androsterone has been researched along with Klinefelter Syndrome in 11 studies
Klinefelter Syndrome: A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| OKANO, K | 1 |
| MATSUMOTO, K | 1 |
| AKEHI, A | 1 |
| MIZUTANI, S | 1 |
| KIKKAWA, H | 1 |
| SEKI, T | 1 |
| Smith, DA | 1 |
| Walker, MS | 1 |
| Christiansen, P | 1 |
| Rivera, R | 1 |
| Dorfman, RI | 1 |
| Forchielli, E | 1 |
| Scurry, MT | 1 |
| Bruton, J | 1 |
| Barry, KG | 1 |
| Garmendia, F | 1 |
| Nicolis, GL | 1 |
| Gabrilove, JL | 1 |
| Froland, A | 2 |
| Frandsen, VA | 1 |
| Johnsen, SG | 1 |
| Jeffcoate, SL | 1 |
| Brooks, RV | 1 |
| Lim, NY | 1 |
| London, DR | 1 |
| Prunty, FT | 1 |
| Spathis, GS | 1 |
| Gleispach, H | 1 |
| Glatzl, J | 1 |
| Ludvik, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Aromatase Inhibition and Testosterone Replacement in Sex Steroids, Pituitary Hormones, Markers of Bone Turnover, Muscle Strength, and Cognition in Older Men[NCT00104572] | Phase 2 | 44 participants (Actual) | Interventional | 2004-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
bone mineral density lumbar spine for all arms testosterone gel, anastrozole and placebo (NCT00104572)
Timeframe: 1 year
| Intervention | g/cm2 (Mean) |
|---|---|
| Transdermal Testosterone | 0.042 |
| Aromatase Inhibitor | 0.008 |
| Placebo | 0.047 |
"Primary outcome HOMA-IR for all groups testosterone gel, anastrozole and placebo Insulin resistance measure by HOMA-IR is a score if a person is insulin resistance the score should be between minimum 0.7- maximum 2 or more.~Absolute changes in HOMAIR in all treatment arms, calculation time frame 1 year minus baseline point." (NCT00104572)
Timeframe: 1 year
| Intervention | score on a scale (Mean) |
|---|---|
| Transdermal Testosterone | -0.05 |
| Aromatase Inhibitor | 0.15 |
| Placebo | -0.11 |
"rectal ultrasound prostate volume for all groups testosterone gel, anastrozole and placebo.~Absolute changes in prostate volume in all treatment arms, calculation time frame 1 year minus baseline point." (NCT00104572)
Timeframe: 1 year
| Intervention | cc (Mean) |
|---|---|
| Transdermal Testosterone | 4.5 |
| Aromatase Inhibitor | -1.66 |
| Placebo | -1.05 |
Overnight Growth hormone measures (total hormone secretion) for groups testosterone gel, anastrozole and placebo (NCT00104572)
Timeframe: 1 year
| Intervention | ng/ml/8h (Mean) |
|---|---|
| Transdermal Testosterone | 5.8 |
| Aromatase Inhibitor | 10 |
| Placebo | 7.7 |
11 other studies available for androsterone and Klinefelter Syndrome
| Article | Year |
|---|---|
STUDIES ON THE URINARY STEROIDS IN BILATERAL GYNECOMASTIA.
Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Neoplasms; Androsterone; Estradiol; Estriol; Estrone; Eti | 1963 |
Changes in plasma steroids and bone density in Klinefelter's syndrome.
Topics: Adult; Age Factors; Aged; Androsterone; Bone and Bones; Dehydroepiandrosterone; Estradiol; Female; H | 1977 |
Studies on the relationship between spermatogenesis and urinary levels of follicle stimulating hormone and luteinizing hormone in oligospermic men.
Topics: Adult; Androgens; Androsterone; Biological Assay; Castration; Follicle Stimulating Hormone; Humans; | 1975 |
A modified method for the analysis of urinary 17-ketosteroids, pregnanediol and pregnanetriol by gas liquid chromatography in normal subjects and subjects with various endocrine disorders.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androsterone; Chromatography, Gas; Cushing Syndrom | 1967 |
The effect of chorionic gonadotropin on steroid excretion.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Adolescent; Adult; Androsterone; Chorionic G | 1971 |
The determination of urinary pregnanetriol and the neutral 17-ketosteroids by gas-liquid chromatography.
Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre | 1971 |
Adrenal and gonadal contribution to androgen and oestrogen excretion in Klinefelter's syndrome.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adult; Androsterone; Dehydroepiandrosterone; D | 1973 |
Androgen production in hypogonadal men.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Androgens; Androsterone; Carbon Isotopes; Chorionic Go | 1967 |
[Hormone examination in children with Klinefelter's syndrome].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Age Factors; An | 1969 |
Klinefelter's syndrome. Clinical, endocrinological and cytogenetical studies.
Topics: 17-Ketosteroids; Adolescent; Adult; Aged; Androsterone; Autoantibodies; Biopsy; Body Constitution; C | 1969 |
[Basic principles of modern androgenic therapy].
Topics: Androgens; Androsterone; Humans; Hypogonadism; Infertility, Male; Klinefelter Syndrome; Male; Methyl | 1970 |