3-Kinases; Phosphorylation; ras Proteins; Rats; Smad3 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1; Triterpenes; Wnt Signaling Pathway | 2018 |
Atrial overexpression of microRNA-27b attenuates angiotensin II-induced atrial fibrosis and fibrillation by targeting ALK5.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Collagen; Fibrosis; Gene Expression; Heart Atria; Male; Mice, Inbred C57BL; MicroRNAs; Molecular Targeted Therapy; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein | 2018 |
C1QTNF1 attenuates angiotensin II-induced cardiac hypertrophy via activation of the AMPKa pathway.
Topics: Adipokines; AMP-Activated Protein Kinase Kinases; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Phosphorylation; Protein Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasoconstrictor Agents | 2018 |
Ultrastructural and mechanical changes in tubular epithelial cells by angiotensin II and aldosterone as observed with atomic force microscopy.
Topics: Aldosterone; Angiotensin II; Animals; Cell Line; Epithelial Cells; Fibrosis; Kidney Tubules, Proximal; Mechanical Phenomena; Microscopy, Atomic Force; Rats; Renin-Angiotensin System; Stress, Mechanical | 2018 |
Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca
Topics: Angiotensin II; Animals; Calcium; Calcium Signaling; Endoplasmic Reticulum; Fibroblasts; Fibrosis; Heart Function Tests; Mice, Knockout; Models, Biological; Myocardial Infarction; Myocardium; Nogo Proteins; Rats; SEC Translocation Channels; Transforming Growth Factor beta1; Up-Regulation | 2018 |
Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor.
Topics: Angiotensin II; Animals; Collagen; Dipeptides; Disease Models, Animal; Fibrosis; GTP-Binding Proteins; Human Umbilical Vein Endothelial Cells; Humans; Mice; Myocardium; Myofibroblasts; Protein Glutamine gamma Glutamyltransferase 2; Small Molecule Libraries; Transforming Growth Factor beta1; Transglutaminases | 2018 |
Leflunomide counter
Topics: Angiotensin II; Aniline Compounds; Animals; Cardiomegaly; Crotonates; Fibrosis; Hydroxybutyrates; Leflunomide; Mice; Nitriles; Proto-Oncogene Proteins c-akt; Toluidines | 2018 |
Effect of NF-κB inhibitor on Toll-like receptor 4 expression in left ventricular myocardium in two-kidney-one-clip hypertensive rats.
Topics: Angiotensin II; Animals; Fibrosis; Heart Ventricles; Hypertension, Renovascular; Male; Myocardium; NF-kappa B; Pyrrolidines; Random Allocation; Rats; Thiocarbamates; Toll-Like Receptor 4 | 2018 |
Membrane rafts-redox signalling pathway contributes to renal fibrosis via modulation of the renal tubular epithelial-mesenchymal transition.
Topics: Angiotensin II; Animals; Cells, Cultured; Epithelial-Mesenchymal Transition; Fibrosis; Hypertension, Renal; Kidney Diseases; Kidney Tubules, Proximal; Male; Membrane Microdomains; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta1 | 2018 |
Adiponectin attenuates kidney injury and fibrosis in deoxycorticosterone acetate-salt and angiotensin II-induced CKD mice.
Topics: Adiponectin; Angiotensin II; Animals; Cell Proliferation; Desoxycorticosterone Acetate; Disease Models, Animal; Fibrosis; Hepatitis A Virus Cellular Receptor 1; Kidney; Lipocalin-2; Low Density Lipoprotein Receptor-Related Protein-2; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidase 2; NADPH Oxidases; Nephrectomy; Receptors, Cell Surface; Renal Insufficiency, Chronic; Signal Transduction; Transcription Factor RelA; Up-Regulation | 2018 |
Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Progression; Feedback, Physiological; Female; Fibrosis; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptidyl-Dipeptidase A; Renin-Angiotensin System; Sex Characteristics | 2018 |
Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Artemisia; Cardiomyopathies; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Coumarins; Extracellular Matrix; Fibroblasts; Fibronectins; Fibrosis; Myocardium; Myofibroblasts; Phytotherapy; Rats; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2018 |
CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Chemokine CCL2; Chemokines; Cytokines; Fibrosis; Gene Deletion; Gene Expression; Inflammasomes; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Cells; Myocytes, Cardiac; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; RNA, Messenger; Signal Transduction | 2018 |
CD1d-dependent natural killer T cells attenuate angiotensin II-induced cardiac remodelling via IL-10 signalling in mice.
Topics: Adoptive Transfer; Angiotensin II; Animals; Antigens, CD1d; Cardiomegaly; Cells, Cultured; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Fibrosis; Galactosylceramides; Hypertension; Inflammation Mediators; Interleukin-10; Male; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Natural Killer T-Cells; NF-kappa B; Signal Transduction; STAT3 Transcription Factor; Transforming Growth Factor beta1; Ventricular Remodeling | 2019 |
A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model.
Topics: Angiotensin II; Animals; Cell Proliferation; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Fibroblasts; Fibrosis; Kidney; Mice; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinoxalines; Renal Insufficiency, Chronic; Thiazolidinediones | 2018 |
CTGF/CCN2 is an autocrine regulator of cardiac fibrosis.
Topics: Angiotensin II; Animals; Autocrine Communication; Connective Tissue Growth Factor; Fibrosis; Heart Failure; Humans; Mice; Myocytes, Cardiac; Myofibroblasts; Ventricular Remodeling | 2018 |
Nigella sativa extract is a potent therapeutic agent for renal inflammation, apoptosis, and oxidative stress in a rat model of unilateral ureteral obstruction.
Topics: Angiotensin II; Animals; Apoptosis; Captopril; Chemokine CCL2; Creatinine; Fibrosis; Inflammation; Kidney; Kidney Diseases; Losartan; Male; Malondialdehyde; Nigella sativa; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Renin-Angiotensin System; Tumor Necrosis Factor-alpha; Urea; Ureteral Obstruction | 2018 |
Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving 'SIRT1 and PGC-1α'.
Topics: Angiotensin II; Animals; Caloric Restriction; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Fibrosis; Hypertension; Male; Mice, Inbred C57BL; Myocardium; Obesity; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; Ventricular Remodeling | 2018 |
Glaucocalyxin A attenuates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Cell Movement; Cell Proliferation; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Fibrosis; Male; Myofibroblasts; Rats; Rats, Sprague-Dawley | 2018 |
Downregulation of microRNA-429 contributes to angiotensin II-induced profibrotic effect in rat kidney.
Topics: Actins; Albuminuria; Angiotensin II; Animals; Cadherins; Calcium-Binding Proteins; Cell Line; Cell Transdifferentiation; Collagen; Down-Regulation; Epithelial-Mesenchymal Transition; Fibrosis; Kidney Tubules, Proximal; Male; MicroRNAs; Podocytes; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Cilostazol ameliorates heart failure with preserved ejection fraction and diastolic dysfunction in obese and non-obese hypertensive mice.
Topics: Angiotensin II; Animals; Biomarkers; Biopsy; Blood Pressure; Cilostazol; Diastole; Disease Models, Animal; Disease Progression; Echocardiography; Energy Metabolism; Fibrosis; Heart Failure; Hypertension; Immunohistochemistry; Male; Mice; Renin; Stroke Volume; Vasodilator Agents; Ventricular Dysfunction, Left | 2018 |
Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Dioxolanes; Extracellular Matrix; Fibroblasts; Fibrosis; Heart; Humans; Malondialdehyde; MAP Kinase Signaling System; Myofibroblasts; Phosphorylation; Piper; Rats; Reactive Oxygen Species | 2018 |
Reduction of cardiac TGFβ-mediated profibrotic events by inhibition of Hsp90 with engineered protein.
Topics: Angiotensin II; Animals; Cell Survival; Cells, Cultured; Collagen; Disease Models, Animal; Extracellular Matrix; Fibroblasts; Fibrosis; Fluorescent Antibody Technique; HSP90 Heat-Shock Proteins; Mice; Mice, Knockout; Microscopy, Confocal; Models, Molecular; Myocardium; Peptides; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Signal Transduction; Transforming Growth Factor beta | 2018 |
Adiponection, a novel player to save the kidneys.
Topics: Acetates; Adiponectin; Angiotensin II; Animals; Desoxycorticosterone Acetate; Fibrosis; Mice; Renal Insufficiency, Chronic | 2018 |
Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice.
Topics: Angiotensin II; Animals; Benzoates; Blood Pressure; Cardiomegaly; Fibrosis; Furans; Gene Expression; Heart; Hypertension; Male; Mice; Myocardium; Pyrazoles; Signal Transduction; Ubiquitin-Activating Enzymes; Ventricular Remodeling | 2018 |
Angiotensin II requires an intact cardiac thyrotropin-releasing hormone (TRH) system to induce cardiac hypertrophy in mouse.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Drinking; Fibrosis; Gene Expression Profiling; Hypertrophy, Left Ventricular; Immunohistochemistry; Mice; Myocardium; NIH 3T3 Cells; Phenotype; Rats; RNA Interference; RNA, Small Interfering; Thyrotropin-Releasing Hormone | 2018 |
The cofilin phosphatase slingshot homolog 1 restrains angiotensin II-induced vascular hypertrophy and fibrosis in vivo.
Topics: Angiotensin II; Animals; Aorta; Disease Models, Animal; Female; Fibrosis; Hypertension; Hypertrophy; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Phosphoprotein Phosphatases; Transforming Growth Factor beta1; Vascular Remodeling | 2019 |
MiR-101a ameliorates AngII-mediated hypertensive nephropathy by blockade of TGFβ/Smad3 and NF-κB signalling in a mouse model of hypertension.
Topics: Angiotensin II; Animals; Base Sequence; Cell Line; Disease Models, Animal; Fibrosis; Hypertension, Renal; Kidney; Male; Mice; MicroRNAs; Nephritis; NF-kappa B; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta | 2019 |
Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis.
Topics: Actins; Adventitia; Angiotensin II; Animals; Aorta; Aortic Diseases; Disease Models, Animal; Febuxostat; Fibroblasts; Fibrosis; Gout Suppressants; Hypertension; Macrophages; Male; Mice, Inbred C57BL; Transforming Growth Factor beta1; Vascular Remodeling; Xanthine Oxidase | 2019 |
Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro.
Topics: Angiotensin II; Animals; Benzofurans; Cell Movement; Cell Proliferation; Collagen Type I; Fibroblasts; Fibrosis; Heart; I-kappa B Proteins; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley | 2018 |
Single-Stranded DNA-Binding Protein 1 Abrogates Cardiac Fibroblast Proliferation and Collagen Expression Induced by Angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Cell Proliferation; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; DNA-Binding Proteins; Fibrillar Collagens; Fibrosis; Heart; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Myocardium; Myofibroblasts; Tumor Suppressor Protein p53; Valsartan; Vasoconstrictor Agents | 2018 |
Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1.
Topics: Angiotensin II; Animals; Caspase 1; Caspase Inhibitors; Caspases; Caspases, Initiator; Coumarins; Enzyme Activation; Extracellular Matrix; Fibrosis; Gene Silencing; Interleukin-1beta; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Rats; RNA, Small Interfering; Ureteral Obstruction | 2019 |
MicroRNA-323a-3p Promotes Pressure Overload-Induced Cardiac Fibrosis by Targeting TIMP3.
Topics: 3' Untranslated Regions; Angiotensin II; Animals; Antagomirs; Cells, Cultured; Collagen Type I; Fibroblasts; Fibrosis; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardium; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta1 | 2018 |
Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney.
Topics: Albuminuria; Angiotensin I; Angiotensin II; Animals; Anti-Inflammatory Agents; Antioxidants; Collagen Type IV; Fibronectins; Fibrosis; Kidney; Male; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Peptide Fragments; Plant Extracts; Proto-Oncogene Proteins; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Renal Insufficiency, Chronic; Renin-Angiotensin System; Resveratrol; Superoxide Dismutase | 2018 |
The miRNA-184 drives renal fibrosis by targeting HIF1AN in vitro and in vivo.
Topics: Actins; Angiotensin II; Animals; Cell Line; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Databases, Genetic; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Kidney; Mice; MicroRNAs; Mixed Function Oxygenases; Rats; Renal Insufficiency, Chronic; RNA, Messenger; Ureteral Obstruction | 2019 |
Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice.
Topics: Angiotensin II; Animals; Calcineurin; Cardiomegaly; Disease Progression; Fibrosis; Gene Expression Profiling; Mice; Mice, Knockout; Myocytes, Cardiac; Signal Transduction; Vasoconstrictor Agents | 2019 |
Xanthine Oxidase Inhibition as a Potential Treatment for Aortic Stiffness in Hypertension.
Topics: Angiotensin II; Febuxostat; Fibrosis; Humans; Hypertension; Macrophages; Vascular Stiffness; Xanthine Oxidase | 2019 |
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Topics: Angiotensin II; Animals; Blotting, Western; Cardiomyopathies; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart Ventricles; Immunohistochemistry; Inflammation; Intermediate-Conductance Calcium-Activated Potassium Channels; Male; Monocytes; Myocardium; Myofibroblasts; Rats; Rats, Sprague-Dawley; RNA | 2019 |
Immunoproteasome Subunit β5i Promotes Ang II (Angiotensin II)-Induced Atrial Fibrillation by Targeting ATRAP (Ang II Type I Receptor-Associated Protein) Degradation in Mice.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Atrial Remodeling; Disease Models, Animal; Fibrosis; Heart Atria; Immunoproteins; Mice; Oxidative Stress; Proteasome Endopeptidase Complex; Receptor, Angiotensin, Type 1 | 2019 |
Suppression of angiotensin II-induced pathological changes in heart and kidney by the caveolin-1 scaffolding domain peptide.
Topics: Angiotensin II; Angiotensins; Animals; Bone Marrow Cells; Capillary Permeability; Caveolin 1; Cell Movement; Fibrosis; Heart; Hypertrophy, Left Ventricular; Kidney; Male; Mice; Mice, Inbred C57BL; Myocardium; Peptide Fragments; Renin-Angiotensin System; Signal Transduction | 2018 |
Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease.
Topics: Angiotensin II; Animals; Biopsy; Blood Pressure; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibroblast Growth Factors; Fibrosis; Gene Expression Regulation; Heart Rate; Heart Ventricles; Humans; Hypertension; Mice, Knockout; Myocardium; Rats, Sprague-Dawley; RNA, Messenger | 2019 |
Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Apelin; Biopsy; Cardiomegaly; Disease Models, Animal; Echocardiography; Fibrosis; Heart Failure; Hypertension; Mice; Mice, Knockout; Myocardial Contraction; Myocytes, Cardiac; Peptidyl-Dipeptidase A; Ventricular Dysfunction; Ventricular Remodeling | 2019 |
NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice.
Topics: Action Potentials; Angiotensin II; Animals; Atrial Fibrillation; Atrial Remodeling; Disease Models, Animal; Disease Progression; Fibrosis; Heart Atria; Heart Rate; Hypertension; Male; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Receptors, Atrial Natriuretic Factor; Time Factors | 2019 |
Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis.
Topics: Angiotensin II; Animals; Collagen; Diterpenes; Down-Regulation; Enzyme Activation; Epoxy Compounds; Fibroblasts; Fibrosis; Heart Ventricles; Inflammasomes; Isoproterenol; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocardium; NLR Family, Pyrin Domain-Containing 3 Protein; Phenanthrenes; Smad Proteins; Transforming Growth Factor beta1 | 2019 |
Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition.
Topics: Angiotensin II; Animals; Cardiomegaly; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Proto-Oncogene Protein c-ets-1; Signal Transduction; Transforming Growth Factor beta1; Twist Transcription Factors; Zinc Finger E-box-Binding Homeobox 1 | 2019 |
Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis.
Topics: Angiotensin II; Animals; Fibroblasts; Fibronectins; Fibrosis; Heart Diseases; Male; Mice; Mice, Inbred C57BL; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2019 |
Novel role of the clustered miR-23b-3p and miR-27b-3p in enhanced expression of fibrosis-associated genes by targeting TGFBR3 in atrial fibroblasts.
Topics: Angiotensin II; Atrial Fibrillation; Cell Proliferation; Collagen Type III; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart Atria; Humans; MicroRNAs; Proteoglycans; Receptors, Transforming Growth Factor beta; Sick Sinus Syndrome; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1 | 2019 |
Transactivation domain of Krüppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis.
Topics: Adventitia; Angiotensin II; Animals; Cell Movement; Cells, Cultured; Chemokine CCL2; Collagen; Fibroblasts; Fibrosis; HEK293 Cells; Humans; Inflammation; Kruppel-Like Transcription Factors; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Protein Domains; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Smad Proteins; Vascular Cell Adhesion Molecule-1 | 2019 |
Urine Angiotensin II Signature Proteins as Markers of Fibrosis in Kidney Transplant Recipients.
Topics: ADP-ribosyl Cyclase; Adult; Angiotensin II; Antigens, CD; Biomarkers; Case-Control Studies; Female; Fibrosis; Glutamate-Ammonia Ligase; GPI-Linked Proteins; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Laminin; Male; Mass Spectrometry; Middle Aged; Predictive Value of Tests; rhoB GTP-Binding Protein; Thiolester Hydrolases; Thrombospondin 1; Treatment Outcome; Urinalysis | 2019 |
Biomarkers for Chronic Rejection: In Angiotensin Proteins We Trust?
Topics: Angiotensin II; Biomarkers; Fibrosis; Graft Rejection; Humans; Kidney Transplantation | 2019 |
2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury.
Topics: 2-Methoxyestradiol; Angiotensin II; Animals; Blood Pressure; Fibrosis; Glomerular Filtration Rate; Hypertension; Hypertrophy, Left Ventricular; Isoproterenol; Kidney; Kidney Diseases; Male; Rats, Sprague-Dawley; Renin-Angiotensin System; Vascular Remodeling; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Unique mechanistic insights into the beneficial effects of angiotensin-(1-7) on the prevention of cardiac fibrosis: A metabolomic analysis of primary cardiac fibroblasts.
Topics: Angiotensin I; Angiotensin II; Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Differentiation; Cell Proliferation; Cells, Cultured; Fibroblasts; Fibrosis; Gas Chromatography-Mass Spectrometry; Glutathione; Heart Diseases; Male; Metabolome; Oxidative Stress; Peptide Fragments; Rats, Sprague-Dawley; Reactive Oxygen Species | 2019 |
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury.
Topics: Angiotensin II; Animals; Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Cytokines; Disease Models, Animal; Fibrosis; G2 Phase Cell Cycle Checkpoints; HEK293 Cells; Humans; Inflammation; Kidney; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Signal Transduction; Ureteral Obstruction | 2019 |
LncRNA PVT1 regulates atrial fibrosis via miR-128-3p-SP1-TGF-β1-Smad axis in atrial fibrillation.
Topics: Adult; Angiotensin II; Animals; Atrial Fibrillation; Cell Proliferation; Collagen Type I; Collagen Type II; Female; Fibroblasts; Fibrosis; Heart Atria; Humans; Male; Mice, Inbred C57BL; MicroRNAs; Middle Aged; RNA, Long Noncoding; Smad Proteins; Sp1 Transcription Factor; Transforming Growth Factor beta1 | 2019 |
Lovastatin attenuates angiotensin II induced cardiovascular fibrosis through the suppression of YAP/TAZ signaling.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Anticholesteremic Agents; Cardiovascular Diseases; Cell Cycle Proteins; Cell Line; Fibrosis; Lovastatin; Male; Mice, Inbred C57BL; Myocardium; Signal Transduction; Trans-Activators; YAP-Signaling Proteins | 2019 |
Kangxianling decoction prevents renal fibrosis in rats with 5/6 nephrectomy and inhibits Ang II-induced ECM production in glomerular mesangial cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Collagen; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Fibronectins; Fibrosis; Glomerular Mesangium; Kidney; Kidney Diseases; Male; MAP Kinase Signaling System; Mesangial Cells; Nephrectomy; Rats, Sprague-Dawley; Transforming Growth Factor beta; Up-Regulation | 2019 |
Epigenetic modulation of tenascin C in the heart: implications on myocardial ischemia, hypertrophy and metabolism.
Topics: Angiotensin II; Animals; Cardiomegaly; Coronary Artery Disease; DNA Methylation; Energy Metabolism; Epigenesis, Genetic; Extracellular Matrix; Extracellular Matrix Proteins; Fibrosis; Heart Diseases; Humans; Hypertrophy; Hypoxia; Male; Matrix Metalloproteinase 2; MicroRNAs; Myocardial Infarction; Myocardium; Nerve Tissue Proteins; Rats; Tenascin; Ventricular Remodeling | 2019 |
COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis.
Topics: Adenosine; Angiotensin II; Animals; Cell Line; Connective Tissue Growth Factor; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Fibrosis; Humans; Male; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Scleroderma, Systemic; Skin; Transforming Growth Factor beta1 | 2019 |
Inhibition of STAT3 activation mediated by toll-like receptor 4 attenuates angiotensin II-induced renal fibrosis and dysfunction.
Topics: Aminosalicylic Acids; Angiotensin II; Animals; Benzenesulfonates; Cells, Cultured; Disease Models, Animal; Fibrosis; Humans; Hypertension, Renal; Infusions, Subcutaneous; Kidney Diseases; Mice; Mice, Inbred C57BL; Nephritis; RNA, Small Interfering; STAT3 Transcription Factor; Toll-Like Receptor 4 | 2019 |
Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p.
Topics: Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Fibrosis; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; MicroRNAs; Myocytes, Cardiac; Protein Serine-Threonine Kinases; RNA, Circular | 2019 |
Myocardin ablation in a cardiac-renal rat model.
Topics: Angiotensin II; Animals; Cardio-Renal Syndrome; Cardiomyopathy, Dilated; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Ventricles; Male; Myocytes, Cardiac; Nuclear Proteins; Rats; RNA Interference; RNA, Small Interfering; Trans-Activators; Transforming Growth Factor beta; Ventricular Function | 2019 |
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Topics: Adult; Aged; Angiotensin II; Cell Movement; Cell Proliferation; Collagen; Fibroblasts; Fibrosis; Humans; Middle Aged; Myocardial Infarction; Myocardium; Phosphorylation; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta3; Up-Regulation | 2019 |
Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice.
Topics: Angiotensin II; Animals; Drugs, Chinese Herbal; Fibrosis; Ghrelin; Inflammation; Kidney Diseases; Mice; Treatment Outcome | 2019 |
Alamandine attenuates long‑term hypertension‑induced cardiac fibrosis independent of blood pressure.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Collagen Type I; Collagen Type I, alpha 1 Chain; Fibrosis; Heart Ventricles; Hypertension; Imidazoles; Male; Matrix Metalloproteinase 9; Oligopeptides; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Inbred SHR; Renin-Angiotensin System | 2019 |
Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis.
Topics: Adult; Angiotensin II; Animals; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Glomerulonephritis; Healthy Volunteers; Humans; Hypertension, Renal; Kidney Glomerulus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Middle Aged; Nephritis; Primary Cell Culture; Protein Serine-Threonine Kinases; Transcription Factor RelA | 2019 |
Schizandrin B attenuates angiotensin II induced endothelial to mesenchymal transition in vascular endothelium by suppressing NF-κB activation.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cyclooctanes; Cytokines; Disease Models, Animal; Endothelium, Vascular; Fibrosis; Gene Expression Regulation; Inflammation; Lignans; Male; Mice; Mice, Inbred C57BL; NF-kappa B p50 Subunit; Oxidative Stress; Phenotype; Polycyclic Compounds; Signal Transduction; Vascular Remodeling | 2019 |
Puerarin Decreases Collagen Secretion in AngII-Induced Atrial Fibroblasts Through Inhibiting Autophagy Via the JNK-Akt-mTOR Signaling Pathway.
Topics: Angiotensin II; Animals; Autophagy; Cardiovascular Agents; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Heart Atria; Isoflavones; JNK Mitogen-Activated Protein Kinases; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases | 2019 |
Endothelial Forkhead Box Transcription Factor P1 Regulates Pathological Cardiac Remodeling Through Transforming Growth Factor-β1-Endothelin-1 Signal Pathway.
Topics: Angiotensin II; Animals; Aorta; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Fibrosis; Forkhead Transcription Factors; Heart Failure; Humans; Mice; Mice, Knockout; Myocardium; Nanotubes, Peptide; Repressor Proteins; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta1; Ventricular Remodeling | 2019 |
IMM-H007 improves heart function via reducing cardiac fibrosis.
Topics: Adenosine; AMP-Activated Protein Kinases; Angiotensin II; Animals; Collagen; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Myocardium; Myofibroblasts; Phosphorylation; Smad2 Protein; Transforming Growth Factor beta1 | 2019 |
Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Cardiomegaly; Cardiotonic Agents; Deoxyadenosines; Fibrosis; Hemodynamics; Male; Mice, Inbred C57BL; Models, Biological; Myocytes, Cardiac; Oxidative Stress; Phosphorylation; Pressure; Signal Transduction | 2019 |
B-cell lymphoma/leukaemia 10 and angiotensin II-induced kidney injury.
Topics: Acute Kidney Injury; Albuminuria; Angiotensin II; Animals; B-Cell CLL-Lymphoma 10 Protein; Cell Movement; Disease Models, Animal; Fibrosis; Hepatitis A Virus Cellular Receptor 1; Kidney; Kidney Transplantation; Lipocalin-2; Macrophages; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Podocytes; T-Lymphocyte Subsets; Time Factors | 2020 |
Podoplanin neutralization improves cardiac remodeling and function after acute myocardial infarction.
Topics: Angiotensin II; Animals; Antibodies, Neutralizing; Cardiomyopathies; Cell Survival; Cicatrix; Echocardiography; Fibrosis; Heart Failure; Heart Transplantation; Hemodynamics; Humans; Hypertrophy, Left Ventricular; Inflammation; Macrophages; Membrane Glycoproteins; Mice; Monocytes; Myocardial Infarction; Myocardial Ischemia; Myocytes, Cardiac; Regeneration; Vasoconstrictor Agents; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis.
Topics: Angiotensin II; Animals; Bleomycin; Calcium-Binding Proteins; Calpain; Carbon Tetrachloride; Cell Line; Dogs; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Isoenzymes; Liver Cirrhosis; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; Myocardium; Protein Biosynthesis; Protein Multimerization; RNA Stability; Signal Transduction; Transforming Growth Factor beta | 2019 |
Protocatechuic acid attenuates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts through inhibiting the NOX4/ROS/p38 signaling pathway.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Fibrosis; Hydroxybenzoates; Myocardial Infarction; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction | 2019 |
Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-β1 signaling pathway.
Topics: Angiotensin II; Animals; Cardiomegaly; Down-Regulation; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibrosis; Glucuronidase; Klotho Proteins; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocytes, Cardiac; Signal Transduction; Transforming Growth Factor beta1; Ventricular Remodeling | 2019 |
Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Anti-Inflammatory Agents; Antioxidants; Cells, Cultured; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Failure; Inflammation Mediators; Kaempferols; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2019 |
A high-fat diet rich in corn oil induces cardiac fibrosis in rats by activating JAK2/STAT3 and subsequent activation of ANG II/TGF-1β/Smad3 pathway: The role of ROS and IL-6 trans-signaling.
