angiotensin ii has been researched along with Aortic Aneurysm, Abdominal in 439 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (0.23) | 18.2507 |
2000's | 54 (12.30) | 29.6817 |
2010's | 259 (59.00) | 24.3611 |
2020's | 125 (28.47) | 2.80 |
Authors | Studies |
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Azuma, K; Goto, H; Masuyama, A; Mita, T; Mitsumata, M; Miyatsuka, T; Mochida, A; Nakajima, K; Nishida, Y; Osonoi, Y; Watada, H | 1 |
Bin, J; Cai, D; Chen, Y; Li, C; Liao, W; Liao, Y; Lin, Z; Ma, Y; Shi, X; Song, H; Sun, Y; Wei, G; Yang, Y; Zheng, H; Zhong, L | 1 |
Becares, M; Bermeo, H; Briones, AM; García-Redondo, AB; González-Amor, M; Guerra, S; Jorge, I; Martínez-González, J; Montezano, AC; Redondo, JM; Rios, FJ; Rodrigues-Díez, R; Rodríguez, C; Ruiz-Rodríguez, MJ; Salaices, M; Touyz, RM; Vázquez, J; Zalba, G | 1 |
Agic, MB; Kunath, A; Mani, K; Näsström, M; Petri, MH; Ramilo, AB; Wågsäter, D; Wanhainen, A | 1 |
Bian, H; Cho, K; Han, N; Jiang, B; Li, X; Wang, L; Wang, Y; Wu, P; Yin, J; Zhang, X; Zhang, Y | 1 |
Bai, Y; He, X; Huang, J; Le, T; Liu, S; Wu, K | 1 |
Duan, Z; Li, W; Li, X; Liu, Y; Wang, Z; Xiao, L; Zhong, Z | 1 |
Balboa Ramilo, A; Becirovic-Agic, M; Mani, K; Petri, MH; Wågsäter, D; Wanhainen, A | 1 |
Patrick, AC; Shridas, P; Tannock, LR | 1 |
Chen, X; Liu, X; Lou, J; Tang, L; Weng, Y; Xu, C | 1 |
Cassis, LA; Daugherty, A; Lu (吕红), HS; Sawada (澤田悠), H | 1 |
Agarwal, G; Annex, BH; Benson, TW; Blomkalns, AL; Fujise, K; Fukai, T; Fulton, DJ; Guha, A; Horimatsu, T; Huo, Y; Kim, HW; Lee, R; Long, X; Ogbi, M; Ushio-Fukai, M; Weintraub, NL; Winkler, MA; Young, L | 1 |
Chen, H; Guo, M; Hu, J; Peng, N; Qi, Y; Shen, S; Sun, X; Xu, B; Xu, J; Zhang, Q; Zhang, W; Zhang, Y | 1 |
Chang, WH; Lu, HY; Shih, CC; Wu, TC | 1 |
Li, J; Liao, S; Song, J; Wang, Y; Wei, W; Xu, Y; Xu, Z; Zhu, S | 1 |
Cassis, LA; de Beer, FC; Dugan, AJ; Ji, A; Leung, SW; Noffsinger, VP; Shridas, P; Tannock, LR; Thatcher, SE; Trumbauer, AC; Webb, NR | 1 |
Kraemer, M; Morris, AJ; Smyth, SS; Ubele, M; Van Hoose, PM; Yang, L | 1 |
Ao-Ieong, WS; Chen, CH; Ho, HH; Jiang, WC; Layne, MD; Orekhov, AN; Sobenin, IA; Wang, J; Yet, SF | 1 |
Chacar, S; Fares, N; Hajal, J; Jreije, A; Khouzami, L; Medlej-Hashim, M; Saliba, Y | 1 |
Bao, Y; Cai, C; Chen, X; Du, C; Lou, J; Tang, L; Weng, Y; Zhu, K | 1 |
Gao, A; Guo, X; Su, G; Wang, Z; Yu, F; Yu, L; Zhang, C; Zhang, J; Zhang, M; Zhang, Y | 1 |
Che, X; Chen, L; Chen, T; Geng, N; Lyu, Y; Shao, Q; Sun, L; Tao, Z; Xiao, Q; Zhang, H | 1 |
Ge, X; Lu, Y; Meng, L; Meng, X; Sui, W; Wang, X; Zhang, Y; Zhong, M | 1 |
Chao de la Barca, JM; Eid, M; Fassot, C; Faure, J; Fouquet, O; Henrion, D; Loufrani, L; Reynier, P; Richard, A; Robert, P; Tessier, L; Wetterwald, C | 1 |
Ding, S; Feng, ZH; Geng, N; Guo, X; Huang, L; Lin, GQ; Lin, N; Lyu, YY; Pu, J; Qian, K; Shen, Z; Sun, LY; Wang, YL; Yuan, AC; Zhang, HY; Zhang, L | 1 |
Hong, Y; Li, X; Lin, Y; Yang, H | 1 |
Bailey, MA; Bleichert, S; Brostjan, C; Busch, A; Eilenberg, W; Ibrahim, N; Klopf, J; Neumayer, C; Stiglbauer-Tscholakoff, A | 1 |
Fan, T; Feng, X; Gao, R; Ge, W; Guo, W; Hou, Y; Jin, M; Jing, H; Li, B; Lu, J; Pang, J; Wang, J; Yan, C; Zhang, T | 1 |
Daugherty, A; Hada, Y; Shikata, K; Subramanian, V; Takatsuka, T; Takeuchi, H; Uchida, HA; Umebayashi, R; Wada, J | 1 |
Chang, L; Chang, Z; Chen, YE; Garcia-Barrio, MT; Guo, Y; Liang, W; Lin, JD; Liu, H; Liu, Y; Lu, H; Rom, O; Wang, H; Yang, B; Zhang, J; Zhao, G; Zhao, Y; Zhu, T | 1 |
Alebrahim, D; Attur, M; Byrd, D; Harpel, Z; Lu, C; Maldonado, DJ; Mignatti, P; Pratama, MY; Ramkhelawon, B; Rivera, CF; Silvestro, M; Sleiman Tellaoui, R; Tang, C; Vlahos, J; Zias, AL | 1 |
De Meyer, GRY; De Moudt, S; Fransen, P; Hendrickx, JO; Martinet, W | 1 |
Chai, H; Chen, W; Chen, X; Fan, R; Hu, Y; Huang, F; Jiang, H; Liu, R; Zhou, Y | 1 |
Aono, J; Hamaguchi, M; Ikeda, S; Inoue, K; Kakino, A; Kurata, M; Nakao, Y; Sakaue, T; Sawamura, T; Suehiro, C; Suzuki, J; Takahashi, K; Yamaguchi, O | 1 |
Cai, H; Huang, K; Wu, Y; Youn, JY; Zhang, Y | 1 |
Cai, D; Chen, SY; Murashita, T; Que, X; Sun, C | 1 |
Furuyama, T; Hoshino, T; Kurose, S; Matsubara, Y; Morisaki, K; Yoshino, S; Yoshiya, K; Yoshizumi, T | 1 |
Huang, PH; Lin, SJ; Tsai, HY; Tsai, SH; Wang, JC | 1 |
Cicalese, SM; Eguchi, S; Hashimoto, T; Okuno, K; Rizzo, V; Sparks, MA; Torimoto, K | 1 |
Ding, Q; Du, Y; Li, H; Ma, T; Meng, Q; Sun, D; Zhang, X; Zhang, Z; Zheng, H; Zhuang, J | 1 |
Daugherty, A; Lu, HS; Sawada, H | 1 |
Han, Y; Liu, D; Liu, Y; Tian, X; Yan, C; Zhang, X | 1 |
Almendra-Pegueros, R; Consegal-Pérez, M; Galán, M; Jiménez-Altayó, F; Julve, J; Kassan, M; Martínez-González, J; Navas-Madroñal, M; Pérez, B; Puertas-Umbert, L; Rodriguez, C | 1 |
Cao, Y; Chai, H; Chen, G; Chen, W; Chen, X; Fan, R; Jiang, H; Liu, Y; Qin, W; Qiu, Z; Wang, X; Xu, Y; Yao, Y | 1 |
Guo, R; Li, Y; Tao, L; Xu, Y | 1 |
Chen, CY; Chen, JS; Chen, JW; Huang, PH; Lin, CP; Lin, SJ; Tzeng, IS; Wu, MY | 1 |
Bai, H; Ben, J; Chen, Q; Huang, J; Ji, R; Jia, Y; Jiang, B; Jiang, Y; Li, X; Wang, J; Wang, S; Yang, Q; Zhang, H; Zhou, Z; Zhu, X | 1 |
Chen, D; Du, Y; Du, Z; Hu, C; Jiao, X; Li, F; Li, L; Lv, Q; Qin, Y; Sun, Q; Wang, Y; Yang, Y; Yu, H; Zhang, J; Zhang, X | 1 |
Cai, Q; Davis, FM; Gallagher, KA; Gudjonsson, JE; Henke, PK; Joshi, AD; Mangum, K; Melvin, WJ; Tsoi, LC | 1 |
Ge, Y; Guo, J; Ikezoe, T; Li, Z; Qin, M; Shi, J; Shoji, T; Wang, Y; Xu, B | 1 |
Chen, Y; Lei, C; Li, F; Liu, B; Lv, Y; Song, W; Wu, J; Wu, X; Xie, T; Zheng, Y | 1 |
Chen, X; Fang, X; Jiang, J; Lau, H; Liu, X; Pryke, L; Tang, L; Vyas, P; Xu, B; Xu, C; Yao, L; Yu, L | 1 |
Adam, M; Ahdab, M; Baldus, S; Geißen, S; Guthoff, H; Hof, A; Landerer, M; Mehrkens, D; Mollenhauer, M; Niehues, J; Schäkel, J; Schorscher, M; von Stein, P; Winkels, H; Zimmermann, O | 1 |
Ballasy, NN; Belke, D; Fedak, PWM; Gomes, KP; Jadli, AS; Patel, VB; Wijesuriya, TM | 1 |
Kaga, S; Mori, K; Nakajima, H; Nakamura, S; Ogawa, Y; Okuma, H; Tsuchiya, K; Uchinuma, H | 1 |
Alramahi, A; Berzins, SP; Fang, Y; Golledge, J; Magliano, DJ; Nguyen, DT; Oqueli, E; Parker, K; Pyke, SJR; Sargisson, O; Thihlum, L; Wallace, ME; Wang, Y | 1 |
Alsac, JM; Arock, M; Caligiuri, G; Castier, Y; Clément, M; Coscas, R; Delbosc, S; Deschamps, L; Deschildre, C; Eggel, A; Even, G; Gaston, AT; Gautier, G; Guedj, K; Launay, P; Le Borgne, M; Loste, A; Louedec, L; Michel, JB; Morvan, M; Nicoletti, A; Procopio, E; Sénémaud, J | 1 |
Cao, M; Chen, X; Ding, J; Liao, M; Liao, Y; Qiu, Z; Wang, M; Wang, Y; Wu, H; Yan, X; Zhang, H; Zheng, J; Zhou, Y | 1 |
Dev, R; Dhakal, P; Guerau-de-Arellano, M; Hans, CP; Kuivaniemi, H; Partida-Sanchez, S; Ruiz-Rosado, JD; Sharma, N | 1 |
Da, J; Jin, X; Li, D; Li, G; Mi, L; Wang, Z; Xue, M | 1 |
Cheng, C; Cheng, J; Li, H; Lu, L; Ma, J; Sui, W; Xu, J; Xu, X; Xue, F; Yang, J; Zhang, C; Zhang, J; Zhang, M; Zhang, Y | 1 |
Aghayev, T; Eguchi, S; Fatkhullina, AR; Gankovskaya, LV; Khoreva, MV; Koltsova, EK; Kossenkov, AV; Makhov, P; Peshkova, IO; Sykes, SM; Tan, YF; Titerina, EK | 1 |
Golledge, J; Huynh, P; Jose, RJ; Krishna, SM; Lazzaroni, S; Moran, CS | 1 |
Ailawadi, G; Cullen, JM; Fashandi, AZ; Hawkins, RB; Lu, G; Mast, A; Montgomery, W; Salmon, M; Sharma, AK; Spinosa, M; Su, G; Upchurch, GR | 1 |
Agarwal, G; Ahmadieh, S; Benjamin, S; Benson, TW; Blomkalns, AL; Edgell, A; Fulton, DJ; Gilreath, N; Horimatsu, T; Huo, Y; Kim, D; Kim, HW; Mann, A; Moses, M; Offermanns, S; Ogbi, M; Patel, S; Pye, J; Reid, L; Robbins, N; Singh, N; Stansfield, BK; Thompson, A; Weintraub, NL | 1 |
Dweck, MR; Fletcher, AJ; Syed, MBJ | 1 |
Cicalese, S; Eguchi, S; Okuno, K | 1 |
Cao, XR; Dong, B; Dong, XF; Hei, NH; Kong, J; Li, JL; Ma, H; Wang, YL | 1 |
Ding, R; Hu, Y; Li, Q; Liu, Z; Lu, W; Xiao, H; Xie, D; Xie, J; Ye, B; Zheng, G; Zhong, L; Zhong, Y; Zhong, Z | 1 |
Chang, CW; Hsu, JH; Kuo, CH; Lai, CH; Lee, FT; Liu, CP; Wu, HL; Yeh, JL | 1 |
Cao, XR; Dong, B; Hei, NH; Li, JL; Ma, H; Wang, YL; Yan, WJ | 1 |
Cheng, Z; Fu, XM; Li, JM; Liao, XB; Peng, HL; Wu, QY; Zhang, GS; Zhao, Y; Zhou, XM; Zhou, YZ | 1 |
Li, H; Li, S; Liu, G; Shen, G; Sun, Q; Wang, H; Xu, Y; Yao, Y; Yuan, C | 1 |
Cheng, K; Cheng, Z; Yao, Y | 1 |
Liu, Z; Shen, J; Yin, L; Yue, J | 1 |
Cai, Z; Chen, Y; Fang, W; Fu, Y; Kong, W; Li, L; Li, Z; Sun, Y; Wang, L; Yang, L; Yao, F; Zhao, Z; Zhou, Y; Zhu, H | 1 |
Li, L; Li, Y; Ma, W; Pan, S; Shi, X; Tian, Y; Wang, H; Xu, C | 1 |
Biros, E; Golledge, J; Kleinschnitz, C; Krishna, SM; Moran, CS; Morton, SK; Panousis, C; Seto, SW | 1 |
Breyer, RM; Fujita, T; Goda, M; Hiromi, T; Ichikawa, Y; Ishikawa, Y; Ishiwata, R; Kurotaki, D; Mamun, A; Masuda, M; Minami, T; Nishihara, H; Suzuki, S; Takeuchi, I; Tamura, T; Uchida, K; Umemura, M; Yasuda, S; Yokoyama, U | 1 |
Chen, L; FitzGerald, GA; Jiang, T; Monslow, J; Puré, E; Tang, SY; Todd, L; Yang, G; Zhang, J | 1 |
Agarwal, G; Albert, B; Calomeni, EP; Debski, A; Gadde, N; Go, MR; Hans, CP; Jones, B; Mahajan, A; Sharma, N; Tonniges, JR; Yeung, DA | 1 |
Chang, L; Chang, Z; Chen, YE; Fan, Y; Garcia-Barrio, MT; Guo, Y; Liang, W; Lu, H; Rom, O; Sun, J; Wang, H; Xiong, W; Zhang, J; Zhao, G; Zhao, Y; Zhu, T | 1 |
Choi, ET; Cicalese, S; Cooper, HA; Eguchi, S; Kasahara, S; Kawai, T; Okuno, K; Otaka, N; Preston, KJ; Rizzo, V; Scalia, R; Uchida, HA | 1 |
Belenchia, AM; Hans, CP; Pulakat, L; Sharma, N; Toedebusch, R | 1 |
Khalil, RA; Li, L; Li, Y; Ma, W; Pan, S; Wang, B; Wang, H | 1 |
Achilefu, S; Deng, Z; Libby, P; Liu, CL; Liu, T; Liu, X; Nahrendorf, M; Shi, GP; Sukhova, GK; Tang, R; Wang, X; Wang, Y; Wojtkiewicz, GR; Zhang, JY | 1 |
Chen, Z; Li, H; Pan, Y; Wang, G; Zhang, H | 1 |
Bin, J; Feng, X; He, X; Lai, Y; Liao, W; Liao, Y; Song, H; Wei, G; Xu, T; Yang, Y; Zheng, H; Zhong, L | 1 |
Li, L; Li, Y; Ma, W; Pan, S; Pan, Y; Shi, X; Tian, Y; Wang, H; Xu, C | 1 |
Bumdelger, B; Ishida, M; Karasaki, K; Kokubo, H; Otani, M; Sakai, C; Yoshizumi, M | 1 |
Chen, X; Lio, I; Liu, J; Wang, S; Wei, Z; Xiao, J; Yang, C; Zhang, H | 1 |
Grochot-Przęczek, A; Hajduk, K; Józkowicz, A; Klóska, D; Kopacz, A; Neumayer, C; Piechota-Polanczyk, A; Werner, E | 1 |
Brangsch, J; Buchholz, R; Hamm, B; Karst, U; Klopfleisch, R; Kosch, O; Makowski, MR; Mangarova, DB; Mohtashamdolatshahi, A; Paysen, H; Schnorr, J; Taupitz, M; Wiekhorst, F | 1 |
Chen, S; Chen, Y; Cui, L; Li, F; Liu, B; Liu, Z; Shao, J; Yang, D; Zhang, H; Zheng, Y | 1 |
Li, Q; Liu, HL; Liu, X; Ma, D; Shi, WB; Suzuki, T; Wen, JK; Zhang, XH; Zhao, YB; Zheng, B | 1 |
Davis, FM; Obi, AT | 1 |
Cai, Z; Huang, J; Ou, Y; Pan, B; Wang, W; Wang, X; Yang, J; Yang, P | 1 |
Cho, MJ; Jeong, SJ; Jung, IH; Kim, S; Ko, NY; Lee, SH; Min, JK; Oh, GT; Park, JG | 1 |
Clarke, MW; Golledge, J; Krishna, SM; Moran, CS; Morton, SK; Moxon, JV; Nsengiyumva, V; Seto, SW | 1 |
Aslanidou, L; Di Lorenzo, A; Lovric, G; Sasset, L; Stergiopulos, N; Trachet, B | 1 |
Kurashiki, T; Miyake, T; Morishita, R; Nakagami, H; Nishimura, M | 1 |
Chau, LY; Chen, IM; Chen, JW; Chen, YH; Chiang, MT; Hsu, FF; Hsu, YW; Huang, PH; Leu, HB; Liu, FT; Tsai, MS | 1 |
Li, X; Lu, Y; Ma, Q; Tan, H; Tie, Y; Zhang, X | 1 |
Cai, L; Ding, Y; Fu, W; Li, X; Shi, Z; Tang, H; Xie, T; Zhou, M | 1 |
Furuta, M; Ishida, Y; Kimura, A; Kondo, T; Kuninaka, Y; Mukaida, N; Nosaka, M; Taruya, A | 1 |
Ait-Oufella, H; Al-Rifai, R; Boissonnas, A; Boufenzer, A; Bruneval, P; Chinetti, G; Clauser, E; Derive, M; Esposito, B; Giraud, A; Guerin, C; Guyonnet, L; Joffre, J; Lang, S; Lareyre, F; Laurans, L; Mallat, Z; Pinet, F; Raffort, J; Santos-Zas, I; Silvestre, JS; Soulat-Dufour, L; Taleb, S; Tedgui, A; Vandestienne, M; Vilar, J; Zhang, Y | 1 |
Han, Y; Liu, D; Tian, X; Wang, S; Yan, C; Zhang, X | 1 |
Arshad, M; Böckler, D; Dihlmann, S; Hakimi, M; Peters, AS; Wortmann, M | 1 |
Egashira, K; Katsuki, S; Koga, JI; Matoba, T; Nakano, K; Nakashiro, S; Tsutsui, H; Umezu, R | 1 |
Grochot-Przęczek, A; Hajduk, K; Józkowicz, A; Klóska, D; Kopacz, A; Piechota-Polańczyk, A; Werner, E | 1 |
Chen, Y; Du, J; Jia, LX; Jia, MZ; Liu, X; Lu, WW; Ni, XQ; Ning, ZP; Qi, YF; Ren, JL; Tang, CS; Yu, YR; Zhang, LS; Zhang, YR; Zhu, Q | 1 |
Chen, Y; Lai, S; Li, F; Li, Y; Liu, B; Sun, B; Wang, H; Wang, W; Zhang, X; Zheng, Y | 1 |
Gao, P; LeMaire, SA; Long, X; Luo, W; Maegdefessel, L; Miano, JM; Shan, S; Shen, YH; Singer, HA; Slivano, OJ; Tabuchi, A; Zhang, W; Zhao, J | 1 |
Chen, J; Chen, L; Chen, Q; Deng, N; Li, W; Liu, D; Shi, L; Si, X; Song, H; Sun, W; Wang, L; Zhang, J; Zhong, L; Zhou, W | 1 |
Balakrishnan, A; Howatt, DA; Javidan, A; Jiang, W; Moorleghen, JJ; Muniappan, L; Okuyama, M; Saido, TC; Subramanian, V; Thiagarajan, D; Uchida, HA; Yang, L | 1 |
Audu, C; Billi, AC; Daugherty, A; Davis, FM; denDekker, A; Gallagher, KA; Gudjonsson, JE; Joshi, AD; Kunkel, SL; Lu, HS; Melvin, WJ; Moore, BB; Obi, AT; Tsoi, LC; Wasikowski, R; Wolf, S; Xing, X | 1 |
Bruche, S; Channon, KM; Davies, R; Dubé, KN; Fischer, R; Handa, A; Hester, SS; Jones, A; Lee, R; Munshaw, S; Neal, G; Patel, J; Redpath, AN; Sattler, M; Smart, N | 1 |
Dhital, S; Eberth, JF; Hasanain, S; Lane, BA; Lessner, SM; Nosoudi, N; Parasaram, V; Vyavahare, NR; Wang, X | 1 |
Daugherty, A; Howatt, DA; Kukida, M; Lu, HS; Moorleghen, JJ; Ohno-Urabe, S; Poglitsch, M; Sawada, H | 1 |
Boodagh, P; Ghim, M; Gona, K; Graham, M; Han, J; Jung, JJ; Kukreja, G; Liu, X; Rajendran, S; Sadeghi, MM; Salarian, M; Sanzida, N; Toczek, J; Wei, L; Zhang, J | 1 |
Althagafi, MG; Besla, R; Byrne, JS; Chen, Y; Cybulsky, MI; Li, A; Lindsay, T; Pacheco, S; Robbins, CS; Ulndreaj, A | 1 |
Arendt, BK; Ebtehaj, S; Franchi, F; Lanza, IR; Parvizi, M; Rodriguez-Porcel, M | 1 |
Bando, YK; Fang, L; Hiramatsu-Ito, M; Kato, K; Kawanishi, H; Murohara, T; Ogawa, H; Ohashi, K; Otaka, N; Ouchi, N; Ozaki, Y; Shibata, R; Shimizu, Y; Takefuji, M; Takikawa, T | 1 |
Huang, Y; Pan, Y; Xie, C; Xie, X; Ye, F; Zhang, N | 1 |
Cai, L; Ding, Y; Li, X; Shi, Z; Tang, H; Zhou, M | 1 |
Cai, Y; Long, X; Lou, D; Mohan, A; Shi, H; Wang, J; Xiong, J; Yan, C; Zhang, C; Zhang, Y; Zhao, H | 1 |
Antoniadou, C; Arelaki, S; Argyriou, C; Chrysanthopoulou, A; Georgiadis, GS; Giatromanolaki, A; Gkaliagkousi, E; Lazaridis, A; Mitsios, A; Ntinopoulou, M; Papadopoulos, V; Pateinakis, P; Ritis, K; Skendros, P | 1 |
