angiotensin ii has been researched along with Aortic Aneurysm, Thoracic in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (6.52) | 29.6817 |
| 2010's | 28 (60.87) | 24.3611 |
| 2020's | 15 (32.61) | 2.80 |
| Authors | Studies |
|---|---|
| Ageedi, W; Coselli, JS; Dawson, A; Frankel, WC; LeMaire, SA; Li, Y; Shen, HY; Zhang, C | 1 |
| Asano, K; Cantalupo, A; Ramirez, F; Sedes, L | 1 |
| Assi, R; Caulk, AW; He, C; Humphrey, JD; Jiang, B; Li, G; Lovoulos, CJ; Murtada, SI; Qin, L; Ren, P; Schwartz, MA; Tellides, G; Wang, M | 1 |
| Avril, S; Bersi, MR; Humphrey, JD; Long, AS; Tellides, G; Weiss, D | 1 |
| Daugherty, A; Franklin, MK; Howatt, DA; Lu, HS; Moorleghen, JJ; Mullick, AE; Ohno-Urabe, S; Sawada, H; Ye, D | 1 |
| Atchison, DK; Bergin, IL; Bitzer, M; Converso-Baran, K; Ganesh, SK; Hartman, JR; Ju, W; O'Connor, CL; Smrcka, AV; Wang, Y; Zhang, H | 1 |
| Chiminazzo, V; Del Río-García, Á; López-Larrea, C; Martín, M; Mohamedi, Y; Rodrigues-Díez, RR; Rodríguez, I; Ruiz-Ortega, M; Suárez-Álvarez, B; Tejera-Muñoz, A | 1 |
| Ballasy, NN; Belke, D; Fedak, PWM; Gomes, KP; Jadli, AS; Mackay, CDA; Meechem, M; Patel, VB; Thompson, J; Wijesuriya, TM | 1 |
| Pan, Y; Zha, Z; Zheng, Z; Zhou, M | 1 |
| Quan, X; Xie, Z; Zhang, L; Zhao, J; Zhao, Z | 1 |
| Chen, HZ; Chen, YN; Ding, YN; Hao, DL; Liu, DP; Lv, SJ; Sun, LH; Tang, X; Wang, HP; Wang, HY; Wang, L; Wang, TT; Wang, XM; Wei, ZY; Xu, HS; Yao, F; Zhang, ZQ; Zhao, X; Zhou, Z | 1 |
| Hong, X; Jin, L; Liu, Y; Zhao, HM | 1 |
| Chen, L; Chen, X; Hou, Y; Hu, Y; Lin, Y; Lv, X | 1 |
| Cui, M; Fu, X; Liang, K; Ma, J; Zhai, S; Zhang, D; Zhang, K | 1 |
| Dong, N; Klenotic, PA; Li, R; Lin, Z; Narla, G; Wang, Y; Wei, W; Xie, F; Xu, Q; Zhang, C; Zhou, X | 1 |
| Airhart, N; Angelov, SN; Dichek, DA; Hu, JH; Shi, M; Wei, H | 1 |
| Aslanidou, L; Fraga-Silva, RA; Piersigilli, A; Segers, P; Sordet-Dessimoz, J; Stampanoni, MFM; Stergiopulos, N; Trachet, B; Villanueva-Perez, P | 1 |
| Coselli, JS; Curci, JA; Hughes, M; Krishnamoorthy, S; LeMaire, SA; Milewicz, DM; Ren, P; Shen, YH; Wu, D; Zhang, C; Zhang, L; Zou, S | 1 |
| Chen, J; Deng, P; Ding, X; Huang, X; Ren, L; Wang, K; Wang, S; Wu, C; Wu, J; Xia, J; Ye, P; Yue, Z; Zhang, A | 1 |
| Baig, F; Barallobre-Barreiro, J; Barwari, T; Catibog, N; Didangelos, A; Fava, M; Jahangiri, M; Joshi, A; Lu, R; Lynch, M; Mayr, M; Mayr, U; Yin, X | 1 |
| Fujiwara, T; Hara, H; Kanaya, T; Komuro, I; Maemura, S; Takeda, N | 1 |
| Channon, KM; Douglas, G; Hale, AB; Kerr, AG; Patel, J | 1 |
| Milewicz, DM; Ramirez, F | 1 |
| Hirata, Y; Kitagawa, T; Kurobe, H; Matsuoka, Y; Maxfield, MW; Sata, M; Sugasawa, N | 1 |
| Bavaria, JE; Branchetti, E; Ferrari, G; Gorman, JH; Gorman, RC; Grau, JB; Jackson, BM; Lai, EK; Parmacek, MS; Poggio, P; Sainger, R; Shang, E | 1 |
