androsterone and Hirsutism studies

Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.

Research Excerpts

Excerpt	Relevance	Reference
"Urinary steroid fractionations of 17-ketosteroids were carried out in 3 normally-ovulating young women and in 2 women with hirsutism."	7.66	Effect of dexamethasone and ACTH on the secretion pattern of fractionated 17-ketosteroids in hirsutism. ( Gunasegaram, R, 1979)
"To evaluate the reliability of plasma androsterone glucuronide (ADTG) as a parameter of androgenicity at the target tissue level, we studied the origin of ADTG in women, by measuring the plasma conversion rate of different possible precursors as well as by measuring ADTG levels in ovariectomized women and women with Addison's disease."	3.68	Origin and significance of plasma androsterone glucuronide levels: a parameter of adrenal androgen secretion and hepatic 5 alpha-reductase activity. ( Giagulli, VA; Giorgino, R; Vermeulen, A, 1993)
"As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase activity, we measured, as parameters of 5 alpha-reductase activity, plasma levels of 5 alpha-androstane-3 alpha,17 beta-diol glucuronide (ADG) and androsterone glucuronide (ADTG) as well as their precursor levels in obese women without hirsutism, obese hirsute women, non-obese hirsute women, and non-obese, non-hirsute women."	3.68	Increased free testosterone but normal 5 alpha-reduced testosterone metabolites in obese premenopausal women. ( Abbaticchio, G; Cignarelli, M; De Pergola, G; Giagulli, VA; Giorgino, F; Giorgino, R; Vermeulen, A, 1992)
"Urinary steroid fractionations of 17-ketosteroids were carried out in 3 normally-ovulating young women and in 2 women with hirsutism."	3.66	Effect of dexamethasone and ACTH on the secretion pattern of fractionated 17-ketosteroids in hirsutism. ( Gunasegaram, R, 1979)
" The classification of the anti-androgens, their indications, side-effects, dosage schemes and results of treatment are reviewed."	2.36	[Clinical aspects of the anti-androgens]. ( Holtzhausen, GH, 1979)
"Androsterone glucuronide was raised in all groups but was higher in patients with raised DHEAS."	1.29	Substrate dependency of C19 conjugates in hirsute hyperandrogenic women and the influence of adrenal androgen. ( Carmina, E; Gentzschein, E; Lobo, RA; Stanczyk, FZ, 1995)
"We hypothesized that because the treatment of hirsutism requires a prolonged duration, a longer observation period is required for changes in serum 3 alpha-androstanediol glucuronide to be measured."	1.29	Time-dependent changes in serum 3 alpha-androstanediol glucuronide correlate with hirsutism scores after ovarian suppression. ( Carmina, E; Gentzchein, E; Lobo, RA; Stanczyk, FZ, 1995)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (77.78)	18.7374
1990's	11 (20.37)	18.2507
2000's	1 (1.85)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
JULESZ, M	2
FAREDIN, I	1
TOTH, I	1
D AVID, MA	1
KOVACS, K	1
KLEINFELDER, H	1
HUSMAN, F	1
DIGNAM, WJ	1
PION, RJ	1
LAMB, EJ	1
SIMMER, HH	1
ZAMPI, G	1
BORGHI, A	1
TOCCAFONDI, R	2
GIUSTI, G	1
MAHESH, VB	1
GREENBLATT, RB	1
AYDAR, CK	1
ROY, S	1
PUEBLA, RA	1
ELLEGOOD, JO	1
CONRAD, SH	1
LINDBERG, MC	1
HERRMANN, WL	1
Korenman, SG	1
Wilson, H	1
Blaquier, J	1
Dorfman, RI	2
Forchielli, E	2
Duffy, DM	1
Legro, RS	1
Chang, L	1
Stanczyk, FZ	5
Lobo, RA	6
Carmina, E	4
Gentzschein, E	2
Gilad, S	1
Chayen, R	2
Tordjman, K	1
Kisch, E	1
Stern, N	1
Zwicker, H	1
Rittmaster, RS	2
Giagulli, VA	2
Giorgino, R	2
Vermeulen, A	3
Gentzchein, E	1
Szilágyi, A	1
Homoki, J	1
Bellyei, S	1
Szabó, I	1
Moyer, TP	1
Carpenter, PC	1
Jiang, N	1
Machacek, D	1
Holtzhausen, GH	1
Gunasegaram, R	1
Meikle, AW	1
Stringham, JD	1
Wilson, DE	1
Dolman, LI	1
De Pergola, G	1
Giorgino, F	1
Cignarelli, M	1
Abbaticchio, G	1
Miles, RA	1
Cassidenti, DL	1
Kiddy, DS	1
Sharp, PS	1
White, DM	1
Scanlon, MF	1
Mason, HD	1
Bray, CS	1
Polson, DW	1
Reed, MJ	1
Franks, S	1