Dong, N; Klenotic, PA; Li, R; Lin, Z; Narla, G; Wang, Y; Wei, W; Xie, F; Xu, Q; Zhang, C; Zhou, X | 1 |
Balboa, A; Becirovic-Agic, M; Busch, A; de Waard, V; Gäbel, G; Golledge, J; Holdt, LM; Lindeman, JHN; Ludwig, S; Maegdefessel, L; Mahlmann, A; Northoff, BH; Petri, M; Teupser, D; Wågsäter, D; Wanhainen, A | 1 |
Clancy, P; Crossman, DJ; Emeto, TI; Golledge, J; Jose, R; Krishna, SM; Li, J; Moxon, J; Norman, P; Seto, SW | 1 |
Li, Y; Lu, G; Sun, D; Wang, DW; Yan, J; Zuo, H | 1 |
Balakrishnan, A; Da Cunha, V; Dajee, M; Daugherty, A; Gutstein, DE; Howatt, DA; Johns, DG; Lu, H; Moorleghen, J; Rateri, DL; Xie, X | 1 |
Chang, BI; Cheng, TL; Kuo, CH; Lai, CH; Lee, FT; Shi, GY; Wang, KC; Wu, HL; Yang, YJ | 1 |
Ait-Oufella, H; Cabuzu, D; Esposito, B; Giraud, A; Joffre, J; Kluwe, J; Lafont, A; Mallat, Z; Potteaux, S; Seguier, S; Tedgui, A; Vandestienne, M; Vilar, J; Zeboudj, L | 1 |
Chen, K; Wang, Q; Yan, P; Yang, D; Yang, Y | 1 |
Airhart, N; Angelov, SN; Dichek, DA; Hu, JH; Shi, M; Wei, H | 1 |
Amin, HZ; Emoto, T; Fukunaga, A; Hayashi, T; Hirata, KI; Kasahara, K; Kitano, N; Matsumoto, T; Mizoguchi, T; Nishigori, C; Rikitake, Y; Sasaki, N; Tabata, T; Yamashita, T; Yodoi, K; Yoshida, N | 1 |
Aoki, H; Baba, O; Hasegawa, K; Horie, T; Ide, Y; Izuhara, M; Kimura, M; Kimura, T; Koyama, S; Kuwabara, Y; Minatoya, K; Nakao, T; Nakazeki, F; Nishi, H; Nishiga, M; Nishino, T; Ohno, S; Ono, K; Sakamoto, K; Sowa, N; Usami, S | 1 |
Aslanidou, L; Fraga-Silva, RA; Piersigilli, A; Segers, P; Sordet-Dessimoz, J; Stampanoni, MFM; Stergiopulos, N; Trachet, B; Villanueva-Perez, P | 1 |
Bakoyiannis, C; Damaskos, C; Georgopoulos, S; Liakakos, T; Moris, D; Patelis, N; Perrea, D; Schizas, D | 1 |
Boyer, MJ; Cooper, HA; Eguchi, S; Forrester, SJ; Hashimoto, T; Kawai, T; Kobayashi, T; Kwok, HF; Obama, T; Preston, KJ; Rizzo, V; Scalia, R; Takayanagi, T; Tsuji, T | 1 |
Blanco, VM; Blomkalns, AL; Cassis, LA; Chatterjee, T; Daugherty, A; Fu, X; Fulton, DJ; Gavrila, D; Hazen, SL; Huo, Y; Kim, HW; Lindower, PD; McCormick, ML; Neltner, BS; Ogbi, M; Stansfield, BK; Thomas, M; Thompson, RW; Weintraub, NL; Weiss, RM | 1 |
Angelov, SN; Dichek, DA; Zhu, J | 1 |
Alsiraj, Y; Blalock, E; Cassis, LA; Daugherty, A; Fleenor, B; Thatcher, SE | 1 |
Akerman, AW; Barrs, RW; Grespin, RT; Ikonomidis, JS; Jones, JA; LaRue, RAC; McDonald, LT; Mukherjee, R; Ruddy, JM; Stroud, RE | 1 |
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Agrawal, R; Ali, ZA; Anderson, JP; Ashley, EA; Chun, HJ; Kojima, Y; Kundu, RK; Leeper, NJ; Lenardo, MJ; Patterson, AJ; Pearl, NE; Quertermous, T; Sheikh, AY; Tsao, PS; Zheng, L | 1 |
Campbell, JH; Cullen, B; Golledge, J; Moran, CS | 1 |
Hayashi, T; Inoue, N; Jin, D; Katayama, H; Kitaura, Y; Miyazaki, M; Muramatsu, M; Takai, S; Tamai, H | 2 |
Aoki, M; Fujiwara, Y; Makino, H; Miyake, T; Morishita, R; Nishimura, M; Shiraya, S; Yamakawa, S | 1 |
Cai, JF; Chen, H; Chen, HS; Chen, XF; Chen, XQ; Gui, C; Hou, J; Jiang, JJ; Lu, HS; Tang, LJ; Wang, JA; Xie, XJ | 1 |
Aikawa, E; Aikawa, M; Deguchi, JO; Huang, H; Lee, RT; Libby, P; Sylvan, J; Whittaker, P | 1 |
Ramos, KS; Zhang, Y | 1 |
Cassis, LA; Charnigo, R; Daugherty, A; Gupte, M; Howatt, DA; Rateri, DL; Thayer, S; Zhang, X | 1 |
Fujikura, K; Konofagou, EE; Luo, J; Tilson, MD; Tyrie, LS | 1 |
Beeri, R; Berlatzky, Y; Bulut, A; Gavish, L; Gertz, SD; Gilon, D; Harlev, M; Reissman, P; Rubinstein, C | 1 |
Cockerill, GW; Deb, R; Dunkley, M; Gaze, D; Gnaneswaran, Y; Howe, F; Jones, A; Loftus, IM; Nasr, H; Thompson, MM; Torsney, E | 1 |
Cullen, B; Golledge, J; Moxon, JV; Nyara, M; Rush, C; Trollope, A | 1 |
de Winther, MP; Gijbels, MJ; Lutgens, E; Pöttgens, C; Thelen, M; Xanthoulea, S | 1 |
Cassis, LA; Charnigo, R; Daugherty, A; Police, SB; Thatcher, SE | 1 |
Aravindhan, K; Bernard, RE; Boyle, RJ; Gardner, SD; Gough, PJ; Jucker, BM; Newman, MJ; Olzinski, AR; Turner, GH; Willette, RN | 1 |
Anandan, SK; Chen, D; Cheng, Y; Gless, R; Mehra, U; Vincelette, J; Wang, YX; Webb, HK; Zhang, LN | 1 |
Beasley, D; Galper, JB; Moulton, KS; Naggar, JC; Park, HJ; Welzig, CM; Zhang, Y | 1 |
Weintraub, NL | 1 |
Bai, L; Beckers, L; Biessen, EA; Cleutjens, K; Daemen, MJ; Heeneman, S; Herías, MV; Lutgens, E; Lutgens, SP; Saftig, P; Wijnands, E | 1 |
Aravindhan, K; Bernard, RE; Gough, PJ; Jucker, BM; Karr, HW; Mirabile, RC; Olzinski, AR; Turner, GH; Willette, RN | 1 |
Campbell, JH; Cullen, B; Daugherty, A; Golledge, J; Moran, CS; Norman, PE; Rush, C; Secomb, E; Wood, F | 1 |
Allard, MF; Ang, LS; Boivin, WA; Chamberlain, CM; Cooper, DM; Folkesson, M; Granville, DJ; Hendel, A; McManus, BM; Swedenborg, J; Williams, SJ; Zhao, H | 1 |
Ahluwalia, N; Anderson, TJ; Gerszten, RE; Hardy, GJ; Kristo, F; Lin, AY; Passeri, J; Scherrer-Crosbie, M; Sinha, S | 1 |
Kato, K; Lengfeld, J; Liu, B; Morgan, S; Yamanouchi, D; Zhang, F | 1 |
Ait-Oufella, H; Bonnin, P; Combadière, C; Herbin, O; Huang, J; Johnson, JL; Mallat, Z; Offenstadt, G; Ramkhelawon, B; Rénia, L; Taleb, S; Tedgui, A; Tharaux, PL; Wang, Y | 1 |
Gopal, K; Jahan, P; Kumar, K; Kumar, MJ; Nandini, R | 1 |
Hashimoto, T; Kanematsu, M; Kanematsu, Y; Kurihara, C; Liang, EI; Makino, H; Nuki, Y; Tsou, TL | 1 |
Aktas, H; Bronson, RT; Chen, T; Halperin, JA; Hu, W; Qin, X; Shahsafaei, A; Shi, GP; Wu, G | 1 |
Batifoulier-Yiannikouris, F; Cassis, LA; Daugherty, A; Police, SB; Putnam, K; Thatcher, S | 1 |
Chisolm, GM; Eagleton, MJ; Graham, LM; Liao, M; Parine, B; Xu, J | 1 |
Cassis, LA; Charnigo, R; Daugherty, A; Kristo, F; Lu, H; Rateri, DL; Uchida, HA | 1 |
Choke, E; Cockerill, GW; Dawson, J; Howe, F; Loftus, IM; Thompson, MM; Wilson, WR | 1 |
Libby, P; Lopez-Ilasaca, M; Macfarlane, L; Schulte, S; Shi, GP; Sukhova, GK; Sun, C; Sun, J | 1 |
Asagami, T; Dalman, RL; Dua, MM; Miyama, N; Schultz, GM; Sho, E; Sho, M; Yeung, JJ | 1 |
Cullen, B; Golledge, J; Moran, C; Rush, C | 1 |
Bailey, W; Boyanovsky, BB; Daugherty, A; de Beer, FC; Forrest, K; Gelb, MH; Howatt, DA; Shridas, P; Webb, NR; Zack, M | 1 |
Barr, KN; Choi, G; Connolly, AJ; Dalman, RL; Eastham-Anderson, JR; Goergen, CJ; Greve, JM; Hedehus, M; Huynh, DT; Taylor, CA; Tsao, PS | 1 |
Berges, A; Lebrun, S; Lietz, M; Stolle, K; Wallerath, T | 1 |
Azuma, J; Barr, KN; Connolly, AJ; Dalman, RL; Goergen, CJ; Gogineni, A; Greve, JM; Grewall, A; Kallop, DY; Magdefessel, L; Taylor, CA; Tsao, PS; Weimer, RM | 1 |
Bruemmer, D; Cohn, D; Daugherty, A; Findeisen, HM; Gizard, F; Heywood, EB; Howatt, DA; Jones, KL; Lovett, DH; Zhao, Y | 1 |
Fukuda, D; Libby, P; Rocha, VZ; Shi, GP; Shimizu, K; Shvartz, E; Sukhova, G; Tang, EH; Zheng, C | 1 |
Gerszten, RE; Keliher, E; Leuschner, F; Marinelli, B; Nahrendorf, M; Pittet, MJ; Robbins, CS; Swirski, FK; Weissleder, R | 1 |
Dong, XR; Hoglund, VJ; Majesky, MW | 1 |
Bi, H; Chen, WA; Daugherty, A; Hong, B; Luo, Y; Wang, JA; Wang, Y; Xie, X; Zhang, S | 1 |
Gleason, RL; Joseph, G; Maiellaro-Rafferty, K; Taylor, WR; Wan, W; Weiss, D | 1 |
Antiga, L; De Backer, J; De Santis, G; Loeys, B; Renard, M; Segers, P; Staelens, S; Trachet, B | 1 |
Azuma, J; Dalman, RL; Deng, A; Dyer, JS; Hsu, M; Maegdefessel, L; Spin, JM; Tedesco, MM; Tsao, PS | 1 |
Cassis, LA; Charnigo, R; Daugherty, A; Howatt, DA; Moorleghen, JJ; Rateri, DL | 1 |
Bi, H; Daugherty, A; Wang, JA; Wang, Y; Xie, X; Xu, Y; Zhang, G; Zhang, S | 1 |
Cassis, LA; Daugherty, A; Lu, H | 1 |
Cassis, LA; Daugherty, A; Poduri, A; Subramanian, V; Uchida, HA | 1 |
Inoue, T; Kikumoto, Y; Makino, H; Sugiyama, H; Takiue, K; Uchida, HA | 1 |
Abraham, T; Ang, LS; Bleackley, RC; Boivin, WA; Carmine-Simmen, K; Granville, DJ; McManus, BM; Williams, SJ; Zhao, H | 1 |
Arsenescu, R; Arsenescu, V; Baker, N; Cassis, LA; Karounos, M; Parulkar, M; Zhang, X | 1 |
Cassis, LA; Curtiss, LK; Daugherty, A; Howatt, DA; Lu, H; Moore, KJ; Owens, AP; Rateri, DL; Tobias, PS | 1 |
Balakrishnan, A; Howatt, DA; Ijaz, T; Moorleghen, JJ; Subramanian, V; Uchida, HA | 1 |
Cai, H; Chalupsky, K; Chen, P; Galis, Z; Gao, L; Nguyen, A; Siu, KL; Weintraub, NL | 1 |
Cardenas, JC; Church, FC; Rein, CM | 1 |
Cassis, LA; Charnigo, R; Daugherty, A; Howatt, DA; Lu, H; Moorleghen, JJ; Subramanian, V; Wang, S | 1 |
Angsana, J; Chaikof, EL; Ford, ML; Haller, CA; Park, PW; Smith, SV; Wen, J; Xiao, J | 1 |
Azhar, M; Fouts, M; Haskett, D; Larson, D; Speicher, E; Utzinger, U; Vande Geest, J | 1 |
Bruemmer, D; Daugherty, A; Lu, H; Rateri, DL | 1 |
Azuma, J; Chin, JT; Dalman, RL; Deng, A; Leeper, NJ; Maegdefessel, L; McConnell, MV; Merk, DR; Raaz, U; Raiesdana, A; Schoelmerich, AM; Spin, JM; Toh, R; Tsao, PS | 1 |
Caligiuri, G; Clement, M; Fornasa, G; Gaston, AT; Groyer, E; Guedj, K; Kaveri, SV; Khallou-Laschet, J; Michel, JB; Morvan, M; Nicoletti, A; Tedgui, A | 1 |
Azuma, J; Dalman, RL; Deng, A; Leeper, NJ; Maegdefessel, L; McConnell, MV; Merk, DR; Raaz, U; Raiesdana, A; Schoelmerich, AM; Spin, JM; Toh, R; Tsao, PS | 1 |
Liu, L; Shi, GP | 1 |
Fazio, S; Guo, Z; Kon, V; Linton, MF; Perati, PR; Prins, PA; Ramesh, A; Sampson, UK | 1 |
Fang, F; Li, Y; Liu, N; Ma, G; Sheng, Z; Teng, GJ; Wang, Y; Wen, S; Yao, Y; Zhang, Y | 1 |
Eagleton, MJ; Ehrman, B; Graham, LM; Xu, J | 1 |
Asada, Y; Endo, GJ; Hatakeyama, K; Imamura, T; Kitamura, K; Matsuyama, M; Nagamachi, S; Nishimura, M; Onitsuka, T; Sakamoto, S; Sato, Y; Sekita, Y; Tsuruda, T; Yoshimura, K | 1 |
Bruemmer, D; Cassis, LA; Charnigo, R; Daugherty, A; Rateri, DL; Thatcher, SE; Zhang, X | 1 |
Lee, J; Liang, B; Viollet, B; Wang, S; Xia, L; Zhang, C; Zhang, M; Zhang, Y; Zhu, H; Zou, MH | 1 |
Aoki, H; Fujita, T; Ichikawa, Y; Ishikawa, Y; Ishiwata, R; Jin, H; Jin, MH; Katayama, Y; Kato, Y; Kumagaya, S; Masuda, M; Minamisawa, S; Okumura, S; Sato, M; Sugimoto, Y; Suzuki, O; Suzuki, S; Yokoyama, U | 1 |
Brown, PM; Cao, RY; Funk, CD; Li, X; Maruyama, T; Song, H; St Amand, T; Wang, CP; Yoon, SH; Zelt, DT | 1 |
Golledge, J; Krishna, SM; Moxon, JV; Norman, PE; Rush, C; Seto, SW; Walker, PJ | 1 |
Bailey, W; Boyanovsky, BB; Dixon, L; Shridas, P; Webb, NR | 1 |
Chen, H; Liu, L; Shi, GP; Shi, MA; Sukhova, GK; Sun, J; Zhang, J | 1 |
Cao, X; Du, J; Guo, J; Li, H; Pan, L; Qin, Y; Shi, GP; Tang, C; Zhang, H; Zhang, Y | 1 |
Csiszar, K; Fong, SF; Joseph, G; O'Donnell, RE; Rafferty, K; Remus, EW; Taylor, WR; Weiss, D | 1 |
Beeri, R; Berlatzky, Y; Bulut, A; Gavish, L; Gavish, LY; Gertz, SD; Gilon, D; Harlev, M; Reissman, P; Rubinstein, C | 1 |
Feng, J; Hu, J; Huang, Y; Kong, W; Liu, B; Liu, Z; Luo, H; Ma, K; Wang, X; Xie, J; Xu, Q; Zhan, S; Zhang, L; Zheng, J; Zhu, Y | 1 |
Gitlin, JM; Loftin, CD; Mukherjee, K | 1 |
Asano, T; Fujita, T; Gao, J; Hasegawa, Y; Imai, J; Ishigaki, Y; Kaneko, K; Katagiri, H; Ogihara, T; Oka, Y; Saito, T; Shimosawa, T; Uno, K; Yamada, T | 1 |
Baxter, BT; Charolidi, N; Cockerill, GW; Gaze, D; Laing, K; Meisinger, T; Petrova, S; Pirianov, G; Shoreim, A; Torsney, E; Xiong, W | 1 |
Cassis, LA; Daugherty, A; Howatt, DA; Lu, H; Moorleghen, JJ; Rateri, DL; Xie, X | 1 |
Jackson, CL; Rodgers, KJ | 1 |
Beceiro, S; Cheng, J; Garg, V; Guggilam, A; Hans, CP; Huang, N; Koenig, SN; Kuivaniemi, H; Partida-Sánchez, S | 1 |
Baldwin, TA; Basu, R; Das, SK; Fan, D; Kandalam, V; Kassiri, Z; Lee, J; Oudit, GY; Wang, X | 1 |
Hao, S; Kolodgie, FD; Mizrahi, B; Nguyen, BT; Ozaki, CK; Savion, N; Schneiderman, J; Tao, M; Virmani, R; Yu, P | 1 |
Du, J; Jia, L; Liu, O; Liu, X; Qin, Y; Wang, X; Wang, Y; Zhang, H | 1 |
Dalman, RL; Fujimura, N; Glover, KJ; Hu, X; Iida, Y; Schultz, JR; Tanaka, H; Turner, CR; Wang, W; Xu, B; Xuan, H | 1 |
Dalloz, M; Esposito, B; Mallat, Z; Pérez, N; Ponnuswamy, P; Romain, M; Taleb, S; Tedgui, A; Wang, Y; Yoshimura, A | 1 |
Golledge, J; Jose, RJ; Körner, H; Moran, CS; Moxon, JV; Norman, PE; Roomberg, A; Rush, C | 1 |
Dole, W; Martin-McNulty, B; Rutledge, JC; Sullivan, ME; Tham, DM; Vergona, R; Wang, YX; Wilson, DW | 1 |
Athanassious, CN; Da Cunha, V; Martin-McNulty, B; Powers, AF; Rutledge, JC; Sullivan, ME; Tham, DM; Wang, YX; Wilson, DW | 1 |
Carmeliet, P; Deng, GG; Dole, WP; Freay, A; Halks-Miller, M; Loskutoff, DJ; Martin-McNulty, B; Sukovich, DA; Thinnes, T; Wang, YX | 1 |
Cassis, LA; Daugherty, A; Manning, MW | 3 |
da Cunha, V; Deng, GG; Ho, JJ; Martin-McNulty, B; Rutledge, JC; Sullivan, ME; Tham, DM; Vergona, R; Wang, YX; Wilson, DW | 1 |
Cassis, LA; Daugherty, A; Lodder, RA; Manning, MW; Urbas, A | 1 |
Arias-Magallona, S; Blaschke, F; Bruemmer, D; Collins, AR; Fishbein, MC; Graf, K; Hsueh, WA; Kintscher, U; Law, RE; Noh, G; Territo, M; Wang, W | 1 |
Cassis, LA; Daugherty, A | 1 |
Cassis, LA; D'Souza, SS; Daugherty, A; Henriques, TA; Huang, J | 1 |
Cassis, L; Daugherty, A | 3 |
Charo, IF; Egashira, K; Hiasa, K; Ihara, Y; Ishibashi, M; Kura, S; Ohtani, K; Sunagawa, K; Takeshita, A; Tsuzuki, T; Zhao, Q | 1 |
Cassis, LA; Daugherty, A; Helton, MJ; Howatt, DA; King, VL | 1 |
da Cunha, V; Deng, GD; Dole, WP; Feng, Q; Halks-Miller, M; Johns, A; Kauser, K; Light, DR; Lu, X; Mahmoudi, M; Martin-McNulty, B; Schirm, S; Schroeder, M; Subramanyam, B; Tseng, JL; Vincelette, J; Wang, YX | 1 |
Cassis, LA; Daugherty, A; Dellsperger, KC; Gavrila, D; Li, WG; McCormick, ML; Miller, FJ; Oberley, LW; Thomas, M; Weintraub, NL | 1 |
Golledge, J; Karan, M; Ketheesan, N; McCann, M; Moran, CS; Norman, P | 1 |
Gitlin, JM; King, VL; Loftin, CD; Trivedi, DB | 1 |
Bishop-Bailey, D; Mitchell, JA; Warner, TD | 1 |
Cassis, LA; Daugherty, A; Dellsperger, KC; Gavrila, D; McCormick, ML; Miller, FJ; Thomas, M; Weintraub, NL | 1 |
Barisione, C; Charnigo, R; Daugherty, A; Howatt, DA; Moorleghen, JJ; Rateri, DL | 1 |
Gitlin, JM; Langenbach, R; Loftin, CD; Trivedi, DB | 1 |
Cassis, LA; Daugherty, A; Rateri, DL | 1 |
Croze, E; Fitch, RM; Sullivan, ME; Velichko, S; Vergona, R; Vincelette, J; Wang, YX; Zhang, LN | 1 |
Fukumoto, H; Furubayashi, K; Ibaraki, T; Jin, D; Katsumata, T; Miyazaki, M; Muramatsu, M; Nishimoto, M; Takai, S | 1 |
Adams, MA; Cao, RY; Funk, CD; Habenicht, AJ | 1 |
Dear, AE; Dousha, LF; Gaspari, TA; Liu, HB; Vinh, A; Widdop, RE | 1 |