Topics: Angiotensin II; Animals; Corn Oil; Diet, High-Fat; Fibrosis; Heart Diseases; Heart Ventricles; Humans; Interleukin-6; Janus Kinase 2; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Smad3 Protein; STAT3 Transcription Factor; Transforming Growth Factor beta1 | 2019 |
Role of leptin signaling in the pathogenesis of angiotensin II-mediated atrial fibrosis and fibrillation.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Atria; Leptin; Male; Mice; Mice, Inbred C57BL; Myocardium; Rats; Rats, Sprague-Dawley; Rats, Zucker; Signal Transduction | 2013 |
Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16.
Topics: Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Fibroblast Growth Factor 2; Fibroblast Growth Factors; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Knockout | 2013 |
Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2).
Topics: Adenoviridae; Adenoviridae Infections; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Connective Tissue Growth Factor; Enalapril; Fibrosis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Animal; Peptidyl-Dipeptidase A; Physical Conditioning, Animal; Renin-Angiotensin System; Signal Transduction; Transforming Growth Factor beta1 | 2013 |
Angiotensin II regulates microRNA-132/-212 in hypertensive rats and humans.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Endothelin-1; Female; Fibrosis; Gene Expression Regulation; Humans; Hypertension; Mice; Mice, Inbred C57BL; MicroRNAs; Oligonucleotide Array Sequence Analysis; Organ Specificity; Rats, Sprague-Dawley; Reproducibility of Results; Vasoconstrictor Agents | 2013 |
Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling.
Topics: Aging; Angiotensin II; Animals; Apoptosis; Ascorbic Acid; bcl-2-Associated X Protein; Biomarkers; Calcium-Binding Proteins; Cardiomegaly; Caspase 3; Disease Models, Animal; Fibrosis; Heart Failure; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Ventricular Remodeling | 2013 |
Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing.
Topics: Aldosterone; Angiotensin II; Animals; Apoptosis; Atrial Fibrillation; Atrial Natriuretic Factor; Atrial Remodeling; Blood Pressure; Cardiac Pacing, Artificial; Dogs; Fibrosis; Gap Junctions; GAP-43 Protein; Heart Atria; Inflammation; Interleukin-6; Kidney; Myocytes, Cardiac; Sympathectomy; Tumor Necrosis Factor-alpha | 2013 |
Early fibroblast progenitor cell migration to the AngII-exposed myocardium is not CXCL12 or CCL2 dependent as previously thought.
Topics: Angiotensin II; Animals; Benzylamines; Cell Movement; Cell Proliferation; Chemokine CCL2; Chemokine CXCL12; Cyclams; Fibroblasts; Fibrosis; Heterocyclic Compounds; Male; Mice; Mice, Inbred C57BL; Myocardium; Receptors, CXCR4; Stem Cells; Up-Regulation; Vasoconstrictor Agents | 2013 |
Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling.
Topics: Angiotensin II; Animals; Fibrosis; Hypertension; Male; Mice; MicroRNAs; Myocardium; NF-kappa B; Smad7 Protein; Sp1 Transcription Factor; Transforming Growth Factor beta; Ventricular Remodeling | 2013 |
Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice.
Topics: Angiotensin II; Animals; Antibodies; Blood Pressure; Cytokines; Fibrosis; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Granulocyte Colony-Stimulating Factor; Inflammation; Malondialdehyde; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocardium; Neutrophil Infiltration; Proto-Oncogene Proteins c-akt; STAT3 Transcription Factor | 2013 |
Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-β signalling.
Topics: Angiotensin II; Animals; Calcium-Binding Proteins; Cardiomegaly; Extracellular Matrix Proteins; Fibrosis; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; Signal Transduction; Transforming Growth Factor beta; Vasoconstrictor Agents | 2014 |
Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis.
Topics: Angiotensin II; Animals; Antioxidants; Cell Line; Class Ia Phosphatidylinositol 3-Kinase; Collagen Type I; Dinoprost; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Kidney Diseases; Kidney Tubules; Lipid Peroxidation; Losartan; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridones; Rats; Rats, Sprague-Dawley; Signal Transduction; Transfection; Ureteral Obstruction | 2013 |
Nifedipine inhibits angiotensin II-induced cardiac fibrosis via downregulating Nox4-derived ROS generation and suppressing ERK1/2, JNK signaling pathways.
Topics: Actins; Angiotensin II; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Signaling; Cell Differentiation; Cell Proliferation; Cell Separation; Connective Tissue Growth Factor; Down-Regulation; Fibronectins; Fibrosis; Fluorescent Antibody Technique; Heart Diseases; In Vitro Techniques; Male; MAP Kinase Signaling System; NADPH Oxidase 4; NADPH Oxidases; Nifedipine; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vasoconstrictor Agents | 2013 |
Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis.
Topics: Angiotensin II; Animals; Clopidogrel; Fibrosis; Hypertension; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Myocarditis; Myocardium; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Transforming Growth Factor beta | 2013 |
Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension.
Topics: Angiotensin II; Animals; Disease Models, Animal; Down-Regulation; Fibrosis; Heart; Hypertension; Inflammation; Male; Mice; Mice, Knockout; MicroRNAs; Myocardium; NF-kappa B; Signal Transduction; Smad7 Protein | 2013 |
Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction.
Topics: Angiotensin II; Animals; Antioxidants; Ascorbic Acid; Blood Pressure; Calcium-Binding Proteins; Cardiomegaly; Cellular Senescence; Diastole; Echocardiography; Fibrosis; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Transgenic; Oxidative Stress; Promoter Regions, Genetic; Superoxides | 2013 |
Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species.
Topics: Angiotensin II; Animals; Biological Availability; Fibronectins; Fibrosis; Gene Silencing; Intracellular Space; Mesangial Cells; Mitochondria; Models, Biological; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Rats; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Up-Regulation | 2013 |
Role of expression of endothelin-1 and angiotensin-II and hypoxia-inducible factor-1α in the kidney tissues of patients with diabetic nephropathy.
Topics: Adult; Aged; Angiotensin II; Diabetic Nephropathies; Disease Progression; Endothelin-1; Female; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Kidney; Male; Middle Aged; Nephritis, Interstitial | 2013 |
A novel heart failure mice model of hypertensive heart disease by angiotensin II infusion, nephrectomy, and salt loading.
Topics: Angiotensin II; Animals; Animals, Newborn; Blood Pressure; Cells, Cultured; Disease Models, Animal; Disease Progression; Fibrosis; Gene Expression Regulation; Heart Failure; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Myocardium; Nephrectomy; Neuropeptides; Oxidative Stress; Pulmonary Edema; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Sodium Chloride, Dietary; Time Factors; Ventricular Function, Left | 2013 |
Critical role of CXCL16 in hypertensive kidney injury and fibrosis.
Topics: Angiotensin II; Animals; Blood Pressure; Chemokine CXCL16; Chemokine CXCL6; Cytokines; Fibrosis; Hypertension, Renal; Inflammation; Kidney; Macrophages; Mice; Mice, Knockout; Myofibroblasts; Nephritis; NF-kappa B; T-Lymphocytes | 2013 |
Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Biphenyl Compounds; Cardiomegaly; Cardiotonic Agents; Collagen; Connective Tissue Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Gene Expression Regulation; Irbesartan; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Phosphorylation; PPAR alpha; PPAR delta; PPAR gamma; Receptor, Angiotensin, Type 1; RNA, Messenger; Signal Transduction; Tetrazoles; Transforming Growth Factor beta | 2013 |
Telmisartan delays myocardial fibrosis in rats with hypertensive left ventricular hypertrophy by TGF-β1/Smad signal pathway.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blotting, Western; Collagen; Echocardiography; Fibrosis; Hemodynamics; Hypertension; Hypertrophy, Left Ventricular; Male; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Telmisartan; Transforming Growth Factor beta1 | 2014 |
Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation.
Topics: Angiotensin II; Animals; Cytokines; Fibrosis; Heart Diseases; Inflammation; Inflammation Mediators; Macrophage Activation; Macrophages; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Toll-Like Receptor 2 | 2014 |
A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblasts.
Topics: A Kinase Anchor Proteins; Actins; Angiotensin II; Animals; Cell Differentiation; Cell Movement; Collagen; Enzyme Activation; Fibroblasts; Fibrosis; Gene Silencing; GTP-Binding Protein alpha Subunits, G12-G13; Heart Ventricles; Minor Histocompatibility Antigens; Models, Biological; Myofibroblasts; Phenotype; Rats; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation | 2014 |
Mechanisms with clinical implications for atrial fibrillation-associated remodeling: cathepsin K expression, regulation, and therapeutic target and biomarker.
Topics: Adult; Aged; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Atrial Fibrillation; Biomarkers; Cardiac Pacing, Artificial; Case-Control Studies; Cathepsin K; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Heart Atria; Humans; Male; Middle Aged; Myocytes, Cardiac; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphopeptides; Phosphorylation; Procollagen; Protein Kinase Inhibitors; Rabbits; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Signal Transduction; Superoxides; Up-Regulation | 2013 |
Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function.
Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Cardiomyopathies; Collagen; Diet; Extracellular Matrix; Fibroblasts; Fibrosis; Fumarates; Homocysteine; Mice; Myocardium; Proto-Oncogene Proteins c-akt; Renin; Renin-Angiotensin System; Signal Transduction | 2013 |
Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes.
Topics: Angiotensin II; Animals; Cell Cycle; Cell Differentiation; Fibroblasts; Fibrosis; Flow Cytometry; Histone Deacetylase Inhibitors; Humans; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Protein Isoforms | 2014 |
Antagonist of C5aR prevents cardiac remodeling in angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiovascular Agents; Collagen; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Fibrosis; Hypertension; Mice, Inbred C57BL; Myocardium; Peptides, Cyclic; Receptor, Anaphylatoxin C5a; RNA, Messenger; Time Factors; Transforming Growth Factor beta1; Ventricular Remodeling | 2014 |
Autocrine and paracrine function of Angiotensin 1-7 in tissue repair during hypertension.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Apoptosis; Autocrine Communication; Disease Models, Animal; Fibrosis; Hypertension; Kidney; Male; Myocardium; Paracrine Communication; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Ventricular Remodeling | 2014 |
Epigenetic regulation of fibrocyte differentiation?
Topics: Angiotensin II; Animals; Fibroblasts; Fibrosis; Histone Deacetylase Inhibitors; Humans; Male | 2014 |
Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro.
Topics: Angiotensin II; Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Enzyme Activation; Fibroblasts; Fibrosis; Gene Expression; Gene Knockout Techniques; Geranyltranstransferase; Myocardium; Protein Prenylation; Rats; rhoA GTP-Binding Protein; RNA Interference; Transforming Growth Factor beta1 | 2014 |
Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis.
Topics: Actins; Angiotensin II; Animals; Cadherins; Cells, Cultured; Culture Media, Conditioned; Cyclic GMP-Dependent Protein Kinase Type I; Cytokines; Disease Models, Animal; Fibrosis; Inflammation Mediators; Kidney Diseases; Kidney Tubules, Proximal; Macrophages; Male; Mice; Mice, Transgenic; Phosphodiesterase 5 Inhibitors; Phosphorylation; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Smad2 Protein; Sulfones; Time Factors; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction | 2014 |
The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure.
Topics: Adoptive Transfer; Angiotensin II; Animals; CD8 Antigens; CD8-Positive T-Lymphocytes; Cytokines; Fibrosis; Flow Cytometry; Hypertension; Inflammation Mediators; Lymphocyte Activation; Macrophages; Mice; Mice, 129 Strain; Mice, Knockout; Mice, Transgenic; Myocardium; Receptors, Antigen, T-Cell; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
Cryptotanshinone attenuates cardiac fibrosis via downregulation of COX-2, NOX-2, and NOX-4.
Topics: Angiotensin II; Animals; Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Fibroblasts; Fibrosis; Male; Membrane Glycoproteins; Myocardial Infarction; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Phenanthrenes; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Up-Regulation | 2014 |
Smooth muscle cell-specific Hif-1α deficiency suppresses angiotensin II-induced vascular remodelling in mice.
Topics: Angiotensin II; Animals; Fibrosis; Gene Expression Regulation; Hemodynamics; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Superoxides; Vascular Remodeling | 2014 |
TRPM7 is involved in angiotensin II induced cardiac fibrosis development by mediating calcium and magnesium influx.
Topics: Actins; Angiotensin II; Animals; Boron Compounds; Calcium; Cell Proliferation; Cells, Cultured; Connective Tissue Growth Factor; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Fibroblasts; Fibrosis; Magnesium; Male; Nerve Tissue Proteins; NFATC Transcription Factors; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; TRPM Cation Channels | 2014 |
Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy.
Topics: Adiponectin; Angiotensin II; Animals; Autophagy; Cardiomyopathies; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Fibrosis; Immunohistochemistry; In Vitro Techniques; Inflammation; Macrophages; Mice; Mice, Knockout; Real-Time Polymerase Chain Reaction | 2014 |
Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts.
Topics: Analysis of Variance; Angiotensin II; Animals; Apoptosis; Cell Movement; Cell Proliferation; Female; Fibrinogen; Fibrinolysin; Fibroblasts; Fibrosis; Heart Ventricles; Humans; Mice; Mice, Inbred C57BL; Myocardium; Plasminogen Activator Inhibitor 1; Vitronectin | 2014 |
Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiomyopathies; Fibrosis; Heart Failure, Diastolic; Hypertrophy, Left Ventricular; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinase-3; Ventricular Remodeling | 2014 |
Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis.
Topics: Angiotensin II; Animals; Animals, Newborn; Arachidonic Acids; Biomarkers; Cardiomegaly; Chemokine CCL2; Disease Models, Animal; Epoxide Hydrolases; Fibrosis; Hypertension; Interleukin-6; Male; Metabolome; Mice; Mice, Inbred C57BL; Myocardium; Myofibroblasts; Ventricular Remodeling | 2014 |
Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.
Topics: Age Factors; Aged; Angiotensin II; Animals; Atrial Fibrillation; Atrial Remodeling; Case-Control Studies; Cells, Cultured; Computer Simulation; Down-Regulation; Female; Fibrosis; Heart Rate; Humans; Male; MAP Kinase Kinase 4; Mice; Mice, Knockout; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Signal Transduction; Transfection; Transforming Growth Factor beta1 | 2014 |
Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice.
Topics: Angiotensin II; Animals; Cell Line; Cellular Senescence; Cytoprotection; Fibrosis; Gene Expression Regulation; Gene Knockout Techniques; Ghrelin; Humans; Ion Channels; Kidney; Kidney Tubules, Proximal; Male; Mice; Mitochondria; Mitochondrial Proteins; Mitochondrial Size; Oxidative Stress; Reactive Oxygen Species; Receptors, Ghrelin; Uncoupling Protein 2 | 2014 |
NF-κB-mediated integrin-linked kinase regulation in angiotensin II-induced pro-fibrotic process in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen Type I; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Mutant Proteins; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Serine-Threonine Kinases; Rats; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering | 2014 |
High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling.
Topics: Actins; Angiotensin II; Arteries; Cells, Cultured; Fibroblast Growth Factor 2; Fibroblasts; Fibronectins; Fibrosis; Heart; Humans; Interleukin-1beta; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Molecular Weight; Myocardium; Myofibroblasts; Plasminogen Activator Inhibitor 1; Procollagen; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Up-Regulation | 2014 |
Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.
Topics: Angiotensin II; Animals; Carrier Proteins; Collagen Type I; Fibrosis; Heart Diseases; Inflammasomes; Interleukin-18; Interleukin-1beta; Mice; Mice, Knockout; Mitochondrial Proteins; Myocardium; Myofibroblasts; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Signal Transduction; Smad Proteins, Receptor-Regulated; Transforming Growth Factor beta; Vasoconstrictor Agents | 2014 |
Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides.
Topics: Actins; Angiotensin II; Animals; Antigens, Differentiation; Antihypertensive Agents; Atrophy; Blood Pressure; Cadherins; Chemokine CCL2; Fibrosis; Gene Expression; Hydralazine; Intracellular Signaling Peptides and Proteins; Kidney Tubules; Male; Membrane Proteins; Mice; Mice, Knockout; Osteopontin; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Sodium Chloride; Vasoconstrictor Agents | 2015 |
CXCR6 plays a critical role in angiotensin II-induced renal injury and fibrosis.
Topics: Albuminuria; Angiotensin II; Animals; Blood Pressure; Bone Marrow Transplantation; Cytokines; Disease Models, Animal; Fibrosis; Green Fluorescent Proteins; Hypertension; Inflammation Mediators; Kidney; Kidney Diseases; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myofibroblasts; Receptors, CXCR; Receptors, CXCR6; Signal Transduction; T-Lymphocytes; Time Factors | 2014 |
Effects of emodin and irbesartan on ventricular fibrosis in Goldblatt hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blotting, Western; Cardiomyopathies; Collagen; Echocardiography; Emodin; Enzyme Inhibitors; Fibrosis; Heart Ventricles; Hydroxyproline; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Irbesartan; Male; Matrix Metalloproteinase 2; Myocardium; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tetrazoles | 2014 |
HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Heart Failure; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Indoles; Male; Mice; Mice, Knockout; Muscle, Skeletal; Muscular Atrophy; Myocardium; Signal Transduction; Stroke Volume; Systole; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2014 |
γδT Cell-derived interleukin-17A via an interleukin-1β-dependent mechanism mediates cardiac injury and fibrosis in hypertension.
Topics: Angiotensin II; Animals; Fibrosis; Hypertension; Interleukin-17; Interleukin-1beta; Interleukin-6; Mice; Myocardium; T-Lymphocytes; Transforming Growth Factor beta | 2014 |
Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis.
Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Disease Progression; Female; Fibrosis; Humans; Immunoenzyme Techniques; Kidney Diseases; Mice; Mice, Knockout; Real-Time Polymerase Chain Reaction; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RGS Proteins; RNA, Messenger; Ureteral Obstruction | 2014 |
Inhibition of STAT3 acetylation is associated with angiotesin renal fibrosis in the obstructed kidney.
Topics: Acetylation; Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line; Fibrosis; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Phosphorylation; Rats; Resveratrol; Signal Transduction; STAT3 Transcription Factor; Stilbenes | 2014 |
Renal sympathetic denervation suppresses ventricular substrate remodelling in a canine high-rate pacing model.
Topics: Aldosterone; Angiotensin II; Animals; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Catheter Ablation; Disease Models, Animal; Disease Progression; Dogs; Female; Fibrosis; Heart Failure; Heart Ventricles; Kidney; Male; Natriuretic Peptide, Brain; Sympathectomy; Time Factors; Transforming Growth Factor beta; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2014 |
Renal expression of advanced oxidative protein products predicts progression of renal fibrosis in patients with IgA nephropathy.
Topics: Adult; Advanced Oxidation Protein Products; Angiotensin II; Biopsy; Disease Progression; Female; Fibrosis; Glomerulonephritis, IGA; Humans; Kidney Tubules; Male; Prospective Studies; Transforming Growth Factor beta1 | 2014 |
Differences in cell-type-specific responses to angiotensin II explain cardiac remodeling differences in C57BL/6 mouse substrains.
Topics: Angiotensin II; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Galectin 3; Heart; Heart Ventricles; Hypertrophy, Left Ventricular; In Vitro Techniques; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocardium; Osteopontin; Ventricular Remodeling | 2014 |
Angiotensin-(1-7) prevents angiotensin II-induced fibrosis in cremaster microvessels.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Arterioles; Blood Pressure; Chronic Disease; Connective Tissue Growth Factor; Dual Specificity Phosphatase 1; Fibrosis; Hypertension; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Muscle, Skeletal; Peptide Fragments; Phosphorylation; Rats; Rats, Inbred Lew; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Vasoconstrictor Agents | 2015 |
P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells.
Topics: Acetylation; Angiotensin II; Animals; Cell Line; E1A-Associated p300 Protein; Epithelial Cells; Fibrosis; Kidney Tubules; Rats; STAT3 Transcription Factor | 2014 |
Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy.
Topics: Angiotensin II; Animals; Atorvastatin; Disease Models, Animal; Fibrosis; Heptanoic Acids; Humans; Kidney; Kidney Diseases; Mice; Monomeric GTP-Binding Proteins; Pyrroles; Receptor, Angiotensin, Type 1; Signal Transduction; Ureteral Obstruction | 2014 |
Qishenyiqi protects ligation-induced left ventricular remodeling by attenuating inflammation and fibrosis via STAT3 and NF-κB signaling pathway.
Topics: Angiotensin II; Animals; Captopril; Drugs, Chinese Herbal; Fibrosis; Heart Failure; Heart Ventricles; Hemodynamics; Inflammation; Interleukin-6; Ligation; Male; Matrix Metalloproteinases; NADPH Oxidases; NF-kappa B; Oxidative Stress; Protective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor; Ventricular Remodeling | 2014 |
Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activation.
Topics: Angiotensin II; Anilides; Animals; Blood Pressure; Body Weight; Cell Proliferation; Cells, Cultured; Collagen Type III; Connective Tissue Growth Factor; Curcumin; Fibroblasts; Fibronectins; Fibrosis; Heart Ventricles; Male; Plasminogen Activator Inhibitor 1; PPAR gamma; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2014 |
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.
Topics: Angiotensin II; Animals; Cardiomegaly; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic Nucleotide Phosphodiesterases, Type 5; Fibrosis; Genetic Markers; Hypertension; Mice; Muscle, Smooth; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Vasoconstrictor Agents | 2014 |
Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis.
Topics: Angiotensin II; Animals; Clusterin; Fibrosis; Humans; Kidney Diseases; Male; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 | 2014 |
Angiotensin II activates signal transducers and activators of transcription 3 via Rac1 in the atrial tissue in permanent atrial fibrillation patients with rheumatic heart disease.
Topics: Adult; Aged; Angiotensin II; Atrial Fibrillation; Atrial Remodeling; Female; Fibrosis; Heart Atria; Humans; Male; Middle Aged; Organ Size; rac1 GTP-Binding Protein; Rheumatic Heart Disease; Signal Transduction; STAT3 Transcription Factor | 2015 |
Pioglitazone inhibits angiotensin II-induced atrial fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway.
Topics: Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Cell Proliferation; Fibrosis; Heart Atria; Male; Mice; Mice, Inbred C57BL; Myofibroblasts; NF-kappa B; Pioglitazone; Signal Transduction; Thiazolidinediones; TNF Receptor-Associated Factor 6; Transforming Growth Factor beta1 | 2015 |
Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent.
Topics: Aging; Angiotensin II; Animals; Biomarkers; Cell Adhesion Molecules; Cellular Senescence; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Interleukin-13; Interleukin-4; Interleukin-6; Mitogen-Activated Protein Kinase Kinases; Myocardium; Myocytes, Cardiac; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta1 | 2014 |
Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atrial Remodeling; B-Cell CLL-Lymphoma 10 Protein; Cell Adhesion; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Fibrosis; Heart Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Myocardium; NF-kappa B | 2014 |
Ets-1 targeted by microrna-221 regulates angiotensin II-induced renal fibroblast activation and fibrosis.
Topics: Angiotensin II; Animals; Cell Line; Cell Proliferation; Down-Regulation; Female; Fibroblasts; Fibronectins; Fibrosis; Gene Expression; Kidney; Kidney Diseases; Mice; Mice, Inbred BALB C; MicroRNAs; Proto-Oncogene Protein c-ets-1; Rats; Up-Regulation | 2014 |
Angiotensin II removes kidney resistance conferred by ischemic preconditioning.
Topics: Angiotensin II; Animals; Creatinine; Fibrosis; Ischemic Preconditioning; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Receptor, Angiotensin, Type 1; Signal Transduction | 2014 |
MMP-12 deficiency attenuates angiotensin II-induced vascular injury, M2 macrophage accumulation, and skin and heart fibrosis.
Topics: Angiotensin II; Animals; Endothelial Cells; Fibrosis; Macrophages; Matrix Metalloproteinase 12; Mice; Mice, Knockout; Myocardium; Receptors, Platelet-Derived Growth Factor; Skin; Thrombospondin 1; Transforming Growth Factor beta1; Vascular System Injuries | 2014 |
Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension.
Topics: Albumins; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Echocardiography; Fibrosis; Heart; Heart Rate; Hypertension; Inflammation; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocytes, Cardiac; Phenotype; Sodium Chloride, Dietary | 2015 |
Baicalein attenuates angiotensin II-induced cardiac remodeling via inhibition of AKT/mTOR, ERK1/2, NF-κB, and calcineurin signaling pathways in mice.
Topics: Angiotensin II; Animals; Calcineurin Inhibitors; Cytokines; Disease Models, Animal; Enzyme Activation; Fibrosis; Flavanones; Gene Expression Regulation; Hypertension; Hypertrophy, Left Ventricular; Inflammation Mediators; Lipoxygenase Inhibitors; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; NF-kappa B; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Ventricular Function, Left; Ventricular Remodeling | 2015 |
Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Humans; Inflammasomes; Inflammation Mediators; Interleukin-1beta; Macrophage Activation; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Time Factors | 2015 |
SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis.
Topics: Angiotensin II; Animals; Cells, Cultured; Endoplasmic Reticulum Stress; ErbB Receptors; Fibronectins; Fibrosis; Intracellular Signaling Peptides and Proteins; Kidney; Male; Membrane Proteins; Mesangial Cells; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats, Inbred Dahl; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Insufficiency, Chronic; Serine Proteases; Sp1 Transcription Factor; Sterol Regulatory Element Binding Protein 1; Thiazoles; Transforming Growth Factor beta1; Up-Regulation | 2015 |
Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Line; Disease Models, Animal; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Epigenesis, Genetic; Fibrosis; Gene Expression Regulation; Humans; Mice; Models, Biological; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Trans-Activators; Transcriptional Activation | 2015 |
Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor κB signaling.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Proliferation; Constriction, Pathologic; Disease Models, Animal; Extracellular Matrix; Fibrosis; Focal Adhesions; Gene Silencing; Male; Myocardium; Myofibroblasts; NF-kappa B; Rats, Sprague-Dawley; Signal Transduction; Sirtuins; Transcription, Genetic; Up-Regulation | 2015 |
Cardiac steatosis potentiates angiotensin II effects in the heart.
Topics: Angiotensin II; Animals; Cardiomyopathies; Cells, Cultured; Diacylglycerol O-Acyltransferase; Fibrosis; Heart Ventricles; Lipid Metabolism; Mice; Mice, Inbred DBA; Myocytes, Cardiac; Reactive Oxygen Species; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta2; Triglycerides | 2015 |
Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression.
Topics: Angiotensin II; Animals; Cell Line; Collagen Type I; Enzyme Activation; Fibronectins; Fibrosis; Galectin 3; Heart Failure; Male; Mice; Myocardium; Protein Kinase C; Pulmonary Artery; Rats, Sprague-Dawley; Ultrasonography | 2015 |
Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice.