Thompson, DL	1
Horton, N	1
Shapiro, MS	1
Zelefsky, S	1
Werber, MM	1
Matteri, RK	1
Gentzschein, EE	1
Delgado, C	1
Muller, LM	1
Phillipou, G	1
Mauvais-Jarvis, P	3
Baulieu, EE	1
Rivera, R	1
Göbel, P	1
Mahesh, VG	1
McDonough, PG	1
Garmendia, F	1
Nicolis, GL	1
Gabrilove, JL	1
Fazekas, AG	1
Lanthier, A	1
Crook, D	1
Bianchi, G	1
Rolandi, E	1
Madeddu, G	1
Botella-Llusia, J	1
Guadalix, FJ	1
Bagazgoitia, FJ	1
Ruiz, MC	1
Jacobs, RD	1
Lobotsky, J	1
Moses, AM	1
Klaiber, EL	1
Lloyd, CW	1
Lederer, J	1
Gandy, HM	1
Peterson, RE	1
Metcalf, MG	3
Pal, SB	1
Luisi, M	1
Franchi, F	1
Romanelli, R	1
Fassorra, C	1
Neri, R	1
Barletta, D	1
Bozzi, M	1
Jenkins, JS	1
Ash, S	1
Guillemant, S	1
Corvol, P	1
Crepy, O	1
Verdonck, L	1
Makin, HL	1
Trafford, DJ	1
Aakvaag, A	1
Vogt, JH	1
Fylling, P	1
Gillich, KH	1
Bercovici, JP	1
Floch, HH	1
Jabloński, K	1
Bauer, A	1
Karolak, A	1
Dobryszycka, W	1
Szamatowicz, M	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Pilot Study on the Effects of Fasting Mimicking Diet (FMD) in Women With Polycystic[NCT05196568]				100 participants (Anticipated)	Interventional	2021-07-01	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Hormonal and clinical effects of chronic gonadotropin-releasing hormone agonist treatment in polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2000, Volume: 14, Issue:5 Topics: Adult; Androsterone; Drug Implants; Estradiol; Etiocholanolone; Female; Follicle Stimulating Hormone	2000
Measurement of testosterone and 17-ketosteroids in plasma by the double isotope dilution derivative technique. The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:7 Topics: 17-Ketosteroids; Acetates; Adenoma; Androgen-Insensitivity Syndrome; Androgens; Androsterone; Carbon	1968

Article	Year
STUDIES OF THE URINARY STEROIDS IN HIRSUTISM AND VIRILISM. Acta medica Academiae Scientiarum Hungaricae, 1963, Volume: 19 Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Androsterone; Cushing Syndrome; Es	1963
[THE EXCRETION OF ADRENAL CORTEX STEROIDS IN PATIENTS WITH HIRSUTISM AFTER ORAL ADMINISTRATION OF METOPIRON]. Klinische Wochenschrift, 1963, Dec-01, Volume: 41 Topics: 17-Ketosteroids; Administration, Oral; Adrenal Cortex; Adrenal Cortex Hormones; Androsterone; Etioch	1963
PLASMA ANDROGENS IN WOMEN. II. PATIENTS WITH POLYCYSTIC OVARIES AND HIRSUTISM. Acta endocrinologica, 1964, Volume: 45 Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Androgens; Androsterone; Blood Chemical Ana	1964
URINARY STEROID EXCRETION PATTERNS IN HIRSUTISM. I. USE OF ADRENAL AND OVARIAN SUPPRESSION TESTS IN THE STUDY OF HIRSUTISM. The Journal of clinical endocrinology and metabolism, 1964, Volume: 24 Topics: 17-Ketosteroids; Adrenal Glands; Amenorrhea; Androsterone; Chemistry Techniques, Analytical; Dexamet	1964
SIGNIFICANCE OF PLASMA DEHYDROISOANDROSTERONE AND ANDROSTERONE SULFATES IN THE DIAGNOSIS OF VIRILIZING DISORDERS. American journal of obstetrics and gynecology, 1965, Feb-15, Volume: 91 Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Amenorrhea; Androsterone; Blood C	1965
On the role of androstenedione and testosterone as precursors of urinary androsterone and 5-beta-androsterone. Steroids, 1966, Volume: 8, Issue:5 Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Androstanes; Androsterone; Carbon Isotopes; Female; Hirsut	1966
Formation of epitestosterone by human blood and adrenal tissue. Acta endocrinologica, 1967, Volume: 54, Issue:2 Topics: Adrenal Glands; Androsterone; Blood; Female; Hirsutism; Humans; In Vitro Techniques; Male; Testoster	1967
Metabolism of dihydrotestosterone to 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide is greater in the peripheral compartment than in the splanchnic compartment. Fertility and sterility, 1995, Volume: 64, Issue:4 Topics: Administration, Cutaneous; Adolescent; Adult; Androstane-3,17-diol; Androsterone; Dihydrotestosteron	1995