Deng, GG; Dole, WP; Gu, JM; Halks-Miller, M; Kauser, K; Liu, P; Qian, HS; Sullivan, ME; Vergona, R | 1 |
FitzGerald, GA; Lawson, JA; Lee, E; Puré, E; Rader, DJ; Ricciotti, E; Song, W; Wang, M | 1 |
Cassis, LA; Daugherty, A; Henriques, T; Yiannikouris, FB; Zhang, X | 1 |
Cassis, LA; Daugherty, A; Lu, H; Rateri, DL | 1 |
Berk, BC; Haendeler, J; Sottile, J | 1 |
Deng, GG; Dole, WP; Freay, AD; Halks-Miller, M; Li, WW; Martin-McNulty, B; Morser, J; Sukovich, DA; Sullivan, ME; Vergona, R; Wang, YX | 1 |
17 review(s) available for angiotensin ii and Aortic Aneurysm, Abdominal
Article | Year |
---|---|
Role of Serum Amyloid A in Abdominal Aortic Aneurysm and Related Cardiovascular Diseases.
Topics: Angiotensin II; Aortic Aneurysm, Abdominal; Biomarkers; Cardiovascular Diseases; Gene Expression Regulation; Humans; Serum Amyloid A Protein | 2021 |
Twenty Years of Studying AngII (Angiotensin II)-Induced Abdominal Aortic Pathologies in Mice: Continuing Questions and Challenges to Provide Insight Into the Human Disease.
Topics: Age Factors; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Blood Pressure; Disease Models, Animal; Female; Heart Disease Risk Factors; Humans; Hypercholesterolemia; Male; Mice; Mice, Transgenic; Models, Cardiovascular; Receptors, Angiotensin; Sex Factors | 2022 |
Animal models in the research of abdominal aortic aneurysms development.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Female; Genetic Predisposition to Disease; Hemodynamics; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Elastase; Phenotype; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sus scrofa; Vascular Remodeling | 2017 |
Pathogenic and Therapeutic Significance of Angiotensin II Type I Receptor in Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Clinical Trials as Topic; Disease Models, Animal; Disease Progression; Humans; Receptor, Angiotensin, Type 1; Telmisartan; Valsartan | 2018 |
Dissecting abdominal aortic aneurysm in Angiotensin II-infused mice: the importance of imaging.
Topics: Aneurysm, Ruptured; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Dissection; Disease Models, Animal; Hematoma; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Mice; Tomography, X-Ray Computed | 2015 |
Monocytes, Macrophages and Other Inflammatory Mediators of Abdominal Aortic Aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Inflammation Mediators; Macrophages; Mice; Monocytes; Spleen | 2015 |
Angiotensin II and Abdominal Aortic Aneurysms: An update.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Disease Models, Animal; Humans; Mice; Molecular Targeted Therapy | 2015 |
Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Dissection; Disease Models, Animal; Female; Incidence; Male; Mice; Mice, Inbred C57BL | 2015 |
Atherosclerosis and aortic aneurysm - is inflammation a common denominator?
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Cytokines; Diet, Western; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; Risk Factors; Sedentary Behavior; Smoking | 2016 |
Complex pathologies of angiotensin II-induced abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Connective Tissue; Disease Models, Animal; Disease Progression; Female; Humans; Hypercholesterolemia; Male; Mice; Peptides; Renin-Angiotensin System; Time Factors | 2011 |
Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Disease Models, Animal; Humans; Mice; Renin-Angiotensin System; Species Specificity | 2011 |
Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II-induced abdominal aortic aneurysm in mice.
Topics: Adventitia; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Chemokine CCL2; Disease Models, Animal; Female; Fibroblasts; Humans; Hyperhomocysteinemia; Incidence; Interleukin-6; Male; Mice; Mice, Mutant Strains; Middle Aged; NADPH Oxidase 4; NADPH Oxidases; Reactive Oxygen Species; Risk Factors; Signal Transduction; Smad2 Protein; Smad3 Protein; Vasculitis; Vasoconstrictor Agents | 2012 |
Mouse models of abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Calcium Chloride; Cholesterol; Disease Models, Animal; Extracellular Matrix Proteins; Female; Genetic Engineering; Genetic Predisposition to Disease; Humans; Hyperlipidemias; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Knockout; Mice, Mutant Strains; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pancreatic Elastase; Protease Inhibitors; Receptors, LDL; Renin; Species Specificity | 2004 |
Angiotensin II-mediated development of vascular diseases.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Arteriosclerosis; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Humans; Hyperlipidemias; Macrophages; Vascular Diseases | 2004 |
Angiotensin II and abdominal aortic aneurysms.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Aneurysm, Abdominal; Humans; Mice | 2004 |
Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Humans; Models, Biological; Renin-Angiotensin System | 2006 |
The role of the renin-angiotensin system in aortic aneurysmal diseases.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Humans; Mice; Renin-Angiotensin System; Risk Factors | 2008 |
422 other study(ies) available for angiotensin ii and Aortic Aneurysm, Abdominal
Article | Year |
---|---|
Defective autophagy in vascular smooth muscle cells enhances the healing of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Autophagy; Cells, Cultured; Infusion Pumps, Implantable; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle | 2021 |
Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; RNA, Circular | 2022 |
Interferon-stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Carotid Intima-Media Thickness; Elastin; Humans; Hypertension; Inflammation; Interferons; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2022 |
miR-10b promotes aortic aneurysm formation and aortic rupture in angiotensin II-induced ApoE-deficient mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; MicroRNAs | 2021 |
Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Cinnamates; Depsides; Disease Models, Animal; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Rosmarinic Acid | 2022 |
Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; RNA, Long Noncoding; Signal Transduction | 2021 |
Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.
Topics: ADAM10 Protein; Angiotensin II; Aortic Aneurysm, Abdominal; Case-Control Studies; Fibronectins; Gene Silencing; Humans; MicroRNAs; Myocytes, Smooth Muscle; Oxidative Stress; RNA, Circular | 2021 |
The tyrosine kinase inhibitor Bosutinib does not inhibit angiotensin II-induced abdominal aortic aneurysm: Validation of the importance of PDGFR and c-Kit tyrosine kinases by Imatinib.
Topics: Angiotensin II; Aniline Compounds; Aortic Aneurysm, Abdominal; Humans; Imatinib Mesylate; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Quinolines | 2022 |
Platelet protects angiotensin II-driven abdominal aortic aneurysm formation through inhibition of inflammation.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Platelets; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout | 2022 |
Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Male; Mice; Receptors, Immunologic; Receptors, Prostaglandin | 2022 |
Trimethylamine N-Oxide Promotes Abdominal Aortic Aneurysm Formation by Aggravating Aortic Smooth Muscle Cell Senescence in Mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Disease Models, Animal; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle | 2022 |
Tolvaptan reduces angiotensin II-induced experimental abdominal aortic aneurysm and dissection.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Knockout, ApoE; Tolvaptan | 2022 |
Interleukin-22 Deficiency Reduces Angiotensin II-Induced Aortic Dissection and Abdominal Aortic Aneurysm in ApoE-/- Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Dissection; Apolipoproteins E; Interleukin-22; Interleukins; Mice | 2022 |
Adipocyte-Derived Serum Amyloid A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J Mice.
Topics: Adipocytes; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Doxycycline; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Obesity; Serum Amyloid A Protein | 2022 |
Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Phosphatidate Phosphatase | 2022 |
Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Collagen; Cysteine; Disease Models, Animal; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle | 2022 |
Calcitriol Supplementation Protects Against Apoptosis and Alleviates the Severity of Abdominal Aortic Aneurysm Induced by Angiotensin II and Anti-TGFβ.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Calcitriol; Dietary Supplements; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Transforming Growth Factor beta | 2022 |
Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Endothelial Cells; Fibroblasts; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Sequence Analysis, RNA | 2022 |
An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle | 2022 |
Nuclear receptor Nur77 protects against oxidative stress by maintaining mitochondrial homeostasis via regulating mitochondrial fission and mitophagy in smooth muscle cell.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Homeostasis; Mice; Mitochondrial Dynamics; Mitophagy; Myocytes, Smooth Muscle; Nuclear Receptor Subfamily 4, Group A, Member 1; Oxidative Stress | 2022 |
Statin therapy protects against abdominal aortic aneurysms by inducing the accumulation of regulatory T cells in ApoE
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Dysbiosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Mice, Knockout; Simvastatin; T-Lymphocytes, Regulatory | 2022 |
Metabolomic Profiling of Angiotensin-II-Induced Abdominal Aortic Aneurysm in Ldlr
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Energy Metabolism; Glutamine; Glycine; Hypercholesterolemia; Hyperlipidemias; Lipids; Metabolomics; Mice; Mice, Inbred C57BL; Nitric Oxide; Receptors, LDL | 2022 |
Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.
Topics: Aconitate Hydratase; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Citric Acid Cycle; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Receptor Subfamily 1, Group D, Member 1 | 2022 |
[Role of nicotinamide phosphoribosyltransferase in delaying smooth muscle cell senescence and protecting abdominal aortic aneurysm].
Topics: Angiotensin II; Aortic Aneurysm, Abdominal; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nicotinamide Phosphoribosyltransferase | 2022 |
Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Catheterization; Central Venous Catheters; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Ultrasonography | 2022 |
Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Mice; Mice, Knockout; Myocytes, Smooth Muscle | 2022 |
Edaravone Attenuated Angiotensin II-Induced Atherosclerosis and Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Atherosclerosis; Edaravone; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL; RNA, Messenger | 2022 |
BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Epigenesis, Genetic; Homeostasis; Humans; Inflammation; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle | 2022 |
The Nonproteolytic Intracellular Domain of Membrane-Type 1 Matrix Metalloproteinase Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis in Mice-Brief Report.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Cholesterol; Elastin; Matrix Metalloproteinase 14; Mice; Netrin-1; Proprotein Convertase 9; Subtilisins | 2022 |
Disparate biomechanical properties of the aorta in non-aneurysmal and aneurysmal mice treated with angiotensin II.
Topics: Adrenergic Agents; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagen; Elastin; Mice; Mice, Inbred C57BL; Pulse Wave Analysis | 2022 |
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; DEAD-box RNA Helicases; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Knockout, ApoE; Proto-Oncogene Proteins c-akt | 2022 |
LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Atherosclerosis; Collagen; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Plaque, Atherosclerotic; Scavenger Receptors, Class E | 2023 |
Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication.
Topics: Angiotensin II; Animals; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Disease Models, Animal; Folic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Nifedipine | 2022 |
ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm.
Topics: Adenosine Deaminase; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; I-kappa B Kinase; Inflammation; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; NF-kappa B; RNA-Binding Proteins | 2023 |
Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2-p38 pathway-dependent manner.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Interleukins; Macrophages; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Receptors, Interleukin | 2023 |
Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Hyperuricemia; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mice; Reactive Oxygen Species; Retrospective Studies; Signal Transduction; Uric Acid | 2023 |
Smooth muscle angiotensin II type 1A receptor is required for abdominal aortic aneurysm formation induced by angiotensin II plus β-aminopropionitrile.
Topics: Aminopropionitrile; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Muscle, Smooth; Myocytes, Smooth Muscle; Receptor, Angiotensin, Type 1 | 2023 |
Netrin-1 Monoclonal Antibody-Functionalized Nanoparticle Loaded with Metformin Prevents the Progression of Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Nanoparticles; Netrin-1; Phenotype | 2023 |
Divergent Roles of Matrix Metalloproteinase 12 in Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Humans; Matrix Metalloproteinase 12; Matrix Metalloproteinase 9 | 2023 |
RelB represses miR-193a-5p expression to promote the phenotypic transformation of vascular smooth muscle cells in aortic aneurysm.