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 1; Fibrosis; Gene Expression Regulation; Histological Techniques; Hypertension; Immunohistochemistry; Injections, Subcutaneous; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Oxidative Stress; Peptide Fragments; Peptidyl-Dipeptidase A; Proto-Oncogene Mas; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled | 2015 |
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Cardiovascular Agents; Disease Models, Animal; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Imidazoles; Lung; Male; Monocrotaline; Myocardium; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pulmonary Fibrosis; Pyridines; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Signal Transduction; Vascular Remodeling; Ventricular Dysfunction, Right; Ventricular Function, Right; Ventricular Remodeling | 2015 |
Activation of the cardiac proteasome promotes angiotension II-induced hypertrophy by down-regulation of ATRAP.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Cardiomegaly; Down-Regulation; Enzyme Activation; Fibrosis; Inflammation; Male; Mice, Inbred C57BL; Models, Biological; Myocardium; p38 Mitogen-Activated Protein Kinases; Polyubiquitin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Proteolysis; Receptor, Angiotensin, Type 1; Signal Transduction; STAT3 Transcription Factor; Ubiquitinated Proteins | 2015 |
Tumor necrosis factor: a mechanistic link between angiotensin-II-induced cardiac inflammation and fibrosis.
Topics: Angiotensin II; Animals; Cell Migration Assays; Female; Fibroblasts; Fibrosis; Inflammation Mediators; Male; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocytes, Cardiac; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2015 |
KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice.
Topics: Angiotensin II; Animals; Biomarkers; Caffeic Acids; Catalase; Cell Adhesion Molecules; Chemokines; Collagen Type I; Cytoprotection; Fibronectins; Fibrosis; Gene Expression Regulation; Inflammation; Kidney; Lipid Peroxidation; Male; Mice; Oxidative Stress; Smad3 Protein; Superoxide Dismutase; Transforming Growth Factor beta1; Ureteral Obstruction | 2015 |
PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.
Topics: Angiotensin II; Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Collagen; Enzyme Activation; Fibroblasts; Fibrosis; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; p38 Mitogen-Activated Protein Kinases; Protein Kinase C beta; Protein Kinase C-delta; Rats, Sprague-Dawley; Ventricular Dysfunction, Right | 2015 |
Hyperoxia downregulates angiotensin-converting enzyme-2 in human fetal lung fibroblasts.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Angiotensin-Converting Enzyme 2; Carbon Dioxide; Cell Survival; Fibroblasts; Fibrosis; Gases; Humans; Hydroxamic Acids; Hyperoxia; Lung; Oxygen; Peptidyl-Dipeptidase A; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Bile Ducts, Extrahepatic; Cell Line; Cell Proliferation; Cholestasis, Extrahepatic; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Hyperplasia; Ligation; Losartan; Male; Rats, Inbred F344; Renin-Angiotensin System; Signal Transduction | 2015 |
Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice.
Topics: Angiotensin II; Animals; Catalase; Cytochrome P-450 CYP1B1; Disease Models, Animal; Drinking; Estradiol; Female; Fibrosis; Genotype; Hypertension; Kidney; Kidney Diseases; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Natriuresis; Oxidative Stress; Phenotype; Renin-Angiotensin System; Sex Factors; Superoxide Dismutase; Superoxides; Tyrosine; Urination | 2015 |
CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression.
Topics: Aging; Angiotensin II; Animals; Autophagy; Cells, Cultured; Disease Susceptibility; Fibrosis; Lysosomes; Male; Mice; Myocardium; Myocytes, Cardiac; Phagosomes; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Recombinant Proteins; Repressor Proteins | 2015 |
Suppression of TGF-β1/Smad signaling pathway by sesamin contributes to the attenuation of myocardial fibrosis in spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Antioxidants; Blood Pressure; Collagen Type I; Collagen Type III; Dioxoles; Fibroblasts; Fibrosis; Heart Ventricles; Lignans; Male; Malondialdehyde; Myocardium; NADPH Oxidases; Organ Size; Phosphorylation; Rats, Inbred SHR; Signal Transduction; Smad3 Protein; Smad7 Protein; Superoxide Dismutase; Systole; Transforming Growth Factor beta1 | 2015 |
Nonclassical resident macrophages are important determinants in the development of myocardial fibrosis.
Topics: Actins; Administration, Intravenous; Angiotensin II; Animals; Antigens, Ly; Clodronic Acid; Collagen; CX3C Chemokine Receptor 1; Electrocardiography; Fibrosis; Inflammation Mediators; Liposomes; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; Myocardium; NIH 3T3 Cells; Receptors, Chemokine | 2015 |
Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function.
Topics: Angiotensin II; Animals; Aorta; Arginase; Cell Proliferation; Fibrosis; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulse Wave Analysis; Rats; Vascular Stiffness | 2015 |
Chronic blockade of class I PI3-kinase attenuates Ang II-induced cardiac hypertrophy and autophagic alteration.
Topics: Angiotensin II; Animals; Autophagy; Cardiomegaly; Fibrosis; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2015 |
Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction.
Topics: Angiotensin II; Animals; Blood Vessels; Cardiotonic Agents; Collagen; Fibrosis; Heart Function Tests; Hemodynamics; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardial Infarction; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Ultrasonography; Valsartan | 2015 |
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Connective Tissue Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Geranyltranstransferase; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein | 2015 |
Renal denervation suppresses atrial fibrillation in a model of renal impairment.
Topics: Aldosterone; Angiotensin II; Animals; Atrial Fibrillation; Autonomic Denervation; C-Reactive Protein; Catheter Ablation; Disease Models, Animal; Dogs; Fibrosis; Heart Atria; Hemodynamics; Interleukin-6; Ischemia; Kidney; Models, Cardiovascular; Norepinephrine; Renal Artery; Renal Artery Obstruction; Renin; Renin-Angiotensin System; Sympathetic Nervous System | 2015 |
Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.
Topics: Adenoviridae; Aged; Angiotensin II; Animals; Cell Survival; Cells, Cultured; Collagen; Female; Fibrosis; Gene Silencing; Genetic Vectors; Humans; In Vitro Techniques; Male; Mice, Knockout; MicroRNAs; Myocardium; Myofibroblasts; Osteopontin; Phosphatidylinositol 3-Kinases; PTEN Phosphohydrolase; Recombinant Proteins; Transcription Factors | 2015 |
Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes.
Topics: Angiotensin II; Animals; Cells, Cultured; Collagen Type I; Epigenesis, Genetic; Fibrosis; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Indoles; Inflammation; Kidney; Male; Mice; Mice, Inbred ICR; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2015 |
β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats.
Topics: Angiotensin II; Animals; beta Catenin; Blood Pressure; Cyclin D1; Fibrosis; Humans; Hypertension; Kidney; Kidney Diseases; Lisinopril; Proto-Oncogene Proteins c-myc; Pyrvinium Compounds; Rats; Signal Transduction | 2015 |
Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease.
Topics: Angiotensin II; Animals; Antigens, CD; Cadherins; Cells, Cultured; Disease Progression; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Feedback, Physiological; Fibrosis; Gene Expression Regulation; Humans; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Glomerulus; Mice; Mice, Transgenic; NF-kappa B; Organ Culture Techniques; Renal Insufficiency, Chronic; RNA, Small Interfering; Up-Regulation | 2015 |
Preservation of Glucagon-Like Peptide-1 Level Attenuates Angiotensin II-Induced Tissue Fibrosis by Altering AT1/AT 2 Receptor Expression and Angiotensin-Converting Enzyme 2 Activity in Rat Heart.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Collagen; Fibrosis; Gene Expression; Glucagon-Like Peptide 1; Linagliptin; Liraglutide; Male; Myocardium; Peptidyl-Dipeptidase A; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Smad Proteins; Transforming Growth Factor beta1 | 2015 |
Cytosolic Phospholipase A2α Is Essential for Renal Dysfunction and End-Organ Damage Associated With Angiotensin II-Induced Hypertension.
Topics: Angiotensin II; Animals; Endothelins; Fibrosis; Group IV Phospholipases A2; Hypertension; Kidney; Kidney Diseases; Male; Mice; Renal Circulation; Vascular Resistance | 2016 |
TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis.
Topics: Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Atrial Fibrillation; Cell Communication; Cell Proliferation; Chemotaxis; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart Atria; Humans; Losartan; Macrophages; Mice; Mice, Inbred C57BL; RNA, Small Interfering; Signal Transduction | 2015 |
M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure.
Topics: Angiotensin II; Animals; Antigens, CD; Antigens, Ly; Aorta; Arginase; Blood Pressure; Collagen; Elastin; Fibrosis; Hypertension; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Receptors, CCR2 | 2015 |
A state of reversible compensated ventricular dysfunction precedes pathological remodelling in response to cardiomyocyte-specific activity of angiotensin II type-1 receptor in mice.
Topics: Angiotensin II; Animals; Cell Death; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Heart Function Tests; Humans; Hypertrophy, Left Ventricular; Macrophages; Male; Mice; Models, Cardiovascular; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; Transgenes; Ventricular Dysfunction; Ventricular Remodeling | 2015 |
Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice.
Topics: Angiotensin II; Animals; Apolipoprotein B-100; Blood Pressure; Cytokines; Disease Models, Animal; Fibrosis; Gene Expression; Hypertension; Immunization; Kidney Diseases; Lymphocyte Depletion; Male; Mice; Mice, Knockout; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Peptides; Reactive Oxygen Species; T-Lymphocyte Subsets; Vaccines, Subunit | 2015 |
Leukemia inhibitory factor attenuates renal fibrosis through Stat3-miR-29c.
Topics: Angiotensin II; Animals; Cells, Cultured; Collagen Type I; Collagen Type III; Computational Biology; Extracellular Matrix Proteins; Fibrosis; Gene Knockdown Techniques; Interleukin-6; Kidney; Kidney Diseases; Leukemia Inhibitory Factor; Mice; MicroRNAs; Nephritis, Interstitial; Rats; STAT3 Transcription Factor; Transfection; Ureteral Obstruction | 2015 |
Sildenafil Does Not Prevent Heart Hypertrophy and Fibrosis Induced by Cardiomyocyte Angiotensin II Type 1 Receptor Signaling.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Cardiomegaly; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Piperazines; Purines; Receptor, Angiotensin, Type 1; Signal Transduction; Sildenafil Citrate; Sulfonamides; Up-Regulation | 2015 |
Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Heart; Hypertension; Interleukin-4; Macrophages; Mice; Mice, Knockout; Myocardium; Signal Transduction; Up-Regulation; Ventricular Remodeling | 2015 |
Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism.
Topics: Acute Kidney Injury; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cells, Cultured; Cytoprotection; Disease Models, Animal; Disease Progression; Fibrosis; Kidney; Losartan; Lymphocyte Activation; Male; Nephrectomy; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Renin-Angiotensin System; Sodium Chloride, Dietary; Th17 Cells; Time Factors | 2015 |
Oleanolic acid alleviated pressure overload-induced cardiac remodeling.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Cardiomegaly; Diabetic Cardiomyopathies; Echocardiography; Fibrosis; Glucose; Hypertension; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oleanolic Acid; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Ventricular Remodeling | 2015 |
Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.
Topics: Angiotensin II; Animals; Antigens, CD; Apoptosis; Apyrase; Cells, Cultured; Fibrosis; Hypertension; Immune Tolerance; Kidney; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Neutrophils; Proto-Oncogene Proteins c-vav; Renal Insufficiency; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 2015 |
Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Acetophenones; Aged; Angiotensin II; Animals; Cardio-Renal Syndrome; Cardiotonic Agents; Cell Line; Disease Models, Animal; Epoxide Hydrolases; Female; Fibrosis; Humans; Kidney Failure, Chronic; Male; Middle Aged; Myocytes, Cardiac; Rats, Sprague-Dawley; Stroke Volume; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2015 |
A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.
Topics: Angiotensin II; Animals; Antioxidants; Atrial Natriuretic Factor; Connective Tissue Growth Factor; Diet; Fibroblasts; Fibrosis; Flavonoids; Food; Heart; Hydrogen Peroxide; Hypertrophy; Luteolin; Male; Myocardium; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta1; Ventricular Remodeling | 2015 |
Pentoxifylline Ameliorates Cardiac Fibrosis, Pathological Hypertrophy, and Cardiac Dysfunction in Angiotensin II-induced Hypertensive Rats.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Hypertension; Inflammation Mediators; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley | 2016 |
Rivaroxaban Inhibits Angiotensin II-Induced Activation in Cultured Mouse Cardiac Fibroblasts Through the Modulation of NF-κB Pathway.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Factor Xa Inhibitors; Fibroblasts; Fibrosis; Mice; Myocardium; NF-kappa B; Receptor, PAR-2; Rivaroxaban; Signal Transduction | 2015 |
Tumor Necrosis Factor - Alpha Is Essential for Angiotensin II-Induced Ventricular Remodeling: Role for Oxidative Stress.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Collagen Type I; Collagen Type III; Connective Tissue Growth Factor; Fibrosis; Heart; Hypertension; Male; MAP Kinase Signaling System; Mice; Myocardium; NADPH Oxidases; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Receptor, Angiotensin, Type 1; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Ventricular Remodeling | 2015 |
Adenosine A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1 -adrenoceptor stimulation in vivo.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adrenergic alpha-1 Receptor Agonists; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cell Culture Techniques; Dose-Response Relationship, Drug; Fibrosis; Insulin-Like Growth Factor I; Male; Matrix Metalloproteinase 2; Mice; Myocytes, Cardiac; Oxidative Stress; Phenylephrine; Rats; Receptor, Adenosine A1; Up-Regulation | 2016 |
Vaccination against type 1 angiotensin receptor prevents streptozotocin-induced diabetic nephropathy.
Topics: Angiotensin II; Animals; Biomarkers; Blood Chemical Analysis; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Fibrosis; Kidney Function Tests; Male; Peptide Fragments; Podocytes; Rats; Receptor, Angiotensin, Type 1; Renin; Signal Transduction; Smad3 Protein; Streptozocin; Transforming Growth Factor beta1; Vaccines | 2016 |
Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis.
Topics: Aging; Angiotensin II; Animals; Aorta; Blood Pressure; Body Weight; Chemokine CCL2; Diet, High-Fat; Disease Models, Animal; Endothelium, Vascular; Fibrosis; Glucagon-Like Peptide-1 Receptor; Heart; Heart Diseases; Hypertension; I-kappa B Proteins; Immunohistochemistry; Incretins; Inflammation; Interleukin-10; Liraglutide; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocardium; NF-kappa B p50 Subunit; Obesity; Oxidative Stress; Real-Time Polymerase Chain Reaction; Vasoconstrictor Agents; Vimentin | 2016 |
Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis.
Topics: Angiotensin II; Animals; Benzimidazoles; Benzoates; Cardiotonic Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fibrosis; Heart Diseases; Insulin Resistance; Male; Rats; Rats, Wistar; Telmisartan; Treatment Outcome; Umbelliferones; Vasoconstriction | 2015 |
Novel Epidermal Growth Factor Receptor Inhibitor Attenuates Angiotensin II-Induced Kidney Fibrosis.
Topics: Actins; Angiotensin II; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cells, Cultured; Collagen Type IV; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Gene Knockdown Techniques; Kidney Diseases; MAP Kinase Signaling System; Mesangial Cells; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-akt; Rats; Renin-Angiotensin System; Repressor Proteins; RNA, Small Interfering; src-Family Kinases; Transforming Growth Factor beta | 2016 |
Autophagy activation attenuates angiotensin II-induced cardiac fibrosis.
Topics: Angiotensin II; Animals; Autophagy; Cells, Cultured; Extracellular Matrix; Fibroblasts; Fibrosis; Male; Mice; Mice, Inbred C57BL; Myocardium; Rats; Rats, Sprague-Dawley | 2016 |
Improving vagal activity ameliorates cardiac fibrosis induced by angiotensin II: in vivo and in vitro.
Topics: Angiotensin II; Animals; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Collagen; Constriction, Pathologic; Drug Evaluation, Preclinical; Fibroblasts; Fibrosis; Gene Knockdown Techniques; Heart Diseases; Male; Pyridostigmine Bromide; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Vagus Nerve | 2015 |
Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation.
Topics: Action Potentials; Angiotensin II; Animals; Atrial Fibrillation; Atrial Remodeling; Cell Transdifferentiation; Cells, Cultured; Connexin 43; Fibrosis; Heart Atria; Linoleic Acids; Mice; Mice, Inbred C57BL; Nitro Compounds; Smad2 Protein | 2016 |
Ets-1 upregulation mediates angiotensin II-related cardiac fibrosis.
Topics: Angiotensin II; Animals; Cell Proliferation; Collagen; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Heart; Losartan; Male; Myocardium; Plasminogen Activator Inhibitor 1; Proto-Oncogene Protein c-ets-1; Rats; Rats, Sprague-Dawley; Up-Regulation | 2015 |
Differential regulation of angiotensin II-induced extracellular signal regulated kinase-1/2 and -5 in progressive glomerulonephritis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Fibrosis; Glomerular Mesangium; Glomerulonephritis; Inflammation; Mitogen-Activated Protein Kinase 3; Rats; Renin-Angiotensin System; Signal Transduction | 2016 |
Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts.
Topics: Alendronate; Angiotensin II; Animals; Cells, Cultured; Collagen Type I; Depression, Chemical; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Fibrosis; Male; Molecular Targeted Therapy; Myocardium; Rats, Wistar; rho-Associated Kinases; Signal Transduction | 2015 |
Telmisartan inhibited angiotensin II-induced collagen metabolic imbalance without directly targeting TGF-β 1/Smad signaling pathway in cardiac fibroblasts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Benzimidazoles; Benzoates; Blotting, Western; Cells, Cultured; Collagen; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibrosis; Rats; Signal Transduction; Smad Proteins; Telmisartan; Transforming Growth Factor beta1 | 2015 |
Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced Cardiomyopathy.
Topics: Angiotensin II; Animals; Biomarkers; Cardiomyopathies; Cytokines; Denervation; Fibrosis; Heart Atria; Heart Ventricles; Inflammation Mediators; Isoproterenol; Kidney; Kidney Diseases; Male; Myocardium; Natriuretic Peptide, Brain; Peptide Fragments; Procollagen; Rats, Sprague-Dawley; Renin-Angiotensin System | 2015 |
Different regulation of miR-29a-3p in glomeruli and tubules in an experimental model of angiotensin II-dependent hypertension: potential role in renal fibrosis.
Topics: Angiotensin II; Animals; Base Sequence; Blood Pressure; Down-Regulation; Fibrosis; Glomerular Filtration Rate; Hypertension; Kidney Glomerulus; Kidney Tubules; Male; Matrix Metalloproteinase 2; MicroRNAs; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2016 |
Attenuation of Tubular Injury and Renal Fibrosis by TI-HU-YIN via Reduction in Transforming Growth Factor-β1 Expression in Unilateral Ureteral Obstruction Mice.
Topics: Angiotensin II; Animals; Cells, Cultured; Drugs, Chinese Herbal; Fibrosis; Kidney Tubules; Macrophages; Male; Mice; Mice, Inbred C57BL; Renin-Angiotensin System; Transforming Growth Factor beta1; Ureteral Obstruction | 2015 |
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
Topics: 3' Untranslated Regions; Adipokines; Angiotensin II; Animals; Apelin; Base Sequence; Binding Sites; Cell Proliferation; Cells, Cultured; Fibroblasts; Fibrosis; Gene Expression; Heart Diseases; Intercellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; RNA Interference | 2016 |
Mitigation of myocardial fibrosis by molecular cardiac surgery-mediated gene overexpression.
Topics: Angiotensin II; Animals; Calcium; Cardiomyopathies; Collagen; Disease Models, Animal; Enzyme Induction; Fibronectins; Fibrosis; Genetic Therapy; Heart Failure; Hemodynamics; Male; Myocardial Infarction; Myocardium; Myofibroblasts; Receptor, Angiotensin, Type 1; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sheep; Time Factors; Transforming Growth Factor beta | 2016 |
Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis.
Topics: Angiotensin II; Animals; Apoptosis; B-Lymphocytes; Cardiomyopathies; Collagen; Cytokines; Disease Models, Animal; Fibroblasts; Fibrosis; Genetic Predisposition to Disease; Heart Failure; Hypertrophy, Left Ventricular; Immunoglobulin G; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, SCID; Myocardium; NG-Nitroarginine Methyl Ester; Phenotype; Sialic Acid Binding Ig-like Lectin 2; Signal Transduction; Sodium Chloride; Stroke Volume; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2016 |
May the fibrosis be with you: Is discoidin domain receptor 2 the receptor we have been looking for?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Collagen; Discoidin Domain Receptors; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Losartan; Myocardium; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Signal Transduction | 2016 |
Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Genetically Modified; Apoptosis; Cell Differentiation; Cell Line; Disease Models, Animal; ELAV-Like Protein 1; Fibrosis; Green Fluorescent Proteins; Humans; Immunophenotyping; Interleukin-10; Kidney; Kidney Tubules; Male; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Transforming Growth Factor beta; Ureteral Obstruction | 2016 |
BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Angiotensin II; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type I; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Inhibitor of Differentiation Protein 1; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NFATC Transcription Factors; Phenylephrine; Phosphorylation; Pyrazoles; Pyrimidines; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Smad Proteins; Time Factors; Transfection | 2016 |
MiR-30a regulates the atrial fibrillation-induced myocardial fibrosis by targeting snail 1.
Topics: 3' Untranslated Regions; Angiotensin II; Animals; Atrial Fibrillation; Binding Sites; Cardiomyopathies; Cell Adhesion Molecules; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; MicroRNAs; Myocardium; Rabbits; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Snail Family Transcription Factors; Time Factors; Transcription Factors; Transfection | 2015 |
Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure Overload in Mice.
Topics: Angiotensin II; Animals; Animals, Newborn; Aortic Diseases; Basigin; Blood Proteins; Cells, Cultured; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Heart Failure; Hypertrophy, Left Ventricular; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinases; Mechanotransduction, Cellular; Mice, Knockout; Myocardium; Myocytes, Cardiac; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left | 2016 |
Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal injury in unilateral ureteral obstructed mice.
Topics: Amides; Angiotensin II; Animals; Disease Models, Animal; Fibrosis; Fumarates; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Nephritis, Interstitial; Renin; Renin-Angiotensin System; RNA, Messenger; Toll-Like Receptor 2; Ureteral Obstruction | 2016 |
Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Proliferation; Collagen Type I; Collagen Type III; Curcumin; Electrocardiography; Fibrosis; Isoproterenol; Male; Matrix Metalloproteinase 9; Myocardium; Myofibroblasts; Rats, Sprague-Dawley; Smad3 Protein; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2017 |
Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats.
Topics: Age Factors; Angiotensin II; Animals; Blood Pressure; Chymases; Cromolyn Sodium; Crosses, Genetic; Diastole; Disease Models, Animal; Estrogens; Female; Fibrosis; Heart Ventricles; Hypertrophy, Left Ventricular; Infusions, Subcutaneous; Mast Cells; Ovariectomy; Rats, Inbred BN; Rats, Inbred F344; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2016 |
Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation.
Topics: Angiotensin II; Animals; Blood Pressure; CD36 Antigens; Chemokine CXCL1; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Fibrosis; Fluorescent Dyes; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1beta; Interleukin-6; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Nephrectomy; NLR Family, Pyrin Domain-Containing 3 Protein; Peptides; Renal Insufficiency, Chronic; Ureteral Obstruction | 2016 |
Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats.
Topics: Action Potentials; Angiotensin II; Animals; Atrial Fibrillation; Atrial Function, Left; Atrial Remodeling; Bradykinin; Cathepsin A; Connexin 43; Diabetes Mellitus, Type 2; Disease Models, Animal; Fibrosis; Heart Rate; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Protease Inhibitors; Rats, Zucker; Time Factors | 2016 |
N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys.
Topics: Acetylcysteine; Angiotensin II; Animals; Antioxidants; Cell Line; Fibroblasts; Fibrosis; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Renin-Angiotensin System; Ureteral Obstruction | 2016 |
The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Fibrosis; Hypertension; Kidney; Mice; Mice, Knockout; Myocardium; Receptor, Anaphylatoxin C5a | 2016 |
Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro.
Topics: Angiotensin II; Animals; Cells, Cultured; Curcumin; Enzyme Activation; Fibroblasts; Fibrosis; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Sirtuin 1; Structure-Activity Relationship | 2016 |
Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Antlers; Aorta; Blood Pressure; Cell Proliferation; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Gene Expression Regulation; Hypertrophy; Myocardium; Oxidative Stress; Peptides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Vasoconstriction | 2016 |
Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-β.
Topics: Angiotensin II; Animals; Calcium-Binding Proteins; Cardiomegaly; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Heart Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Cardiovascular; Myocardium; Signal Transduction; Transforming Growth Factor beta1; Ventricular Remodeling | 2016 |
P‑selectin increases angiotensin II‑induced cardiac inflammation and fibrosis via platelet activation.
Topics: Angiotensin II; Animals; Blood Platelets; Disease Models, Animal; Endothelial Cells; Fibrosis; Gene Expression; Hypertension; Immunohistochemistry; Male; Mice; Mice, Knockout; Myocarditis; Myocardium; P-Selectin; Platelet Activation | 2016 |
TNF/Ang-II synergy is obligate for fibroinflammatory pathology, but not for changes in cardiorenal function.
Topics: Angiotensin II; Animals; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibrosis; Flow Cytometry; Heart; Heart Diseases; Inflammation; Kidney; Kidney Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Tumor Necrosis Factor, Type I; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2016 |
Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension.
Topics: Angiotensin II; Animals; Biomarkers; Blood Pressure; Cardiomyopathies; Cell Adhesion Molecules; Disease Models, Animal; Fibrosis; Gene Expression; Gene Expression Regulation; Hypertension; Male; Oxidative Stress; Rats; Reactive Oxygen Species; Sodium Chloride, Dietary | 2016 |
[Effect of Danzhi Jiangtang Capsule on Myocardial Fibrosis in Diabetic Rats].
Topics: Angiotensin II; Animals; Blood Glucose; Capsules; Collagen Type III; Diabetes Mellitus, Experimental; Down-Regulation; Drugs, Chinese Herbal; Fibrosis; Glucose; Injections, Intraperitoneal; Insulin; Matrix Metalloproteinase 2; Myocardium; Phosphorylation; Rats; Smad3 Protein; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1; Up-Regulation | 2015 |
Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis.
Topics: Adolescent; Adult; Aged; Angiotensin II; Calpain; Cell Proliferation; Cells, Cultured; Collagen Type I; Enzyme Activation; Epithelium; Female; Fibrosis; Humans; Male; Middle Aged; Pleura; Pleural Effusion, Malignant; Renin-Angiotensin System; Signal Transduction; Tuberculosis, Pleural; Young Adult | 2016 |
Endoplasmic reticulum stress in bone marrow-derived cells prevents acute cardiac inflammation and injury in response to angiotensin II.
Topics: Angiotensin II; Animals; Apoptosis; Bone Marrow Cells; Endoplasmic Reticulum Stress; Fibrosis; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Neutrophils; Transcription Factor CHOP | 2016 |
Renal denervation significantly attenuates cardiorenal fibrosis in rats with sustained pressure overload.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Cardiomyopathies; Disease Models, Animal; Fibrosis; Heart Atria; Heart Ventricles; Humans; Kidney; Losartan; Myocardium; Natriuretic Peptide, Brain; Peptide Fragments; Procollagen; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Sympathectomy | 2016 |
Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis.