| Anzai, A; Endo, J; Fukuda, K; Ito, K; Katsumata, Y; Kohno, T; Matsuhashi, T; Okada, Y; Sano, M; Shimizu-Hirota, R; Shimoda, M; Shinmura, K; Shirakawa, K; Ueha, S; Yamada, Y; Yamamoto, T; Yan, X | 1 |
| Basu, R; Fan, D; Kassiri, Z; Lee, J; Sakamuri, SS; Shen, M; Wang, X | 1 |
| Chang, Q; Guo, X; Liu, P; Liu, W; Pei, H; Qian, X; Sun, X; Wang, C | 1 |
| Alfranca, A; Arroyo, AG; Camafeita, E; Denhardt, DT; García-Redondo, AB; Guo, D; Martín-Alonso, M; Martínez, F; Méndez-Barbero, N; Milewicz, D; Pollán, Á; Redondo, JM; Salaices, M; Sánchez-Camacho, C; Seiki, M; Vázquez, J | 1 |
| Balakrishnan, A; Cassis, LA; Daugherty, A; Howatt, DA; Lu, H; Moorleghen, JJ; Rateri, DL | 1 |
| Balakrishnan, A; Cassis, LA; Chen, X; Daugherty, A; Howatt, DA; Moorleghen, JJ; Rateri, DL | 1 |
| Bachner-Hinenzon, N; Ben-Zvi, D; Cao, X; Fisch, S; Gertler, A; Kachel, E; Kolodgie, F; Kotev Emeth, S; Lavee, J; Raanani, E; Savion, N; Schäfer, K; Schneiderman, J; Schoen, FJ; Simon, A; Solomon, G; Virmani, R | 1 |
| Du, J; Jia, L; Lan, F; Liu, Y; Piao, C; Ren, W; Wang, X | 1 |
| Chiba, Y; Imanishi, M; Matsunaga, S; Nakagawa, T; Tamaki, T; Tomita, N; Tomita, S; Ueno, M; Yamamoto, K | 1 |
| Milewicz, DM; Prakash, SK; Ramirez, F | 1 |
| Coselli, JS; Curci, JA; LeMaire, SA; Lloyd, EE; Milewicz, DM; Ren, P; Shen, YH; Wu, D; Xie, W; Xu, G; Zhang, L; Zhang, Q; Zhang, S; Zheng, Y | 1 |
| Gopal, K; Jahan, P; Kumar, K; Kumar, MJ; Nandini, R | 1 |
| Hashimoto, T; Kanematsu, M; Kanematsu, Y; Kurihara, C; Liang, EI; Makino, H; Nuki, Y; Tsou, TL | 1 |
| Chang, EI; Ikonomidis, JS; Jones, JA; Koval, C; Sheats, N; Spinale, FG; Stroud, RE; Zavadzkas, JA | 1 |
| Dong, XR; Hoglund, VJ; Majesky, MW | 1 |
| Bruemmer, D; Daugherty, A; Lu, H; Rateri, DL | 1 |
| Coselli, JS; LeMaire, SA; Nguyen, MT; Ren, P; Shen, YH; Wang, XL; Wu, D; Zhang, L; Zou, S | 1 |
| Hamano, K; Ikeda, Y; Mikamo, A; Nagasawa, A; Suzuki, R; Tsuchida, M; Yamashita, O; Yoshimura, K | 1 |
| Ayabe, N; Babaev, VR; Fazio, S; Fogo, AB; Ichikawa, I; Kon, V; Linton, MF; Tang, Y; Tanizawa, T | 1 |
| Brasier, AR; Buja, LM; Estrera, AL; Guo, D; Liu, Y; Marian, AJ; Milewicz, DM; Pannu, H; Papke, CL; Presley, C; Raman, CS; Safi, HJ; Scherer, S; Tran-Fadulu, V; Vick, GW | 1 |
| Cassis, LA; Daugherty, A; Lu, H; Rateri, DL | 1 |
6 review(s) available for angiotensin ii and Aortic Aneurysm, Thoracic
| Article | Year |
|---|---|
Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Thoracic; Aortic Dissection; Humans; Marfan Syndrome; Mice | 2022 |
TGF-β Signaling-Related Genes and Thoracic Aortic Aneurysms and Dissections.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Fibrillin-1; Humans; Loeys-Dietz Syndrome; Signal Transduction; Transforming Growth Factor beta | 2018 |
Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections.