Topics: Adult; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cell Movement; Cell Proliferation; Cyclin D1; Cyclin E; Down-Regulation; Female; Humans; Male; Mice; MicroRNAs; Muscle, Smooth, Vascular; Receptors, CXCR4; Transcription Factor RelB | 2023 |
Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Endoplasmic Reticulum Stress; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Reactive Oxygen Species | 2023 |
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; CARD Signaling Adaptor Proteins; Disease Models, Animal; Endoplasmic Reticulum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria | 2023 |
Taxifolin ameliorates abdominal aortic aneurysm by preventing inflammation and apoptosis and extracellular matrix degradation via inactivating TLR4/NF-κB axis.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Disease Models, Animal; Extracellular Matrix; Humans; Inflammation; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; NF-kappa B; Toll-Like Receptor 4 | 2023 |
Tributyrin Intake Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm in
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Elastin; Epigenesis, Genetic; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout | 2023 |
Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Scavenger | 2023 |
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE-/- mice.
Topics: Angiopoietin-Like Protein 8; Angiotensin II; Animals; Aorta; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Knockout, ApoE; Peptide Hormones | 2023 |
The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Histone Methyltransferases; Histones; Humans; Janus Kinases; Lysine; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Tissue Inhibitor of Metalloproteinase-3 | 2023 |
Pharmacological Inhibition of Gasdermin D Suppresses Angiotensin II-Induced Experimental Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Body Weight; Disease Models, Animal; Disulfiram; Gasdermins; Male; Mice; Mice, Inbred C57BL | 2023 |
Plasma Lipidomics Analysis Reveals the Potential Role of Lysophosphatidylcholines in Abdominal Aortic Aneurysm Progression and Formation.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Biomarkers; Disease Models, Animal; Lipidomics; Lysophosphatidylcholines; Mice; Mice, Inbred C57BL | 2023 |
CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE
Topics: Angiotensin II; Animals; Antibodies, Monoclonal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Knockout, ApoE; Proteomics | 2023 |
Vascular Ultrasound for In Vivo Assessment of Arterial Pathologies in a Murine Model of Atherosclerosis and Aortic Aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Atherosclerosis; Carotid Intima-Media Thickness; Collagen; Disease Models, Animal; Mice; Mice, Inbred C57BL | 2023 |
Inhibition of smooth muscle cell death by Angiotensin 1-7 protects against abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis Regulatory Proteins; Disease Models, Animal; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Reactive Oxygen Species | 2023 |
Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Leptin; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Obesity; Phosphatidylinositol 3-Kinases; Receptor, Melanocortin, Type 4 | 2023 |
Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins; Apolipoproteins E; Apoptosis; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout | 2023 |
Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Immunoglobulin E; Interleukin-4; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE | 2023 |
ATRQβ-001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Calcium Phosphates; Disease Models, Animal; Inflammation; Macrophages; Mice; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Random Allocation; Vaccines, Virus-Like Particle; Vasoconstrictor Agents | 2019 |
Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm.
Topics: ADP-ribosyl Cyclase 1; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Cells, Cultured; Collagen; Cytokines; Dipeptides; Disease Models, Animal; Extracellular Matrix; Gene Expression Regulation; Humans; Male; Membrane Glycoproteins; Mice; Myocytes, Smooth Muscle; Receptors, Notch; Signal Transduction | 2019 |
Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apoptosis; Cell Proliferation; Down-Regulation; Humans; Male; Matrix Metalloproteinases; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Rats; Rats, Sprague-Dawley; Ribonucleases; Signal Transduction; Transcription Factors; Transcriptional Activation; Up-Regulation | 2019 |
Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice.
Topics: Angiotensin I; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Peptide Fragments | 2020 |
IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development.
Topics: Aneurysm; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure; Cell Differentiation; Cytokines; Disease Models, Animal; Female; Hematopoietic Stem Cells; Interleukin-27; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Knockout, ApoE; Myeloid Cells; Myelopoiesis; Receptors, Interleukin; Signal Transduction | 2019 |
Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; CD11 Antigens; Cholesterol; Dendritic Cells; Leukocyte Elastase; Lymphocyte Count; Male; Mice, Knockout, ApoE; Random Allocation; Vascular Remodeling | 2019 |
Female Mice Exhibit Abdominal Aortic Aneurysm Protection in an Established Rupture Model.
Topics: Administration, Oral; Aminopropionitrile; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Knockout, ApoE; Protective Factors; Sex Factors | 2020 |
Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacin; Niacinamide; Receptors, G-Protein-Coupled; Receptors, LDL; Signal Transduction; Sirtuin 1 | 2020 |
Imaging cellular activity and proliferation in the aortic wall.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Fluorine Radioisotopes; Male; Mice; Mice, Knockout, ApoE; Positron Emission Tomography Computed Tomography; Reproducibility of Results; Time Factors | 2021 |
Depletion of CD11c+ cell attenuates progression of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Dendritic Cells; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout | 2020 |
Pro-Renin Receptor Overexpression Promotes Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-Knockout Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Macrophages; Male; Matrix Metalloproteinases; Mice; Mice, Knockout, ApoE; Myocytes, Smooth Muscle; Receptors, Cell Surface; Renin; Renin-Angiotensin System; Signal Transduction; Vacuolar Proton-Translocating ATPases | 2020 |
Alterations in gut microbiota of abdominal aortic aneurysm mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Bacteria; Disease Models, Animal; Dysbiosis; Feces; Gastrointestinal Microbiome; Intestines; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Ribotyping | 2020 |
Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Apoptosis Regulatory Proteins; Cells, Cultured; Disease Models, Animal; Male; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Piperidines; Rats, Sprague-Dawley; Signal Transduction; Vascular Calcification; Xanthines | 2020 |
AVE0991, a nonpeptide angiotensin-(1-7) mimic, inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E knockout mice.
Topics: Angiotensin I; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Disease Models, Animal; Humans; Imidazoles; Immunohistochemistry; Lipids; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Molecular Mimicry; Myocytes, Smooth Muscle; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments | 2020 |
A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy.
Topics: Aminosalicylic Acids; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortitis; Apoptosis; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Disease Models, Animal; Janus Kinase 2; Male; Mice, Knockout, ApoE; NF-kappa B; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Sulfonamides; Vascular Remodeling | 2020 |
Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm.
Topics: 3' Untranslated Regions; ADAM Proteins; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Binding Sites; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation, Enzymologic; Macrophages; Male; Membrane Proteins; Mice, Knockout, ApoE; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Signal Transduction | 2020 |
Evaluation of a smart activatable MRI nanoprobe to target matrix metalloproteinases in the early-stages of abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Contrast Media; Disease Models, Animal; Ferric Compounds; Gene Expression Regulation; Humans; Magnetic Resonance Imaging; Matrix Metalloproteinases; Mice; Nanoparticles | 2020 |
A Modified Murine Abdominal Aortic Aneurysm Rupture Model Using Elastase Perfusion and Angiotensin II Infusion.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Cytokines; Dilatation, Pathologic; Disease Models, Animal; Inflammation Mediators; Male; Mice, Inbred C57BL; Pancreatic Elastase; Time Factors; Vascular Remodeling | 2020 |
Runx2 (Runt-Related Transcription Factor 2)-Mediated Microcalcification Is a Novel Pathological Characteristic and Potential Mediator of Abdominal Aortic Aneurysm.
Topics: Adult; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Case-Control Studies; Core Binding Factor Alpha 1 Subunit; Dilatation, Pathologic; Disease Models, Animal; Durapatite; Female; Humans; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Middle Aged; Signal Transduction; Vascular Calcification; Vascular Remodeling | 2020 |
MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Line; Cell Plasticity; Disease Models, Animal; Disease Susceptibility; Gene Expression; Humans; Inflammation; Macrophage Activation; Macrophages; Mice; Mice, Knockout; MicroRNAs; RAW 264.7 Cells; RNA Interference; Scavenger Receptors, Class E; Toll-Like Receptor 2 | 2020 |
Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice.
Topics: ADAM17 Protein; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Factor XII; Mice | 2020 |
Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Calcium Chloride; Gene Expression; Gene Expression Regulation; Humans; Inflammation; Interleukin-6; Macrophages; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Knockout, ApoE; Mice, Transgenic; Monocytes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein-Lysine 6-Oxidase; Receptors, Cytokine; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction | 2020 |
Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; ARNTL Transcription Factors; Atherosclerosis; Cells, Cultured; Crosses, Genetic; Diet, High-Fat; Gene Deletion; Gene Expression; Hyperlipidemias; Inflammation; Integrases; Macrophages, Peritoneal; Mice; Mice, Knockout; Muramidase; Myeloid Cells; Promoter Regions, Genetic; Receptors, LDL | 2020 |
Collagen fibril abnormalities in human and mice abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagen; Disease Models, Animal; Extracellular Matrix; Humans; Mice; Mice, Knockout | 2020 |
Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Aminopropionitrile; Aneurysm, Ruptured; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cholesterol; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Gain of Function Mutation; Gene Expression Regulation; Genetic Vectors; Humans; Loss of Function Mutation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Transcriptome | 2020 |
Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm.
Topics: Aminopropionitrile; Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Case-Control Studies; Cell Adhesion; Cells, Cultured; Disease Models, Animal; Dynamins; Humans; Leukocytes; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Mitochondria, Muscle; Mitochondrial Dynamics; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxygen Consumption; Phosphorylation; Quinazolinones | 2021 |
AT2R agonist NP-6A4 mitigates aortic stiffness and proteolytic activity in mouse model of aneurysm.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Collagen; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Knockout; Osteopontin; Phenotype; Proteolysis; Receptor, Angiotensin, Type 2; Vascular Stiffness | 2020 |
MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.
Topics: ADAMTS4 Protein; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Biopsy; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Extracellular Matrix; Gene Expression Regulation; Humans; Mice; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; RNA Interference | 2020 |
Reduced Nhe1 (Na
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Blood Glucose; Cells, Cultured; Endothelial Cells; Fluorescent Dyes; Genotype; Humans; Hydrogen-Ion Concentration; Immunoglobulin E; Lipids; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Receptors, IgE; Rhodamines; Sodium-Hydrogen Exchanger 1; Tumor Protein, Translationally-Controlled 1 | 2020 |
LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through miR-4685-5p/LBX2 feedback loop.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Disease Progression; Feedback, Physiological; Female; Gene Expression Regulation; Homeodomain Proteins; Humans; Mice; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; RNA, Long Noncoding; Signal Transduction | 2020 |
Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Carboxy-Lyases; China; Disease Models, Animal; Humans; Inflammation; Kelch-Like ECH-Associated Protein 1; Macrophages; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; NF-E2-Related Factor 2; Succinates | 2020 |
MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cell Differentiation; Cells, Cultured; Male; Mice; Mice, Transgenic; MicroRNAs; Muscle, Smooth, Vascular; Nerve Tissue Proteins | 2020 |
Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation.
Topics: Adventitia; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cholesterol; Collagen Type I; Disease Models, Animal; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Osteoprotegerin; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2020 |
All-trans retinoic acid attenuates the progression of Ang II-induced abdominal aortic aneurysms in ApoE
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout, ApoE; Tretinoin | 2020 |
Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure; Collagen; Elastin; Humans; Inflammation; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Signal Transduction; Simvastatin; Transcription, Genetic; Vascular Cell Adhesion Molecule-1 | 2020 |
Ex vivo magnetic particle imaging of vascular inflammation in abdominal aortic aneurysm in a murine model.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; Feasibility Studies; Humans; Inflammation; Magnetic Iron Oxide Nanoparticles; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Knockout, ApoE | 2020 |
Identification of potential proteases for abdominal aortic aneurysm by weighted gene coexpression network analysis.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Biomarkers; Gene Expression Profiling; Gene Regulatory Networks; Male; Mice; Mice, Knockout, ApoE; Peptide Hydrolases; Transcriptome | 2020 |
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Topics: Aged; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Cellular Senescence; Echocardiography; Endothelial Cells; Eukaryotic Translation Initiation Factor 5A; Female; GTP Phosphohydrolases; Humans; Kruppel-Like Transcription Factors; Male; Mice; Mice, Knockout; Mitochondria; Mitochondrial Dynamics; Peptide Initiation Factors; Primary Cell Culture; Promoter Regions, Genetic; Protein Binding; Reactive Oxygen Species; RNA-Binding Proteins | 2020 |
Recognizing the evolving and beneficial role of regulatory T cells in aneurysm growth.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Mice; T-Lymphocytes, Regulatory | 2020 |
LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Cells, Cultured; Disease Models, Animal; Down-Regulation; Extracellular Matrix; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; RNA, Long Noncoding; Signal Transduction; Tissue Inhibitor of Metalloproteinases | 2021 |
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Biomarkers; Biopsy; Cell Adhesion Molecules; Cytokines; Disease Models, Animal; Disease Susceptibility; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Mice; Mice, Knockout; Models, Biological; Myocytes, Smooth Muscle; Peroxiredoxins; Reactive Oxygen Species; Ultrasonography | 2020 |
Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Blood Pressure; Caloric Restriction; Cholecalciferol; Dietary Supplements; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Humans; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Up-Regulation; Vitamin D Deficiency | 2020 |
Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Dissection; Aortography; Computed Tomography Angiography; Dilatation, Pathologic; Disease Models, Animal; Endothelium, Vascular; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Time Factors; Vascular Remodeling; Vasoconstriction; X-Ray Microtomography | 2020 |
Prevention of Progression of Aortic Aneurysm by Peptide Vaccine Against Ang II (Angiotensin II) in a Rat Model.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; Hemocyanins; Immunoconjugates; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; NF-kappa B; Rats, Wistar; Signal Transduction; Vaccines, Subunit | 2020 |
Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation.
Topics: Adventitia; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortitis; Case-Control Studies; Cells, Cultured; Cytokines; Disease Models, Animal; Disease Progression; Extracellular Matrix; Fibroblasts; Galectin 1; Humans; Inflammation Mediators; Macrophages, Peritoneal; Male; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout, ApoE; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Signal Transduction; Up-Regulation; Vascular Remodeling | 2021 |
Specific inhibition of SHP2 suppressed abdominal aortic aneurysm formation in mice by augmenting the immunosuppressive function of MDSCs.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Benzenesulfonates; Disease Models, Animal; Hydrazones; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Myeloid-Derived Suppressor Cells; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Signal Transduction | 2021 |
Factor Xa inhibitor rivaroxaban suppresses experimental abdominal aortic aneurysm progression via attenuating aortic inflammation.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortitis; Calcium Chloride; Cell Adhesion Molecules; Cytokines; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Factor Xa Inhibitors; Humans; Inflammation Mediators; Male; Mice, Knockout, ApoE; Retrospective Studies; Rivaroxaban; Signal Transduction; Vascular Remodeling | 2021 |
Prevention of CaCl
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Chemokine CCL3; Disease Models, Animal; Humans; Inflammation Mediators; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Receptors, CCR1; Receptors, CCR5; Signal Transduction; Specific Pathogen-Free Organisms | 2020 |
TREM-1 orchestrates angiotensin II-induced monocyte trafficking and promotes experimental abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cell Movement; Gene Deletion; Humans; Interleukin-1beta; Matrix Metalloproteinase 2; Mice; Mice, Knockout, ApoE; Monocytes; Triggering Receptor Expressed on Myeloid Cells-1; Tumor Necrosis Factor-alpha | 2021 |
TRPV5 attenuates abdominal aortic aneurysm in mice by regulating KLF4-dependent phenotype switch of aortic vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Calcium Channels; Cell Differentiation; Dependovirus; Down-Regulation; Gene Transfer Techniques; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Male; MAP Kinase Signaling System; Mice; Muscle, Smooth, Vascular; TRPV Cation Channels; Up-Regulation | 2021 |
The C57Bl/6J mouse strain is more susceptible to angiotensin II-induced aortic aneurysm formation than C57Bl/6N.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Phenotype | 2021 |
Nanoparticle-Mediated Delivery of Pitavastatin to Monocytes/Macrophages Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Apoe
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Chemokine CCL2; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Monocytes; Nanoparticles; Polylactic Acid-Polyglycolic Acid Copolymer; Quinolines | 2022 |
A Dual Role of Heme Oxygenase-1 in Angiotensin II-Induced Abdominal Aortic Aneurysm in the Normolipidemic Mice.
Topics: Aneurysm; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cardiovascular Diseases; Cell Line; Collagen; Genotype; Heme Oxygenase-1; Humans; Hyperlipidemias; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Oxidative Stress; Plasminogen Activator Inhibitor 1; Receptor, Angiotensin, Type 2; Serpin E2; Skin; Swine; Tissue Inhibitor of Metalloproteinase-2 | 2021 |
Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
Topics: ADAM10 Protein; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Calcium Chloride; Cell Movement; Chromones; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Knockout; Mice, Transgenic; Morpholines; Neuropeptides; NLR Family, Pyrin Domain-Containing 3 Protein; Peptide Hormones; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, Notch1; Transcription Factor HES-1 | 2021 |
Inhibition of CXCR2 alleviates the development of abdominal aortic aneurysm in Apo E-/- mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Macrophages; Mice; Mice, Inbred C57BL; Receptors, Interleukin-8B | 2021 |
MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Trans-Activators | 2021 |
MicroRNA-23b prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching via FoxO4 suppression.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cell Cycle Proteins; Forkhead Transcription Factors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; MicroRNAs; Myocytes, Smooth Muscle; Phenotype | 2022 |
Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice.
Topics: Aged; Aged, 80 and over; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Calpain; Cells, Cultured; Cytoskeleton; Dilatation, Pathologic; Disease Models, Animal; Extracellular Matrix; Female; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Rats; Receptors, LDL; Vascular Remodeling | 2021 |
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Histone Demethylases; Inflammation; Inflammation Mediators; Jumonji Domain-Containing Histone Demethylases; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Up-Regulation | 2021 |
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Becaplermin; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Thymosin | 2021 |
Systemic delivery of targeted nanotherapeutic reverses angiotensin II-induced abdominal aortic aneurysms in mice.
Topics: Angiotensin II; Animals; Antibodies; Aortic Aneurysm, Abdominal; Drug Delivery Systems; Elastin; Hydrolyzable Tannins; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Serum Albumin, Bovine | 2021 |
Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-Infused Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Disease Models, Animal; Infusions, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Vasoconstrictor Agents | 2021 |
Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Macrophages; Male; Mice; Mice, Inbred C57BL; Phagocytes; Tomography, X-Ray Computed | 2021 |
Adventitial recruitment of Lyve-1- macrophages drives aortic aneurysm in an angiotensin-2-based murine model.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Disease Models, Animal; Inflammation; Inflammation Mediators; Macrophages; Membrane Transport Proteins; Mice; Signal Transduction | 2021 |
Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout | 2021 |
Omentin attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice.
Topics: Adipokines; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cytokines; Disease Models, Animal; GPI-Linked Proteins; Lectins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-akt | 2022 |
CCL7 contributes to angiotensin II-induced abdominal aortic aneurysm by promoting macrophage infiltration and pro-inflammatory phenotype.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cell Differentiation; Cell Movement; Cells, Cultured; Chemokine CCL7; Human Umbilical Vein Endothelial Cells; Humans; Janus Kinase 2; Macrophages; Male; Mice; Mice, Inbred C57BL; Phenotype; Receptors, CCR1; STAT1 Transcription Factor; Vascular Remodeling | 2021 |
Artesunate Attenuated the Progression of Abdominal Aortic Aneurysm in a Mouse Model.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Artesunate; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL | 2021 |
Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; beta-Galactosidase; Biomarkers; Cellular Senescence; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation, Enzymologic; Histones; Male; Mice; Mice, Knockout, ApoE; RNA, Messenger; Sirtuin 1; Up-Regulation | 2021 |
Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Aortic Aneurysm, Abdominal; Autophagy; Case-Control Studies; Cells, Cultured; Coculture Techniques; Collagen; Endothelium; Essential Hypertension; Extracellular Traps; Humans; Kidney; Neutrophils; Reactive Oxygen Species; Thrombin; Thromboinflammation; Thromboplastin; Vasoconstrictor Agents | 2021 |
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.