Topics: Angiotensin II; Animals; Autophagy; Autophagy-Related Protein 5; Cell Cycle; Cell Cycle Checkpoints; Cell Division; Collagen Type I; Epithelial Cells; Fibrosis; G2 Phase; Gene Deletion; Humans; Kidney; Kidney Diseases; Kidney Tubules; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Signal Transduction; Sirolimus | 2016 |
Suppressive effect of epigallocatechin-3-O-gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo.
Topics: Angiotensin II; Animals; Anthracenes; Catechin; Cell Proliferation; Cells, Cultured; Endoglin; Fibrosis; Heart Failure; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Models, Biological; Myocardial Infarction; Myocardium; Promoter Regions, Genetic; Protein Binding; Rats, Wistar; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1 | 2016 |
Estrogen receptor beta signals to inhibition of cardiac fibrosis.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Collagen Type I; Collagen Type III; Disease Models, Animal; Estrogen Receptor beta; Fibrosis; Male; Mice; Myofibroblasts; Rats; Signal Transduction | 2016 |
[Effect and potential mechanism of β3-adrenoceptor activation on fibrosis in cardiac fibroblast cell].
Topics: Angiotensin II; Cells, Cultured; Collagen Type I; Collagen Type III; Fibroblasts; Fibrosis; Humans; Myocardium; Receptors, Adrenergic, beta-3; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2016 |
MicroRNA-214 exerts a Cardio-protective effect by inhibition of fibrosis.
Topics: Angiotensin II; Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibroblasts; Fibrosis; Heart; Male; MicroRNAs; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Transfection; Transforming Growth Factor beta1 | 2016 |
Suppressive Effects of Glucose-Dependent Insulinotropic Polypeptide on Cardiac Hypertrophy and Fibrosis in Angiotensin II-Infused Mouse Models.
Topics: Angiotensin II; Animals; Apolipoproteins E; Cardiomegaly; Cell Line; Fibrosis; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Transforming Growth Factor beta1 | 2016 |
Partial inhibition of activin receptor-like kinase 4 attenuates pressure overload-induced cardiac fibrosis and improves cardiac function.
Topics: Activin Receptors, Type I; Angiotensin II; Animals; Aorta; Apoptosis; Blood Pressure; Cardiomegaly; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen; Disease Models, Animal; Fibroblasts; Fibrosis; Haploinsufficiency; Heterozygote; Male; Mice; Myocardium; Myocytes, Cardiac; Signal Transduction; Smad2 Protein; Smad3 Protein; Stroke Volume; Transforming Growth Factor beta; Up-Regulation; Ventricular Dysfunction, Left | 2016 |
Store-Operated Ca
Topics: Angiotensin II; Animals; Calcium; Calcium Signaling; Fibroblasts; Fibrosis; Male; Mice; Mice, Inbred C57BL; Myocardium; ORAI1 Protein; Rats; Rats, Sprague-Dawley; Stromal Interaction Molecule 1 | 2016 |
Human Endomyocardial Biopsy Specimen-Derived Stromal Cells Modulate Angiotensin II-Induced Cardiac Remodeling.
Topics: Adult; Angiotensin II; Animals; Biopsy; Cardiomegaly; Cell Proliferation; Cell Transdifferentiation; Collagen; Female; Fibroblasts; Fibrosis; Humans; Immunomodulation; Male; Mice, Inbred C57BL; Myocardium; Myofibroblasts; Oxidative Stress; Stromal Cells; Vascular Remodeling; Ventricular Function, Left | 2016 |
Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Fibrosis; Genetic Predisposition to Disease; Hypertension; Male; Mice, Knockout; Muscle, Smooth, Vascular; Myocardium; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitrites; Phenotype; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Stromal Interaction Molecule 1; Time Factors; Transcription Factor CHOP; Transforming Growth Factor beta; Vasodilation; Vasodilator Agents | 2016 |
Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II.
Topics: ADAM17 Protein; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Fibrosis; Humans; Hypertension; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Myocytes, Cardiac; Random Allocation; Renin-Angiotensin System; Sensitivity and Specificity; Signal Transduction; Vascular Remodeling; Ventricular Remodeling | 2016 |
New EGFR inhibitor, 453, prevents renal fibrosis in angiotensin II-stimulated mice.
Topics: Angiotensin II; Animals; Apoptosis; ErbB Receptors; Fibrosis; Kidney; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2016 |
PPAR-γ is involved in the protective effect of 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside against cardiac fibrosis in pressure-overloaded rats.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiotonic Agents; Cell Differentiation; Cell Proliferation; Collagen Type I; Collagen Type III; Fibroblasts; Fibronectins; Fibrosis; Gene Expression Regulation; Glucosides; Heart; Male; Myocardium; Plasminogen Activator Inhibitor 1; PPAR gamma; Pressure; Rats; Stilbenes | 2016 |
Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice.
Topics: Angiotensin II; Animals; Aryldialkylphosphatase; Blood Pressure; Blotting, Western; Cardiomegaly; Echocardiography; Fibrosis; Gene Expression Regulation, Enzymologic; Heart; Humans; Male; Matrix Metalloproteinases; Mice, Inbred C57BL; Mice, Transgenic; Multigene Family; Myocardium; Reverse Transcriptase Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinases; Ventricular Remodeling | 2016 |
FGF23 promotes myocardial fibrosis in mice through activation of β-catenin.
Topics: Angiotensin II; Animals; beta Catenin; Cells, Cultured; Collagen; Dependovirus; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibrosis; Humans; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 4; Reperfusion Injury; RNA, Small Interfering; Transforming Growth Factor beta; Up-Regulation | 2016 |
Development of nonfibrotic left ventricular hypertrophy in an ANG II-induced chronic ovine hypertension model.
Topics: Angiotensin II; Animals; Autopsy; Fibrosis; Heart; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging; Models, Animal; Risk Factors; Sheep; Vasoconstrictor Agents; Ventricular Remodeling | 2016 |
C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.
Topics: Angiotensin II; Animals; Blood Pressure; Chemokine CCL2; Chemokine CCL5; Essential Hypertension; Female; Fibrosis; Hypertension; Kidney; Kidney Diseases; Macrophages; Male; Mice; Mice, Knockout; Nephrectomy; Renin-Angiotensin System; T-Lymphocytes; Ureteral Obstruction | 2016 |
Zofenopril exerts a cardiovascular protective effect on rats infused with angiotensin II beyond angiotensin-converting enzyme inhibition.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Captopril; Cardiomegaly; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Hydroxyproline; Hypertension; Male; Myocardium; Rats, Wistar; Superoxides; Time Factors; Vasodilation; Vasodilator Agents | 2016 |
Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion.
Topics: Acetyl-CoA Carboxylase; Angiotensin II; Animals; Cardiomegaly; Diastole; Disease Models, Animal; Echocardiography; Energy Metabolism; Fatty Acids; Fibrosis; Gene Deletion; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Myocardium; Organelle Biogenesis; Oxidation-Reduction; Oxidative Stress; Ventricular Dysfunction | 2016 |
Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.
Topics: 3' Untranslated Regions; Angiotensin II; Animals; Binding Sites; Cardiomyopathies; Cells, Cultured; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Fibrosis; Gene Expression Regulation; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; Myofibroblasts; NF-kappa B; Oligonucleotides; Polycomb Repressive Complex 2; PPAR gamma; RNA Interference; Signal Transduction; Transfection | 2016 |
Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression.
Topics: Adenoviridae; Aging; Angiotensin II; Animals; Animals, Newborn; Base Sequence; Extracellular Matrix; Fibroblasts; Fibrosis; Gene Expression Regulation; Gene Silencing; Gene Transfer Techniques; Hypertension; Matrix Metalloproteinase 9; Membrane Proteins; Models, Biological; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Promoter Regions, Genetic; Rats, Sprague-Dawley; Transcription Factors | 2017 |
Overexpression of SerpinE2/protease nexin-1 Contribute to Pathological Cardiac Fibrosis via increasing Collagen Deposition.
Topics: Angiotensin II; Animals; Aorta; Collagen; Constriction; Disease Models, Animal; ets-Domain Protein Elk-1; Fibrosis; Gene Knockdown Techniques; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Models, Biological; Myocardium; Myofibroblasts; RNA, Messenger; Serpin E2; Transforming Growth Factor beta | 2016 |
Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Cardiomegaly; Coronary Vessels; Fibrosis; Hypertension; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Receptor, PAR-1; Signal Transduction; Vascular Remodeling | 2017 |
Renal Denervation Attenuates Multi-Organ Fibrosis and Improves Vascular Remodeling in Rats with Transverse Aortic Constriction Induced Cardiomyopathy.
Topics: Alanine Transaminase; Angiotensin II; Animals; Aorta; Blood Pressure; Carbazoles; Cardiomegaly; Cardiomyopathies; Carvedilol; Constriction; Cystatin C; Denervation; Fibrosis; Heart Rate; Kidney; Malondialdehyde; Natriuretic Peptide, Brain; Organ Specificity; Oxidative Stress; Peptide Fragments; Procollagen; Propanolamines; Rats, Sprague-Dawley; Superoxide Dismutase; Transforming Growth Factor beta1; Vascular Remodeling | 2016 |
Effects of exendin-4 on the intrarenal renin-angiotensin system and interstitial fibrosis in unilateral ureteral obstruction mice: Exendin-4 and unilateral ureteral obstruction.
Topics: Actins; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Collagen Type I; Exenatide; Fibronectins; Fibrosis; Kidney; Male; Mice, Inbred BALB C; Peptide Fragments; Peptides; Peptidyl-Dipeptidase A; Renin-Angiotensin System; RNA, Messenger; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Ureteral Obstruction; Venoms | 2016 |
Suppression of ROS Production by Exendin-4 in PSC Attenuates the High Glucose-Induced Islet Fibrosis.
Topics: Angiotensin II; Animals; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Exenatide; Fibrosis; Glucose; Glucose Intolerance; Islets of Langerhans; Pancreatic Stellate Cells; Peptides; Rats; Rats, Inbred OLETF; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta1; Venoms | 2016 |
Substance P Inhibits the Collagen Synthesis of Rat Myocardial Fibroblasts Induced by Ang II.
Topics: Angiotensin II; Animals; Cells, Cultured; Collagen; Collagen Type I; Collagen Type III; Fibroblasts; Fibrosis; Heart; Myocardium; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Smad3 Protein; Substance P; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2016 |
MiR-22 may Suppress Fibrogenesis by Targeting TGFβR I in Cardiac Fibroblasts.
Topics: Angiotensin II; Animals; Base Sequence; Cells, Cultured; Collagen; Down-Regulation; Fibroblasts; Fibrosis; Gene Silencing; Male; Mice, Inbred C57BL; MicroRNAs; Myocardial Infarction; Myocardium; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta | 2016 |
Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Cells, Cultured; Disease Models, Animal; Diuretics; Fibroblasts; Fibrosis; Furosemide; Heart Failure; Heart Ventricles; Hydrochlorothiazide; Male; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Recovery of Function; Signal Transduction; Smad2 Protein; Stroke Volume; Transforming Growth Factor beta1; Valsartan; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Cells, Cultured; Disease Models, Animal; Fibrosis; Hypertension; Hypertrophy; Mesenteric Arteries; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Proto-Oncogene Protein c-ets-1; Rats, Inbred Dahl; Recombinant Proteins; Repressor Proteins; RNA Interference; Signal Transduction; Sodium Chloride, Dietary; Time Factors; Transfection; Vascular Remodeling | 2017 |
Polyphenol rich ethanolic extract from Boerhavia diffusa L. mitigates angiotensin II induced cardiac hypertrophy and fibrosis in rats.
Topics: Angiotensin II; Animals; Antioxidants; Cardiomegaly; Ethanol; Fibrosis; Glutathione; Heart; Lipid Peroxidation; Male; Myocardium; Nyctaginaceae; Oxidative Stress; Plant Extracts; Plants, Medicinal; Polyphenols; Quercetin; Rats; Rats, Wistar; Reactive Oxygen Species | 2017 |
Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis.
Topics: Angiotensin II; Animals; Cardiomegaly; Collagen Type I; Collagen Type III; Feedback, Physiological; Fibrosis; Hemodynamics; Hydroxyproline; Liver X Receptors; Male; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Peptidyl-Dipeptidase A; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridones; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Signal Transduction; Systole; Ventricular Dysfunction | 2017 |
Differential response of bone and kidney to ACEI in db/db mice: A potential effect of captopril on accelerating bone loss.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biomarkers; Bone and Bones; Bone Resorption; Calcium; Captopril; Diabetes Mellitus, Experimental; Femur; Fibrosis; Kidney; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Renin-Angiotensin System; RNA, Messenger; Tibia; Vitamin D3 24-Hydroxylase; X-Ray Microtomography | 2017 |
Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.
Topics: Angiotensin II; Animals; Arsenic Trioxide; Arsenicals; Collagen; Fibrosis; Gene Silencing; Mice; Myocardium; Myofibroblasts; Nuclear Proteins; Oxides; Promyelocytic Leukemia Protein; Protein Binding; Sumoylation; Transcription Factors; Transforming Growth Factor beta1; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases | 2017 |
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Topics: Angiotensin II; Animals; Apoptosis; Biopsy; Blood Pressure; Disease Models, Animal; Endoplasmic Reticulum Stress; Fibrosis; Gene Expression Profiling; Humans; Hypertension; Inflammation; Male; Mice; Mice, Knockout; Nephrosclerosis; Phenylbutyrates; Proteinuria; Renal Insufficiency, Chronic; Transcription Factor CHOP; Transcriptome; Urinalysis | 2017 |
Effect of captopril on radiation-induced TGF-β1 secretion in EA.Hy926 human umbilical vein endothelial cells.
Topics: A549 Cells; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Blotting, Western; Captopril; Cells, Cultured; Fibrosis; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; NF-kappa B; Signal Transduction; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; X-Rays | 2017 |
Synthesis of the novel PARP-1 inhibitor AG-690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiotonic Agents; Fibrosis; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Poly (ADP-Ribose) Polymerase-1; Sirtuin 1; Thioglycolates; Ventricular Remodeling; Xanthines | 2017 |
Elevated Serotonin Interacts with Angiotensin-II to Result in Altered Valve Interstitial Cell Contractility and Remodeling.
Topics: Angiotensin II; Animals; Aortic Valve; Blood Pressure; Cell Proliferation; Cells, Cultured; Cytoskeleton; Disease Models, Animal; Female; Fibrillar Collagens; Fibrosis; Heart Valve Diseases; Hypertension; Mechanotransduction, Cellular; Mice, Inbred C57BL; Receptor, Angiotensin, Type 1; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Serotonin; Stroke Volume; Sus scrofa; Ventricular Function, Left | 2018 |
Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling.
Topics: Acetylation; Activating Transcription Factor 3; Angiotensin II; Animals; Binding Sites; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Genetic Predisposition to Disease; Heart Failure; Histone Deacetylase 1; Histones; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; MAP Kinase Kinase 3; Mice, Knockout; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenotype; Promoter Regions, Genetic; Protein Kinase Inhibitors; Signal Transduction; Time Factors; Transforming Growth Factor beta; Ventricular Function, Left; Ventricular Remodeling | 2017 |
β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; beta-Arrestin 1; beta-Arrestin 2; Biphenyl Compounds; Cell Line; Collagen Type I; Disease Models, Animal; Extracellular Matrix; Fibroblasts; Fibronectins; Fibrosis; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Rats; Receptor, Angiotensin, Type 1; RNA Interference; Signal Transduction; Tetrazoles; Time Factors; Transfection; Ureteral Obstruction | 2017 |
Overexpressed connective tissue growth factor in cardiomyocytes attenuates left ventricular remodeling induced by angiotensin II perfusion.
Topics: Actins; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Collagen Type I; Connective Tissue Growth Factor; Echocardiography; Fibrosis; Heart; Heart Ventricles; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta; Vasoconstrictor Agents; Ventricular Remodeling | 2017 |
Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Transdifferentiation; Cells, Cultured; Epithelial Cells; Fibrosis; Humans; Kidney; Kidney Diseases; Kidney Tubules; MAP Kinase Signaling System; Mesoderm; Rats; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2008 |
Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis.
Topics: Adiponectin; Angiotensin II; Animals; Cardiomegaly; Chemotaxis; Female; Fibrosis; Hypoglycemic Agents; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Myocardium; Myocytes, Cardiac; Pioglitazone; PPAR gamma; Thiazolidinediones; Vasoconstrictor Agents | 2008 |
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Substitution; Angiotensin II; Animals; Cells, Cultured; Fibronectins; Fibrosis; Gene Expression Regulation; Glomerular Mesangium; Humans; Hypertrophy; Kidney Diseases; Mutation, Missense; NADPH Oxidase 4; NADPH Oxidases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Reactive Oxygen Species; RNA, Small Interfering; src-Family Kinases; Vasoconstrictor Agents | 2008 |
Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats.
Topics: Angiotensin II; Animals; Antioxidants; Blood Pressure; Collagen Type I; Fibroblasts; Fibrosis; Gene Expression Regulation; Hypertension; Immunohistochemistry; Membrane Glycoproteins; Models, Biological; Myocardium; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Rats; RNA, Messenger; Systole; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1 | 2008 |
Cellular physiology of rat cardiac myocytes in cardiac fibrosis: in vitro simulation using the cardiac myocyte/cardiac non-myocyte co-culture system.
Topics: Angiotensin II; Angiotensinogen; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cell Separation; Cells, Cultured; Coculture Techniques; Diuretics, Osmotic; Endothelin-1; Fibrosis; Leucine; Mannitol; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptors, Angiotensin; Renin; Thymidine; Transforming Growth Factor beta1; Tritium | 2008 |
Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways.
Topics: Angiotensin II; Atorvastatin; Cell Line; Cell Transdifferentiation; Connective Tissue Growth Factor; Epithelial Cells; Fibrosis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase Kinases; Phenotype; Protein Kinase Inhibitors; Pyrroles; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Simvastatin; Time Factors; Transfection | 2008 |
Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta; Collagen; Elastin; Enzyme Activation; Fibrosis; Heart Diseases; Hypertension; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lipid Metabolism; Male; Neutrophil Infiltration; Oligopeptides; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Smad2 Protein; Transforming Growth Factor beta1; Vasoconstrictor Agents | 2008 |
Perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure sensitizes offspring to angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Carcinogens, Environmental; Cardiomegaly; Collagen; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Gestational Age; Hypertension; Kidney; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADPH Oxidase 2; NADPH Oxidases; Polychlorinated Dibenzodioxins; Pregnancy; Prenatal Exposure Delayed Effects; Procollagen; Renin-Angiotensin System; RNA, Messenger; Telemetry; Time Factors; Ultrasonography | 2008 |
Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomyopathies; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Fibrosis; Hypertrophy; Metallothionein; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; NADP; Oxidative Stress; Ventricular Remodeling | 2008 |
Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.
Topics: Age Factors; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Fibrosis; Heart Rate; Humans; Hypertension; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Mutation; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Stroke Volume; Time Factors; Ventricular Remodeling | 2009 |
Blocking of angiotensin II is more than blocking of transforming growth factor-beta.
Topics: Angiotensin II; Fibrosis; Humans; Kidney Diseases; Models, Biological; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2008 |
Cardioprotective effects of granulocyte colony-stimulating factor in angiotensin II-induced cardiac remodelling.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Disease Models, Animal; Fibrosis; Granulocyte Colony-Stimulating Factor; Heart Rate; Humans; Hypertension; Hypertrophy, Left Ventricular; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Myocardium; Osteopontin; Peptidyl-Dipeptidase A; Phosphorylation; Recombinant Proteins; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Ventricular Function, Left; Ventricular Remodeling | 2009 |
Role of angiotensin II, endothelin-1 and L-type calcium channel in the development of glomerular, tubulointerstitial and perivascular fibrosis.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Calcium Channels, L-Type; Disease Models, Animal; Endothelin-1; Fibrosis; Kidney Failure, Chronic; Kidney Glomerulus; Kidney Tubules; Male; Rats | 2008 |
Insights into mechanisms linking cardiac hypertrophy and atrial fibrosis: evidence for a role of histone deacetylase in atrial fibrillation pathophysiology and therapy.
Topics: Angiotensin II; Animals; Atrial Fibrillation; Cardiomegaly; Connexins; Enzyme Inhibitors; Fibrosis; Gap Junction alpha-5 Protein; Histone Deacetylase Inhibitors; Histone Deacetylases; Homeodomain Proteins; Hydroxamic Acids; Mice; Mice, Transgenic; Time Factors | 2008 |
Changes in hemodynamic and neurohumoral control cause cardiac damage in one-kidney, one-clip hypertensive mice.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Baroreflex; Blood Pressure; Cardiomegaly; Constriction; Disease Models, Animal; Fibrosis; Heart Rate; Hemodynamics; Hypertension, Renovascular; Kidney Cortex; Male; Mice; Muscarinic Antagonists; Renal Artery; Renin; Renin-Angiotensin System; Sympathetic Nervous System; Time Factors; Vagus Nerve | 2008 |
Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin.
Topics: Angiotensin II; Animals; Arrhythmias, Cardiac; Cardiomegaly; Connexins; Enzyme Inhibitors; Fibrosis; Gap Junction alpha-5 Protein; Histone Deacetylase Inhibitors; Histone Deacetylases; Homeodomain Proteins; Hydroxamic Acids; Mice; Mice, Transgenic; Time Factors | 2008 |
EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy.
Topics: Angiotensin II; Animals; Antioxidants; Atrial Natriuretic Factor; Camellia sinensis; Cardiomegaly; Catechin; Cell Proliferation; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endothelins; Enzyme Inhibitors; Fibroblasts; Fibrosis; Hydroxyproline; Male; Myocardium; Nitric Oxide Synthase Type II; Nitrites; Organ Size; Plant Extracts; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Transcription Factors | 2009 |
[Mechanisms of losartan for inhibition of myocardial fibrosis following myocardial infarction in rats].
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Losartan; Male; Myocardial Infarction; Myocardium; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger | 2008 |
Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fibrosis; Heart Failure; Hyperglycemia; Male; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Tetrazoles | 2009 |
Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling.
Topics: Adenoviridae; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Collagen; Disease Models, Animal; Echocardiography; ErbB Receptors; Fibrosis; Intracellular Signaling Peptides and Proteins; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Signal Transduction | 2009 |
Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt.
Topics: Angiotensin II; Animals; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fibrosis; Heart Diseases; Kidney Diseases; Mineralocorticoid Receptor Antagonists; Rats; Sodium Chloride, Dietary; Spironolactone | 2009 |
Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype.
Topics: Angiotensin II; Animals; Apolipoproteins E; Blood Pressure; Carotid Artery Diseases; Carotid Artery, Common; Collagen Type I; Disease Models, Animal; Enzyme Activation; Fibrosis; Gene Expression Profiling; Hemorrhage; Infusion Pumps, Implantable; Infusions, Subcutaneous; Macrophages; Matrix Metalloproteinase 13; Matrix Metalloproteinase 8; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Procollagen; Severity of Illness Index; Tissue Inhibitor of Metalloproteinases | 2009 |
Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
Topics: Angiotensin II; Animals; Antigens, Surface; Cyclooxygenase 2; ELAV Proteins; ELAV-Like Protein 1; Electrophoretic Mobility Shift Assay; Fibrosis; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Hypertension; Immunohistochemistry; Immunoprecipitation; Kidney Diseases; Male; Plasminogen Activator Inhibitor 1; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger | 2009 |
Renal functional, not morphological, abnormalities account for salt sensitivity in Dahl rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cyclic GMP; Diastole; Dose-Response Relationship, Drug; Fibrosis; Glomerulosclerosis, Focal Segmental; Hemodynamics; Hypertension; Kidney; Kidney Glomerulus; Kidney Medulla; Organ Size; Proteinuria; Rats; Rats, Inbred Dahl; Sodium; Sodium Chloride, Dietary; Systole; Time Factors; Vascular Resistance; Vasoconstriction | 2009 |
Osteopontin modulates angiotensin II-induced inflammation, oxidative stress, and fibrosis of the kidney.
Topics: Angiotensin II; Animals; Fibrosis; Inflammation; Kidney; Mice; Mice, Knockout; Osteopontin; Oxidative Stress | 2009 |
Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis.
Topics: Angiotensin II; Animals; Antioxidants; Blood Pressure; Blotting, Northern; Blotting, Western; Body Weight; Cells, Cultured; DNA; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Fibrosis; Heart Rate; Interleukin-6; Luciferases; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Promoter Regions, Genetic; Rats; Resveratrol; Stilbenes; Vascular Diseases | 2009 |
Angiotensin II activates connective tissue growth factor and induces extracellular matrix changes involving Smad/activation and p38 mitogen-activated protein kinase signalling pathways in human dermal fibroblasts.
Topics: Angiotensin II; Connective Tissue Growth Factor; Enzyme Inhibitors; Extracellular Matrix; Fibroblasts; Fibronectins; Fibrosis; Humans; p38 Mitogen-Activated Protein Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Skin; Smad Proteins; Smad7 Protein | 2009 |
Renal damage inhibited in mice lacking angiotensinogen gene subjected to unilateral ureteral obstruction.
Topics: Angiotensin II; Angiotensinogen; Animals; Female; Fibrosis; Kidney Diseases; Mice; Mice, Inbred C57BL; Ureteral Obstruction | 2009 |
Regulatory T cells ameliorate angiotensin II-induced cardiac damage.
Topics: Adoptive Transfer; Angiotensin II; Animals; Cardiomegaly; Fibrosis; Heart Diseases; Immunosuppression Therapy; Male; Mice; Mice, Inbred Strains; T-Lymphocytes, Regulatory; Treatment Outcome | 2009 |
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist.
Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ergocalciferols; Fibrosis; Glomerular Basement Membrane; Inflammation Mediators; Losartan; Macrophages; Mice; Mice, Inbred DBA; Podocytes; Renin; Renin-Angiotensin System; Time Factors; Vitamins | 2009 |
Role of protein kinase C-delta in angiotensin II induced cardiac fibrosis.
Topics: Acetophenones; Angiotensin II; Animals; Benzopyrans; Cell Proliferation; Collagen; Enzyme Inhibitors; Fibroblasts; Fibrosis; Male; Myocardium; Protein Kinase C-delta; Rats; Rats, Sprague-Dawley; RNA, Small Interfering | 2009 |
Tumor necrosis factor-alpha--converting enzyme roles in hypertension-induced hypertrophy: look both ways when crossing the street.
Topics: ADAM Proteins; ADAM12 Protein; ADAM17 Protein; Angiotensin II; Animals; Cardiomegaly; Fibrosis; Matrix Metalloproteinase 2; Mice; Models, Biological; Myocardium; Rats; RNA Interference; Signal Transduction | 2009 |
Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.
Topics: ADAM Proteins; ADAM12 Protein; ADAM17 Protein; Angiotensin II; Animals; Blood Pressure; Blotting, Western; Cardiomegaly; Echocardiography; Fibrosis; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Myocardium; Rats; Rats, Inbred SHR; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction | 2009 |
NF-kappaB activation is required for adaptive cardiac hypertrophy.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Disease Models, Animal; Female; Fibrosis; I-kappa B Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Myocardium; Myocytes, Cardiac; Myosin Heavy Chains; NF-kappa B; NF-KappaB Inhibitor alpha; Receptor, Angiotensin, Type 1; Sex Characteristics; Signal Transduction; Ventricular Remodeling | 2009 |
Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels.