Substrate dependency of C19 conjugates in hirsute hyperandrogenic women and the influence of adrenal androgen. Human reproduction (Oxford, England), 1995, Volume: 10, Issue:2 Topics: Adrenal Glands; Adult; Androgens; Androstane-3,17-diol; Androsterone; Female; Hirsutism; Humans; Hyp	1995
Assessment of 5 alpha-reductase activity in hirsute women: comparison of serum androstanediol glucuronide with urinary androsterone and aetiocholanolone excretion. Clinical endocrinology, 1994, Volume: 40, Issue:4 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adolescent; Adult; Androstane-3,17-diol; Androstanols; Andros	1994
Androsterone sulfate: physiology and clinical significance in hirsute women. The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:1 Topics: 17-alpha-Hydroxyprogesterone; Adrenocorticotropic Hormone; Adult; Androstenedione; Androsterone; Bio	1993
Origin and significance of plasma androsterone glucuronide levels: a parameter of adrenal androgen secretion and hepatic 5 alpha-reductase activity. The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:4 Topics: Addison Disease; Adolescent; Adrenal Glands; Adult; Aged; Androgens; Androsterone; Cholestenone 5 al	1993
Time-dependent changes in serum 3 alpha-androstanediol glucuronide correlate with hirsutism scores after ovarian suppression. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1995, Volume: 9, Issue:3 Topics: Adult; Androstane-3,17-diol; Androsterone; Female; Hirsutism; Humans; Polycystic Ovary Syndrome; Tes	1995
Laboratory medicine. Series on clinical testing. 2. Fractionation of urinary ketosteroids. Procedure and clinical significance. Mayo Clinic proceedings, 1978, Volume: 53, Issue:9 Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Androsterone; Chemical Fractiona	1978
Effect of dexamethasone and ACTH on the secretion pattern of fractionated 17-ketosteroids in hirsutism. Annals of the Academy of Medicine, Singapore, 1979, Volume: 8, Issue:2 Topics: 17-Ketosteroids; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Adult; Androsterone; De	1979
Plasma 5 alpha-reduced androgens in men and hirsute women: role of adrenals and gonads. The Journal of clinical endocrinology and metabolism, 1979, Volume: 48, Issue:6 Topics: Adrenal Glands; Adult; Androgens; Androstane-3,17-diol; Androstenedione; Androsterone; Dihydrotestos	1979
Increased free testosterone but normal 5 alpha-reduced testosterone metabolites in obese premenopausal women. Clinical endocrinology, 1992, Volume: 36, Issue:6 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstane-3,17-diol; Androsterone; Dehydroepiandroste	1992
Cutaneous application of an androstenedione gel as an in vivo test of 5 alpha-reductase activity in women. Fertility and sterility, 1992, Volume: 58, Issue:4 Topics: Administration, Cutaneous; Adult; Androstane-3,17-diol; Androstenedione; Androsterone; Cholestenone	1992
Peripheral androgen blockade versus glandular androgen suppression in the treatment of hirsutism. Obstetrics and gynecology, 1991, Volume: 78, Issue:5 Pt 1 Topics: Adolescent; Adult; Androgen Antagonists; Androgens; Androstane-3,17-diol; Androstenedione; Androster	1991
Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases. Clinical endocrinology, 1990, Volume: 32, Issue:2 Topics: Androgens; Androstenedione; Androsterone; Biological Transport; Female; Follicle Stimulating Hormone	1990
Androsterone glucuronide is a marker of adrenal hyperandrogenism in hirsute women. Clinical endocrinology, 1990, Volume: 32, Issue:3 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androgens; Androsterone; Biomarkers; Dexamethaso	1990
Fractionation of urinary 17-ketosteroids by gas chromatography: a neglected procedure in the assessment of hyperandrogenicity in the hirsute female. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1989, Volume: 27, Issue:1 Topics: 17-Ketosteroids; Adult; Androsterone; Chorionic Gonadotropin; Chromatography, Gas; Dehydroepiandrost	1989