Topics: Allosteric Regulation; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Case-Control Studies; Dilatation, Pathologic; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Extracellular Signal-Regulated MAP Kinases; Humans; Macrophages; Male; Mice; Mice, Knockout, ApoE; NF-kappa B; Protein Phosphatase 2; RAW 264.7 Cells; Vascular Remodeling | 2021 |
Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Fibrosis; Genomics; Humans; Mice; Mice, Inbred C57BL; Pancreatic Elastase; Swine | 2021 |
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomarkers; Cells, Cultured; Collagen Type III; Disease Models, Animal; Disease Progression; Elastin; Genetic Predisposition to Disease; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Male; Matrix Metalloproteinase 9; Mice, Knockout; Odds Ratio; Phenotype; Proteolysis; Receptors, LDL; Risk Factors; Thrombospondin 1; Time Factors; Tumor Suppressor Proteins; Ultrasonography; Vascular Remodeling | 2017 |
Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Atorvastatin; Calcium Chloride; Cell Line; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Random Allocation | 2017 |
Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Relaxin | 2017 |
Recombinant adeno-associated virus vector carrying the thrombomodulin lectin-like domain for the treatment of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Cytokines; Dependovirus; Disease Models, Animal; Elastin; Genetic Therapy; Genetic Vectors; HMGB1 Protein; Macrophages; Male; Matrix Metalloproteinases; Mice, Knockout, ApoE; Oxidative Stress; Protein Domains; Receptor for Advanced Glycation End Products; Thrombomodulin; Vascular Remodeling | 2017 |
Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Disease Models, Animal; Extracellular Matrix; Fibroblasts; Gingiva; Mice, Inbred C57BL; Mice, Knockout; Protective Agents; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2017 |
UCP-2 is involved in angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.
Topics: Actins; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Endothelial Cells; Gene Expression Regulation; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Uncoupling Protein 2 | 2017 |
TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms.
Topics: Adventitia; Angiotensin II; Animals; Antibodies; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Dilatation, Pathologic; Disease Models, Animal; Female; Genetic Predisposition to Disease; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Phenotype; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Severity of Illness Index; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Tunica Media; Vascular Remodeling | 2017 |
Ultraviolet B Exposure Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Expanding CD4
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Cell Proliferation; Cholesterol, Dietary; Disease Models, Animal; Forkhead Transcription Factors; Lymph Nodes; Lymphocyte Activation; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Phenotype; T-Lymphocytes, Regulatory; Time Factors; Ultraviolet Therapy | 2017 |
Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortitis; Apolipoproteins E; Bone Marrow Transplantation; Calcium Chloride; Cell Line; Chemokine CCL2; Cholesterol, HDL; Dilatation, Pathologic; Disease Models, Animal; Female; Genetic Predisposition to Disease; Humans; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Macrophages, Peritoneal; Male; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phenotype; Signal Transduction; Time Factors; Transfection; Vascular Remodeling | 2017 |
Angiotensin II infusion into ApoE-/- mice: a model for aortic dissection rather than abdominal aortic aneurysm?
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortography; Computed Tomography Angiography; Disease Models, Animal; Disease Progression; Hematoma; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Time Factors; Ultrasonography, Doppler, Pulsed; Vascular Remodeling; X-Ray Microtomography | 2017 |
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile-Induced Abdominal Aortic Aneurysm.
Topics: ADAM17 Protein; Aminopropionitrile; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; ErbB Receptors; Hypertension; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Protein-Lysine 6-Oxidase; Receptor Activity-Modifying Proteins; Signal Transduction | 2017 |
Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine.
Topics: Angiotensin II; Animals; Antioxidants; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Disease Models, Animal; Gene Deletion; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Neutrophils; Oxidative Stress; Pancreatic Elastase; Peroxidase; Reactive Oxygen Species; Serum Amyloid A Protein; Taurine | 2017 |
New Mouse Model of Abdominal Aortic Aneurysm: Put Out to Expand.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Mice | 2017 |
Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic Pathology.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Dilatation, Pathologic; Disease Models, Animal; Female; Genetic Predisposition to Disease; Male; Mice, Inbred C57BL; Mice, Knockout; Orchiectomy; Phenotype; Receptors, LDL; Sex Characteristics; Sex Factors; Sex-Determining Region Y Protein; Testosterone; Vascular Remodeling; Vascular Stiffness; X Chromosome; Y Chromosome | 2018 |
Elevated Wall Tension Initiates Interleukin-6 Expression and Abdominal Aortic Dilation.
Topics: Angiotensin II; Animals; Antigens, CD; Antigens, Differentiation; Antigens, Differentiation, Myelomonocytic; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Arterial Pressure; CD11b Antigen; Cells, Cultured; Chemokine CCL2; Dilatation, Pathologic; Disease Models, Animal; Female; Interleukin-6; Macrophages; Male; Mechanotransduction, Cellular; Mice; Monocytes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; STAT3 Transcription Factor; Stress, Mechanical | 2018 |
Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Decorin; Disease Models, Animal; Humans; Mice; Mice, Knockout; Recombinant Proteins | 2017 |
Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Dissection; Apolipoproteins E; Atherosclerosis; Blood Pressure; Cholesterol; Disease Models, Animal; Gene Knockout Techniques; Genetic Predisposition to Disease; Phenotype; Rats, Sprague-Dawley; Rats, Transgenic; Time Factors; Ultrasonography, Doppler | 2018 |
Cortistatin attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the ERK1/2 signaling pathways.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Cell Line; Disease Models, Animal; Elastin; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout, ApoE; Myocytes, Smooth Muscle; Neuropeptides; Proteolysis; Reactive Oxygen Species | 2018 |
Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Cadherins; Cell Proliferation; Disease Models, Animal; Humans; Male; Matrix Metalloproteinase 7; Mice; Mice, Inbred C57BL; Mice, Knockout; Severity of Illness Index; Signal Transduction | 2017 |
Cardiac and respiratory-gated volumetric murine ultrasound.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Dissection; Biomechanical Phenomena; Cardiac-Gated Imaging Techniques; Disease Models, Animal; Echocardiography, Four-Dimensional; Heart Ventricles; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Myocardial Infarction; Predictive Value of Tests; Reproducibility of Results; Respiratory-Gated Imaging Techniques; Vascular Stiffness; Ventricular Function, Left | 2018 |
Peptidyl-prolyl isomerase Pin1 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in ApoE
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Movement; Cell Proliferation; Cytokines; Humans; Inflammation Mediators; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; NIMA-Interacting Peptidylprolyl Isomerase; Phenotype; Promoter Regions, Genetic; STAT Transcription Factors; Up-Regulation | 2018 |
Loss of vascular smooth muscle cell autophagy exacerbates angiotensin II-associated aortic remodeling.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Autophagy; Hemodynamics; Mice; Mice, Knockout; Muscle, Smooth, Vascular | 2018 |
Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor κB activation.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cells, Cultured; Collagenases; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; JNK Mitogen-Activated Protein Kinases; Mice, Inbred C57BL; Mice, Knockout, ApoE; Phosphorylation; Polysaccharides; Protein Kinase Inhibitors; Signal Transduction; Transcription Factor RelA; Vascular Remodeling | 2018 |
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury.
Topics: Allosteric Regulation; Angiotensin I; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; HEK293 Cells; Homocysteine; Humans; Male; Mice, Inbred C57BL; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Conformation; Receptor, Angiotensin, Type 1; Vascular System Injuries | 2018 |
Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1).
Topics: Adult; Aged; Angiotensin II; Animals; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Aortic Rupture; Autoantigens; Collagen; Diabetes Mellitus, Experimental; Female; Gene Expression Regulation; Humans; Macrophages; Male; Matrix Metalloproteinase 12; Mice; Mice, Knockout; Mice, Knockout, ApoE; Middle Aged; Severity of Illness Index; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Vasoconstrictor Agents | 2018 |
CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice.
Topics: Angiotensin II; Animals; Antigens, CD1d; Aortic Aneurysm, Abdominal; Apoptosis; Flow Cytometry; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Smooth, Vascular; Natural Killer T-Cells; NIH 3T3 Cells; Real-Time Polymerase Chain Reaction; Receptors, LDL | 2018 |
Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Arginase; Cell Polarity; Disease Models, Animal; Humans; Lectins, C-Type; Macrophages; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Receptors, Cell Surface; Signal Transduction; Sirtuin 1 | 2018 |
Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice: from individual elastic lamella to 3D analysis.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Dissection; Aortic Rupture; Disease Models, Animal; Imaging, Three-Dimensional; Male; Mice; Mice, Inbred C57BL; Microscopy, Phase-Contrast; Synchrotrons | 2018 |
Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure; Cyclin-Dependent Kinase Inhibitor p27; Cyclooxygenase 2; Endothelial Cells; Enzyme Activation; Mice, Inbred C57BL; Phosphorylation; Phosphoserine; Thromboxanes; Vasodilation; Ventricular Remodeling | 2018 |
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.
Topics: Acetates; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Chemokine CCL3; Cyclopropanes; Disease Models, Animal; Leukotriene Antagonists; Matrix Metalloproteinase 9; Mice; Mice, Knockout, ApoE; Quinolines; Receptors, Leukotriene; Sulfides | 2018 |
Cilostazol Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E-Deficient Mice.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Atherosclerosis; Cell Adhesion Molecules; Cells, Cultured; Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Dilatation, Pathologic; Disease Models, Animal; Endothelial Cells; Male; Mice, Knockout, ApoE; Phosphodiesterase 3 Inhibitors; Signal Transduction | 2018 |
Deletion of BMAL1 in Smooth Muscle Cells Protects Mice From Abdominal Aortic Aneurysms.
Topics: Aldosterone; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; ARNTL Transcription Factors; Binding Sites; Desoxycorticosterone Acetate; Dilatation, Pathologic; Disease Models, Animal; Elastin; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Promoter Regions, Genetic; Sodium Chloride, Dietary; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Transcription, Genetic | 2018 |
Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation.
Topics: Angiotensin II; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Movement; Cell Proliferation; Chemokine CCL2; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; MicroRNAs; Muscle, Smooth, Vascular; Nitric Oxide Synthase Type II | 2018 |
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Cell Survival; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophages; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, LDL; T-Lymphocytes | 2018 |
Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.
Topics: ADAM17 Protein; Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cell Line; Cell Proliferation; Disease Models, Animal; Elastin; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Ursolic Acid; Vascular Remodeling; Wound Healing | 2018 |
CD40L Deficiency Protects Against Aneurysm Formation.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Dissection; Aortic Rupture; CD40 Ligand; Chemokines; Cytokines; Dilatation, Pathologic; Disease Models, Animal; Humans; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout, ApoE; Tissue Inhibitor of Metalloproteinase-3 | 2018 |
Plasma cholesterol lowering in an AngII‑infused atherosclerotic mouse model with moderate hypercholesterolemia.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoprotein B-100; Atherosclerosis; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Hypercholesterolemia; Integrases; Male; Receptors, LDL | 2018 |
H19 Induces Abdominal Aortic Aneurysm Development and Progression.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Case-Control Studies; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pancreatic Elastase; Receptors, LDL; RNA, Long Noncoding; Swine; Swine, Miniature; Tumor Suppressor Protein p53; Up-Regulation | 2018 |
RANKL-mediated osteoclastogenic differentiation of macrophages in the abdominal aorta of angiotensin II-infused apolipoprotein E knockout mice.
Topics: Angiotensin II; Animals; Antibodies, Neutralizing; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Dissection; Cell Transdifferentiation; Disease Models, Animal; Janus Kinase 2; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteoclasts; Osteogenesis; RANK Ligand; RAW 264.7 Cells; Signal Transduction; STAT5 Transcription Factor | 2018 |
Development and growth trends in angiotensin II-induced murine dissecting abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Dissection; Apolipoproteins E; Disease Models, Animal; Disease Progression; Male; Mice; Ultrasonography | 2018 |
Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Ginkgo biloba; Male; Mice, Inbred C57BL; Mice, Knockout; Plant Extracts | 2019 |
PM2.5 promotes abdominal aortic aneurysm formation in angiotensin Ⅱ-infused apoe-/- mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; beta-Galactosidase; Biomarkers; Cell Line; Chemokine CCL2; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Elastin; Humans; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Particulate Matter; Reactive Oxygen Species | 2018 |
Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice.
Topics: Adenylate Kinase; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Endoplasmic Reticulum Stress; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peptide Hormones; Phosphorylation | 2018 |
Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Benzoquinones; Disease Models, Animal; Gene Expression Regulation; Glutathione; Glutathione Peroxidase; Humans; Interleukin-6; Mice; NF-kappa B; Phosphorylation; STAT3 Transcription Factor | 2018 |
Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Aortitis; Atherosclerosis; Bone Marrow Transplantation; Disease Models, Animal; Macrophages; Male; Mice, Knockout, ApoE; Monocytes; Plaque, Atherosclerotic; Whole-Body Irradiation | 2018 |
Recombinant leptin attenuates abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Inflammation; Injections, Intraperitoneal; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Recombinant Proteins; T-Lymphocytes; Th1 Cells | 2018 |
PPARγ agonist rosiglitazone alters the temporal and spatial distribution of inflammation during abdominal aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Disease Models, Animal; Inflammation; Male; Mice; Mice, Knockout; Models, Biological; PPAR gamma; Rosiglitazone; Th2 Cells; Thiazolidinediones; Vasodilator Agents | 2018 |
Rapamycin Treatment Attenuates Angiotensin II -induced Abdominal Aortic Aneurysm Formation via VSMC Phenotypic Modulation and Down-regulation of ERK1/2 Activity.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cells, Cultured; Down-Regulation; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Sirolimus | 2018 |
A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein E deficient mice.
Topics: Angiotensin II; Animal Feed; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Diseases; Atherosclerosis; Brachiocephalic Trunk; Dilatation, Pathologic; Disease Models, Animal; Fatty Acids, Omega-3; Male; Mice, Knockout, ApoE; Nutritive Value; Nuts; Plaque, Atherosclerotic; Polyphenols; Severity of Illness Index; Time Factors | 2018 |
Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms.
Topics: Administration, Oral; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Conformation; Oxidative Stress; Pancreatic Elastase; Rats; Rats, Sprague-Dawley; Sapogenins; Signal Transduction | 2019 |
PARP-1 (Poly[ADP-Ribose] Polymerase 1) Inhibition Protects From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm in Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Blood Pressure; Collagen; Cytokines; DNA Damage; Endothelial Cells; Intercellular Adhesion Molecule-1; Mice; Mice, Knockout; Myocytes, Smooth Muscle; NF-kappa B; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; RNA, Small Interfering; Signal Transduction | 2018 |
PARP-1 (Poly[ADP-Ribose] Polymerase-1).
Topics: Adenosine Diphosphate Ribose; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Mice | 2018 |
Long-Term Effects of the Abdominal Aortic Aneurysm Model in Rabbits Prepared by Pancreatic Elastase Combined With Angiotensin II.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Hemodynamics; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pancreatic Elastase; Rabbits; Time Factors; Ultrasonography, Doppler, Color; Vascular Remodeling | 2019 |
von Willebrand factor deficiency does not influence angiotensin II-induced abdominal aortic aneurysm formation in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Dilatation, Pathologic; Disease Models, Animal; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Vasoconstrictor Agents; von Willebrand Factor | 2018 |
Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b/SIRT1/HO-1 signaling.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Chalcones; Cytokines; Disease Models, Animal; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; MicroRNAs; Signal Transduction; Sirtuin 1 | 2019 |
Invited commentary.
Topics: Angiotensin II; Aortic Aneurysm, Abdominal; Humans; JNK Mitogen-Activated Protein Kinases; NF-kappa B; Polysaccharides | 2018 |
Gambogic acid prevents angiotensin II‑induced abdominal aortic aneurysm through inflammatory and oxidative stress dependent targeting the PI3K/Akt/mTOR and NF‑κB signaling pathways.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Garcinia; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Xanthones | 2019 |
Chemokine (C-X-C motif) receptor 2 blockade by SB265610 inhibited angiotensin II-induced abdominal aortic aneurysm in Apo E
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Humans; Macrophages; Male; Mice; Mice, Knockout, ApoE; Phenylurea Compounds; Receptors, Interleukin-8B; Signal Transduction; Triazoles | 2019 |
ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation.
Topics: Acetylation; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Female; Histones; Humans; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Neurofibromin 1; Transcription Factors | 2019 |
Circular RNA microarray expression profile in 3,4-benzopyrene/angiotensin II-induced abdominal aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Benzo(a)pyrene; Disease Models, Animal; Gene Ontology; Gene Regulatory Networks; Male; Mice, Inbred C57BL; MicroRNAs; Myocytes, Smooth Muscle; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Reproducibility of Results; RNA, Circular; Transcriptome | 2019 |
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Topics: Alleles; Angiotensin II; Animals; Antibodies; Aortic Aneurysm, Abdominal; Biomarkers; Disease Models, Animal; Humans; Interleukin-6; Linear Models; Mice; Polymorphism, Single Nucleotide; Receptors, Interleukin-6; Signal Transduction; Survival Rate; Transforming Growth Factor beta | 2019 |
Caloric Restriction Exacerbates Angiotensin II-Induced Abdominal Aortic Aneurysm in the Absence of p53.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Caloric Restriction; Disease Models, Animal; Energy Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Signal Transduction; Tumor Suppressor Protein p53 | 2019 |
Knockdown of lncRNA
Topics: Aged; Aged, 80 and over; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Disease Models, Animal; Extracellular Matrix; Gene Knockdown Techniques; Humans; Inflammation; Mice; Middle Aged; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; RNA, Long Noncoding; RNA, Small Interfering | 2019 |
Establishment of Novel Murine Model showing Vascular Inflammation-derived Cognitive Dysfunction.
Topics: Aging; Angiotensin II; Animals; Antigens, Differentiation; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Calcium-Binding Proteins; Cognitive Dysfunction; Disease Models, Animal; Genes, MHC Class II; Hippocampus; Inflammation; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia | 2019 |
c‑Jun/Ap‑1 is upregulated in an Ang II‑induced abdominal aortic aneurysm formation model and mediates Chop expression in mouse aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cells, Cultured; Disease Models, Animal; Gene Silencing; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Transcription Factor AP-1; Transcription Factor CHOP | 2019 |
Concurrent Molecular Magnetic Resonance Imaging of Inflammatory Activity and Extracellular Matrix Degradation for the Prediction of Aneurysm Rupture.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Contrast Media; Disease Models, Animal; Disease Progression; Elastin; Extracellular Matrix; Feasibility Studies; Ferrosoferric Oxide; Gadolinium DTPA; Inflammation Mediators; Magnetic Resonance Imaging; Male; Mice, Knockout, ApoE; Molecular Imaging; Predictive Value of Tests; Reproducibility of Results; Time Factors | 2019 |
Smooth muscle-specific LKB1 deletion exaggerates angiotensin II-induced abdominal aortic aneurysm in mice.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Gene Deletion; Humans; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Protein Serine-Threonine Kinases; Sp1 Transcription Factor | 2019 |
Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction.