Topics: Angiotensin II; Animals; Blood Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Fibrosis; Gene Expression Regulation; Humans; Hypertrophy; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Mutant Proteins; Organ Specificity; Phosphorylation; Phosphoserine; Protein Biosynthesis; rho-Associated Kinases; rhoA GTP-Binding Protein; Serum Response Element; Signal Transduction; Transcription, Genetic | 2009 |
Beneficial effects of combination therapy with olmesartan and azelnidipine in murine polycystic kidneys.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Azetidinecarboxylic Acid; Blotting, Western; Calcium Channel Blockers; Dihydropyridines; Drug Synergism; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Imidazoles; Immunohistochemistry; Kidney; Mice; NADPH Oxidases; Nitric Oxide Synthase Type III; Polycystic Kidney Diseases; Tetrazoles | 2009 |
Pressure-induced renal injury in angiotensin II versus norepinephrine-induced hypertensive rats.
Topics: Angiotensin II; Animals; Blood Pressure; Catheterization; Disease Models, Animal; Fibrosis; Glomerulosclerosis, Focal Segmental; Heart Rate; Hypertension, Renal; Kidney Cortex Necrosis; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Renal Artery; Sodium Chloride, Dietary; Vasoconstrictor Agents | 2009 |
Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone.
Topics: Adiponectin; AMP-Activated Protein Kinases; Angiotensin II; Animals; Blotting, Western; Cardiomegaly; Cardiotonic Agents; Collagen Type I; Collagen Type II; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phosphorylation; Pioglitazone; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones | 2010 |
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arginine; Blood Pressure; Fibrosis; Hypertension, Renal; Kidney Cortex; Male; NADPH Oxidases; Nitrates; Nitrites; Oxidative Stress; Protein-Arginine N-Methyltransferases; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Vasoconstrictor Agents | 2010 |
Infusion of angiotensin-(1-7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Cell Proliferation; Cells, Cultured; Collagen Type I; Disease Models, Animal; Dose-Response Relationship, Drug; Fibronectins; Fibrosis; Gene Expression Regulation; Glomerulonephritis; Infusion Pumps, Implantable; Infusions, Subcutaneous; Isoantibodies; Kidney; Male; Mesangial Cells; Peptide Fragments; Peptidyl-Dipeptidase A; Plasminogen Activator Inhibitor 1; Proteinuria; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Time Factors; Transforming Growth Factor beta1 | 2010 |
Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Apoptosis; Blood Pressure; Cell Proliferation; Cells, Cultured; Chronic Disease; Collagen; Disease Models, Animal; Fibrinolysin; Fibrosis; Glomerular Filtration Rate; Imidazoles; Kidney; Kidney Diseases; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nephrectomy; Phosphorylation; Plasminogen Activator Inhibitor 1; Podocytes; Proteinuria; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; RNA, Messenger; Time Factors | 2010 |
Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis.
Topics: Angiotensin II; Animals; Blotting, Western; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Hypertension; Male; Mice; Mice, Inbred BALB C; Myocardium; Probability; Random Allocation; RNA, Messenger; Smad2 Protein; Syndecan-1 | 2010 |
Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.
Topics: Angiotensin II; Animals; Atrophy; Coronary Circulation; Fibrosis; Genotype; Kidney; Male; Mice; Mice, Knockout; Myocardium; Natriuretic Peptide, Brain; Perfusion; Phenotype; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling | 2010 |
Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.
Topics: Angiotensin II; Animals; Apoptosis; Binding Sites; Cardiomegaly; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; Fibrosis; Gene Expression Regulation; Infusion Pumps, Implantable; Infusions, Subcutaneous; LIM Domain Proteins; MEF2 Transcription Factors; Mice; Mice, Transgenic; Myocardium; Myogenic Regulatory Factors; Myosin Heavy Chains; Nuclear Proteins; Promoter Regions, Genetic; Signal Transduction; Transcriptional Activation; Ventricular Myosins; Ventricular Remodeling | 2010 |
Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation.
Topics: Aged; Angiotensin II; Animals; Animals, Newborn; Atrial Fibrillation; Cadherins; Connective Tissue Growth Factor; Connexin 43; Female; Fibroblasts; Fibrosis; Gene Expression Profiling; Heart Atria; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Transgenic; Middle Aged; Myocardium; Myocytes, Cardiac; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta1 | 2010 |
C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease.
Topics: Analysis of Variance; Angiotensin II; Animals; Blood Pressure; C-Reactive Protein; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Fibrosis; Heart; Heart Rate; Humans; Hypertension; Immunohistochemistry; Inflammation; Interleukin-1beta; Mice; Myocardium; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Tumor Necrosis Factor-alpha; Up-Regulation; Ventricular Remodeling | 2010 |
Endothelial nitric oxide synthase-independent protective action of statin against angiotensin II-induced atrial remodeling via reduced oxidant injury.
Topics: Analysis of Variance; Angiotensin II; Animals; Antioxidants; Atrial Fibrillation; Blood Pressure; Blotting, Western; Cardiomegaly; Cyclic N-Oxides; Echocardiography; Fibrosis; Heart Atria; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide Synthase Type III; Oxidative Stress; Quinolines; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad3 Protein; Spin Labels; Transforming Growth Factor beta1 | 2010 |
Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomegaly; Fibrosis; Heart Ventricles; Imidazoles; Leucine; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Transgenic | 2010 |
Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation.
Topics: Angiotensin II; Animals; Cell Separation; Collagen; Cyclic AMP Response Element-Binding Protein; Down-Regulation; E1A-Associated p300 Protein; Epoprostenol; Fibroblasts; Fibrosis; Hyperlipidemias; Mice; Mice, Knockout; Models, Biological; Myocardium; NADPH Oxidases; Phosphorylation; Receptors, Epoprostenol; Signal Transduction; Transforming Growth Factor beta | 2010 |
Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse.
Topics: Actins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atrophy; Ceruletide; Collagen; Disease Models, Animal; Fibrosis; Losartan; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreas; Pancreatitis, Chronic; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Severity of Illness Index; Signal Transduction | 2010 |
Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease.
Topics: Angiotensin II; Angiotensins; Animals; Blood Pressure; Cardiomegaly; Chymosin; Enzyme Precursors; Fibrosis; Hypertension; Kidney Diseases; Male; Random Allocation; Rats; Rats, Transgenic; Renin; Retrospective Studies; Sodium Chloride, Dietary | 2010 |
Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Chemokine CCL2; Collagen; Fibroblasts; Fibrosis; Hypertension; Lung Diseases, Interstitial; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasoconstrictor Agents | 2010 |
Celecoxib, but not rofecoxib or naproxen, attenuates cardiac hypertrophy and fibrosis induced in vitro by angiotensin and aldosterone.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cardiomegaly; Celecoxib; Collagen; Cyclooxygenase 2 Inhibitors; Female; Fibroblasts; Fibrosis; Heart; Hep G2 Cells; Hepatocytes; Humans; Lactones; Male; Myocardium; Myocytes, Cardiac; Naproxen; Pyrazoles; Rats; Renin-Angiotensin System; Sulfonamides; Sulfones; Vasoconstrictor Agents | 2010 |
ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Disease Models, Animal; Fibrosis; Gene Expression; Male; Myocardial Infarction; Myocardium; Peptidyl-Dipeptidase A; Random Allocation; Rats; Rats, Inbred WKY; Ventricular Remodeling | 2010 |
Trimetazidine inhibits pressure overload-induced cardiac fibrosis through NADPH oxidase-ROS-CTGF pathway.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cell Proliferation; Cells, Cultured; Collagen; Connective Tissue Growth Factor; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Fibroblasts; Fibrosis; Hypertension; Male; Malondialdehyde; Myocardium; NADPH Oxidases; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors; Trimetazidine; Vasodilator Agents | 2010 |
Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice.
Topics: Angiotensin II; Animals; Antibodies; Benzhydryl Compounds; Blood Pressure; Cardiomegaly; Chemokine CCL2; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibrosis; HSP70 Heat-Shock Proteins; Hypertension; Male; Mice; Mice, Inbred ICR; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Transport; Pyrrolidinones; Signal Transduction; Time Factors; Toll-Like Receptor 4; Transcription, Genetic; Transforming Growth Factor beta1; Ventricular Remodeling | 2010 |
Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.
Topics: Amides; Angiotensin II; Animals; Base Sequence; Cell Transdifferentiation; Chlorocebus aethiops; Collagen; Collagen Type I; COS Cells; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Male; Mice; Mice, Knockout; Molecular Sequence Data; Myocardial Infarction; Myocardium; Myocytes, Smooth Muscle; Phenotype; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta1; Ventricular Remodeling | 2010 |
Silibinin attenuates cardiac hypertrophy and fibrosis through blocking EGFR-dependent signaling.
Topics: Angiotensin II; Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Shape; Cells, Cultured; Dose-Response Relationship, Drug; ErbB Receptors; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Silybin; Silymarin | 2010 |
Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice.
Topics: Analysis of Variance; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Echocardiography; Fibrosis; Heart Atria; Heparin Cofactor II; Mice; Mice, Transgenic; Myocardium; Natriuretic Peptide, Brain; Oxidative Stress; Transforming Growth Factor beta1; Ventricular Remodeling | 2010 |
Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Cardiomegaly; Cells, Cultured; CHO Cells; Collagen Type I, alpha 1 Chain; Cricetinae; Cricetulus; Down-Regulation; Fibrosis; Humans; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Peptidyl-Dipeptidase A; Recombinant Proteins | 2010 |
Salt-induced cardiac hypertrophy and interstitial fibrosis are due to a blood pressure-independent mechanism in Wistar rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Collagen Type I; Collagen Type III; Disease Models, Animal; Drinking; Eating; Echocardiography; Fibrosis; Gene Expression; Heart Ventricles; Hydralazine; Hypertension; Losartan; Male; Myocardium; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin; Renin-Angiotensin System; Sodium; Sodium Chloride, Dietary; Transforming Growth Factor beta; Urine | 2010 |
Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats.
Topics: Adenoviridae; Angiotensin II; Animals; Animals, Genetically Modified; Apoptosis; Capillaries; Cell Proliferation; Disease Models, Animal; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Heart Failure, Diastolic; Humans; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Rats; Recombinant Proteins; RNA, Messenger; Vascular Endothelial Growth Factor B | 2011 |
Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model.
Topics: Albuminuria; Anemia; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Chronic Disease; Desoxycorticosterone; Disease Models, Animal; Disease Progression; Fibrosis; Genetic Predisposition to Disease; Glomerulonephritis; Heart Diseases; Hydralazine; Hypertension; Imidazoles; Infusion Pumps, Implantable; Infusions, Subcutaneous; Kidney; Kidney Diseases; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Nephrectomy; Sodium Chloride, Dietary; Species Specificity; Telemetry; Tetrazoles; Time Factors; X-Ray Microtomography | 2010 |
Angiotensin II induces tumor progression and fibrosis in intrahepatic cholangiocarcinoma through an interaction with hepatic stellate cells.
Topics: Angiotensin II; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Blotting, Western; Cholangiocarcinoma; Disease Progression; Fibrosis; Glial Fibrillary Acidic Protein; Hepatic Stellate Cells; Humans; Immunohistochemistry; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2010 |
Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells.
Topics: Actins; Angiotensin II; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Transdifferentiation; Cells, Cultured; Collagen Type I; Collagen Type III; Fibrosis; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Kidney Medulla; Male; Procollagen-Proline Dioxygenase; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; RNA Interference; Tissue Inhibitor of Metalloproteinase-1; Transfection; Up-Regulation; Vimentin | 2011 |
Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction.
Topics: Allopurinol; Angiotensin II; Animals; Blood Pressure; Diastole; Electrocardiography; Enzyme Inhibitors; Fibrosis; Heart Diseases; Heart Failure, Diastolic; Heart Function Tests; Heart Rate; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress; Real-Time Polymerase Chain Reaction; RNA, Messenger; Smad Proteins; Transforming Growth Factor beta1 | 2012 |
Cellular FLICE-inhibitory protein protects against cardiac remodeling induced by angiotensin II in mice.
Topics: Angiotensin II; Animals; Cardiomegaly; CASP8 and FADD-Like Apoptosis Regulating Protein; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Humans; Male; Mice; Mice, Transgenic; Myocardium; Vasoconstrictor Agents; Ventricular Remodeling | 2010 |
MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Animals; Cardiomegaly; Fibrosis; Gene Expression Regulation, Enzymologic; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 7; Mice; Mice, Inbred C57BL; Myocardium; Rats; Rats, Sprague-Dawley; RNA Interference; Transcription, Genetic; Up-Regulation | 2011 |
Aortic adventitial fibroblasts participate in angiotensin-induced vascular wall inflammation and remodeling.
Topics: Adoptive Transfer; Angiotensin II; Animals; Aorta; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Coculture Techniques; Connective Tissue; Culture Media, Conditioned; Cytokines; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibrosis; Flow Cytometry; Humans; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Paracrine Communication; Polymerase Chain Reaction; Receptors, CCR2; Time Factors | 2011 |
Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells.
Topics: AC133 Antigen; Actins; Angiotensin II; Animals; Antigens, CD; Bone Marrow Cells; Cell Division; Cell Movement; Cells, Cultured; Chemokine CXCL12; Chimera; Collagen; Extracellular Matrix; Fibrosis; Glycoproteins; Green Fluorescent Proteins; Infusions, Subcutaneous; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Smooth; Myocardium; Myofibroblasts; Peptides; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; RNA, Messenger; von Willebrand Factor | 2011 |
Atrial fibrillation induces myocardial fibrosis through angiotensin II type 1 receptor-specific Arkadia-mediated downregulation of Smad7.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Atrial Fibrillation; Cells, Cultured; Collagen; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Losartan; Models, Animal; Myocardium; Rabbits; Receptor, Angiotensin, Type 1; RNA, Small Interfering; Smad7 Protein; Transforming Growth Factor beta1; Ubiquitin-Protein Ligases | 2011 |
Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor β1.
Topics: Angiotensin II; Animals; Cell Communication; Cells, Cultured; Coculture Techniques; Collagen Type I; Collagen Type I, alpha 1 Chain; Connective Tissue Growth Factor; Electric Stimulation; Fibroblasts; Fibrosis; Heart Atria; Mice; Myocytes, Cardiac; NADPH Oxidases; Reactive Oxygen Species; Tachycardia; Transforming Growth Factor beta1 | 2011 |
Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
Topics: Angiotensin II; Animals; Aorta; Atorvastatin; Blotting, Western; Cells, Cultured; Fibrosis; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Simvastatin; Smad Proteins; Transforming Growth Factor beta; Vasoconstrictor Agents | 2010 |
Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading.
Topics: Actins; Adrenomedullin; Angiotensin II; Animals; Antigens, Ly; Apoptosis; Capillaries; Coronary Vessels; Fibrosis; Glycoproteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Membrane Proteins; Mice; Mice, Knockout; Myocardium; Proto-Oncogene Proteins c-kit; Simvastatin; Sodium Chloride, Dietary; Treatment Outcome | 2011 |
Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of angiotensin II.
Topics: Angiotensin II; Animals; Apoptosis; Collagen; Disease Models, Animal; Female; Fibrosis; Gene Expression Regulation; Infusion Pumps, Implantable; Infusions, Subcutaneous; Male; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Inbred BN; Rats, Inbred F344; Recovery of Function; Sex Factors; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2011 |
Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.
Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blotting, Western; Collagen; Cytokines; Female; Fibrosis; Gene Expression; Humans; Immunohistochemistry; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; NADPH Oxidases; Oxidative Stress; Peptidyl-Dipeptidase A; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Heart rate reduction by ivabradine reduces diastolic dysfunction and cardiac fibrosis.
Topics: Aldosterone; Angiotensin II; Animals; Benzazepines; Cyclic Nucleotide-Gated Cation Channels; Diastole; Echocardiography, Doppler, Pulsed; Fibrosis; Heart Atria; Heart Rate; Heart Ventricles; Hemodynamics; Hypercholesterolemia; Ivabradine; Oxidative Stress; Rabbits; Sinoatrial Node; Ventricular Dysfunction, Left | 2010 |
[The role of renin-angiotensin system independent angiotensin II production in progression and fibrosis of intrahepatic cholangiocarcinoma].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Disease Progression; Fibrosis; Hepatic Stellate Cells; Humans; Receptor, Angiotensin, Type 1; Telmisartan | 2010 |
Angiotensin II: breathtaking in the renal medulla.
Topics: Actins; Angiotensin II; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Transdifferentiation; Collagen Type I; Collagen Type III; Fibrosis; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Procollagen-Proline Dioxygenase; Proliferating Cell Nuclear Antigen; Rats; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation; Vimentin | 2011 |
IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Apoptosis; Blotting, Western; Bone Marrow Transplantation; Cardiomegaly; Cell Proliferation; Cells, Cultured; DNA, Complementary; Echocardiography; Fibrosis; Gene Expression Profiling; Hypertension; Immunity, Innate; Interferon Regulatory Factor-3; Leukocyte Common Antigens; Mice; Mice, Inbred ICR; Mice, Knockout; Proto-Oncogene Proteins c-bcl-2; Ventricular Remodeling | 2011 |
Pregnancy protects against antiangiogenic and fibrogenic effects of angiotensin II in rat hearts.
Topics: Angiotensin II; Animals; Collagen; Female; Fibrosis; Heart; Myocardium; Neovascularization, Physiologic; Pregnancy; Rats; Rats, Wistar; Ventricular Remodeling | 2011 |
Nicorandil inhibits angiotensin-II-induced proliferation of cultured rat cardiac fibroblasts.
Topics: Angiotensin II; Animals; Animals, Newborn; Cardiotonic Agents; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Fibroblasts; Fibrosis; Heart Ventricles; Nicorandil; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2011 |
Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.
Topics: Angiotensin II; Animals; Apelin; Cardiovascular Diseases; Fibrosis; Intercellular Signaling Peptides and Proteins; Male; Mice; Plasminogen Activator Inhibitor 1 | 2011 |
Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Adhesion Molecules; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Fibroblasts; Fibrosis; Guanine Nucleotide Exchange Factors; Infusions, Subcutaneous; Losartan; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; ras Proteins; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Messenger; Signal Transduction; Smad2 Protein; Smad3 Protein; Time Factors; Transfection; Transforming Growth Factor beta1; Up-Regulation | 2011 |
Angiotensin II infusion-induced inflammation, monocytic fibroblast precursor infiltration, and cardiac fibrosis are pressure dependent.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Hydralazine; Hypertrophy, Left Ventricular; Inflammation; Inflammation Mediators; Infusion Pumps; Leukocyte Common Antigens; Male; Mice; Mice, Inbred C57BL; Monocytes; Myofibroblasts; Random Allocation | 2011 |
Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Benzoates; Collagen Type III; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Hypertrophy; Intracellular Signaling Peptides and Proteins; Kidney; Mice; NADPH Oxidases; Oxidative Stress; Peptidyl-Dipeptidase A; PPAR gamma; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Superoxides; Telmisartan; Transforming Growth Factor beta1; Up-Regulation | 2011 |
Hemin decreases cardiac oxidative stress and fibrosis in a rat model of systemic hypertension via PI3K/Akt signalling.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Antihypertensive Agents; Antioxidants; Apoptosis; Cardiomyopathies; Caspase 3; Cells, Cultured; Collagen Type I; Disease Models, Animal; Enzyme Activation; Fibrosis; Heme Oxygenase (Decyclizing); Hemin; Hemodynamics; Hypertension, Renovascular; Losartan; Male; Myocytes, Cardiac; NADPH Oxidases; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Rats; Rats, Wistar; rhoA GTP-Binding Protein; Signal Transduction; Time Factors; Ventricular Function, Left | 2011 |
MG132 treatment attenuates cardiac remodeling and dysfunction following aortic banding in rats via the NF-κB/TGFβ1 pathway.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Collagen; Constriction; Fibrosis; Hemodynamics; Hypertension; Leupeptins; Male; Myocardium; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta1; Ubiquitin; Ultrasonography; Ventricular Remodeling | 2011 |
Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.
Topics: Actins; Angiotensin II; Animals; Apoptosis; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Fibrosis; Janus Kinase 2; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Neointima; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; STAT5 Transcription Factor; Vascular System Injuries | 2011 |
Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion.
Topics: Angiotensin II; Animals; CARD Signaling Adaptor Proteins; Fibrosis; Inflammation; Interleukin-1beta; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Myocardium; Myofibroblasts; NF-kappa B; Transforming Growth Factor beta | 2011 |
Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis.
Topics: Actins; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Down-Regulation; Fibrosis; Male; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis, Chronic; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Angiotensin; Renin-Angiotensin System; Transforming Growth Factor beta | 2011 |
New take on the role of angiotensin II in cardiac hypertrophy and fibrosis.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomegaly; Fibrosis; Humans; Hypertension; Inflammation; Mice; Myocardium; Oxidative Stress; Receptor, Angiotensin, Type 1; Sodium; Ventricular Remodeling | 2011 |
A2B adenosine receptor-mediated induction of IL-6 promotes CKD.
Topics: Adenosine Deaminase; Angiotensin II; Animals; Chronic Disease; Collagen; Fibrosis; Humans; Interleukin-6; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A2B; Signal Transduction; Ureteral Obstruction | 2011 |
Beneficial effects of angiotensin (1-7) in diabetic rats with cardiomyopathy.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Dyslipidemias; Fibrosis; Heart Ventricles; Hypertrophy, Left Ventricular; Lipids; Nitrates; Nitrites; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2011 |
Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms.
Topics: Adenoviridae; Angiotensin II; Animals; Collagen Type III; Disease Models, Animal; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Humans; Hypertension; Ligation; Male; Myocardial Infarction; Natriuretic Peptide, Brain; Neovascularization, Physiologic; Organothiophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Ventricular Dysfunction, Left; Ventricular Remodeling | 2011 |
CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis.
Topics: Analysis of Variance; Angiotensin II; Animals; Biomarkers; Blood Pressure; Bone Marrow Cells; Cardiomegaly; Cell Movement; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Diseases; Heart Rate; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Receptors, CCR2; Stem Cells; Stroke Volume; Time Factors; Ultrasonography; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling | 2011 |
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomyopathy, Dilated; Collagen; Fibrosis; Heart Failure; Heart Rate; Interferon-gamma; Interleukin-4; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phenotype; Pulmonary Atelectasis; Stroke Volume; T-Lymphocytes, Helper-Inducer; Ventricular Remodeling | 2011 |
Effect of the plasminogen-plasmin system on hypertensive renal and cardiac damage.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Fibrinolysin; Fibrosis; Glomerulonephritis; Heart Diseases; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Plasminogen; Plasminogen Activator Inhibitor 1; Prevalence; Risk Factors; Tissue Plasminogen Activator | 2011 |
IκBβ attenuates angiotensin II-induced cardiovascular inflammation and fibrosis in mice.
Topics: Angiotensin II; Animals; Cells, Cultured; Cytokines; Fibrosis; Hypertension; I-kappa B Proteins; Inflammation Mediators; Mice; Mice, Knockout; Myocardium | 2011 |
Suppression of Nrf2 signaling by angiotensin II in murine renal epithelial cells.
Topics: Actins; Angiotensin II; Animals; Basic-Leucine Zipper Transcription Factors; Biomarkers; Cell Line; Cell Nucleus; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; Kidney; Mice; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2011 |
Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling.
Topics: Adiponectin; AMP-Activated Protein Kinases; Analysis of Variance; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Genes, Reporter; Hydrogen Peroxide; Hypertrophy, Left Ventricular; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NADPH Oxidases; Natriuretic Peptide, Brain; NF-kappa B; Oxidants; Oxidative Stress; Phosphorylation; Rats; Reactive Oxygen Species; Recombinant Proteins; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Ventricular Remodeling | 2011 |
Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Fibrosis; Mice; Muscle, Skeletal; Muscular Dystrophies; Myoblasts; NADPH Oxidases; Reactive Oxygen Species; Receptor, Angiotensin, Type 1 | 2011 |
Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Cadherins; Cell Adhesion; Fibrosis; Male; Microscopy, Electron, Transmission; Microvilli; Models, Biological; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renin; TOR Serine-Threonine Kinases | 2011 |
MiR-133a regulates collagen 1A1: potential role of miR-133a in myocardial fibrosis in angiotensin II-dependent hypertension.
Topics: Angiotensin II; Animals; Collagen Type I; Collagen Type I, alpha 1 Chain; Fibrosis; Gene Expression Regulation; Heart Diseases; Hypertension; Male; MicroRNAs; Rats; Rats, Sprague-Dawley | 2012 |
Combining angiotensin II blockade and renin receptor inhibition results in enhanced antifibrotic effect in experimental nephritis.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cells, Cultured; Drug Therapy, Combination; Enalaprilat; Fibronectins; Fibrosis; Glomerulonephritis; Isoantibodies; Male; Plasminogen Activator Inhibitor 1; Prorenin Receptor; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; RNA, Small Interfering; Transforming Growth Factor beta1 | 2011 |
The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Cardiomegaly; Fibrosis; Heart; Heart Rate; Hypertension; Male; Mice; Mice, Inbred BALB C; Myocardium; Pyridones | 2012 |
Angiotensin-II and rosuvastatin influence matrix remodeling in human mesangial cells via metalloproteinase modulation.
Topics: Angiotensin II; Cells, Cultured; Extracellular Matrix; Fatty Acids, Nonesterified; Fibrosis; Fluorobenzenes; Glucose; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mesangial Cells; Metalloproteases; Pyrimidines; RNA, Small Interfering; Rosuvastatin Calcium; Sulfonamides; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta | 2011 |
Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model.
Topics: Angiotensin II; Animals; Cell Degranulation; Fibrosis; Humans; In Vitro Techniques; Kidney; Kidney Diseases; Losartan; Male; Mast Cells; Mice; Rats; Renin; Renin-Angiotensin System; Ureteral Obstruction | 2012 |
Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage.
Topics: Adult; Angiotensin II; Animals; Biopsy; Blood Pressure; Disease Progression; Endothelin-1; Female; Fibrosis; Humans; Hypertension, Renal; Interleukin-6; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Middle Aged; Organ Culture Techniques; Proteinuria; Renal Insufficiency, Chronic; Signal Transduction; Vasoconstrictor Agents | 2012 |
EGFR signaling promotes TGFβ-dependent renal fibrosis.
Topics: Angiotensin II; Animals; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Kidney; LLC-PK1 Cells; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Smad2 Protein; Smad3 Protein; Swine; Transforming Growth Factor beta | 2012 |
Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Cardiomegaly; Drug Interactions; Dual Specificity Phosphatase 1; Fibrosis; Hypertension; Male; MAP Kinase Signaling System; Myocardium; Peptide Fragments; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasoconstrictor Agents; Ventricular Remodeling | 2012 |
Drugs of the future for Peyronie's disease.
Topics: Adult; Angiotensin II; Animals; Connective Tissue Growth Factor; Disease Models, Animal; Drug Design; Drug Therapy; Endothelin-1; Fibrosis; Humans; Inflammation; Male; Middle Aged; Penile Induration; Platelet-Derived Growth Factor; Transforming Growth Factor beta1; Wound Healing | 2012 |
Lentil polyphenol extract prevents angiotensin II-induced hypertension, vascular remodelling and perivascular fibrosis.
