angelmarin has been researched along with Pancreatic-Neoplasms* in 2 studies
2 other study(ies) available for angelmarin and Pancreatic-Neoplasms
| Article | Year |
|---|---|
Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation.
Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds. Topics: Antineoplastic Agents; Biological Products; Cell Line, Tumor; Cell Survival; Coumarins; Drug Screening Assays, Antitumor; Food; Humans; Inhibitory Concentration 50; Molecular Structure; Pancreatic Neoplasms; Plant Extracts; Stereoisomerism; Stress, Physiological; Structure-Activity Relationship | 2012 |
Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.
The CH(2)Cl(2)-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 microg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 microg/ml. Topics: Angelica; Antineoplastic Agents; Cell Survival; Coumarins; Humans; Pancreatic Neoplasms; Plant Extracts; Plants, Medicinal; Time Factors; Tumor Cells, Cultured | 2006 |