Topics: Anemia, Megaloblastic; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Blood Pressure; Disease Models, Animal; Genetic Loci; Hypertension; Macrophages; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Mitochondria; Phenotype; Tetrahydrofolate Dehydrogenase; Ultrasonography | 2019 |
LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cells, Cultured; Disease Models, Animal; Humans; Inflammation; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; RNA, Long Noncoding; Signal Transduction; Transcription, Genetic; Up-Regulation | 2019 |
Testosterone inhibits aneurysm formation and vascular inflammation in male mice.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure; Disease Models, Animal; Flutamide; Inflammation; Interleukin-1beta; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Androgen; Testosterone | 2019 |
ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Benzoic Acid; Chymases; Colitis; Enzyme Precursors; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Serine Proteinase Inhibitors | 2019 |
Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.
Topics: Aged; Aged, 80 and over; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apelin; Apoptosis; Cardiovascular Agents; Diet, High-Fat; Disease Models, Animal; Female; Gene Knockdown Techniques; Humans; Male; Mice, Transgenic; Middle Aged; Myocytes, Smooth Muscle; Neprilysin; Oxidative Stress; Peptidyl-Dipeptidase A; Phenylephrine; Primary Cell Culture; Proteolysis; Receptors, LDL; RNA, Small Interfering; Vascular Remodeling | 2019 |
Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Dissection; Biomarkers; Contrast Media; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Extracellular Matrix; Humans; Magnetic Resonance Imaging; Mice, Knockout, ApoE; Predictive Value of Tests; Proof of Concept Study; Time Factors; Tropoelastin; Up-Regulation; Vascular Remodeling | 2020 |
SGLT-2 (Sodium-Glucose Cotransporter 2) Inhibition Reduces Ang II (Angiotensin II)-Induced Dissecting Abdominal Aortic Aneurysm in ApoE (Apolipoprotein E) Knockout Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Dissection; Apolipoproteins E; Benzhydryl Compounds; Cells, Cultured; Chemokines; Glucosides; Humans; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Sodium-Glucose Transporter 2 Inhibitors | 2019 |
Regulatory T cells protected against abdominal aortic aneurysm by suppression of the COX-2 expression.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Survival; Cyclooxygenase 2; Dinoprostone; Macrophages; Male; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Phenotype; RAW 264.7 Cells; T-Lymphocytes, Regulatory | 2019 |
CYP2J2 overexpression increases EETs and protects against angiotensin II-induced abdominal aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Arachidonic Acids; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Humans; Macrophages; Mice; Muscle, Smooth, Vascular; PPAR gamma | 2013 |
β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arrestins; Benzamides; beta-Arrestin 2; beta-Arrestins; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Chemokine CCL2; Chemokine CCL3; Cyclooxygenase 2; Disease Models, Animal; Elastic Tissue; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; Time Factors | 2013 |
Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects.
Topics: Aminopropionitrile; Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Disease Progression; Inflammation Mediators; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Sirtuin 1; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Topics: Angiotensin II; Animals; Aorta; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Atherosclerosis; Genotype; Imidazoles; Male; Mice; Mice, Inbred C57BL; Pyridines; Receptor, Angiotensin, Type 2 | 2013 |
Exploration of the mechanisms by which 3,4-benzopyrene promotes angiotensin II-induced abdominal aortic aneurysm formation in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Benzo(a)pyrene; Disease Models, Animal; Drug Administration Schedule; Injections, Intraperitoneal; Macrophages; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; NF-kappa B; Smoking; Time Factors | 2014 |
β-Carotene Attenuates Angiotensin II-Induced Aortic Aneurysm by Alleviating Macrophage Recruitment in Apoe(-/-) Mice.
Topics: alpha-Tocopherol; Angiotensin II; Animals; Antioxidants; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; beta Carotene; Cholesterol, LDL; Dietary Supplements; Disease Models, Animal; Lymphocytes; Macrophages; Male; Mice, Knockout; Organ Size; Plaque, Atherosclerotic | 2013 |
Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; CD4-Positive T-Lymphocytes; Cytokines; Elastin; Inflammation; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Elastase; Phospholipid Transfer Proteins | 2013 |
Natural regulatory T cells limit angiotensin II-induced aneurysm formation and rupture in mice.
Topics: Angiotensin II; Animals; Antibodies, Monoclonal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; B7-1 Antigen; B7-2 Antigen; CD28 Antigens; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Inflammation Mediators; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Leukocyte Reduction Procedures; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Regulatory; Time Factors | 2013 |
Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation.
Topics: Amlodipine; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Atorvastatin; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Drug Therapy, Combination; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipids; Male; Matrix Metalloproteinases; Mice; Mice, Knockout; Pyrroles; rho-Associated Kinases | 2013 |
Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.
Topics: Angiotensin II; Animals; Aorta; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calpain; Diet, High-Fat; Enzyme Inhibitors; Filamins; Gene Expression Regulation; Male; Mice; Mice, Knockout; Receptors, LDL; Signal Transduction; Sulfonamides | 2013 |
Zoledronate attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of Rho/ROCK-dependent JNK and NF-κB pathway.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cell Adhesion; Cell Line; Coculture Techniques; Dilatation, Pathologic; Diphosphonates; Disease Models, Animal; Dose-Response Relationship, Drug; Elastin; Endothelial Cells; Enzyme Activation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NF-kappa B; Phosphorylation; Receptors, LDL; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Vascular Cell Adhesion Molecule-1; Zoledronic Acid | 2013 |
Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase.
Topics: ADAM Proteins; ADAM17 Protein; Adenoviridae; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Caveolin 1; Cells, Cultured; Gene Expression Regulation; Gene Silencing; Heparin-binding EGF-like Growth Factor; Immunohistochemistry; Inflammation; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Smooth Muscle; Oxidative Stress; Promoter Regions, Genetic; Protein-Lysine 6-Oxidase; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; RNA Interference; Signal Transduction | 2014 |
Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms.
Topics: Amyloid Precursor Protein Secretases; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Dibenzazepines; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Notch1; Signal Transduction | 2013 |
Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms.
Topics: Actins; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomarkers; Cells, Cultured; Collagen; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Male; Mice, Inbred C57BL; Mice, Knockout; Orchiectomy; Risk Factors; Sex Factors; Testosterone; Time Factors; Ultrasonography; Vascular Remodeling | 2015 |
Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: role of serum cholesterol and temporal effects of exposure.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Cholesterol; Elastin; Hypercholesterolemia; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Time Factors; Ultrasonography | 2014 |
Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model.
Topics: Amides; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Blood Pressure; Disease Models, Animal; Fumarates; Hypertension; Hypertrophy; Mice; Mice, Inbred C57BL; Mice, Knockout | 2014 |
Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice.
Topics: Administration, Oral; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biopterins; Folic Acid; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Radiography; Superoxides; Tetrahydrofolate Dehydrogenase; Ultrasonography; Vascular Remodeling | 2014 |
PPARδ reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice by regulating extracellular matrix homeostasis and inflammatory responses.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Extracellular Matrix; Homeostasis; Inflammation; Infusion Pumps; Male; Mice; PPAR delta | 2014 |
Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; LIM Domain Proteins; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Proteins; Mice, Knockout; Phosphoproteins; Reactive Oxygen Species; Signal Transduction | 2014 |
Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice.
Topics: Adult; Aged; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Profiling; GPI-Linked Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Middle Aged; Oligonucleotide Array Sequence Analysis; Oligonucleotides, Antisense; Time Factors; Tissue Inhibitor of Metalloproteinase-3; Up-Regulation | 2014 |
Adiponectin attenuates abdominal aortic aneurysm formation in hyperlipidemic mice.
Topics: Adiponectin; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Enzyme Activation; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Knockout | 2014 |
New ways to dismantle a ticking time bomb: microRNA 712/205 and abdominal aortic aneurysm development.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Endothelial Cells; Female; Humans; Male; MicroRNAs; Oligonucleotides, Antisense | 2014 |
Regulatory T cells prevent angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E knockout mice.
Topics: Adoptive Transfer; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Blotting, Western; CD4-Positive T-Lymphocytes; Cytokines; Gene Expression; Humans; Inflammation Mediators; Macrophages; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocytes, Smooth Muscle; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Regulatory | 2014 |
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cathepsin G; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Macrophages; Mice; Myocytes, Smooth Muscle; Peptidyl-Dipeptidase A | 2015 |
NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.
Topics: Angiotensin II; Animals; Antibodies; Aortic Aneurysm, Abdominal; Disease Models, Animal; Interleukin-1beta; Macrophages; Matrix Metalloproteinase 12; Matrix Metalloproteinase 9; Membrane Glycoproteins; Mice; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Reactive Oxygen Species | 2014 |
Inhibiting the Th17/IL-17A-related inflammatory responses with digoxin confers protection against experimental abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cardiotonic Agents; Digoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inflammation; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3; Pancreatic Elastase; Survival Rate; Swine; Th17 Cells | 2014 |
Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomarkers; Biopterins; Folic Acid; Hematinics; Male; Mice; Mice, Knockout; Phenylalanine; Vasoconstrictor Agents | 2014 |
Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.
Topics: Aged; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aortic Aneurysm, Abdominal; Diminazene; Disease Models, Animal; Enzyme Activation; Female; Humans; Hypercholesterolemia; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Peptidyl-Dipeptidase A; Receptors, LDL; Renin-Angiotensin System; RNA, Messenger | 2014 |
Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and rupture in the apolipoprotein E-knockout mouse.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Blood Pressure; Cathepsins; Dilatation, Pathologic; Disease Models, Animal; Humans; Inflammation Mediators; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; Osteoprotegerin; Pancreatic Elastase; Proteolysis | 2014 |
High-fat diet- and angiotensin II-induced aneurysm concurrently elicits splenic hypertrophy.
Topics: alpha-Tocopherol; Angiotensin II; Animals; Antioxidants; Aortic Aneurysm, Abdominal; Apolipoproteins E; beta Carotene; Diet, High-Fat; Dietary Supplements; Male; Mice, Knockout; Splenomegaly; T-Lymphocytes; Vasoconstrictor Agents | 2014 |
5-Lipoxygenase pathway in experimental abdominal aortic aneurysms.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Arachidonate 5-Lipoxygenase; Bone Marrow Transplantation; Disease Models, Animal; Disease Progression; Humans; Hypercholesterolemia; Lipoxygenase Inhibitors; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Neutrophil Infiltration; Pancreatic Elastase; Receptors, LDL; Signal Transduction; Transplantation Chimera | 2014 |
Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Differentiation; Cells, Cultured; Collagen; Dipeptides; Disease Models, Animal; Disease Progression; Elastin; Gene Expression Regulation; Humans; Macrophages; Male; Matrix Metalloproteinases; Mice, Knockout; Middle Aged; Receptor, Notch1; Signal Transduction; Time Factors; Transforming Growth Factor beta2 | 2014 |
Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Humans; Inflammasomes; Inflammation Mediators; Interleukin-1beta; Macrophage Activation; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Time Factors | 2015 |
Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.
Topics: Aneurysm; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Arterial Pressure; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Elastin; Gene Deletion; Ligands; Low Density Lipoprotein Receptor-Related Protein-1; Macrophages; Male; Matrix Metalloproteinase 2; Mesenteric Artery, Superior; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Norepinephrine; Receptors, LDL; RNA, Messenger; Tumor Suppressor Proteins; Urokinase-Type Plasminogen Activator | 2015 |
Arrest of progression of pre-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by low level laser phototherapy.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Lasers, Semiconductor; Low-Level Light Therapy; Mice; Mice, Inbred C57BL | 2014 |
A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse.
Topics: Amino Acid Oxidoreductases; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Cytokines; Disease Models, Animal; Disease Progression; Elastin; Inflammation Mediators; Injections, Intraperitoneal; Male; Mice, Knockout; Peptides; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Smad2 Protein; Smad3 Protein; Thrombospondin 1; Time Factors; Transforming Growth Factor beta1 | 2015 |
Angiotensin II mobilizes spleen monocytes to promote the development of abdominal aortic aneurysm in Apoe-/- mice.
Topics: Angiotensin II; Animals; Antigens, Ly; Aortic Aneurysm, Abdominal; Apolipoproteins E; B-Lymphocytes; Bone Marrow Transplantation; Cell Movement; Cells, Cultured; Disease Models, Animal; DNA-Binding Proteins; Hypercholesterolemia; Male; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Spleen; Splenectomy; Time Factors | 2015 |
Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model.
Topics: Aminopropionitrile; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Cells, Cultured; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum Stress; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Matrix; Humans; Interleukin-6; Male; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Rats, Sprague-Dawley; Time Factors | 2015 |
Dissecting abdominal aortic aneurysm in Ang II-infused mice: suprarenal branch ruptures and apparent luminal dilatation.
Topics: Aneurysm, Ruptured; Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Dissection; Contrast Media; Dilatation, Pathologic; Disease Models, Animal; Male; Mice, Inbred C57BL | 2015 |
Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Aortography; Biomarkers; Disease Models, Animal; Disease Progression; Enzyme Activation; Feasibility Studies; Male; Matrix Metalloproteinases; Mice, Inbred C57BL; Mice, Transgenic; Molecular Imaging; Multimodal Imaging; Predictive Value of Tests; Radiopharmaceuticals; Risk Assessment; Risk Factors; Time Factors; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2015 |
Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Flow Cytometry; Forkhead Transcription Factors; Immunity, Cellular; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes, Regulatory | 2015 |
Combined treatment with bexarotene and rosuvastatin reduces angiotensin-II-induced abdominal aortic aneurysm in apoE(-/-) mice and angiogenesis.
Topics: Angiogenesis Inhibitors; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Bexarotene; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Rosuvastatin Calcium; Signal Transduction; Tetrahydronaphthalenes | 2015 |
ApoB-100-related peptide vaccine protects against angiotensin II-induced aortic aneurysm formation and rupture.
Topics: Aneurysm, Ruptured; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoprotein B-100; Disease Models, Animal; Immunity, Cellular; Macrophages; Male; Mice; Mice, Knockout; T-Lymphocytes; Vaccines | 2015 |
Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomarkers; Disease Models, Animal; Elastin; Macrophages; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; Sensitivity and Specificity; Serum Amyloid A Protein | 2015 |
ApoA-I/HDL-C levels are inversely associated with abdominal aortic aneurysm progression.
Topics: Aged; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoprotein A-I; Apolipoproteins E; Biomarkers; Cholesterol, HDL; Chromatography, Liquid; Denmark; Disease Models, Animal; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Male; Mice, Inbred C57BL; Mice, Knockout; Molecular Mimicry; Multivariate Analysis; Nanotechnology; Peptides; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Proteomics; Registries; Spain; Tandem Mass Spectrometry | 2015 |
Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms.
Topics: Aged; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Chemokines; Forkhead Transcription Factors; Humans; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; T-Lymphocytes, Regulatory | 2015 |
An animal-specific FSI model of the abdominal aorta in anesthetized mice.
Topics: Anesthesia; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Mice; Mice, Knockout; Models, Cardiovascular | 2015 |
Dipeptidyl peptidase-4 inhibitor decreases abdominal aortic aneurysm formation through GLP-1-dependent monocytic activity in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Cell Movement; Cells, Cultured; Chemotaxis; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Fibroblasts; Glucagon-Like Peptide 1; Humans; Infusion Pumps, Implantable; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Monocytes; Reactive Oxygen Species; Sitagliptin Phosphate; U937 Cells | 2015 |
Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Apoptosis; Disease Models, Animal; Enzyme Activators; Extracellular Matrix; Ginsenosides; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Severity of Illness Index; Signal Transduction; Vascular Remodeling | 2015 |
Thrombospondin-1 (TSP1) contributes to the development of vascular inflammation by regulating monocytic cell motility in mouse models of abdominal aortic aneurysm.
Topics: Adoptive Transfer; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Bone Marrow Transplantation; Calcium Phosphates; Cell Line; Cell Movement; Disease Models, Animal; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Pancreatic Elastase; Radiation Chimera; Recombinant Proteins; Thrombospondin 1; Up-Regulation | 2015 |
Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice.
Topics: Angiotensin II; Animals; Anticholesteremic Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoprotein A-I; Apolipoprotein B-100; Apolipoproteins B; Apolipoproteins E; Azetidines; Diet, Western; Disease Models, Animal; Ezetimibe; Female; Hypercholesterolemia; Male; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL; Sex Factors | 2015 |
Morphological and Biomechanical Differences in the Elastase and AngII apoE(-/-) Rodent Models of Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomechanical Phenomena; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Disease Progression; Humans; Mice; Mice, Knockout; Pancreatic Elastase; Rats | 2015 |
Telemetric Blood Pressure Assessment in Angiotensin II-Infused ApoE-/- Mice: 28 Day Natural History and Comparison to Tail-Cuff Measurements.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Blood Pressure Determination; Gene Deletion; Male; Mice; Mice, Inbred C57BL; Telemetry | 2015 |
Effects of long-term chloroquine administration on the natural history of aortic aneurysms in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Autophagy; Chloroquine; Collagen; Disease Models, Animal; Disease Progression; Elastin; Male; Mice, Inbred C57BL; Mice, Knockout; Time Factors | 2015 |
TRIF adaptor signaling is important in abdominal aortic aneurysm formation.
Topics: Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins; Apolipoproteins E; CD3 Complex; Elastin; Gene Expression Regulation; Humans; Inflammation; Mice; Mice, Knockout; Signal Transduction; Toll-Like Receptors | 2015 |
Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Base Sequence; Binding Sites; Calcium Chloride; Cell Line, Tumor; Disease Models, Animal; Early Growth Response Protein 1; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Macrophages; Male; Mice, Knockout; Molecular Sequence Data; Pioglitazone; PPAR gamma; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Thiazolidinediones; Time Factors; Transfection; TRPP Cation Channels | 2015 |
Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Disease Models, Animal; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Mice; Mice, Inbred C57BL; Platelet Aggregation Inhibitors | 2015 |
Dose-Dependent Bidirectional Effect of Angiotensin IV on Abdominal Aortic Aneurysm via Variable Angiotensin Receptor Stimulation.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Blood Pressure; Lipids; Mice; Mice, Knockout; Receptors, Angiotensin | 2015 |
Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Aortic Aneurysm, Abdominal; Calcium Channels, L-Type; Humans; Hypertension; Mice; Mice, Transgenic; NADPH Oxidases; Nifedipine; Nitric Oxide Synthase Type III; Oxidative Stress; Phenylketonurias | 2015 |
Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Gene Expression Regulation; Humans; Macrophages; Male; Mice; Mice, Knockout; Signal Transduction; STAT3 Transcription Factor; Toll-Like Receptor 4 | 2015 |
Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortitis; Calcium Chloride; Cell Membrane; Cells, Cultured; Chemotaxis; Disease Models, Animal; Elastin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation Mediators; Macrophages, Peritoneal; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Retrospective Studies; RNA Interference; Signal Transduction; Thrombomodulin; Time Factors; Transfection | 2015 |
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Apolipoproteins E; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Infusion Pumps, Implantable; Male; Mice; Mice, Transgenic | 2015 |
Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E(-/-) Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Bortezomib; Disease Models, Animal; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2015 |
Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice.