Androgen sulfate and glucuronide conjugates in nonhirsute and hirsute women with polycystic ovarian syndrome. American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:6 Pt 1 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androgens; Androstenedione; Androsterone; Biomarkers;	1989
Urinary 5 alpha-androstane-3 alpha,17 beta-diol levels in normal and hirsute women: discriminating power and relation to other urinary steroids. Journal of steroid biochemistry, 1988, Volume: 31, Issue:6 Topics: Adult; Analysis of Variance; Androstane-3,17-diol; Androstanols; Androsterone; Etiocholanolone; Fema	1988
Studies on testosterone metabolism. IV. Urinary 5-alpha- and beta-androstanediols and testosterone glucuronide from testosterone and dehydrolsoandrosterone sulfate in normal people and hirsute women. The Journal of clinical endocrinology and metabolism, 1965, Volume: 25, Issue:9 Topics: Adult; Androgens; Androsterone; Dehydroepiandrosterone; Female; Glucuronates; Hirsutism; Humans; Mal	1965
A modified method for the analysis of urinary 17-ketosteroids, pregnanediol and pregnanetriol by gas liquid chromatography in normal subjects and subjects with various endocrine disorders. Acta endocrinologica, 1967, Volume: 54, Issue:1 Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androsterone; Chromatography, Gas; Cushing Syndrom	1967
[Adrenal hirsutism (3-beta-hydroxysteroid dehydrogenase deficiency). Studies using chromatographic separation of the urinary 17-ketosteroid fraction. 3. On the differential diagnosis of adrenal hirsutism (M. Cushing, congenital adrenogenital syndrome)]. Endokrinologie, 1968, Volume: 52, Issue:5 Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre	1968
New advances in the field of androgenic steroidogenesis of the human skin. Acta medica Academiae Scientiarum Hungaricae, 1968, Volume: 25, Issue:3 Topics: 17-Ketosteroids; Androgens; Androsterone; Carbon Isotopes; Chromatography, Thin Layer; Culture Techn	1968
Urinary steroid excretion in a hirsute patient with ovarian cortical stromal hyperplasia and endometrial carcinoma. American journal of obstetrics and gynecology, 1969, Jun-15, Volume: 104, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Androgens; Androsterone; Dehydroepiandrosterone; Dexamethasone; Estr	1969
The determination of urinary pregnanetriol and the neutral 17-ketosteroids by gas-liquid chromatography. Steroids, 1971, Volume: 18, Issue:2 Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre	1971
Metabolism of androgens by isolated human beard hair follicles. Steroids, 1971, Volume: 18, Issue:4 Topics: Adult; Alcohols; Androgens; Androstanes; Androsterone; Chromatography, Paper; Chromatography, Thin L	1971
The routine measurement of urinary 17-oxosteroids and 17-oxogenic steroids using gas-liquid chromatography. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 40, Issue:1 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adult; Androgens; Androsterone; Chromat	1972
Circadian variations of urinary 11-deoxy-17-ketosteroids in normal and hirsute women. Rivista critica di clinica medica, 1970, Volume: 70, Issue:1 Topics: 17-Ketosteroids; Adolescent; Adult; Androsterone; Circadian Rhythm; Dehydroepiandrosterone; Dexameth	1970
[Effect of wedge excision of the ovary on steroid excretion in virilism]. Zentralblatt fur Gynakologie, 1974, Jul-12, Volume: 96, Issue:28 Topics: 17-Ketosteroids; Adult; Androsterone; Chorionic Gonadotropin; Dehydroepiandrosterone; Dexamethasone;	1974
Studies of adrenocortical function of women with hirsutism: response to 5 units of ACTH. Metabolism: clinical and experimental, 1966, Volume: 15, Issue:4 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Androsterone; Dehydroepiand	1966