Topics: Administration, Oral; Angiotensin II; Animals; Aorta; Drinking; Fibrosis; Heart; Hypertension; Kidney; Lens Plant; Male; Plant Extracts; Polyphenols; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vascular Diseases | 2012 |
Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice.
Topics: Angiotensin II; Animals; Aryl Hydrocarbon Hydroxylases; Blood Pressure; CSK Tyrosine-Protein Kinase; Cytochrome P-450 CYP1B1; Disease Models, Animal; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Hypertension; Kidney; Male; Mice; Mice, Knockout; NADPH Oxidases; Protein-Tyrosine Kinases; Reactive Oxygen Species; Sodium; src-Family Kinases; Vascular Resistance | 2012 |
Endogenous aldosterone is involved in vascular calcification in rat.
Topics: Aldosterone; Alkaline Phosphatase; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Calcium; Captopril; Cholecalciferol; Collagen; Fibrosis; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Nicotine; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone; Vascular Calcification | 2012 |
Fibroblast progenitor cells are recruited into the myocardium prior to the development of myocardial fibrosis.
Topics: AC133 Antigen; Actins; Angiotensin II; Animals; Antigens, CD; Biomarkers; Cell Movement; Cells, Cultured; Chemokine CCL2; Chemokines; Collagen; Disease Models, Animal; Ectodysplasins; Extracellular Matrix; Fibroblasts; Fibrosis; Glycoproteins; Heart; Male; Mesenchymal Stem Cells; Myocardium; Myocytes, Cardiac; Peptides; Rats; Rats, Inbred Lew | 2012 |
Smad3 mediates ANG II-induced hypertensive kidney disease in mice.
Topics: Actins; Albuminuria; Angiotensin II; Animals; Chemokine CCL2; Collagen Type I; Collagen Type IV; Creatinine; Female; Fibronectins; Fibrosis; Hypertension; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta; Ubiquitin-Protein Ligases | 2012 |
Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aortic Coarctation; Cardiomegaly; Connexin 43; Enalapril; Fibrosis; Hydrogen Sulfide; Male; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley | 2012 |
Myocardial migration by fibroblast progenitor cells is blood pressure dependent in a model of angII myocardial fibrosis.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cell Movement; Collagen; Fibroblasts; Fibrosis; Heart; Hypertension; Male; Mice; Myocardium; Renin-Angiotensin System; Stem Cells | 2012 |
Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy.
Topics: Angiotensin II; Animals; Coronary Vessels; Disease Models, Animal; Fibrosis; Genetic Therapy; Heart; Heart Ventricles; Mice; Mice, Knockout; Muscular Atrophy, Spinal; NADPH Oxidases; Oxidative Stress; Receptor, Angiotensin, Type 1; Spinal Cord; Survival of Motor Neuron 1 Protein; Ventricular Remodeling | 2012 |
Cardiac lineage protein-1 (CLP-1) regulates cardiac remodeling via transcriptional modulation of diverse hypertrophic and fibrotic responses and angiotensin II-transforming growth factor β (TGF-β1) signaling axis.
Topics: Angiotensin II; Angiotensinogen; Animals; Cardiomegaly; Extracellular Matrix; Fibroblasts; Fibrosis; Heterozygote; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myosin Heavy Chains; RNA-Binding Proteins; Signal Transduction; Smad3 Protein; STAT3 Transcription Factor; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta1; Ventricular Remodeling | 2012 |
Angiotensin-(1-7) abrogates mitogen-stimulated proliferation of cardiac fibroblasts.
Topics: Angiotensin I; Angiotensin II; Animals; Animals, Newborn; Cell Proliferation; Cells, Cultured; Collagen; Cyclooxygenase 2; DNA; Dual Specificity Phosphatase 1; Endothelin-1; Fibroblasts; Fibrosis; Gene Expression Regulation; Heart Diseases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Peptide Fragments; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Rats; Signal Transduction | 2012 |
Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy.
Topics: Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Blood Pressure; Cytokines; Disease Models, Animal; Fibrosis; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephritis; NF-kappa B; Peptidyl-Dipeptidase A; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta; Ubiquitin-Protein Ligases; Ureteral Obstruction | 2012 |
ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy.
Topics: Angiotensin II; Animals; Blood Pressure; Blotting, Northern; Blotting, Western; Cardiomegaly; Disease Models, Animal; Endothelial Cells; Endothelin-1; Fibrosis; Gene Expression Regulation; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Polymerase Chain Reaction; Protein Kinase C-delta; Protein Kinase C-epsilon | 2012 |
Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity.
Topics: Acetophenones; Acute Kidney Injury; Angiotensin II; Animals; Blood Pressure; Creatinine; Disease Progression; Dose-Response Relationship, Drug; Fibrosis; Hemodynamics; Immunohistochemistry; Kidney; Kidney Failure, Chronic; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Renal Circulation; Reperfusion Injury; RNA, Messenger; Vasoconstrictor Agents | 2012 |
Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias.
Topics: Aging; Angiotensin II; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Fibrosis; Heart; Hypokalemia; Male; Myocardium; Myocytes, Cardiac; NADPH Oxidases; Oxidative Stress; Patch-Clamp Techniques; Rats; Rats, Inbred F344; Reactive Oxygen Species; Ventricular Fibrillation | 2012 |
Interleukin-12p35 deletion promotes CD4 T-cell-dependent macrophage differentiation and enhances angiotensin II-Induced cardiac fibrosis.
Topics: Angiotensin II; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Polarity; Cells, Cultured; Fibrosis; Interleukin-12 Subunit p35; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocardium; NF-kappa B; Signal Transduction; Transforming Growth Factor beta | 2012 |
Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis.
Topics: Angiotensin II; Animals; Cell Polarity; Cells, Cultured; Fibrosis; Immediate-Early Proteins; Inflammation; Leukocyte Common Antigens; Macrophage Activation; Macrophages; Male; Mice; Myocardium; Protein Serine-Threonine Kinases; STAT3 Transcription Factor | 2012 |
Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Binding Sites; Blood Pressure; Cardiomegaly; Fibrosis; GATA4 Transcription Factor; Gene Expression Regulation; Heart; Kruppel-Like Transcription Factors; Male; Mice; Mice, Knockout; Myocytes, Cardiac; Promyelocytic Leukemia Zinc Finger Protein; Protein Binding; Receptor, Angiotensin, Type 2; Signal Transduction; Transcription, Genetic | 2012 |
Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis.
Topics: Angiotensin II; Animals; Body Weight; Chemokine CCL2; Fibrosis; Inflammation; Interferon-gamma; Mice; Mice, Knockout; Myocardium; T-Lymphocytes | 2012 |
Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II.
Topics: Angiotensin II; Animals; Collagen; Fibroblasts; Fibrosis; Gene Expression Regulation; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocardium; Phosphorylation; Smad3 Protein; Transforming Growth Factor beta1 | 2012 |
Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Biomarkers; Blood Pressure; Cytochrome P-450 CYP11B2; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart Diseases; Inflammation; Kidney Diseases; Kidney Glomerulus; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mineralocorticoid Receptor Antagonists; Myocardium; Receptors, Mineralocorticoid; Renin-Angiotensin System; Sodium Chloride, Dietary; Spironolactone; Time Factors; Vascular Diseases | 2012 |
Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism.
Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cardiomyopathies; Cardiotonic Agents; Collagen; Desoxycorticosterone; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Fumarates; Heart Ventricles; Indicators and Reagents; Male; Matrix Metalloproteinase 9; Myocardium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Renin | 2012 |
[Hypertension-induced fibrosis: a balance story].
Topics: Aldosterone; Angiotensin II; Animals; Bone Morphogenetic Proteins; Cardiomegaly; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart Failure; Hypertension; Male; Mice; Mice, Transgenic; Myocytes, Cardiac; Natriuretic Peptide, Brain; Renin; Renin-Angiotensin System | 2012 |
Carboxyl terminus of heat shock protein 70-interacting protein inhibits angiotensin II-induced cardiac remodeling.
Topics: Angiotensin II; Angiotensins; Animals; Apoptosis; Fibrosis; Heart; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardium; Myocytes, Cardiac; NF-kappa B; Rats; Ubiquitin-Protein Ligases; Ventricular Remodeling | 2012 |
Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts.
Topics: Angiotensin II; Animals; Connective Tissue Growth Factor; Fibroblasts; Fibrosis; Gene Expression; Heart Atria; Losartan; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Signal Transduction; TNF Receptor-Associated Factor 6; Transforming Growth Factor beta1 | 2012 |
Role of miR-21 in the pathogenesis of atrial fibrosis.
Topics: Angiotensin II; Animals; Connective Tissue Growth Factor; Cornified Envelope Proline-Rich Proteins; DEAD-box RNA Helicases; Fibrosis; Heart Atria; Humans; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Protein-Lysine 6-Oxidase; rac1 GTP-Binding Protein; Ribonuclease III | 2012 |
Angiotensin II contributes to renal fibrosis independently of Notch pathway activation.
Topics: Angiotensin II; Animals; Calcium-Binding Proteins; Cell Line; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Hydronephrosis; Hypertension; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Kidney; Kidney Tubules; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Podocytes; Rats; Receptor, Angiotensin, Type 1; Receptors, Notch; Serrate-Jagged Proteins; Signal Transduction; Transforming Growth Factor beta1 | 2012 |
MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway.
Topics: Angiotensin II; Animals; Animals, Newborn; Cell Proliferation; Cells, Cultured; Chronic Disease; Collagen; Compliance; Echocardiography; Fibroblasts; Fibrosis; Gene Silencing; Hemodynamics; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardial Infarction; Myocardium; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Treatment Outcome; Vasoconstrictor Agents; Ventricular Dysfunction, Left | 2012 |
Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Apoptosis; Collagen; Disease Progression; Fibrosis; Group V Phospholipases A2; Immunohistochemistry; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Prostaglandins | 2012 |
Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1.
Topics: Angiotensin II; Animals; Atherosclerosis; Cyclooxygenase 1; Disease Models, Animal; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix; Fibrosis; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mechanical Phenomena; Membrane Proteins; Mesenteric Arteries; NADPH Oxidase 4; NADPH Oxidases; Phosphorylation; Protein Processing, Post-Translational; Pyrimidines; Rats; Rats, Sprague-Dawley; Rosuvastatin Calcium; Sulfonamides; Vascular Resistance; Vasodilation | 2013 |
DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Cell Proliferation; Collagen; Dose-Response Relationship, Drug; Fibrosis; Male; Mice; Myofibroblasts; Oleanolic Acid; Rats; Triterpenes | 2012 |
Inhibition of PARP prevents angiotensin II-induced aortic fibrosis in rats.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Benzamides; Cells, Cultured; Enzyme Inhibitors; Fibrosis; Male; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Random Allocation; Rats; Rats, Sprague-Dawley | 2013 |
Baicalein potently inhibits Rho kinase activity and suppresses actin stress fiber formation in angiotensin II-stimulated H9c2 cells.
Topics: Actins; Angiotensin II; Animals; Cell Line; Dose-Response Relationship, Drug; Fibrosis; Flavanones; Inhibitory Concentration 50; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphorylation; Phytotherapy; Plant Extracts; Rats; rho-Associated Kinases; Scutellaria baicalensis; Stress Fibers; Vasoconstrictor Agents | 2012 |
Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Arterial Pressure; Benzopyrans; Ethanolamines; Fibrosis; Gene Expression Profiling; Heart; Male; Nebivolol; Oxidative Stress; Rats; Rats, Inbred SHR; Sodium Chloride | 2012 |
(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.
Topics: Adenoviridae; Angiotensin II; Animals; Apoptosis; Cell Proliferation; Enzyme Activation; Extracellular Matrix; Fibrosis; Gene Transfer Techniques; Heart Function Tests; Heart Ventricles; HSP27 Heat-Shock Proteins; Kruppel-Like Transcription Factors; Losartan; Male; MAP Kinase Signaling System; Myocardium; Myocytes, Cardiac; Organ Specificity; Phosphorylation; Prorenin Receptor; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Up-Regulation; Wnt Signaling Pathway | 2012 |
Angiotensin II induces skin fibrosis: a novel mouse model of dermal fibrosis.
Topics: Angiotensin II; Animals; Cells, Cultured; Disease Models, Animal; Fibrosis; Humans; Male; Mice; Mice, Inbred C57BL; Skin Diseases | 2012 |
Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.
Topics: Angiotensin II; Animals; Base Sequence; Calcitriol; Cell Line; Extracellular Matrix Proteins; Fibrosis; Immunohistochemistry; Kidney Diseases; Kidney Tubules; Male; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphorylation; Protective Agents; Protein Phosphatase 2C; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Calcitriol; Renin; RNA, Messenger; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1; Ureteral Obstruction | 2012 |
Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells.
Topics: Angiotensin II; Animals; Cell Line; Connective Tissue Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Fibrosis; Mice; Models, Biological; Muscle Cells; Muscle, Skeletal; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Signal Transduction; Transforming Growth Factor beta1 | 2012 |
Role of the transcription factor erythroblastosis virus E26 oncogen homolog-1 (ETS-1) as mediator of the renal proinflammatory and profibrotic effects of angiotensin II.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Blood Pressure; Blotting, Western; Fibrosis; Gene Expression; Hypertension; Hypertrophy, Left Ventricular; Immunohistochemistry; Inflammation; Ki-67 Antigen; Kidney; Kidney Cortex; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; NADPH Oxidase 4; NADPH Oxidases; Peptides; Proto-Oncogene Protein c-ets-1; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways.
Topics: Angiotensin II; Animals; Antioxidants; Collagen; Disulfides; Fibrosis; Glutamate-Cysteine Ligase; Hemodynamics; Hypertrophy, Left Ventricular; Male; NF-E2-Related Factor 2; Organ Size; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Sulfinic Acids | 2012 |
Treatment with activated protein C (aPC) is protective during the development of myocardial fibrosis: an angiotensin II infusion model in mice.
Topics: Angiotensin II; Animals; Base Sequence; Cytokines; Disease Models, Animal; DNA Primers; Fibrosis; Fluorescent Antibody Technique; Heart Diseases; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Protein C; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Interferon-γ signaling inhibition ameliorates angiotensin II-induced cardiac damage.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Fibrosis; Heart; Inflammation; Interferon-gamma; Interleukin-17; Interleukin-23; Kidney; Membrane Proteins; Mice; Mice, Knockout; Microfilament Proteins; Myocardium; Podocytes; Signal Transduction | 2012 |
Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4.
Topics: Angiotensin II; Animals; Cells, Cultured; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Gallic Acid; Leonurus; Male; Matrix Metalloproteinase 2; Myocardial Infarction; Myocardium; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction | 2013 |
Proteasome inhibition attenuates heart failure during the late stages of pressure overload through alterations in collagen expression.
Topics: Angiotensin II; Animals; Cells, Cultured; Collagen; Disease Models, Animal; Down-Regulation; Fibrosis; Heart Failure; Heart Ventricles; Hypertension; Leupeptins; Male; Proteasome Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta1; Ubiquitin; Ventricular Dysfunction, Left | 2013 |
Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects.
Topics: Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Calcium; Cell Movement; Cell Proliferation; Fibrosis; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Nifedipine; Nitroso Compounds; Oxidative Stress; Rats; Reactive Oxygen Species | 2013 |
Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium-Binding Proteins; Dipeptides; Disease Models, Animal; Fibrosis; Hypertrophy, Left Ventricular; Imidazoles; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microcirculation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptor, Notch1; Tetrazoles; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Remodeling | 2013 |
Beyond the RAAS: dissecting the antifibrotic effects of vitamin D analogues.
Topics: Angiotensin II; Animals; Fibrosis; Humans; Kidney; Mice; Mice, Knockout; Protective Agents; Renal Insufficiency, Chronic; Renin-Angiotensin System; Vitamin D | 2012 |
Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy.
Topics: Angiotensin II; Animals; Apoptosis; Bone Morphogenetic Protein 4; Cardiomegaly; Fibrosis; Heart Failure; Humans; Mice; Myocardium; Myocytes, Cardiac; Physical Conditioning, Animal; Reactive Oxygen Species | 2013 |
NF-κB mediated miR-26a regulation in cardiac fibrosis.
Topics: Angiotensin II; Animals; Cells, Cultured; Collagen Type I; Connective Tissue Growth Factor; Fibrosis; Gene Expression Regulation; I-kappa B Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; MicroRNAs; Models, Cardiovascular; Mutant Proteins; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; RNA, Messenger; Ventricular Remodeling | 2013 |
FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Heart; LIM-Homeodomain Proteins; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Muscle Proteins; Myocytes, Cardiac; rho-Associated Kinases; Transcription Factors; Up-Regulation | 2013 |
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.
Topics: Alendronate; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomegaly; Contraindications; Fibrosis; Gene Expression Regulation; Geranyltranstransferase; Humans; Male; Mice; Myocytes, Cardiac; Natriuretic Peptide, Brain; p38 Mitogen-Activated Protein Kinases; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Signal Transduction; Terpenes; Transforming Growth Factor beta1 | 2013 |
Atrial natriuretic peptide exerts protective action against angiotensin II-induced cardiac remodeling by attenuating inflammation via endothelin-1/endothelin receptor A cascade.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Endothelin-1; Fibrillar Collagens; Fibroblasts; Fibrosis; Heart Diseases; Inflammation; Inflammation Mediators; Infusions, Intravenous; Macrophages; Male; Mitral Valve; Myocardial Contraction; Myocardium; Rats; Rats, Inbred WKY; Receptor, Endothelin A; Signal Transduction; Stroke Volume; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2013 |
Regulation and role of connective tissue growth factor in AngII-induced myocardial fibrosis.
Topics: Angiotensin II; Animals; Bone Marrow Cells; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Separation; Connective Tissue Growth Factor; Cytokines; Extracellular Matrix; Fibroblasts; Fibrosis; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Transforming Growth Factor beta | 2013 |
Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.
Topics: Angiotensin II; Animals; Fibrosis; Gene Expression Regulation; Hypertension; Inflammation; Kidney; Kidney Diseases; Male; Mice; Mice, Knockout; MicroRNAs; NF-kappa B; Proteinuria; Signal Transduction; Smad3 Protein; Smad7 Protein; Sp1 Transcription Factor; Transforming Growth Factor beta | 2013 |
TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Differentiation; Cell Size; Cells, Cultured; Coculture Techniques; Collagen; Cytokines; Fibrosis; Gene Expression; Humans; Inflammation Mediators; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Myofibroblasts; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Transendothelial and Transepithelial Migration; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2013 |
Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.
Topics: Angiotensin II; Animals; Cell Proliferation; Collagen; Connective Tissue Growth Factor; Fibrosis; Gene Expression Regulation; Gene Knockout Techniques; Heart Failure; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Mice; Mice, Knockout; Myofibroblasts; Natriuretic Peptide, Brain; NIH 3T3 Cells; Rats; Rats, Inbred Dahl; S100 Calcium-Binding Protein A4; S100 Proteins; Transcriptome; Tumor Suppressor Protein p53 | 2013 |
Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Collagen; Cytokines; Electrocardiography; Fibrosis; Heart; Hemodynamics; Hypertension; Ischemic Preconditioning, Myocardial; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Phosphorylation; Serine; STAT3 Transcription Factor; Vasoconstrictor Agents | 2013 |
Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Fibrosis; Hypertrophy, Left Ventricular; Losartan; Male; Myocardium; Physical Conditioning, Animal; Rats; Rats, Wistar; RNA, Messenger | 2013 |
AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Calcineurin; Cardiomegaly; Echocardiography; Fibrosis; Gene Expression Regulation; Hypertension; Male; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Stress, Mechanical; Tacrolimus; Tetrazoles; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cells, Cultured; Drug Synergism; Fibroblasts; Fibrosis; Genetic Therapy; Hepatocyte Growth Factor; Humans; Kidney; Kidney Tubules; Losartan; Male; Mice; Mice, Inbred Strains; Muscle, Smooth; Receptor, Angiotensin, Type 1; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ureteral Obstruction | 2002 |
Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Cardiomegaly; Collagen; Fibrosis; Gene Targeting; Guanylate Cyclase; Heart Rate; Heart Ventricles; Hypertension; Imidazoles; Mice; Mice, Knockout; Myocardium; Natriuretic Peptide, Brain; Olmesartan Medoxomil; Organ Size; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Tetrazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Ventricular Remodeling | 2002 |
Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Blotting, Western; Disease Models, Animal; Drug Synergism; Fibrosis; Heart; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension; Immunohistochemistry; Iron Chelating Agents; Iron Overload; Iron-Dextran Complex; Losartan; Male; Myocardium; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Tunica Intima; Vasodilator Agents | 2002 |
Apoptosis, myocardial fibrosis and angiotensin II in the left ventricle of hypertensive rats treated with fosinopril or losartan.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Apoptosis; Blood Pressure; Fibrosis; Fosinopril; Hypertension; Hypertrophy, Left Ventricular; Losartan; Myocardium; Rats; Rats, Inbred SHR | 2002 |
ACE inhibition increases expression of the ETB receptor in kidneys of mice with unilateral obstruction.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Enalapril; Female; Fibrosis; Gene Expression; Kidney; Mice; Mice, Inbred C57BL; Nitric Oxide; Receptor, Endothelin B; Receptors, Endothelin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ureteral Obstruction | 2003 |
Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Cardiomyopathies; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Matrix; Fibroblasts; Fibrosis; Imidazoles; Losartan; Matrix Metalloproteinase 2; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha; Up-Regulation | 2002 |
Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis.
Topics: Angiotensin II; Animals; Bradykinin; Coronary Vessels; Extracellular Space; Fibrosis; Heart Ventricles; Hypertrophy, Left Ventricular; Kallikreins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B2; Receptors, Angiotensin; Receptors, Bradykinin; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
[Effects of lorsartan, fosinopril on myocardial fibrosis, angiotensin II and cardiac remolding in hypertensive rats].
Topics: Angiotensin II; Animals; Antihypertensive Agents; Fibrosis; Fosinopril; Hypertension; Losartan; Male; Myocardium; Random Allocation; Rats; Rats, Inbred SHR; Ventricular Remodeling | 2001 |
Synergistic effects of mycophenolate mofetil and losartan in a model of chronic cyclosporine nephropathy.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arterioles; Blood Pressure; Body Weight; Chronic Disease; Cyclosporine; Drug Synergism; Fibrosis; Gene Expression; Immunosuppressive Agents; Kidney; Kidney Diseases; Losartan; Macrophages; Male; Mycophenolic Acid; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Bosentan; Cardiomyopathies; Dansyl Compounds; Disease Models, Animal; Endothelin-1; Fibrosis; Hypertension; Irbesartan; Male; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cell Surface; Sulfonamides; Tetrazoles; Time Factors; Vasoconstrictor Agents | 2003 |
Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II.
Topics: Angiotensin II; Animals; Blood Pressure; Blotting, Western; Fibrosis; Gene Expression Regulation; Kidney Medulla; Male; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2003 |
Human renal fibroblasts derived from normal and fibrotic kidneys show differences in increase of extracellular matrix synthesis and cell proliferation upon angiotensin II exposure.
Topics: Angiotensin II; Cell Division; Cell Line, Transformed; Extracellular Matrix; Fibroblasts; Fibrosis; Humans; Kidney; Polymerase Chain Reaction; Receptors, Angiotensin | 2003 |
Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure.
Topics: Angiotensin II; Animals; Chymases; Collagen Type I; Collagen Type III; Diastole; Disease Models, Animal; Disease Progression; Dogs; Enzyme Inhibitors; Fibrosis; Heart Failure; Hemodynamics; Mast Cells; Myocardium; Peptidyl-Dipeptidase A; RNA, Messenger; Serine Endopeptidases; Transforming Growth Factor beta; Ventricular Dysfunction, Left | 2003 |
Precocious activation of genes of the renin-angiotensin system and the fibrogenic cascade in IgA glomerulonephritis.
Topics: Adult; Angiotensin II; Angiotensinogen; Case-Control Studies; Collagen Type IV; Fibrosis; Gene Expression; Gene Expression Regulation; Glomerulonephritis, IGA; Humans; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Middle Aged; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin-Angiotensin System; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Expression of bradykinin receptors in the left ventricles of rats with pressure overload hypertrophy and heart failure.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Disease Models, Animal; Echocardiography; Fibrosis; Gene Expression; Heart Failure; Hypertrophy, Left Ventricular; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Bradykinin B2; Receptors, Bradykinin; RNA, Messenger; Vasoconstrictor Agents | 2003 |
Induction of connective tissue growth factor by angiotensin II: integration of signaling pathways.
Topics: Angiotensin II; Animals; Connective Tissue Growth Factor; Fibrosis; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Mice; ras Proteins; Receptors, Angiotensin; rho GTP-Binding Proteins; Signal Transduction; Up-Regulation | 2003 |
Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Cells, Cultured; Connective Tissue Growth Factor; Drug Administration Routes; Drug Administration Schedule; Extracellular Matrix Proteins; Female; Fibrosis; Gene Expression; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; Infusion Pumps, Implantable; Intercellular Signaling Peptides and Proteins; Losartan; Muscle, Smooth, Vascular; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger | 2003 |
Role of angiotensin II in altered expression of molecules responsible for coronary matrix remodeling in insulin-resistant diabetic rats.
Topics: Angiotensin II; Animals; Collagen Type I; Collagen Type III; Coronary Vessels; Diabetes Mellitus, Type 2; Down-Regulation; Fibrin; Fibrosis; Insulin Resistance; Matrix Metalloproteinase 2; Matrix Metalloproteinases; Rats; Rats, Inbred OLETF; Receptor, Melatonin, MT1; Transforming Growth Factor beta | 2003 |
Angiotensin II dependent testicular fibrosis and effects on spermatogenesis after vasectomy in the rat.
Topics: Acetylcysteine; Aldehydes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Enalapril; Fibrosis; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Leydig Cells; Losartan; Male; Rats; Rats, Wistar; Spermatogenesis; Testis; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vasectomy | 2003 |
Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling.
Topics: Angiotensin II; Animals; Apoptosis; Blood Pressure; Body Weight; Cardiomegaly; Coronary Vessels; Disease Models, Animal; Disease Progression; Fibrosis; Gene Expression; Heart Rate; Infusion Pumps, Implantable; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Myocardium; Receptor, Angiotensin, Type 1; Superoxides; Ventricular Remodeling | 2003 |
Angiotensin II-induced ventricular hypertrophy and extracellular signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Gene Expression; Hypertrophy, Left Ventricular; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Natriuretic Peptide, Brain; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasoconstrictor Agents | 2003 |
Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cell Movement; Constriction; Coronary Vessels; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Inflammation; Macrophages; Male; Myocardium; Peptidyl-Dipeptidase A; Pressure; Rats; Rats, Wistar; Tetrazoles | 2004 |
Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors.