Topics: Angiotensin II; Animals; Anti-Allergic Agents; Antibodies, Monoclonal; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Calcium Chloride; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Immunoglobulin E; Inflammation Mediators; Lung; Macrophages; Male; Mast Cells; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Pneumonia; Respiratory Hypersensitivity; Risk Factors; Signal Transduction; Vascular Remodeling | 2016 |
A Dipeptidyl Peptidase-4 Inhibitor but not Incretins Suppresses Abdominal Aortic Aneurysms in Angiotensin II-Infused Apolipoprotein E-Null Mice.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Dipeptidyl-Peptidase IV Inhibitors; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Glucagon-Like Peptide 1; Incretins; Inflammation; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Plaque, Atherosclerotic; Tissue Inhibitor of Metalloproteinase-2 | 2016 |
Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Dissection; Aortic Rupture; Aortic Valve Insufficiency; Aortography; Apolipoproteins E; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Elastic Tissue; Male; Mice, Inbred C57BL; Mice, Knockout; Time Factors; Ultrasonography, Doppler, Pulsed; Vascular Remodeling; X-Ray Microtomography | 2016 |
Modulation of Kinin B2 Receptor Signaling Controls Aortic Dilatation and Rupture in the Angiotensin II-Infused Apolipoprotein E-Deficient Mouse.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Bradykinin; Bradykinin B2 Receptor Antagonists; Calcium Phosphates; Dilatation, Pathologic; Disease Models, Animal; Genetic Predisposition to Disease; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Knockout; Neutrophil Activation; Osteopontin; Osteoprotegerin; Phenotype; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Signal Transduction; Time Factors; Tissue Culture Techniques | 2016 |
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Bone Marrow Transplantation; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Movement; Cells, Cultured; Coculture Techniques; Cysteine Proteinase Inhibitors; Diet, High-Fat; Disease Models, Animal; Endothelial Cells; Genetic Predisposition to Disease; Inflammation; Leukocytes; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Phenotype; Receptors, LDL; Whole-Body Irradiation | 2016 |
Matricellular protein CCN3 mitigates abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Elastin; Gene Deletion; Humans; MAP Kinase Signaling System; Mice; Mice, Knockout; Nephroblastoma Overexpressed Protein; Pancreatic Elastase | 2016 |
Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomarkers; Collagen; Disease Models, Animal; Disease Progression; Elastin; Enzyme Induction; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Severity of Illness Index; Up-Regulation | 2016 |
Ursodeoxycholic Acid Attenuates Acute Aortic Dissection Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice Associated with Reduced ROS and Increased Nrf2 Levels.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; bcl-2-Associated X Protein; Cells, Cultured; Cholagogues and Choleretics; Disease Models, Animal; Down-Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Up-Regulation; Ursodeoxycholic Acid | 2016 |
Peroxisome Proliferator-Activated Receptor γ Level Contributes to Structural Integrity and Component Production of Elastic Fibers in the Aorta.
Topics: Analysis of Variance; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cells, Cultured; Disease Models, Animal; Elastin; Gene Expression Regulation; Humans; Inflammation; Male; Matrix Metalloproteinases; Mice; Mice, Knockout; Middle Aged; Muscle, Smooth, Vascular; PPAR gamma | 2016 |
Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; CD3 Complex; Chymases; Humans; Imatinib Mesylate; Inflammation; Male; Mast Cells; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Signal Transduction | 2016 |
Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Binding Sites; Case-Control Studies; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Down-Regulation; Epigenesis, Genetic; Extracellular Matrix Proteins; Histone Deacetylase Inhibitors; Humans; Inflammation Mediators; Male; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Promoter Regions, Genetic; Recombinant Proteins; RNA Interference; SOX9 Transcription Factor; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 2016 |
TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Rupture; Male; Mice; Mice, Inbred C57BL; Transforming Growth Factor beta | 2016 |
Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Gene Expression; Isoflavones; Male; Matrix Metalloproteinase 2; Mice; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1 | 2016 |
Vitamin D Receptor Activation Reduces Angiotensin-II-Induced Dissecting Abdominal Aortic Aneurysm in Apolipoprotein E-Knockout Mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Dissection; Apolipoproteins E; Calcitriol; Cells, Cultured; Chemokines; Chemotaxis, Leukocyte; Disease Models, Animal; Genetic Predisposition to Disease; Human Umbilical Vein Endothelial Cells; Humans; Ligands; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Phenotype; Receptors, Calcitriol; Retinoid X Receptor alpha; RNA Interference; Signal Transduction; Transfection; Vascular Endothelial Growth Factor A | 2016 |
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cytochrome P-450 CYP1B1; Disease Models, Animal; Flow Cytometry; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Oxidative Stress; Real-Time Polymerase Chain Reaction | 2016 |
Baicalein protects against the development of angiotensin II-induced abdominal aortic aneurysms by blocking JNK and p38 MAPK signaling.
Topics: Angiotensin II; Animals; Antioxidants; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, Western; Elastin; Flavanones; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Protective Agents; Reactive Oxygen Species; Receptor, Angiotensin, Type 1 | 2016 |
Altered PPARγ Coactivator-1 Alpha Expression in Abdominal Aortic Aneurysm: Possible Effects on Mitochondrial Biogenesis.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Citrate (si)-Synthase; Disease Models, Animal; Gene Expression Regulation; Humans; Mice, Knockout; Mitochondria; Mitochondrial Proton-Translocating ATPases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Voltage-Dependent Anion Channels | 2016 |
Osteoclastogenic Differentiation of Macrophages in the Development of Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Calcium Phosphates; Calcium Signaling; Cell Transdifferentiation; Diphosphonates; Disease Models, Animal; Humans; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Osteoclasts; Osteogenesis; RAW 264.7 Cells; Tartrate-Resistant Acid Phosphatase; Time Factors; Tumor Necrosis Factor-alpha; Vascular Calcification | 2016 |
Hypercholesterolemia Induced by a PCSK9 Gain-of-Function Mutation Augments Angiotensin II-Induced Abdominal Aortic Aneurysms in C57BL/6 Mice-Brief Report.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Biomarkers; Cholesterol; Dependovirus; Disease Models, Animal; Gene Transfer Techniques; Genetic Predisposition to Disease; Genetic Vectors; Hypercholesterolemia; Male; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mutation; Oligonucleotides, Antisense; Proprotein Convertase 9; Receptors, LDL; Species Specificity; Time Factors | 2016 |
Silencing of hypoxia inducible factor-1α gene attenuated angiotensin Ⅱ-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Disease Models, Animal; Gene Silencing; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Lentivirus; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Microcirculation; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Up-Regulation | 2016 |
Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Azepines; Cells, Cultured; Disease Models, Animal; Extracellular Matrix; Female; Gene Expression Regulation; Humans; Male; Metalloproteases; Mice; Mice, Inbred C57BL; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA; Triazoles | 2016 |
Hypoxia-Inducible Factor-1α in Smooth Muscle Cells Protects Against Aortic Aneurysms-Brief Report.
Topics: Aminopropionitrile; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Cells, Cultured; Dilatation, Pathologic; Disease Models, Animal; Elastic Tissue; Genetic Predisposition to Disease; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Protein-Lysine 6-Oxidase; Tropoelastin; Vascular Remodeling | 2016 |
Heme oxygenase-1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice.
Topics: Anemia, Hemolytic; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cytokines; Growth Disorders; Heme Oxygenase-1; Iron Metabolism Disorders; Male; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Mice, Knockout; Reactive Oxygen Species | 2016 |
B-Cell Depletion Promotes Aortic Infiltration of Immunosuppressive Cells and Is Protective of Experimental Aortic Aneurysm.
Topics: Angiotensin II; Animals; Antibodies; Antigens, CD20; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; B-Lymphocytes; Biomarkers; Cells, Cultured; Cellular Microenvironment; Coculture Techniques; Cytokines; Dendritic Cells; Disease Models, Animal; Down-Regulation; Genetic Predisposition to Disease; Immunoglobulin M; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Lymphocyte Depletion; Male; Mice, Inbred C57BL; Mice, Knockout; Pancreatic Elastase; Phenotype; T-Lymphocytes, Regulatory | 2016 |
Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.
Topics: Aging; Aneurysm, Ruptured; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortitis; Apolipoproteins E; Calcium Chloride; Chemokine CCL2; Disease Models, Animal; Gene Expression Regulation; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Smooth, Vascular; NF-kappa B; Sirtuin 1 | 2016 |
Female Mice With an XY Sex Chromosome Complement Develop Severe Angiotensin II-Induced Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Female; Male; Mice; Mice, Inbred C57BL; Sex Chromosomes; Vasoconstrictor Agents | 2017 |
The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Aryldialkylphosphatase; Cells, Cultured; Disease Models, Animal; Elastin; Extracellular Matrix; Genetic Predisposition to Disease; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Multigene Family; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Phenotype; Proteolysis; Reactive Oxygen Species; Signal Transduction | 2017 |
NOX isoforms in the development of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Gene Expression Regulation; Humans; Mice; Mutation; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; Polycomb Repressive Complex 1; Protein Isoforms; Superoxides; Tetrahydrofolate Dehydrogenase | 2017 |
MicroRNA-145 Mediates the Formation of Angiotensin II-Induced Murine Abdominal Aortic Aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Collagen; Disease Models, Animal; Elastin; Gene Expression Regulation, Enzymologic; Lentivirus; Matrix Metalloproteinase 2; Mice; Mice, Knockout; MicroRNAs; Transduction, Genetic; Up-Regulation | 2017 |
Bile-ated Cell Death Decreases Aortic Aneurysm Formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm; Aortic Aneurysm, Abdominal; Apolipoproteins; Bile; Cell Death; Endoplasmic Reticulum Stress; Mice; Taurochenodeoxycholic Acid | 2017 |
The water channel AQP1 is expressed in human atherosclerotic vascular lesions and AQP1 deficiency augments angiotensin II-induced atherosclerosis in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aquaporin 1; Coronary Artery Disease; Female; Humans; Mice; Mice, Knockout; Neovascularization, Pathologic; Vasoconstrictor Agents | 2017 |
Angiotensin-Converting Enzyme 2 Inhibits Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice.
Topics: Adenoviridae; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, Western; Disease Models, Animal; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Humans; Immunohistochemistry; Macrophages; Male; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Peptidyl-Dipeptidase A; Signal Transduction | 2018 |
NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Topics: Aged; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Dissection; Biomechanical Phenomena; Caspase 1; Cells, Cultured; Disease Models, Animal; Female; Genetic Predisposition to Disease; Glyburide; Humans; Inflammasomes; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NLR Family, Pyrin Domain-Containing 3 Protein; Phenotype; Proteolysis; Vasoconstriction | 2017 |
Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases.
Topics: Angiotensin II; Animals; Antioxidants; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, Western; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melatonin; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2017 |
Pravastatin activates activator protein 2 alpha to augment the angiotensin II-induced abdominal aortic aneurysms.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Anticholesteremic Agents; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, Western; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Male; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Phosphorylation; Pravastatin; Signal Transduction; Transcription Factor AP-2 | 2017 |
Effect of Bortezomib on Angiotensin Ⅱ-induced Abdominal Aortic Aneurysm in ApoE
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Bortezomib; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Phosphorylation; Proteasome Inhibitors; Random Allocation; Signal Transduction; T-Lymphocytes | 2017 |
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.
Topics: Adipokines; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aortic Aneurysm, Abdominal; Apelin; Apelin Receptors; Atherosclerosis; Blood Vessels; Carrier Proteins; Cell Nucleus; Diet; Disease Models, Animal; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Nitric Oxide; Reactive Oxygen Species; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Signal Transduction; Vasoconstrictor Agents | 2008 |
Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Humans; Interleukin-6; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Osteoprotegerin; PPAR gamma; Receptor, Angiotensin, Type 1 | 2009 |
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice.
Topics: Acetamides; Administration, Oral; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Cholesterol; Chymases; Disease Models, Animal; Enzyme Activation; Enzyme Precursors; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Pyrimidines; Serine Proteinase Inhibitors | 2009 |
Inhibition of experimental abdominal aortic aneurysm in a rat model by the angiotensin receptor blocker valsartan.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Blood Pressure; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neutrophil Infiltration; NF-kappa B; Pancreatic Elastase; Rats; Rats, Wistar; Tetrazoles; Ultrasonography; Valine; Valsartan | 2008 |
Extracellular matrix metalloproteinase inducer (EMMPRIN) is present in smooth muscle cells of human aneurysmal aorta and is induced by angiotensin II in vitro.
Topics: Adult; Aged; Angiotensin II; Aortic Aneurysm, Abdominal; Aortic Dissection; Basigin; Cells, Cultured; Female; Humans; Immunohistochemistry; Male; Middle Aged; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Up-Regulation | 2009 |
Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomechanical Phenomena; Collagen; Collagenases; Connective Tissue; Elastin; Histocytochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout | 2009 |
The development of abdominal aortic aneurysms in mice is enhanced by benzo(a)pyrene.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Rupture; Benzo(a)pyrene; Disease Models, Animal; Elastic Tissue; Macrophages; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Smoking | 2008 |
ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Blood Pressure; Cholesterol, Dietary; Disease Models, Animal; Hydralazine; Hypercholesterolemia; Hypertension; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Norepinephrine; Receptors, LDL; Risk Factors; Time Factors | 2009 |
Pulse wave imaging of normal and aneurysmal abdominal aortas in vivo.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Computer Simulation; Data Interpretation, Statistical; Disease Models, Animal; Electrocardiography; Humans; Image Interpretation, Computer-Assisted; Linear Models; Mice; Mice, Inbred C57BL; Signal Processing, Computer-Assisted; Time Factors; Ultrasonography | 2009 |
Low-level laser irradiation inhibits abdominal aortic aneurysm progression in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Dilatation, Pathologic; Humans; Low-Level Light Therapy; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Ultrasonography | 2009 |
Rosiglitazone reduces the development and rupture of experimental aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Blood Glucose; Body Weight; Cholesterol; Disease Models, Animal; E-Selectin; Humans; Hypercholesterolemia; Hypoglycemic Agents; Interleukin-6; Mice; Mice, Knockout; PPAR gamma; Receptors, Angiotensin; Rosiglitazone; Thiazolidinediones; Tumor Necrosis Factor-alpha | 2009 |
Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Benzimidazoles; Biphenyl Compounds; Chymases; Disease Progression; Lisinopril; Mice; Mice, Knockout; Peptidyl-Dipeptidase A; Tetrazoles | 2009 |
Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Gene Expression; Genome-Wide Association Study; Humans; Male; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Up-Regulation | 2009 |
Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Chemokines; Cytokines; Mice; Mice, Knockout; Receptors, LDL; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction | 2009 |
Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation.
Topics: Adipose Tissue; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Cell Movement; Cytokines; Dietary Fats; Inflammation; Insulin Resistance; Macrophages; Male; Mice; Mice, Inbred C57BL; Obesity; Systole | 2009 |
Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm.
Topics: Analysis of Variance; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Contrast Media; Dextrans; Disease Models, Animal; Ferrosoferric Oxide; Image Processing, Computer-Assisted; Inflammation; Infusion Pumps, Implantable; Macrophages; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice | 2009 |
Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia.
Topics: Administration, Oral; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Biological Availability; Carotid Arteries; Cholesterol; Disease Models, Animal; Down-Regulation; Dyslipidemias; Enzyme Inhibitors; Epoxide Hydrolases; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-1alpha; Interleukin-6; Interleukin-8; Ligation; Male; Mice; Mice, Knockout; Vascular Cell Adhesion Molecule-1 | 2009 |
Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Benzamides; Blood Pressure; Blotting, Western; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; MAP Kinase Kinase Kinase 3; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; Reference Values; Renin-Angiotensin System; Simvastatin | 2009 |
Understanding abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cyclophilin A; Humans; Hyperlipidemias; Inflammation; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Oxidative Stress; Reactive Oxygen Species | 2009 |
Cathepsin K gene disruption does not affect murine aneurysm formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cathepsin C; Cathepsin K; Cathepsins; Collagen; Granulocytes; Lymphocyte Count; Macrophages; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; T-Lymphocytes | 2010 |
In vivo serial assessment of aortic aneurysm formation in apolipoprotein E-deficient mice via MRI.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Doxycycline; Magnetic Resonance Imaging; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Knockout | 2008 |
Peroxisome proliferator-activated receptor ligands reduce aortic dilatation in a mouse model of aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Fenofibrate; Immunohistochemistry; Ligands; Macrophages; Male; Mice; Osteopontin; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Thiazolidinediones; Up-Regulation | 2010 |
Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Extracellular Space; Fibrillin-1; Fibrillins; Granzymes; Humans; Immune System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Perforin; Protein Processing, Post-Translational; Tissue Distribution | 2010 |
Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Benzopyrans; Carboxylic Acids; Chemotaxis; Disease Progression; Immunohistochemistry; Leukotriene B4; Male; Mice; Ultrasonography | 2010 |
Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.
Topics: Amino Acid Chloromethyl Ketones; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Caspase Inhibitors; Caspases; Cells, Cultured; Chemokine CCL2; Chemotaxis; Culture Media, Conditioned; Disease Models, Animal; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protease Inhibitors; Quinolines; Severity of Illness Index; Time Factors | 2010 |
TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Aneurysm, Abdominal; Disease Progression; Inflammation; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Transforming Growth Factor beta; Ultrasonography | 2010 |
High fat diet containing cholesterol induce aortic aneurysm through recruitment and proliferation of circulating agranulocytes in apoE knock out mice model.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Apolipoproteins E; Biomarkers; Blood Pressure; Cell Movement; Cell Proliferation; Chemokine CCL2; Cholesterol, Dietary; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation; Granulocytes; Hypercholesterolemia; Intercellular Adhesion Molecule-1; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Time Factors; Vascular Cell Adhesion Molecule-1; Weight Gain | 2010 |
Pharmacologically induced thoracic and abdominal aortic aneurysms in mice.
Topics: Aminopropionitrile; Amlodipine; Angiotensin II; Animals; Antihypertensive Agents; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Pressure; Desoxycorticosterone; Humans; Hypertension; Male; Mice; Mice, Inbred C57BL; Mineralocorticoids; Protein-Lysine 6-Oxidase | 2010 |
Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; CD59 Antigens; Complement Membrane Attack Complex; Complement System Proteins; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Animal; NF-kappa B; Signal Transduction; Transcription Factor AP-1 | 2010 |
Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Connective Tissue; Dietary Fats; Disease Models, Animal; Disease Progression; Endoglin; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Obesity; RNA, Messenger; Weight Loss | 2010 |
Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formation.
Topics: Aged; Analysis of Variance; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Dissection; Aortic Rupture; Apolipoproteins E; Chi-Square Distribution; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Mice; Mice, Knockout; Phosphorylation; RNA, Messenger; Severity of Illness Index; Sex Factors; STAT1 Transcription Factor; Time Factors | 2010 |
Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice.