[Prolonged prednisone treatment of hirsutism caused by virilizing adrenal hyperplasia without abnormalities on cortisol production]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1967, May-26, Volume: 43, Issue:25 Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adult; Androsterone; Dehydroepiandrosterone; Female; Hirsut	1967
Rapid gas chromatographic assays for androsterone and etiocholanolone in urine. Clinical biochemistry, 1970, Volume: 3, Issue:4 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amenorrhea; Androsterone; Chromatography, Gas; Dexam	1970
The breast cancer discriminant: effect of age, obesity, hirsutism, starvation, and changes in adrenocortical and gonadal activity. The Journal of endocrinology, 1974, Volume: 63, Issue:2 Topics: 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Age	1974
The excretion of androsterone and etiocholanolone as a function of adrenocrotical and gonadal activity. Clinical biochemistry, 1972, Volume: 5, Issue:1 Topics: Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aged; Androsterone; Child; Chorionic Gonad	1972
Urinary steroid excretion in hirsutism. I. Individual 17-ketosteroids (unconjugated and conjugated). Steroids and lipids research, 1972, Volume: 3, Issue:1 Topics: 11-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Age Factors; Androsterone; Etiocholan	1972
[Radioimmunologic determination of plasma progesterone. Preliminary note]. Folia endocrinologica, 1972, Volume: 25, Issue:5 Topics: Androstenedione; Androsterone; Antibodies; Corticosterone; Estradiol; Female; Hirsutism; Humans; Hyd	1972
The metabolism of testosterone by human skin in disorders of hair growth. The Journal of endocrinology, 1973, Volume: 59, Issue:2 Topics: Adult; Androgen-Insensitivity Syndrome; Androstenedione; Androsterone; Chromatography; Female; Hair;	1973
[Action of cyproterone on plasma binding and metabolism of testosterone]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1969, May-28, Volume: 268, Issue:21 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acetates; Androstanes; Androsterone; Carbon Isotopes; Di	1969
Some studies on the biological significance of free testosterone. Journal of steroid biochemistry, 1972, Volume: 3, Issue:3 Topics: 17-Hydroxycorticosteroids; Adult; Aged; Aging; Androstanes; Androsterone; Carrier Proteins; Child; D	1972
Gas-liquid chromatographic fractionation of the urinary 17-oxo- and 17-oxogenic steroids; a simple qualitative aid in the diagnosis and treatment of adrenocortical dysfunction. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 32, Issue:2 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Alcohols; Androstanes; Androster	1971
Plasma and urinary androgens in hirsute women during adrenal and ovarian suppression. Acta endocrinologica, 1970, Volume: 64, Issue:1 Topics: Adult; Amenorrhea; Androstanes; Androstenols; Androsterone; Chromatography, Gas; Depression, Chemica	1970
[Postpuberal adrenogenital syndrome and gravidity]. Medizinische Klinik, 1968, Jul-26, Volume: 63, Issue:30 Topics: 17-Ketosteroids; Abortion, Spontaneous; Adolescent; Adrenal Hyperplasia, Congenital; Age Factors; An	1968
[Influence of sex hormones on the metabolism of androgens]. Revue francaise d'etudes cliniques et biologiques, 1969, Volume: 14, Issue:2 Topics: Adult; Androgens; Androstanes; Androsterone; Carbon Isotopes; Child; Chorionic Gonadotropin; Enzyme	1969
Urinary mucoprotein fractions and 17-ketosteroids in healthy women and in patients with the stein-leventhal syndrome. Archivum immunologiae et therapiae experimentalis, 1969, Volume: 17, Issue:2 Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Androsterone; Chromatography; Female; Hirsutism; Humans; M	1969
[Diagnosis and therapeutic results in cases of hirsutism in women]. Ginekologia polska, 1969, Volume: 40, Issue:6 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Androsterone; Cu	1969

androsterone and Hirsutism

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