Topics: Acute Disease; Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Humans; Losartan; Mice; Signal Transduction; Transforming Growth Factor beta | 2019 |
Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aortic Aneurysm, Thoracic; Aortic Dissection; Disease Models, Animal; Genetic Predisposition to Disease; Humans; Losartan; Marfan Syndrome; Mechanoreceptors; Mice; Muscle, Smooth, Vascular; Signal Transduction; Transforming Growth Factor beta | 2017 |
Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Disease Models, Animal; Humans; Mice; Renin-Angiotensin System; Species Specificity | 2011 |
The role of the renin-angiotensin system in aortic aneurysmal diseases.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Humans; Mice; Renin-Angiotensin System; Risk Factors | 2008 |
40 other study(ies) available for angiotensin ii and Aortic Aneurysm, Thoracic
| Article | Year |
|---|---|
AIM2 Inflammasome Activation Contributes to Aortic Dissection in a Sporadic Aortic Disease Mouse Model.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Caspase 1; Disease Models, Animal; DNA-Binding Proteins; Humans; Inflammasomes; Mice; Mice, Inbred C57BL | 2022 |
mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice.
Topics: Aneurysm, False; Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Aortic Rupture; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; MTOR Inhibitors; RNA; TOR Serine-Threonine Kinases | 2022 |
Evolving Mural Defects, Dilatation, and Biomechanical Dysfunction in Angiotensin II-Induced Thoracic Aortopathies.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Biomechanical Phenomena; Collagen; Dilatation; Dilatation, Pathologic; Mice | 2022 |
Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile-Induced Thoracic Aortopathy in Mice-Brief Report.
Topics: Aminopropionitrile; Angiotensin II; Angiotensinogen; Animals; Aortic Aneurysm, Thoracic; Aortic Rupture; Dilatation, Pathologic; Disease Models, Animal; Irbesartan; Losartan; Lysine; Male; Mice; Mice, Inbred C57BL; Protein-Lysine 6-Oxidase; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System | 2022 |
Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.
Topics: Aneurysm, Ascending Aorta; Angiotensin II; Animals; Aortic Aneurysm; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortic Valve Insufficiency; Death, Sudden; Humans; Hypertension; Mice; Mice, Inbred C57BL | 2022 |
The CCN2 Polymorphism rs12526196 Is a Risk Factor for Ascending Thoracic Aortic Aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Bicuspid Aortic Valve Disease; Humans; Mice; Retrospective Studies; Risk Factors | 2022 |
Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm.
Topics: Angiotensin I; Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Phenotype | 2022 |
Cordycepin suppresses vascular inflammation, apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Apoptosis; Calcium Chloride; Humans; Inflammation; Interleukin-6; Myocytes, Smooth Muscle; Oxidative Stress; Rats; Vascular Endothelial Growth Factor A | 2023 |
Circ_0008285 silencing suppresses angiotensin II-induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via miR-150-5p/BASP1 axis.
Topics: Angiotensin II; Aortic Aneurysm, Thoracic; Apoptosis; Cell Proliferation; Humans; Membrane Proteins; MicroRNAs; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Repressor Proteins; RNA, Circular | 2023 |
SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Epigenesis, Genetic; Humans; Inflammation; Mice; Sirtuins | 2023 |
Changes in expressions of miR-22-3p and MMP-9 in rats with thoracic aortic aneurysm and their significance.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Female; Matrix Metalloproteinase 9; MicroRNAs; Rats; Rats, Sprague-Dawley | 2020 |
Establishment and effect evaluation of an aortic dissection model induced by different doses of β-aminopropionitrile in rats.
Topics: Aminopropionitrile; Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Magnetic Resonance Imaging; Male; Rats, Sprague-Dawley; Time Factors; Vascular Remodeling | 2021 |
LncRNA Xist induces arterial smooth muscle cell apoptosis in thoracic aortic aneurysm through miR-29b-3p/Eln pathway.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Cell Line; Elastin; Humans; Mice; MicroRNAs; Muscle, Smooth, Vascular; Rats; RNA, Long Noncoding; Signal Transduction | 2021 |
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.