Topics: Aneurysm; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; B-Lymphocytes; Female; Gene Expression Regulation; Genotype; Hypercholesterolemia; Lymphocytes; Male; Mice; T-Lymphocytes | 2010 |
Vascular endothelial growth factor enhances angiotensin II-induced aneurysm formation in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Body Weight; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Enzymologic; Humans; Infusion Pumps, Implantable; Injections, Intraperitoneal; Magnetic Resonance Angiography; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Recombinant Proteins; Time Factors; Vascular Endothelial Growth Factor A | 2010 |
Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Cell Adhesion Molecules; Cell Proliferation; Cystatin C; Humans; Inflammation; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle | 2010 |
Hyperglycemia limits experimental aortic aneurysm progression.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Progression; Hypoglycemic Agents; Insulin; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Pancreatic Elastase; Peritonitis; Thioglycolates; Time Factors; Ultrasonography; Vascular Endothelial Growth Factor A | 2010 |
Efficacy of simvastatin in reducing aortic dilatation in mouse models of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Apolipoproteins E; Lipids; Male; Mice; Mice, Transgenic; Plaque, Atherosclerotic; Receptors, Lipoprotein; Simvastatin | 2010 |
Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Group X Phospholipases A2; Humans; Inflammation; Interleukins; Metalloproteases; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2011 |
In vivo quantification of murine aortic cyclic strain, motion, and curvature: implications for abdominal aortic aneurysm growth.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Elastin; Genotype; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motion; Time Factors | 2010 |
Cigarette smoke enhances abdominal aortic aneurysm formation in angiotensin II-treated apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Body Weight; Disease Models, Animal; Male; Matrix Metalloproteinases; Mice; Nicotiana; Smoke; Tissue Inhibitor of Metalloproteinases | 2010 |
Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Biomechanical Phenomena; Blood Pressure; Disease Progression; Elastin; Hypertension; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Models, Cardiovascular; Ultrasonography | 2011 |
Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Bone Marrow Transplantation; Cell Movement; Cells, Cultured; Elastin; Genotype; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Models, Animal; Receptors, LDL; Telomerase; Telomere | 2011 |
Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Bone Marrow Cells; Bone Marrow Transplantation; Chemokine CCL2; Elastin; Female; Gene Deletion; Hyperlipidemias; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Receptors, LDL; Receptors, Prostaglandin E, EP4 Subtype; Risk Factors | 2011 |
Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Autoradiography; Contrast Media; Disease Models, Animal; Female; Flow Cytometry; Fluorodeoxyglucose F18; Macrophages; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Reproducibility of Results; Splenectomy; Time Factors; X-Ray Microtomography | 2011 |
Parsing aortic aneurysms: more surprises.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Cell Communication; Disease Models, Animal; Endothelial Cells; Incidence; Macrophages; Mice; Mice, Knockout; Mice, Mutant Strains; Mutation; Myocytes, Smooth Muscle; Receptor, Angiotensin, Type 1; Receptors, LDL | 2011 |
Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms.
Topics: Angiotensin II; Animal Feed; Animals; Anti-Inflammatory Agents; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Atorvastatin; Blood Pressure; Fluorobenzenes; Gene Expression Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides | 2011 |
Catalase overexpression in aortic smooth muscle prevents pathological mechanical changes underlying abdominal aortic aneurysm formation.
Topics: Analysis of Variance; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomechanical Phenomena; Blood Pressure; Catalase; Collagen; Disease Models, Animal; Elastin; Hydrogen Peroxide; Mice; Mice, Knockout; Mice, Transgenic; Stress, Mechanical; Time Factors; Up-Regulation | 2011 |
An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Computer Simulation; Hemodynamics; Hydrodynamics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Ultrasonography; Vasoconstrictor Agents | 2011 |
Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis | 2011 |
Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Macrophages; Male; Mice; Mice, Inbred C57BL; Vasoconstrictor Agents | 2011 |
Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Biological Products; Chemokine CCL2; Cholesterol; Inflammation; Interleukin-1alpha; Interleukin-6; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Plant Extracts; Tunica Intima | 2012 |
Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms.
Topics: Aneurysm, Ruptured; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Bone Marrow Cells; Disease Models, Animal; Hypercholesterolemia; Incidence; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL; Receptors, Urokinase Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2011 |
Development of angiotensin II-induced abdominal aortic aneurysms is independent of catalase in mice.
Topics: Aldehydes; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Blood Pressure; Body Weight; Catalase; Cholesterol; Lipid Peroxidation; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Oxidative Stress | 2011 |
Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm.
Topics: Acute-Phase Proteins; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Collagen; Decorin; Disease Models, Animal; Granzymes; Mice; Mice, Knockout; Protein Processing, Post-Translational; Recombinant Proteins; Serpins | 2011 |
Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Blood Pressure; Drug Synergism; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Polychlorinated Biphenyls; Real-Time Polymerase Chain Reaction | 2011 |
MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Leukocytes; Male; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; Receptors, LDL; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4 | 2011 |
Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Blotting, Western; Calpain; Cysteine Proteinase Inhibitors; Diet, High-Fat; Disease Models, Animal; Hypercholesterolemia; Male; Mice; Mice, Knockout; Receptors, LDL; Sulfonamides | 2012 |
Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Biopterins; Blood Pressure; Disease Models, Animal; Folic Acid; Genetic Therapy; GTP Cyclohydrolase; Hypertension; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Nitric Oxide; Nitric Oxide Synthase Type III; Tetrahydrofolate Dehydrogenase; Vasoconstrictor Agents; Vitamin B Complex | 2012 |
The controversial role of the urokinase system in abdominal aortic aneurysm formation and rupture.
Topics: Aneurysm, Ruptured; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Bone Marrow Cells; Urokinase-Type Plasminogen Activator | 2011 |
Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Atherosclerosis; Bone Marrow Cells; Bone Marrow Transplantation; Cells, Cultured; Cholesterol; Disease Models, Animal; Hypercholesterolemia; LDL-Receptor Related Protein-Associated Protein; Low Density Lipoprotein Receptor-Related Protein-1; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, LDL; Tumor Suppressor Proteins | 2012 |
Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Bone Marrow Transplantation; CD4-Positive T-Lymphocytes; Chemokines; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Syndecan-1 | 2012 |
The effects of angiotensin II on the coupled microstructural and biomechanical response of C57BL/6 mouse aorta.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomechanical Phenomena; Collagen; Disease Models, Animal; Extracellular Matrix; Mice; Mice, Inbred C57BL | 2012 |
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development.
Topics: Adolescent; Aged; Aneurysm, Ruptured; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Collagen; Disease Models, Animal; Disease Progression; Elastin; Gene Expression; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Middle Aged; Pancreatic Elastase; Protein Isoforms; Swine; Young Adult | 2012 |
A CD31-derived peptide prevents angiotensin II-induced atherosclerosis progression and aneurysm formation.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Aneurysm, Abdominal; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Lymphocyte Activation; Macrophage Activation; Male; Mice; Mice, Knockout; Peptides; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Antigen, T-Cell; T-Lymphocytes; Time Factors | 2012 |
MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apoptosis; Cell Proliferation; Gene Expression Profiling; Humans; Inflammation; Interleukin-6; Mice; Mice, Inbred C57BL; MicroRNAs; Nicotine; Pancreatic Elastase; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Sus scrofa; Up-Regulation | 2012 |
CD31: beyond a marker for endothelial cells.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Aneurysm, Abdominal; Aortic Diseases; Atherosclerosis; Male; Peptides; Platelet Endothelial Cell Adhesion Molecule-1 | 2012 |
Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Benzo(a)pyrene; Cyclophilin A; Inflammation; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Necrosis Factor-alpha | 2012 |
In vivo imaging of macrophages during the early-stages of abdominal aortic aneurysm using high resolution MRI in ApoE mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Pressure; Cytokines; Dextrans; Disease Models, Animal; Humans; Lipids; Macrophages; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phagocytosis | 2012 |
Interleukin-5 is a potential mediator of angiotensin II-induced aneurysm formation in apolipoprotein E knockout mice.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cells, Cultured; Interleukin-10; Interleukin-5; Macrophages, Peritoneal; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Th1 Cells; Th2 Cells; Vasculitis; Vasoconstrictor Agents | 2012 |
Inhibition of development of abdominal aortic aneurysm by glycolysis restriction.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, Western; Calcium Chloride; Cell Adhesion; Cell Proliferation; Cell Survival; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Fluorodeoxyglucose F18; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 1; Glucose Transporter Type 3; Glycolysis; Humans; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-1beta; Interleukin-6; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Positron-Emission Tomography; Radiopharmaceuticals; Tetradecanoylphorbol Acetate; Time Factors; U937 Cells; Up-Regulation | 2012 |
Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms.
Topics: Age Factors; Angiotensin II; Animals; Animals, Newborn; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Female; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptor, Angiotensin, Type 1; Receptors, LDL; Risk Factors; RNA, Messenger; Sex Characteristics; Sex Factors; Testosterone Propionate; Up-Regulation | 2012 |
Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo.
Topics: AMP-Activated Protein Kinases; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Cells, Cultured; Humans; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Nicotine; Phosphorylation; Reactive Oxygen Species; Smoking; Transcription Factor AP-2 | 2012 |
Inhibition of EP4 signaling attenuates aortic aneurysm formation.
Topics: Aged; Aged, 80 and over; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Line; Disease Models, Animal; Enzyme Activation; Female; Gene Deletion; Humans; Interleukin-6; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Knockout; Middle Aged; Myocytes, Smooth Muscle; Naphthalenes; Phenylbutyrates; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Tissue Culture Techniques; Up-Regulation | 2012 |
Prostaglandin receptor EP4 in abdominal aortic aneurysms.
Topics: Adult; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Rupture; Atherosclerosis; Cyclooxygenase 2; Drug Evaluation, Preclinical; Female; Gene Knockdown Techniques; Humans; Macrophages; Male; Mice; Mice, Knockout; Middle Aged; Naphthalenes; Phenylbutyrates; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Ultrasonography | 2012 |
Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model.
Topics: Angiotensin II; Animals; Aorta; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Apoptosis; Azo Compounds; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Endothelial Cells; Fenofibrate; Inflammation; Kidney; Lipoproteins, HDL; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; Sphingosine; Treatment Outcome; Up-Regulation | 2012 |
Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Apoptosis; Collagen; Disease Progression; Fibrosis; Group V Phospholipases A2; Immunohistochemistry; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Prostaglandins | 2012 |
Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice.
Topics: Adoptive Transfer; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Cell Proliferation; Cells, Cultured; Chemotaxis; Disease Models, Animal; Elastin; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Proto-Oncogene Proteins c-kit; Receptors, CCR2 | 2012 |
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Cathepsin K; Cathepsins; CD3 Complex; Cells, Cultured; Collagen; Disease Models, Animal; Elastin; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neovascularization, Pathologic; T-Lymphocytes; Time Factors | 2012 |
The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms.
Topics: Amino Acid Oxidoreductases; Aminopropionitrile; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Extracellular Matrix; Extracellular Matrix Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Protein-Lysine 6-Oxidase; RNA, Messenger; Vasoconstrictor Agents | 2012 |
Low level laser arrests abdominal aortic aneurysm by collagen matrix reinforcement in apolipoprotein E-deficient mice.
Topics: Adventitia; Analysis of Variance; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Collagen; Low-Level Light Therapy; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; Vasoconstrictor Agents | 2012 |
Effectiveness of cyclooxygenase-2 inhibition in limiting abdominal aortic aneurysm progression in mice correlates with a differentiated smooth muscle cell phenotype.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Biomarkers; Celecoxib; Cell Differentiation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Pyrazoles; RNA, Messenger; Severity of Illness Index; Sulfonamides; Time Factors | 2012 |
Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Biomarkers; Disease Models, Animal; Endothelium, Vascular; Femoral Artery; Humans; Hyperplasia; I-kappa B Proteins; Inflammation Mediators; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Signal Transduction; Vascular System Injuries | 2013 |
Elevation of plasma high-density lipoproteins inhibits development of experimental abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Autophagy; Calcium Chloride; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Hypercholesterolemia; Injections, Subcutaneous; JNK Mitogen-Activated Protein Kinases; Lipoproteins, HDL; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Time Factors; Up-Regulation | 2012 |
Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice.
Topics: Administration, Oral; Angiotensin II; Animals; Anti-Bacterial Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Blood Pressure; Cholesterol; Diet, High-Fat; Disease Models, Animal; Doxycycline; Infusion Pumps, Implantable; Male; Mice; Mice, Knockout; Receptors, LDL; Vasoconstrictor Agents | 2012 |
Aneurysm prevention: keep the cat out of the bag.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cathepsins; Male | 2012 |
Inhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteritis; Dipeptides; Disease Models, Animal; Haploinsufficiency; Humans; Macrophages; Male; Mice; Mice, Knockout; Receptor, Notch1; Signal Transduction | 2012 |
Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Female; Hepatitis A Virus Cellular Receptor 2; Humans; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Virus | 2012 |
Locally applied leptin induces regional aortic wall degeneration preceding aneurysm formation in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Delayed-Action Preparations; Dilatation, Pathologic; Disease Models, Animal; Humans; Leptin; Macrophages; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Leptin; RNA, Messenger; Time Factors; Transforming Growth Factor beta; Ultrasonography | 2013 |
Clopidogrel, a platelet P2Y12 receptor inhibitor, reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Platelets; Blood Pressure Determination; Clopidogrel; Cytokines; Immunoenzyme Techniques; Inflammation; Macrophages, Peritoneal; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation Inhibitors; Reactive Oxygen Species; Receptors, Purinergic P2Y12; Ticlopidine; Vasculitis; Vasoconstrictor Agents | 2012 |
Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cells, Cultured; Chemokine CCL5; Chemotaxis, Leukocyte; Disease Models, Animal; Disease Progression; Injections, Intravenous; Leukocytes; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; Oligopeptides; Pancreatic Elastase; Platelet Factor 4; Receptors, CCR5; Time Factors | 2013 |
Overexpression of SOCS3 in T lymphocytes leads to impaired interleukin-17 production and severe aortic aneurysm formation in mice--brief report.
Topics: Angiotensin II; Animals; Antibodies, Neutralizing; Aortic Aneurysm, Abdominal; Aortic Rupture; Bone Marrow Transplantation; Cells, Cultured; Disease Models, Animal; Genotype; Interleukin-17; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neutrophils; Phenotype; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Th17 Cells; Time Factors; Transforming Growth Factor beta; Up-Regulation; Whole-Body Irradiation | 2013 |
Everolimus limits aortic aneurysm in the apolipoprotein E-deficient mouse by downregulating C-C chemokine receptor 2 positive monocytes.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Cell Movement; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Everolimus; Flow Cytometry; Infusion Pumps, Implantable; Infusions, Subcutaneous; Interferon-gamma; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Protein Kinase Inhibitors; Receptor, Macrophage Colony-Stimulating Factor; Receptors, CCR2; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregulation of PPARs.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Arteriosclerosis; Cell Adhesion Molecules; Chemokines; Cyclooxygenase 2; Down-Regulation; Gene Expression Regulation; Isoenzymes; Male; Mice; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors | 2002 |
Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Blood Pressure; Carotid Arteries; Collagen; Drug Administration Schedule; Elasticity; Elastin; Endothelium, Vascular; Male; Mice; Mice, Knockout; Nitroprusside | 2002 |
Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; In Situ Hybridization; Interleukin-6; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger; Urokinase-Type Plasminogen Activator | 2003 |
Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Arteriosclerosis; Cholesterol; Doxycycline; Hyperlipidemias; Lipoproteins; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Mice, Mutant Strains | 2003 |
17 Beta-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Disease Models, Animal; Estradiol; Female; Inflammation; Male; Mice | 2003 |
Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Calibration; Collagen; Elastin; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Spectroscopy, Near-Infrared | 2003 |
Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Cell Movement; Cell Survival; Chemokine CCL2; Cytokines; Gene Expression Regulation; Leukocytes; Macrophages; Mice; Mice, Inbred C57BL; Osteopontin; Receptors, CCR2; Receptors, Chemokine; RNA, Messenger; Sialoglycoproteins | 2003 |
Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Female; Gonadal Steroid Hormones; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Ovariectomy; Sex Characteristics | 2004 |
Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Bone Marrow; Bone Marrow Transplantation; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Monocytes; Receptors, CCR2; Receptors, Chemokine | 2004 |
Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
Topics: Aldosterone; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Blood Pressure; Body Weight; Cholesterol; Diuretics; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mineralocorticoid Receptor Antagonists; Organ Size; Spironolactone | 2005 |
Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Apoptosis; Endothelium, Vascular; Extracellular Matrix; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho-Associated Kinases | 2005 |
Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Antioxidants; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Blood Pressure; Dinoprost; Hyperlipidemias; Lipids; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Mutant Strains; Osteopontin; Oxidative Stress; Sialoglycoproteins; Vasoconstrictor Agents; Vitamin E | 2005 |
Association of osteoprotegerin with human abdominal aortic aneurysm progression.
Topics: Adult; Aged; Angiotensin II; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Biopsy; Biphenyl Compounds; Cell Proliferation; Cells, Cultured; Disease Progression; Gene Expression Regulation, Enzymologic; Glycoproteins; Humans; Irbesartan; Male; Matrix Metalloproteinase 9; Middle Aged; Muscle, Smooth, Vascular; Osteoprotegerin; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Tetrazoles; Ultrasonography | 2005 |
Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Hypercholesterolemia; Male; Mice; Mice, Inbred C57BL; Prostaglandin D2; Pyrazoles; Sulfonamides | 2006 |
COX-2 in cardiovascular disease.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Epoprostenol; Mice; Pyrazoles; Sulfonamides | 2006 |
Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Blood Pressure; Cholesterol; Gene Deletion; Gene Expression Regulation; Macrophages; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; NADPH Oxidases; Oxidative Stress; Phenylephrine; Superoxides; Triglycerides | 2006 |
Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Rupture; Apolipoproteins E; Dilatation, Pathologic; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Reproducibility of Results; Ultrasonography | 2006 |
Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Chemokine CCL2; Chemokine CCL4; Chemotaxis, Leukocyte; Cyclooxygenase 2; Immunohistochemistry; Macrophage Inflammatory Proteins; Macrophages; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Animal; RNA, Messenger; Time Factors | 2007 |
Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Carotid Artery, Common; Cell Division; Drug Interactions; Foam Cells; Immunologic Factors; Interferon-beta; Ligation; Male; Mice; Mice, Mutant Strains; Tunica Intima; Vasoconstrictor Agents | 2008 |
The significance of chymase in the progression of abdominal aortic aneurysms in dogs.
Topics: Acetamides; Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Cell Count; Chymases; Disease Models, Animal; Disease Progression; Dogs; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neutrophils; Pyrimidines; Tunica Media; Ultrasonography | 2007 |
Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arachidonate 5-Lipoxygenase; Blood Pressure; Chemokine CCL4; Indoles; Inflammation; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Genetic; Quinolines; Time Factors | 2007 |
A novel histone deacetylase inhibitor reduces abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Doxycycline; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunohistochemistry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Protease Inhibitors; Rats; Sulfonamides | 2008 |
Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Cytomegalovirus; Fibrosis; Gene Expression; Genetic Therapy; Genetic Vectors; Luciferases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Plasminogen Activator Inhibitor 1; Transduction, Genetic; Urokinase-Type Plasminogen Activator | 2008 |
Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Hyperlipidemias; Intramolecular Oxidoreductases; Male; Mice; Mice, Knockout; Oxidative Stress; Prostaglandin-E Synthases; Prostaglandins; Receptors, LDL; Up-Regulation | 2008 |
Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice.
Topics: Androgens; Angiotensin II; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Dihydrotestosterone; Disease Models, Animal; Drug Implants; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orchiectomy; Ovariectomy; Receptor, Angiotensin, Type 1; RNA, Messenger; Sex Factors; Time Factors; Up-Regulation | 2008 |
Angiotensin II, atherosclerosis, and aortic aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Arteriosclerosis; Mice; Reactive Oxygen Species | 2000 |
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Female; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL | 2000 |
Chronic angiotensin II infusion promotes atherogenesis in low density lipoprotein receptor -/- mice.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Arteriosclerosis; Blood Pressure; Cholesterol; Infusions, Intravenous; Lipoproteins, LDL; Mice; Mice, Inbred C57BL; Severity of Illness Index; Vasoconstrictor Agents | 1999 |
Angiotensin II increases urokinase-type plasminogen activator expression and induces aneurysm in the abdominal aorta of apolipoprotein E-deficient mice.
Topics: Angiotensin II; Animals; Aorta; Aortic Aneurysm, Abdominal; Apolipoproteins E; In Vitro Techniques; Interleukin-6; Mice; Mice, Knockout; Reference Values; Time Factors; Ultrasonography; Urokinase-Type Plasminogen Activator | 2001 |
Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosis; Drug Synergism; Female; Imidazoles; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridines; Severity of Illness Index | 2001 |