Topics: Adult; Aged; Angiotensin II; Angiotensinogen; Autocrine Communication; Blotting, Western; Cathepsin D; Cells, Cultured; Extracellular Matrix; Female; Fibroblasts; Fibrosis; Gene Expression; Humans; Immunohistochemistry; Male; Middle Aged; Procollagen; Receptor, Angiotensin, Type 1; RNA, Messenger; Scleroderma, Systemic; Skin; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Tissue angiotensin II in the regulation of inflammatory and fibrogenic components of repair in the rat heart.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomegaly; Collagen Type I; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Heart; In Situ Hybridization; Infusions, Parenteral; Male; Myocardium; Nephrectomy; NF-kappa B; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Tetrazoles; Valine; Valsartan | 2004 |
PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats.
Topics: Angiotensin II; Animals; Blood Pressure; Collagen; Electrocardiography; Fenofibrate; Fibrosis; Heart; Hypertension; Inflammation; Infusions, Intravenous; Intercellular Adhesion Molecule-1; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis, and renal damage.
Topics: Adrenomedullin; Angiotensin II; Angiotensinogen; Animals; Aorta, Abdominal; Cardiomegaly; Collagen Type I; Constriction; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Fibrosis; Gene Expression Regulation; Genes, fos; Genes, Lethal; Glomerulosclerosis, Focal Segmental; Heterozygote; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Natriuretic Peptide, Brain; Peptides; Peptidyl-Dipeptidase A; Protein Kinase C; Proto-Oncogene Proteins c-fos; Transforming Growth Factor beta; Ventricular Remodeling | 2004 |
From inflammation to fibrosis: a stiff stretch of highway.
Topics: Aldosterone; Angiotensin II; Animals; Aorta, Abdominal; Apoptosis; Cell Adhesion Molecules; Collagen; Coronary Vessels; Cytokines; Fibroblasts; Fibrosis; Humans; Hypertension; Inflammation; Ligation; Macrophages; Myocardium; Myocytes, Cardiac; Necrosis; Oxidative Stress; Rats | 2004 |
Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats.
Topics: Angiotensin II; Animals; Aortic Valve Stenosis; Blood Pressure; Carotid Arteries; Femoral Artery; Fibrosis; Hypertension; Kidney; Kidney Tubular Necrosis, Acute; Male; NF-kappa B; Pressure; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium Chloride, Dietary; Transforming Growth Factor beta | 2004 |
Alpha8beta1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium.
Topics: Angiotensin II; Animals; Blotting, Western; Fibrosis; Immunohistochemistry; Infusion Pumps, Implantable; Injections, Subcutaneous; Integrins; Male; Myocardium; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasoconstrictor Agents | 2004 |
Aldosterone antagonist facilitates the cardioprotective effects of angiotensin receptor blockers in hypertensive rats.
Topics: Aldosterone; Angiotensin II; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Body Weight; Cardiomegaly; Cardiotonic Agents; Collagen Type I; Collagen Type III; Drug Synergism; Fibrosis; Hypertension; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; RNA, Messenger; Spironolactone; Tetrazoles | 2004 |
KLF5/BTEB2, a Krüppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.
Topics: Angiotensin II; Animals; Animals, Newborn; Cells, Cultured; Chromatin; Down-Regulation; Echocardiography; Extracellular Matrix; Fibrosis; HeLa Cells; Heterozygote; Homozygote; Humans; Hypertrophy; Kruppel-Like Transcription Factors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Myocardium; Myosin Heavy Chains; Phenotype; Platelet-Derived Growth Factor; Precipitin Tests; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trans-Activators; Transcription, Genetic; Up-Regulation | 2003 |
Nitric oxide synthase inhibition accelerates the pressor response to low-dose angiotensin II, exacerbates target organ damage, and induces renin escape.
Topics: Angiotensin II; Animals; Biomarkers; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrosis; Infusions, Intravenous; Kidney; Models, Cardiovascular; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Proteinuria; Rats; Rats, Sprague-Dawley; Renin; Time Factors; Troponin T; Vasoconstrictor Agents | 2004 |
Cardiac angiotensin AT2 receptor: what exactly does it do?
Topics: Angiotensin II; Animals; Fibrosis; Genetic Predisposition to Disease; Humans; Hypertrophy, Left Ventricular; Introns; Mice; Mice, Knockout; Myocardium; Phosphoprotein Phosphatases; Polymorphism, Genetic; Prospective Studies; Rats; Receptor, Angiotensin, Type 2; Ventricular Remodeling | 2004 |
Profibrotic effects of angiotensin II in the heart: a matter of mediators.
Topics: Angiotensin II; Animals; Collagen Type I; Collagen Type III; Fibrosis; Humans; Hypertrophy; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Osteopontin; Sialoglycoproteins; Ventricular Remodeling | 2004 |
Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Blotting, Northern; Cardiomegaly; Cell Adhesion; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Fibrosis; Mice; Mice, Knockout; Models, Cardiovascular; Muscle Proteins; Myocardium; Nuclear Proteins; Osteopontin; Repressor Proteins; Sialoglycoproteins; Up-Regulation; Vasoconstrictor Agents | 2004 |
Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy.
Topics: Aldosterone; Angiotensin II; Animals; Apoptosis; Blood Pressure; Cardiomegaly; Cell Size; Eplerenone; Fibrosis; Heart Rate; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Myocytes, Cardiac; Osteopontin; Reverse Transcriptase Polymerase Chain Reaction; Sialoglycoproteins; Spironolactone; Ultrasonography; Ventricular Remodeling | 2004 |
GH suppresses TGF-beta-mediated fibrosis and retains cardiac diastolic function.
Topics: Angiotensin II; Animals; Cells, Cultured; Diastole; Echocardiography; Extracellular Matrix Proteins; Female; Fibroblasts; Fibrosis; Growth Hormone; Insulin-Like Growth Factor I; Matrix Metalloproteinases; Myocardium; Rats; Rats, Inbred WF; Signal Transduction; Transforming Growth Factor beta; Ventricular Remodeling | 2004 |
Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Cardiomyopathies; Cell Differentiation; Cell Division; Cells, Cultured; Collagen; Cyclic AMP; Disease Models, Animal; Fibroblasts; Fibrosis; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Receptors, G-Protein-Coupled; Receptors, Peptide; Relaxin; RNA, Messenger; Transforming Growth Factor beta; Vasoconstrictor Agents | 2004 |
Comparative effects of quinapril with enalapril in rats with heart failure.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomyopathy, Dilated; Collagen Type III; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Fibrosis; Male; Myocardium; Quinapril; Rats; Rats, Inbred Lew; RNA, Messenger; Survival Rate; Tetrahydroisoquinolines; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Function, Left; Ventricular Pressure | 2004 |
Defining "culprit mechanisms" in arrhythmogenic cardiac remodeling.
Topics: Angiotensin II; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Dogs; Fibrosis; Heart Atria; Heart Failure; Humans; Mice; Mice, Transgenic; Models, Animal; Myocardium; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling | 2004 |
Tachycardia-induced remodeling: atria and ventricles take a different route.
Topics: Angiotensin II; Animals; Apoptosis; Dogs; Electrocardiography; Fibrosis; Heart Atria; Heart Block; Heart Ventricles; Humans; MAP Kinase Signaling System; Tachycardia; Ventricular Remodeling | 2004 |
Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure.
Topics: Angiotensin II; Animals; Apoptosis; Blotting, Western; Cardiac Pacing, Artificial; Cell Death; Dogs; Fibrosis; Heart Atria; Heart Failure; Heart Ventricles; Humans; Leukocytes; Mitogen-Activated Protein Kinases; Transforming Growth Factor beta; Ventricular Remodeling | 2004 |
Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Collagen Type I; Coronary Disease; Coronary Vessels; Fibrosis; Heart Ventricles; Imidazoles; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 9; Mice; Mice, Obese; Obesity; Olmesartan Medoxomil; Phosphorylation; Plasminogen Activator Inhibitor 1; Tetrazoles; Thiazepines; Transforming Growth Factor beta | 2004 |
Endogenous angiotensin II induces atherosclerotic plaque vulnerability and elicits a Th1 response in ApoE-/- mice.
Topics: Angiotensin II; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Coronary Artery Disease; Fibrosis; Hypercholesterolemia; Hypertension, Renovascular; Ligation; Mice; Mice, Knockout; Nephrectomy; Renal Artery; Renin; Renin-Angiotensin System; Rupture, Spontaneous; Th1 Cells; Th2 Cells; Vasculitis | 2004 |
Hypertension: a novel regulator of adaptive immunity in atherosclerosis?
Topics: Adaptation, Physiological; Angiotensin II; Animals; Apolipoproteins E; Arteriosclerosis; Collagen; Disease Models, Animal; Fibrosis; Humans; Hypertension; Hypertension, Renovascular; Inflammation; Ligation; Lipids; Macrophages; Mice; Nephrectomy; Phenotype; Rabbits; Renal Artery; Renin-Angiotensin System; Th1 Cells; Th2 Cells | 2004 |
Contribution of angiotensin II to alcohol-induced pancreatic fibrosis in rats.
Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Captopril; Central Nervous System Depressants; Collagen; Cytokines; Ethanol; Fibrosis; Immunohistochemistry; Losartan; Male; Pancreas; Pancreatic Diseases; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Ribonucleases; RNA, Messenger | 2004 |
Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Atrial Natriuretic Factor; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Collagen Type I; Disease Models, Animal; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibrosis; Heart Failure; Homozygote; Hypertrophy, Left Ventricular; Imidazoles; Immunohistochemistry; Male; Mitogen-Activated Protein Kinases; Myocardium; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin; Smad Proteins; Tetrazoles; Time Factors; Trans-Activators; Tyrphostins | 2004 |
Profibrotic influence of high glucose concentration on cardiac fibroblast functions: effects of losartan and vitamin E.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cells, Cultured; Collagen Type I; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Glucose; Leucine; Losartan; Male; Matrix Metalloproteinases; Myocardium; Osmolar Concentration; Proline; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; RNA, Messenger; Vitamin E | 2005 |
Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Amino Acid Substitution; Angiotensin II; Animals; Body Weight; Cardiomyopathy, Hypertrophic, Familial; Cell Size; Death, Sudden, Cardiac; Female; Fibrosis; Gene Expression Profiling; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Mutation, Missense; Myocytes, Cardiac; Organ Size; Phenotype; Phenylephrine; Point Mutation; Protein Isoforms; RNA Splice Sites; RNA, Messenger; Sex Characteristics; Troponin T | 2004 |
Role of aberrant iron homeostasis in the upregulation of transforming growth factor-beta1 in the kidney of angiotensin II-induced hypertensive rats.
Topics: Angiotensin II; Animals; Collagen; Ferritins; Fibrosis; Free Radical Scavengers; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Homeostasis; Hypertension, Renal; Iron; Iron Chelating Agents; Iron Overload; Kidney; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Vasoconstrictor Agents | 2004 |
Combining TGF-beta inhibition and angiotensin II blockade results in enhanced antifibrotic effect.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Drug Synergism; Enalapril; Fibrosis; Glomerulonephritis; Kidney; Male; Mice; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 2004 |
Angiotensin II mediates acinar cell apoptosis during the development of rat pancreatic fibrosis by AT1R.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Disease Models, Animal; Fibrosis; Gene Expression Regulation; In Situ Nick-End Labeling; Losartan; Male; Pancreas; Pancreatic Ducts; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2004 |
Cellular basis for therapeutic choices in heart failure.
Topics: Adrenergic beta-Antagonists; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cardiac Output, Low; Clinical Trials as Topic; Drug Therapy, Combination; Fibrosis; Humans; Mineralocorticoid Receptor Antagonists; Myocardium; Receptors, Adrenergic, beta; Signal Transduction; Ventricular Remodeling | 2004 |
Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin-converting enzyme is related to enhanced breakdown of N-acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3.
Topics: Activin Receptors, Type I; Angiotensin II; Animals; Animals, Genetically Modified; Binding, Competitive; Collagen; DNA-Binding Proteins; DNA, Complementary; Fibrosis; Humans; Hypertrophy, Left Ventricular; Myocardium; Oligopeptides; Peptidyl-Dipeptidase A; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad2 Protein; Smad3 Protein; Substrate Specificity; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Aorta; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Fibrosis; Heart Rate; Hypertrophy; Imidazoles; Myocardium; Pyridines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Telemetry; Tetrazoles; Ventricular Remodeling | 2004 |
Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart.
Topics: Aldosterone; Angiotensin II; Animals; Chemokine CCL2; Deferoxamine; Enzyme Inhibitors; Ferritins; Fibrosis; Free Radical Scavengers; Gene Expression; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Iron; Iron Chelating Agents; Male; Myocardium; Oxidative Stress; Phenylurea Compounds; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Vasoconstrictor Agents | 2005 |
Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling.
Topics: Acetates; Administration, Oral; Angiotensin II; Animals; Antigens, Differentiation; Aorta; Aortic Diseases; Blood Pressure; Chemokine CCL2; Collagen Type I; Collagen Type III; Drug Evaluation, Preclinical; Fibronectins; Fibrosis; Gene Expression Regulation; Glomerulosclerosis, Focal Segmental; Heart; Hypertrophy, Left Ventricular; Indoleacetic Acids; Indoles; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nephrectomy; Osteopontin; Plasminogen Activator Inhibitor 1; Random Allocation; RNA, Messenger; Sialoglycoproteins; Single-Blind Method; Sodium Chloride, Dietary | 2005 |
Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats.
Topics: Actins; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Body Weight; Chronic Disease; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Fibrosis; Genes, ras; Hydroxyproline; Immunohistochemistry; Lisinopril; Male; Organ Size; Pancreatitis; Peptidyl-Dipeptidase A; Peroxidase; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; RNA, Messenger; Tetrazoles | 2005 |
Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist.
Topics: Adrenergic beta-Agonists; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Canrenoic Acid; Fibrosis; Heart Failure; Isoproterenol; Losartan; Male; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta | 2005 |
Magnesium supplementation prevents angiotensin II-induced myocardial damage and CTGF overexpression.
Topics: Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Blood Pressure; Cardiomegaly; Connective Tissue Growth Factor; Dietary Supplements; Fibrosis; Humans; Immediate-Early Proteins; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Magnesium; Male; Myocardium; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tacrolimus | 2005 |
Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Apolipoproteins E; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Collagen Type III; Coronary Vessels; Dose-Response Relationship, Drug; Fibrosis; Gene Expression; Heart Rate; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Myocardium; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger; Up-Regulation | 2005 |
Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts.
Topics: Angiotensin II; Animals; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; CHO Cells; Cricetinae; Fibrosis; Gene Expression; Hepatocyte Growth Factor; Humans; Male; Mesocricetus; Myocytes, Cardiac; Proto-Oncogene Proteins c-met; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ultrasonography; Vasoconstrictor Agents; Ventricular Remodeling | 2005 |
Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism.
Topics: Active Transport, Cell Nucleus; Angiotensin II; Animals; Connective Tissue Growth Factor; Extracellular Matrix Proteins; Fibrosis; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Smad Proteins; Smad2 Protein; Smad4 Protein; Transforming Growth Factor beta; Up-Regulation | 2005 |
Chronic administration of angiotensin-(1-7) attenuates pressure-overload left ventricular hypertrophy and fibrosis in rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Aortic Coarctation; Blood Pressure; Fibrosis; Hypertrophy, Left Ventricular; Male; Myocardium; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2005 |
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Fibrosis; Heart Diseases; Humans; Inflammation; Kidney Diseases; Losartan; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Renin | 2005 |
Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; DNA-Binding Proteins; Fibrosis; Heart Rate; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Myocardium; Receptors, Androgen; RNA, Messenger; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ventricular Remodeling | 2005 |
Pentoxifylline attenuates tubulointerstitial fibrosis by blocking Smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor.
Topics: Actins; Angiotensin II; Animals; Cell Line; Collagen Type I; Connective Tissue Growth Factor; Fibrosis; Gene Expression; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Male; Models, Biological; Pentoxifylline; Rats; Rats, Wistar; Signal Transduction; Smad3 Protein; Smad4 Protein; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1; Ureteral Obstruction | 2005 |
Characterizing the role of endothelin-1 in the progression of cardiac hypertrophy in aryl hydrocarbon receptor (AhR) null mice.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Cardiomegaly; Disease Progression; Echocardiography; Endothelin A Receptor Antagonists; Endothelin-1; Fibrosis; Hypertrophy, Left Ventricular; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Organ Size; Peptides, Cyclic; Receptor, Endothelin A; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2006 |
Animal models of cardiac fibrosis.
Topics: Aldosterone; Angiotensin II; Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Diseases; Heart Ventricles; Humans; Immunohistochemistry; In Situ Hybridization; Isoproterenol; Male; Myocardial Infarction; Myocardium; Phenotype; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2005 |
Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type III; Collagen Type VI; Coronary Vessels; Extracellular Matrix; Fibroblasts; Fibrosis; Ligation; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2006 |
Origin of interstitial fibroblasts in an accelerated model of angiotensin II-induced renal fibrosis.
Topics: Actins; Angiotensin II; Animals; Atrophy; Crotalid Venoms; Disease Models, Animal; Epithelial Cells; Extracellular Matrix; Fibroblasts; Fibrosis; Kidney; Kidney Diseases; Kidney Tubules; Male; Microscopy, Electron; Microscopy, Fluorescence; Myocytes, Smooth Muscle; Rats; Sodium-Potassium-Exchanging ATPase | 2005 |
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Fibrosis; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Protein Serine-Threonine Kinases; Quaternary Ammonium Compounds; rho-Associated Kinases; Vascular Diseases | 2005 |
Effect of FTY720 on chronic cyclosporine nephropathy in rats.
Topics: Angiotensin II; Animals; Chronic Disease; Cyclosporine; Extracellular Matrix Proteins; Fibrosis; Fingolimod Hydrochloride; Immunosuppressive Agents; Kidney; Kidney Diseases; Lymphocytes; Macrophages; Male; Osteopontin; Propylene Glycols; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Sphingosine; T-Lymphocytes; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway.
Topics: Adenoviridae; Angiotensin II; Animals; Blotting, Western; Carbazoles; Cell Nucleus; Cell Proliferation; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Immunohistochemistry; Indoles; Maleimides; NF-kappa B; Pancreas; Protein Kinase C; Rats; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad4 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Collagen; Ectodysplasins; Fibrosis; Heart; Hypertension; Hypertrophy; Macrophages; Male; Membrane Proteins; Mineralocorticoid Receptor Antagonists; Myocarditis; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Spironolactone; Transcription Factor AP-1; Tumor Necrosis Factors; Vascular Cell Adhesion Molecule-1 | 2005 |
High glucose increases extracellular matrix production in pancreatic stellate cells by activating the renin-angiotensin system.
Topics: Angiotensin I; Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Collagen; Connective Tissue Growth Factor; Dose-Response Relationship, Drug; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Fibrosis; Glucose; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Male; Pancreas; Pancreatitis; Ramipril; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Transforming Growth Factor beta | 2006 |
Cardiovascular oxidative stress is reduced by an ACE inhibitor in a rat model of streptozotocin-induced diabetes.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Body Weight; Cardiovascular System; Diabetes Mellitus, Experimental; Drinking; Elastin; Extracellular Space; Fibrosis; Heart Ventricles; Hemodynamics; Male; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides | 2006 |
Smad3 mediates angiotensin II- and TGF-beta1-induced vascular fibrosis: Smad3 thickens the plot.
Topics: Angiotensin II; Animals; Fibrosis; Inflammation; Mice; Muscle, Smooth, Vascular; Smad3 Protein; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury.
Topics: Angiotensin II; Animals; Carotid Arteries; Catheterization; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coronary Restenosis; Fibrosis; Gene Expression Regulation, Enzymologic; Inflammation; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tunica Intima | 2006 |
Role of probucol on endothelial dysfunction of epicardial coronary arteries associated with left ventricular hypertrophy.
Topics: Angiotensin II; Animals; Antioxidants; Bradykinin; Coronary Vessels; Cyclic GMP; Endothelium, Vascular; Fibrosis; Hypertrophy, Left Ventricular; In Vitro Techniques; Lipid Peroxides; Male; Myocytes, Cardiac; Nitrates; Nitrites; Probucol; Serotonin; Superoxide Dismutase; Swine; Vasodilation | 2006 |
An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Diastole; Echocardiography; ErbB Receptors; Fibrosis; Genes, Dominant; Heart; Mice; Mice, Transgenic; Mutation; Myocardium; Phenylalanine; Receptor, Angiotensin, Type 1; Transcriptional Activation; Tyrosine; Ventricular Function, Left | 2006 |
Discoidin domain receptor 1 null mice are protected against hypertension-induced renal disease.
Topics: Angiotensin II; Animals; Chemokine CCL2; Collagen Type I; Collagen Type IV; Cytokines; Discoidin Domain Receptors; Disease Models, Animal; Fibrosis; Hypertension; Inflammation; Kidney Failure, Chronic; Kidney Glomerulus; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Receptor Protein-Tyrosine Kinases; Receptors, Mitogen; Shock, Septic; Vasoconstrictor Agents | 2006 |
Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7).
Topics: Analysis of Variance; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Fibrosis; Heart; Hypertension; Male; Myocardium; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Time Factors; Transforming Growth Factor beta; Ventricular Remodeling | 2007 |
Fibrotic response to angiotensin II is blunted in the kidney, but not in the heart, in insulin-sensitive long-lived transgenic dwarf rats.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Body Weight; Dwarfism; Echocardiography; Fibrosis; Heart Rate; Infusions, Intravenous; Insulin; Insulin-Like Growth Factor I; Kidney; Male; Myocardium; Organ Specificity; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta1 | 2007 |
Prevention of interstitial fibrosis of renal allograft by angiotensin II blockade.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cyclosporine; Female; Fibrosis; Humans; Immunosuppressive Agents; Kidney Transplantation; Losartan; Male; Middle Aged; Postoperative Complications | 2006 |
Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Proliferation; Collagen; Fibroblasts; Fibrosis; Hydroxyproline; Isoproterenol; Lactate Dehydrogenases; Male; Malondialdehyde; Myocardium; Random Allocation; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Urotensins | 2007 |
Pressure overload-induced transient oxidative stress mediates perivascular inflammation and cardiac fibrosis through angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Fibrosis; Heart Ventricles; Hypertension; Inflammation; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Tetrazoles; Time Factors; Ventricular Remodeling | 2006 |
Role of connective tissue growth factor in vascular and renal damage associated with hypertension in rats. Interactions with angiotensin II.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Body Weight; Connective Tissue Growth Factor; Fibrosis; Hypertension; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Cortex; Male; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2006 |
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiomegaly; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension, Renovascular; Ligation; Male; Malondialdehyde; Membrane Glycoproteins; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Rats; Rats, Sprague-Dawley; Renal Artery; Superoxides; Tetrazoles; Valine; Valsartan; Ventricular Function, Left; Ventricular Remodeling | 2007 |
AT1 receptor blockade prevents interstitial and glomerular apoptosis but not fibrosis in pigs with neonatal induced partial unilateral ureteral obstruction.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Apoptosis; Benzimidazoles; Biphenyl Compounds; Capillaries; Caspase 3; Cell Count; Collagen; Female; Fibrosis; Hydroxyproline; Immunohistochemistry; Kidney Glomerulus; Kidney Tubules; Nephritis, Interstitial; Swine; Tetrazoles; Tissue Fixation; Ureteral Obstruction | 2007 |
Decreased endogenous levels of Ac-SDKP promote organ fibrosis.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Collagen; Fibrosis; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Kidney; Male; Myocardium; Oligopeptides; Prolyl Oligopeptidases; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Substance P; Time Factors | 2007 |
Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: involvement of tenascin-C induced by aldosterone-mediated inflammation.
Topics: Aldosterone; Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Body Weight; Cytokines; Disease Models, Animal; Eplerenone; Female; Fibroblasts; Fibrosis; Hypertension; Immunohistochemistry; In Situ Hybridization; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Macrophages; Mice; Mice, Inbred BALB C; Mineralocorticoid Receptor Antagonists; Myocardium; Reverse Transcriptase Polymerase Chain Reaction; Spironolactone; Tenascin; Up-Regulation; Vasoconstrictor Agents | 2007 |
Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy.
Topics: Angiotensin II; Animals; Captopril; Cardiomegaly; Cyclic GMP; Fibrosis; Gene Expression Regulation; Guanylate Cyclase; Heart Ventricles; Hydralazine; Hypertension; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Peptidyl-Dipeptidase A; Receptor, Angiotensin, Type 1; Receptors, Atrial Natriuretic Factor; Renin-Angiotensin System; Signal Transduction; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2007 |
Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction.
Topics: Angiotensin II; Animals; Blood Pressure; Collagen; Fibrosis; Gene Expression Regulation; Heart; Heart Rate; Macrophages; Male; Mice; Mice, Transgenic; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Neovascularization, Pathologic; Ventricular Remodeling | 2007 |
Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2.
Topics: Amidohydrolases; Amlodipine; Angiotensin II; Animals; Arginine; Blood Pressure; Coronary Circulation; Coronary Vessels; Creatine Kinase, MB Form; Enzyme Activation; Enzyme Inhibitors; Fibrosis; Heart Diseases; Imidazoles; Mice; Mice, Transgenic; Myocardium; Nitric Oxide; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptidyl-Dipeptidase A; Pyridines; Time Factors; Tunica Media; Up-Regulation; Vasodilator Agents | 2007 |
Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat.
Topics: Aging; Angiotensin I; Angiotensin II; Animals; Animals, Congenic; Blood Pressure; C-Reactive Protein; Cell Adhesion Molecules; Disease Models, Animal; Female; Fibrosis; Hypertension; Hypertrophy; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Diseases; Membrane Proteins; Ovariectomy; Peptide Fragments; Proteinuria; Rats; Rats, Inbred Lew; Renin; Renin-Angiotensin System; RNA, Messenger; Sodium Chloride, Dietary | 2007 |
A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II.
Topics: Angiotensin II; Animals; Cardiomyopathies; Diabetes Mellitus, Experimental; Fibrosis; Hemodynamics; Humans; Male; Myocardium; Peptides; Rats; Rats, Inbred WKY; Smad2 Protein; Thrombospondin 1; Transforming Growth Factor beta | 2007 |
Endothelial NF-kappaB as a mediator of kidney damage: the missing link between systemic vascular and renal disease?
Topics: Albuminuria; Angiotensin II; Animals; Atherosclerosis; Endothelium, Vascular; Fibrosis; Gemfibrozil; Humans; Hypertension; I-kappa B Proteins; Inflammation; Kidney Diseases; Mice; Models, Cardiovascular; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Synthase Type III; Organ Specificity; Sodium Chloride, Dietary | 2007 |
Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Progression; Fibrosis; Glomerular Mesangium; Humans; Hypertension, Renal; Male; Matrix Metalloproteinase 2; Mice; Mice, Mutant Strains; Osteonectin; Rats; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta1 | 2007 |
Autocrine TGF-beta1 mediates angiotensin II-induced proliferative response of cerebral vessels in vivo.
Topics: Angiotensin II; Animals; Basilar Artery; Cell Proliferation; Female; Fibrosis; Muscle, Smooth, Vascular; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Signal Transduction; Transforming Growth Factor beta1 | 2007 |
NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells.