Topics: Allosteric Regulation; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Case-Control Studies; Dilatation, Pathologic; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Extracellular Signal-Regulated MAP Kinases; Humans; Macrophages; Male; Mice; Mice, Knockout, ApoE; NF-kappa B; Protein Phosphatase 2; RAW 264.7 Cells; Vascular Remodeling | 2021 |
TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms.
Topics: Adventitia; Angiotensin II; Animals; Antibodies; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Dilatation, Pathologic; Disease Models, Animal; Female; Genetic Predisposition to Disease; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Phenotype; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Tunica Media; Vascular Remodeling | 2017 |
Angiotensin II infusion into ApoE-/- mice: a model for aortic dissection rather than abdominal aortic aneurysm?
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortography; Computed Tomography Angiography; Disease Models, Animal; Disease Progression; Hematoma; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Time Factors; Ultrasonography, Doppler, Pulsed; Vascular Remodeling; X-Ray Microtomography | 2017 |
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Topics: ADAMTS4 Protein; Aged; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Thoracic; Aortic Dissection; Apoptosis; Diet, High-Fat; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocytes, Smooth Muscle; Proteolysis; Versicans | 2017 |
MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortic Rupture; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Genetic Predisposition to Disease; JNK Mitogen-Activated Protein Kinases; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Phosphorylation; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta | 2018 |
Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling.
Topics: ADAMTS1 Protein; ADAMTS5 Protein; Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Extracellular Matrix; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, LDL; Tumor Suppressor Proteins; Vascular Remodeling; Versicans | 2018 |
Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Aortitis; Atherosclerosis; Bone Marrow Transplantation; Disease Models, Animal; Macrophages; Male; Mice, Knockout, ApoE; Monocytes; Plaque, Atherosclerotic; Whole-Body Irradiation | 2018 |
Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects.
Topics: Aminopropionitrile; Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Disease Progression; Inflammation Mediators; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Sirtuin 1; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Connective Tissue Growth Factor; ets-Domain Protein Elk-1; Finite Element Analysis; Humans; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Phenotype; Reactive Oxygen Species; Serum Response Factor; Vimentin | 2013 |
Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.
Topics: Acute Disease; Adventitia; Aged; Aminopropionitrile; Angiotensin II; Animals; Antibodies, Monoclonal; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortic Rupture; Aortography; Chemokine CXCL1; Chemokine CXCL12; Chemotaxis, Leukocyte; Dilatation, Pathologic; Disease Models, Animal; Female; Granulocyte Colony-Stimulating Factor; Humans; Inflammation Mediators; Interleukin-6; Interleukin-8; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Neutrophil Activation; Neutrophil Infiltration; Neutrophils; Receptors, Interleukin-8B; Signal Transduction; Time Factors | 2015 |
Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Calcium Chloride; Cells, Cultured; Collagen; Dilatation, Pathologic; Disease Models, Animal; Elastin; Genotype; Male; Matrix Metalloproteinase 2; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; RNA, Messenger; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Ultrasonography; Vascular Remodeling | 2015 |
Angiotensin II Induces an Increase in Matrix Metalloproteinase 2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic Aneurysms Through JNK, ERK1/2, and p38 MAPK Activation.
Topics: Adult; Aged; Angiotensin II; Aorta; Aortic Aneurysm, Thoracic; Cells, Cultured; Dose-Response Relationship, Drug; Female; Humans; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Primary Cell Culture; Up-Regulation | 2015 |
Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.
Topics: Adult; Amino Acid Substitution; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortic Rupture; Extracellular Matrix; Extracellular Matrix Proteins; Genetic Predisposition to Disease; Genetic Therapy; Genetic Vectors; HEK293 Cells; Humans; Lentivirus; Male; Matrix Metalloproteinases, Membrane-Associated; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Mutation, Missense; Osteopontin; Protein Conformation | 2015 |
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Apolipoproteins E; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Infusion Pumps, Implantable; Male; Mice; Mice, Transgenic | 2015 |
TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Male; Mice; Mice, Inbred C57BL; Transforming Growth Factor beta | 2016 |
Local Application of Leptin Antagonist Attenuates Angiotensin II-Induced Ascending Aortic Aneurysm and Cardiac Remodeling.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Aortic Valve; Aortic Valve Stenosis; Cell Proliferation; Cells, Cultured; Female; Humans; Hypertrophy, Left Ventricular; Leptin; Male; Mice; Mice, Knockout, ApoE; Middle Aged; Vascular Stiffness; Vasoconstrictor Agents; Ventricular Remodeling; Young Adult | 2016 |
β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice.