Topics: Acetophenones; Actins; Angiotensin II; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Chemokine CXCL1; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibrosis; Humans; Interleukin-1beta; Male; Mitogen-Activated Protein Kinases; NADPH Oxidases; NF-kappa B; Onium Compounds; Organotin Compounds; Pancreas; Pancreatitis, Chronic; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred Lew; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Time Factors; Transcription Factor AP-1; Transfection | 2008 |
Ultrastructural islet study of early fibrosis in the Ren2 rat model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cell.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Blood Glucose; Blood Pressure; Body Weight; Cell Communication; Disease Models, Animal; Extracellular Matrix; Fibrosis; Hypertension; Islets of Langerhans; Male; Oxidative Stress; Pericytes; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 2007 |
Possible involvement of mast cells in renal fibrosis in patients with IgA nephropathy.
Topics: Adolescent; Adult; Aged; Angiotensin II; Cell Degranulation; Female; Fibrosis; Glomerulonephritis, IGA; Humans; Kidney; Male; Mast Cells; Middle Aged; Nephrosis, Lipoid | 2007 |
Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Cytomegalovirus; Fibrosis; Gene Expression; Genetic Therapy; Genetic Vectors; Luciferases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Plasminogen Activator Inhibitor 1; Transduction, Genetic; Urokinase-Type Plasminogen Activator | 2008 |
Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia.
Topics: Angiotensin II; Angiotensinogen; Angiotensins; Animals; Connective Tissue Growth Factor; Extracellular Matrix; Fibrosis; Glucose-6-Phosphatase; Glycogen Storage Disease Type I; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Diseases; Mice; Mice, Mutant Strains; Receptor, Angiotensin, Type 1; Transforming Growth Factor beta1 | 2008 |
Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Azo Compounds; Blotting, Western; Cardiomegaly; Cell Separation; Collagen; Fibrosis; Galectin 3; Heart Rate; Hypertension; In Vitro Techniques; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Myocardium; Neutrophil Infiltration; Oligopeptides; Stem Cells; Tumor Necrosis Factor-alpha | 2008 |
Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis.
Topics: Adaptation, Physiological; Angiotensin II; Animals; Aorta; Blood Pressure; Cytokines; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Genotype; Hypertrophy, Left Ventricular; Inflammation; Intercellular Signaling Peptides and Proteins; Ligation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Phenotype; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Signal Transduction; Time Factors; Ventricular Function, Left | 2008 |
Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice.
Topics: Angiotensin II; Animals; Blood Pressure; Cholesterol; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart Failure, Diastolic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Pravastatin; rho-Associated Kinases; Ventricular Remodeling | 2008 |
Kidney fibrosis in hypertensive rats: role of oxidative stress.
Topics: Angiotensin II; Animals; Antioxidants; Blood Pressure; Blotting, Western; Collagen; Fibrosis; Gene Expression; Hypertension; Immunohistochemistry; In Situ Hybridization; Kidney; Male; Myofibrils; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor beta1; Up-Regulation | 2008 |
Targeting the calpain/calpastatin system as a new strategy to prevent cardiovascular remodeling in angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; Disease Models, Animal; Fibrosis; Genetic Therapy; Hypertension; Hypertrophy; Hypertrophy, Left Ventricular; Inflammation; Infusion Pumps, Implantable; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Myocardium; NF-kappa B; NFATC Transcription Factors; Renal Artery; Time Factors; Ventricular Remodeling | 2008 |
Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts.
Topics: Angiotensin II; Animals; Cell Proliferation; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; Myocardium; Plasminogen Activator Inhibitor 1; PPAR gamma; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transforming Growth Factor beta1 | 2008 |
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.
Topics: Angiogenic Proteins; Angiotensin II; Animals; Aorta, Thoracic; Apoptosis; Blotting, Western; Constriction; Disease Models, Animal; Disease Progression; Energy Metabolism; Fibrosis; Heart Failure; Hypertrophy, Left Ventricular; Male; Mechanotransduction, Cellular; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Myocardium; Neovascularization, Physiologic; Phosphorylation; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Stress, Mechanical; Ventricular Function, Left; Ventricular Remodeling | 2008 |
Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha.
Topics: Adenoviridae; Adiponectin; AMP-Activated Protein Kinase Kinases; Angiotensin II; Animals; Fibrosis; Heart Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 3; Myocardial Contraction; Myocardium; Myocytes, Cardiac; PPAR alpha; Protein Kinases; Reactive Oxygen Species; Ventricular Dysfunction, Left | 2008 |
The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes.
Topics: Angiotensin II; Animals; Blood Pressure; Bone Marrow; Cells, Cultured; Chemokine CCL21; Collagen Type I; Disease Models, Animal; Fibroblasts; Fibrosis; Hypertension, Renal; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Monocyte Chemoattractant Proteins; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Signal Transduction; Transforming Growth Factor beta1; Ureteral Obstruction; Vasoconstrictor Agents | 2008 |
Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Animals; Carboxypeptidases A; Cell Proliferation; Fibrosis; Heart; Imidazoles; Immunohistochemistry; Leucine; Male; Membranes; Mice; Mice, Knockout; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Protease Inhibitors; Succinates | 2008 |
Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin.
Topics: Angiotensin II; Animals; Calcineurin; Calcium-Binding Proteins; Cardiomegaly; Collagen; Estradiol; Estrogen Receptor beta; Estrogens; Female; Fibrosis; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Muscle Proteins; Myocardium; Myosin Heavy Chains; Ovariectomy | 2008 |
Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Benzimidazoles; Benzoates; Blood Pressure; Cardiomegaly; Dose-Response Relationship, Drug; Fibrosis; Heart Rate; Hypertension; Hypertrophy; Kidney; Losartan; Male; Myocardium; Organ Specificity; Rats; Rats, Inbred Dahl; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sodium, Dietary; Telmisartan | 2008 |
Alpha2-antiplasmin is a critical regulator of angiotensin II-mediated vascular remodeling.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Cell Proliferation; Collagen Type I; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Eye Proteins; Fibrosis; Gelatinases; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nerve Growth Factors; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Serpins; Thoracic Arteries; Tumor Suppressor Protein p53 | 2008 |
Serum transforming growth factor-beta1 as a risk stratifier of sudden cardiac death.
Topics: Angiotensin II; Cost-Benefit Analysis; Death, Sudden, Cardiac; Fibrosis; Humans; Ions; Models, Biological; Models, Theoretical; Myocardium; Risk; Tachycardia, Ventricular; Transforming Growth Factor beta1; Ventricular Fibrillation | 2008 |
Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alphavbeta3-integrin, and TGF-beta1 in response to ANG II and high glucose.
Topics: Acetates; Angiotensin II; Animals; Antibodies; Benzodiazepinones; Blood Glucose; Blood Pressure; Cells, Cultured; Collagen Type I; Diabetes Mellitus, Experimental; Elasticity; Fibrosis; Hypertension; Integrin alphaVbeta3; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Microcirculation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; RNA Interference; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2008 |
Aldosterone, but not angiotensin II, increases profibrotic factors in kidney of adrenalectomized stroke-prone spontaneously hypertensive rats.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Fibrosis; Immunohistochemistry; Kidney; Kidney Diseases; Male; Osteopontin; Plasminogen Activator Inhibitor 1; Rats; Rats, Inbred SHR; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad2 Protein; Smad7 Protein; Transforming Growth Factor beta | 2008 |
Angiotensin-converting enzyme inhibitors, inhibition of brain and peripheral angiotensin-converting enzymes, and left ventricular dysfunction in rats after myocardial infarction.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Baroreflex; Brain; Fibrosis; Hemodynamics; Indoles; Infusions, Intravenous; Injections, Subcutaneous; Kidney; Lisinopril; Male; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Renin-Angiotensin System; Sympathetic Nervous System; Ventricular Dysfunction, Left | 2008 |
Effect of angiotensin II blockade on the fibroproliferative response to phenylephrine in the rat heart.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blotting, Northern; Fibrosis; Glyceraldehyde-3-Phosphate Dehydrogenases; Heart; Imidazoles; Indoles; Losartan; Male; Myocardium; Phenylephrine; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Renin-Angiotensin System; RNA; Tetrazoles | 1995 |
Inhibition of angiotensin-converting enzyme and attenuation of myocardial fibrosis by lisinopril in rats receiving angiotensin II.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Autoradiography; Fibrosis; Immunohistochemistry; Lisinopril; Male; Myocardium; Necrosis; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley | 1995 |
Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biochemical Phenomena; Biochemistry; Biphenyl Compounds; Cardiomyopathies; Collagen; Endomyocardial Fibrosis; Fibrosis; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Imidazoles; Losartan; Microscopy, Polarization; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Spironolactone; Tetrazoles | 1995 |
Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis. Studies in chronic cyclosporine nephrotoxicity in rats.
Topics: Angiotensin II; Animals; Cyclosporine; Endothelin Receptor Antagonists; Endothelins; Fibrosis; Kidney Function Tests; Kidney Glomerulus; Male; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Vasoconstriction | 1995 |
Coronary vascular hyperpermeability and angiotensin II.
Topics: Angiotensin II; Animals; Capillary Permeability; Coronary Disease; Coronary Vessels; Dinoprostone; Dogs; Fibronectins; Fibrosis; Gelatinases; Kinetics; Lymph; Male; Myocardium; Proteins; Serum Albumin | 1995 |
Osteopontin expression in cardiovascular diseases.
Topics: Angiotensin II; Animals; Arteries; Cardiovascular Diseases; Cell Adhesion; Fibrosis; Gene Expression; Inflammation; Integrins; Kidney; Macrophages; Muscle, Smooth, Vascular; Osteopontin; Rats; Receptors, Cytoadhesin; RNA, Messenger; Sialoglycoproteins; Time Factors; Wound Healing | 1995 |
Angiotensin II receptor binding following myocardial infarction in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Collagen; Fibrosis; Foreign-Body Reaction; Imidazoles; Lisinopril; Losartan; Male; Myocardial Infarction; Myocardium; Peptidyl-Dipeptidase A; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1994 |
Aldosterone and cardiac fibrosis: in vitro studies.
Topics: Aldosterone; Androstanols; Angiotensin II; Animals; Cells, Cultured; Collagen; Fibroblasts; Fibrosis; Glucocorticoids; Heart; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley | 1994 |
Renal proliferative and phenotypic changes in rats with two-kidney, one-clip Goldblatt hypertension.
Topics: Angiotensin II; Animals; Cell Division; Cytoskeletal Proteins; Fibrosis; Hypertension, Renovascular; Immunohistochemistry; Kidney; Leukocytes; Macrophages; Male; Phenotype; Rats; Rats, Wistar; Renin | 1994 |
Angiotensin-converting enzyme and myocardial fibrosis in the rat receiving angiotensin II or aldosterone.
Topics: Aldosterone; Angiotensin II; Animals; Autoradiography; Blood Pressure; Collagen; Coronary Vessels; Fibrosis; Heart; Iodine Radioisotopes; Lisinopril; Male; Myocardium; Nephrectomy; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Sodium, Dietary | 1993 |
Continuous versus intermittent angiotensin converting enzyme inhibition in renal hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Creatinine; Fibrosis; Heart Rate; Hypertension, Renovascular; Kidney; Male; Myocardium; Organ Size; Rats; Rats, Wistar; Renin; Urea | 1993 |
Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Heart; Hydroxyproline; Hyperaldosteronism; Hypertrophy, Left Ventricular; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Sprague-Dawley | 1993 |
Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomyopathies; Fibrosis; Hyperaldosteronism; Hypertension; Hypertension, Renovascular; Male; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Spironolactone | 1993 |
Temporal differences in fibroblast proliferation and phenotype expression in response to chronic administration of angiotensin II or aldosterone.
Topics: Actins; Aldosterone; Angiotensin II; Animals; Cell Division; Fibroblasts; Fibrosis; Heart; Infusions, Parenteral; Ischemia; Kidney; Male; Myocardium; Nephrectomy; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors | 1995 |
Cells expressing angiotensin II receptors in fibrous tissue of rat heart.
Topics: Angiotensin II; Animals; Autoradiography; Fibroblasts; Fibrosis; Immunohistochemistry; Male; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Time Factors | 1996 |
Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin.
Topics: Angiotensin II; Animals; Arginine; Bradykinin; Bradykinin Receptor Antagonists; Collagen; Cyclooxygenase Inhibitors; Fibrosis; Indomethacin; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Rats; Rats, Sprague-Dawley | 1996 |
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Collagen; Elastin; Fibrosis; Hypertension; Hypertrophy; Imidazoles; Infusions, Parenteral; Losartan; Male; Muscle, Smooth, Vascular; Phenylephrine; Pyridines; Rats; Rats, Wistar; Reference Values; Tetrazoles | 1996 |
In situ production of angiotensin II by fibrosed rat pericardium.
Topics: Angiotensin I; Angiotensin II; Animals; Fibrosis; In Vitro Techniques; Male; Myocardium; Peptidyl-Dipeptidase A; Pericardium; Rats; Rats, Sprague-Dawley; Reference Values | 1996 |
SPARC is expressed in renal interstitial fibrosis and in renal vascular injury.
Topics: Actins; Angiotensin II; Animals; Collagen; Fibrosis; Glomerulonephritis; Kidney; Male; Muscle, Smooth, Vascular; Osteonectin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Captopril; Cytokines; Enalapril; Fibrin; Fibrinolysin; Fibrosis; Gene Expression Regulation, Enzymologic; Growth Substances; Imidazoles; In Situ Hybridization; Kidney; Male; Plasminogen Activator Inhibitor 1; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; RNA, Messenger; Tetrazoles; Thrombosis; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator; Vasoconstrictor Agents | 1997 |
Angiotensin II receptor blockade and myocardial fibrosis of the infarcted rat heart.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Fibrosis; Imidazoles; Losartan; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1997 |
Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Autoradiography; Binding Sites; Endomyocardial Fibrosis; Fibrosis; Heart Atria; Hypertension; Male; Peptidyl-Dipeptidase A; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Vasoconstrictor Agents | 1997 |
Effects of candesartan cilexetil (TCV-116) and enalapril in 5/6 nephrectomized rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Progression; Enalapril; Fibrosis; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Kidney Failure, Chronic; Male; Nephrectomy; Proteinuria; Rats; Rats, Sprague-Dawley; Tetrazoles; Transforming Growth Factor beta | 1997 |
TCV-116 inhibits interstitial fibrosis and HSP47 mRNA in rat obstructive nephropathy.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Collagen; Fibrosis; Heat-Shock Proteins; Histocytochemistry; HSP47 Heat-Shock Proteins; Male; Prodrugs; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrazoles; Ureteral Obstruction | 1997 |
Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts.
Topics: Angiotensin II; Animals; Calcium; Cell Communication; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Matrix Proteins; Fibroblasts; Fibronectins; Fibrosis; Flow Cytometry; Gene Expression Regulation; Hyperplasia; Hypertrophy; Imidazoles; Kidney; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Receptors, Angiotensin; RNA, Messenger; Transforming Growth Factor beta; Up-Regulation | 1997 |
Fibrosis and myocardial ACE: possible substrate and independence from circulating angiotensin II.
Topics: Aldosterone; Angiotensin II; Animals; Autoradiography; Endomyocardial Fibrosis; Female; Fibrosis; Male; Myocardium; Peptidyl-Dipeptidase A; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Receptors, Bradykinin | 1994 |
Myocardial fibrosis associated with aldosterone or angiotensin II administration: attenuation by calcium channel blockade.
Topics: Aldosterone; Angiotensin II; Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Collagen; Drug Interactions; Fibroblasts; Fibrosis; Heart; Hydroxyproline; Intracellular Fluid; Male; Mibefradil; Myocardium; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Tetrahydronaphthalenes | 1998 |
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Apoptosis; Arginine; Biotin; Cyclosporine; Deoxyuracil Nucleotides; DNA Fragmentation; Enzyme Inhibitors; Fibrosis; Hydralazine; Immunosuppressive Agents; Ischemia; Kidney; Losartan; Macrophages; Male; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Staining and Labeling | 1998 |
Role of P-glycoprotein in chronic cyclosporine nephrotoxicity and its relationship to intrarenal angiotensin II deposits.
Topics: Angiotensin II; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Creatinine; Cyclosporine; Fibrosis; Immunosuppressive Agents; Kidney; Kidney Cortex; Kidney Tubules; Male; Rats; Rats, Sprague-Dawley | 1998 |
Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart.
Topics: Angiotensin II; Animals; Collagen; Fibrosis; Losartan; Male; Myocardial Infarction; Myocardium; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; RNA, Messenger; Transforming Growth Factor beta | 1998 |
Targeting TGF-beta overexpression in renal disease: maximizing the antifibrotic action of angiotensin II blockade.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Eating; Enalapril; Fibronectins; Fibrosis; Glomerulonephritis, Membranoproliferative; Kidney; Losartan; Male; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 1998 |
Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo.
Topics: Aldosterone; Angiotensin II; Animals; Arterioles; Blood Pressure; Cell Division; Collagen; Coronary Vessels; Endothelium, Vascular; Fibrosis; Losartan; Male; Myocardium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin | 1998 |
Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice.
Topics: Angiotensin II; Animals; Cell Communication; Chimera; Female; Fibroblasts; Fibrosis; Genes, Reporter; Lac Operon; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myocardium; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Ventricular Remodeling | 1999 |
Activation of cardiac aldosterone production in rat myocardial infarction: effect of angiotensin II receptor blockade and role in cardiac fibrosis.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; Fibrosis; Gene Expression; Heart; Heart Ventricles; Male; Myocardial Infarction; Myocardium; Norepinephrine; Rats; Rats, Wistar; Steroids | 1999 |
Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Anti-Bacterial Agents; Antihypertensive Agents; Blotting, Northern; Cell Division; Cell Line, Transformed; Epithelial Cells; Fibrosis; Gene Expression; Humans; Kidney Diseases; Kidney Tubules, Proximal; Losartan; Peptides; Plasminogen Activator Inhibitor 1; Protease Inhibitors; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Tissue Plasminogen Activator; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator | 1999 |
Angiotensin II stimulates expression of transforming growth factor beta receptor type II in cultured mouse proximal tubular cells.
Topics: Angiotensin II; Animals; Binding, Competitive; Blotting, Northern; Blotting, Western; Cell Line; Fibrosis; Fluorescent Antibody Technique; Genes, Reporter; Humans; Kidney Diseases; Kidney Tubules, Proximal; Kinetics; Mice; Receptors, Transforming Growth Factor beta; Transfection | 1999 |
Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy.
Topics: Actins; Angiotensin II; Animals; Antigens, CD; Collagen; Fibrosis; Immunohistochemistry; Kidney; Kidney Tubules; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; NF-kappa B; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; Tumor Necrosis Factor-alpha; Ureteral Obstruction | 1999 |
Hypertension and renal injury in experimental polycystic kidney disease.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Enalapril; Fibrosis; Hydralazine; Hypertension, Renal; Kidney Glomerulus; Male; Polycystic Kidney, Autosomal Dominant; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Vasoconstrictor Agents | 1999 |
Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Antibodies; Apoptosis; Blotting, Western; Captopril; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibrosis; Flow Cytometry; Gene Expression; Humans; Peptidyl-Dipeptidase A; Pulmonary Alveoli; Saralasin | 1999 |
Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction.
Topics: Adenocarcinoma; Amino Acid Chloromethyl Ketones; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Antibodies; Antisense Elements (Genetics); Apoptosis; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; fas Receptor; Fibrosis; Gene Expression; Humans; Lisinopril; Lung Neoplasms; Male; Membrane Glycoproteins; Neutralization Tests; Peptidyl-Dipeptidase A; Pulmonary Alveoli; Rats; Rats, Wistar; Receptors, Angiotensin; Renin-Angiotensin System; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured | 1999 |
Angiotensin II type 1 receptor blockade prevents cardiac remodeling in bradykinin B(2) receptor knockout mice.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Female; Fibrosis; Heart Failure; Heart Rate; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Knockout; Myocardium; Nicotinic Acids; Organ Size; Phenotype; Pregnancy; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B2; Receptors, Bradykinin; Tetrazoles | 2000 |
Angiotensin II has multiple profibrotic effects in human cardiac fibroblasts.
Topics: Adolescent; Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Cell Adhesion; Cell Adhesion Molecules; Cell Division; Extracellular Matrix; Fibroblasts; Fibrosis; Heart; Humans; Middle Aged; Myocardium; Plasminogen Activator Inhibitor 1; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Transforming Growth Factor beta | 2000 |
Effect of maximal reduction of angiotensin in renal fibrosis: bad news-good news from a pediatric mouse.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Animals; Disease Models, Animal; Fibrosis; Kidney Diseases; Mice; Plasminogen Activator Inhibitor 1; Renin-Angiotensin System; Transforming Growth Factor beta; Ureteral Obstruction | 2000 |
Is angiotensin II's role in fibrosis as easy as PAI(-1)?
Topics: Angiotensin II; Animals; Fibrosis; Kidney; Kidney Failure, Chronic; Plasminogen Activator Inhibitor 1 | 2000 |
Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathies; Cells, Cultured; Collagen; Cricetinae; Extracellular Matrix; Fibroblasts; Fibrosis; Hepatocyte Growth Factor; Humans; Imidazoles; In Vitro Techniques; Male; Matrix Metalloproteinase 1; Muscle Fibers, Skeletal; Myocardium; Olmesartan Medoxomil; Rats; Tetrazoles; Thiazepines; Ventricular Remodeling | 2000 |
A DNA element in the alpha1 type III collagen promoter mediates a stimulatory response by angiotensin II.
Topics: Angiotensin II; Animals; Base Sequence; Cells, Cultured; Collagen; Extracellular Matrix Proteins; Fibrosis; Gene Expression; Genetic Complementation Test; Heart Diseases; Kidney Diseases; Molecular Sequence Data; Muscle Fibers, Skeletal; Mutagenesis, Site-Directed; Myocardium; Plasmids; Promoter Regions, Genetic; Proteinuria; Rats; RNA, Messenger; Transcription Factors; Transfection; Vasoconstrictor Agents | 2000 |
Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Blotting, Northern; Creatinine; Disease Progression; Fibrosis; Gene Expression; Glomerulosclerosis, Focal Segmental; In Situ Hybridization; Kidney Glomerulus; Male; Mineralocorticoid Receptor Antagonists; Plasminogen Activator Inhibitor 1; Proteinuria; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spironolactone | 2000 |
Renal fibrosis in mice treated with human recombinant transforming growth factor-beta2.
Topics: Angiotensin II; Animals; Corrosion Casting; Endothelin-1; Fibrosis; Glomerular Filtration Rate; Humans; Hypoxia; Ischemia; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Procollagen; Recombinant Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta2; Vasoconstriction | 2000 |
Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal rat.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Body Weight; Cardiovascular System; Collagen; Cyclic GMP; DNA; Drinking; Enalapril; Fibrosis; Losartan; Male; Myocardium; NADPH Dehydrogenase; Rats; Rats, Wistar; Reference Values; Systole; Time Factors | 2000 |
Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat.
Topics: Angiotensin II; Animals; Blood Pressure; Fibrosis; Furosemide; Gene Transfer Techniques; Genetic Therapy; Genotype; Hypertension; Kidney Glomerulus; Kidney Medulla; Kidney Tubules; Necrosis; Norepinephrine; Proteinuria; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Renal Artery; Renin; Sclerosis; Sodium Chloride; Sodium, Dietary; Vascular Resistance | 2001 |
Role of myocytes in myocardial collagen production.
Topics: Angiotensin II; Animals; Animals, Newborn; Cells, Cultured; Coculture Techniques; Collagen; Fibroblasts; Fibrosis; Heart; Myocardium; Perfusion; Rats; Rats, Inbred WKY; RNA, Messenger; Up-Regulation | 2001 |
Effect of N-acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Division; Cells, Cultured; Collagen; DNA; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; Humans; Hypertension; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; Oligopeptides; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System | 2001 |
Contributions of angiotensin II and tumor necrosis factor-alpha to the development of renal fibrosis.
Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antigens, CD; Collagen; Enalapril; Enzyme-Linked Immunosorbent Assay; Fibrosis; Kidney; Lymphotoxin-alpha; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Muscle, Smooth; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; Tumor Necrosis Factor-alpha; Ureteral Obstruction | 2001 |
Induction of cardiac fibrosis by angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Benzoates; Cells, Cultured; Collagen; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Lisinopril; Male; Myocardium; Rats; Rats, Wistar; Telmisartan; Time Factors; Transforming Growth Factor beta | 2000 |
Influence of the renin-angiotensin system on epidermal growth factor expression in normal and cyclosporine-treated rat kidney.
Topics: Angiotensin II; Animals; Apoptosis; Blood Pressure; Cyclosporine; Diet, Sodium-Restricted; Epidermal Growth Factor; Fibrosis; Immunohistochemistry; In Situ Nick-End Labeling; Kidney Glomerulus; Losartan; Male; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System | 2001 |
The expression of AT1 receptor on hepatic stellate cells in rat fibrosis induced by CCl4.
Topics: Alanine Transaminase; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cells, Cultured; Enalapril; Fibrosis; Immunohistochemistry; Liver; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Renin-Angiotensin System | 2001 |
Molecular interactions of vasoactive systems in cardiovascular damage.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin Receptor Antagonists; Enzyme Precursors; Fibrosis; Heart; Humans; Hypertension; Kallikrein-Kinin System; Kallikreins; Kidney; Kinins; Myocardium; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Bradykinin; Renin; Renin-Angiotensin System; Signal Transduction | 2001 |
Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by transforming growth factor beta and angiotensin II.
Topics: Actins; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Collagen; Colon; Diet, Sodium-Restricted; Fibroblasts; Fibrosis; Male; Radiation Injuries; Rats; Rats, Wistar; Receptors, Transforming Growth Factor beta; Sodium, Dietary; Transforming Growth Factor beta | 2002 |
Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy.
Topics: Angiotensin II; Animals; Blood Vessels; Cardiomyopathy, Dilated; Cricetinae; Disease Models, Animal; Fibroblasts; Fibrosis; Gene Expression Regulation; Genetic Therapy; Hepatocyte Growth Factor; Humans; Injections, Intramuscular; Mesocricetus; Plasmids; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; RNA, Messenger; Transcription Factors; Transforming Growth Factor beta | 2002 |
Reactive and reparative myocardial fibrosis in arterial hypertension in the rat.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomegaly; Collagen; Disease Models, Animal; Fibrosis; Hypertension, Renovascular; Male; Myocardium; Rats; Rats, Sprague-Dawley; Sodium, Dietary; Spironolactone | 1992 |
Remodeling of the rat right and left ventricles in experimental hypertension.
Topics: Aldosterone; Angiotensin II; Animals; Cardiomegaly; Collagen; Fibrosis; Heart Ventricles; Hemodynamics; Hypertension; Hypertension, Renovascular; Male; Rats; Rats, Inbred Strains; Staining and Labeling | 1990 |
Cardiac myocyte necrosis induced by angiotensin II.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Blood Pressure; Captopril; Cardiomegaly; DNA; Fibrosis; Heart; Ligation; Male; Myocardium; Necrosis; Rats; Rats, Inbred Strains; Sympatholytics; Vasoconstriction | 1991 |
[A trial diagnosis of latent dilated cardiomyopathy].
Topics: Angiotensin II; Cardiomyopathy, Dilated; Echocardiography; Evaluation Studies as Topic; Exercise Test; Fibrosis; Humans; Hypertrophy; Myocardium | 1987 |