Topics: Actins; Aminopropionitrile; Angiotensin II; Animals; Aortic Aneurysm, Thoracic; Blood Pressure; Body Weight; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Myosin Heavy Chains; Phenotype | 2016 |
Hypoxia-Inducible Factor-1α in Smooth Muscle Cells Protects Against Aortic Aneurysms-Brief Report.
Topics: Aminopropionitrile; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Elastic Tissue; Genetic Predisposition to Disease; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Protein-Lysine 6-Oxidase; Tropoelastin; Vascular Remodeling | 2016 |
NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Dissection; Biomechanical Phenomena; Caspase 1; Cells, Cultured; Disease Models, Animal; Female; Genetic Predisposition to Disease; Glyburide; Humans; Inflammasomes; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NLR Family, Pyrin Domain-Containing 3 Protein; Phenotype; Proteolysis; Vasoconstriction | 2017 |
High fat diet containing cholesterol induce aortic aneurysm through recruitment and proliferation of circulating agranulocytes in apoE knock out mice model.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Apolipoproteins E; Biomarkers; Blood Pressure; Cell Movement; Cell Proliferation; Chemokine CCL2; Cholesterol, Dietary; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation; Granulocytes; Hypercholesterolemia; Intercellular Adhesion Molecule-1; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Time Factors; Vascular Cell Adhesion Molecule-1; Weight Gain | 2010 |
Pharmacologically induced thoracic and abdominal aortic aneurysms in mice.
Topics: Aminopropionitrile; Amlodipine; Angiotensin II; Animals; Antihypertensive Agents; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Pressure; Desoxycorticosterone; Humans; Hypertension; Male; Mice; Mice, Inbred C57BL; Mineralocorticoids; Protein-Lysine 6-Oxidase | 2010 |
Cellular phenotype transformation occurs during thoracic aortic aneurysm development.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Calcium Chloride; Cells, Cultured; Disease Models, Animal; Disease Progression; Endothelin-1; Extracellular Matrix Proteins; Female; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Genotype; Male; Mice; Mice, Inbred C57BL; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate | 2010 |
Parsing aortic aneurysms: more surprises.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Cell Communication; Disease Models, Animal; Endothelial Cells; Incidence; Macrophages; Mice; Mice, Knockout; Mice, Mutant Strains; Mutation; Myocytes, Smooth Muscle; Receptor, Angiotensin, Type 1; Receptors, LDL | 2011 |
AKT2 confers protection against aortic aneurysms and dissections.
Topics: Aged; Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortitis; Apoptosis; Case-Control Studies; Cells, Cultured; Elastic Tissue; Enzyme Induction; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocytes, Smooth Muscle; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Tissue Inhibitor of Metalloproteinase-1 | 2013 |
Important role of the angiotensin II pathway in producing matrix metalloproteinase-9 in human thoracic aortic aneurysms.
Topics: Angiotensin II; Aortic Aneurysm, Thoracic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Smad2 Protein; Transforming Growth Factor beta; Up-Regulation | 2013 |
Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Apolipoproteins E; Atherosclerosis; Chemokine CCL2; Disease Models, Animal; Female; Follow-Up Studies; Hyperlipidemias; Immunohistochemistry; Infusions, Intravenous; Mice; Mice, Inbred C57BL; Receptors, CCR2; Receptors, Chemokine; RNA | 2006 |
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.
Topics: Adult; Amino Acid Sequence; Angiotensin II; Aortic Aneurysm, Thoracic; Child, Preschool; Ductus Arteriosus, Patent; Female; Genetic Testing; Humans; Insulin-Like Growth Factor I; Male; Middle Aged; Models, Molecular; Molecular Sequence Data; Mutation; Myosin Heavy Chains; Pedigree; Sequence Homology, Amino Acid; Vascular Diseases | 2007 |