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androsterone and Adrenal Hyperplasia, Congenital

androsterone has been researched along with Adrenal Hyperplasia, Congenital in 40 studies

Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.

Research Excerpts

ExcerptRelevanceReference
" While preliminary data indicates that both 3 alpha-diolG and androsterone G (ADTG) may arise from adrenal steroid precursors, there have been no reports of C19 steroid glucuronides in women with non-classical, or late-onset congenital adrenal hyperplasia (NC-CAH), who constitute a significant proportion of the hirsute female population."3.68Plasma levels of C19 steroid glucuronides in pre-menopausal women with non-classical congenital adrenal hyperplasia. ( del Blazo, P; Ueshiba, H; Whorwood, CB, 1992)
"Abiraterone acetate (AA) is a prodrug for abiraterone, a potent CYP17A1 inhibitor used to suppress androgens in the treatment of prostate cancer."2.79Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency. ( Auchus, RJ; Buschur, EO; Chang, AY; Gonzalez, M; Hammer, GD; Jiao, J; Madrigal, D; Ramm, C; Smit, JW; Wang, G; Xu, XS; Yu, MK, 2014)
" The classification of the anti-androgens, their indications, side-effects, dosage schemes and results of treatment are reviewed."2.36[Clinical aspects of the anti-androgens]. ( Holtzhausen, GH, 1979)
"Youth with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency develop cardiovascular disease (CVD) risk factors of obesity and hypertension."1.43Carotid Intima-Media Thickness Is Associated with Increased Androgens in Adolescents and Young Adults with Classical Congenital Adrenal Hyperplasia. ( Dao-Tran, A; Davidowitz, E; Geffner, ME; Gilsanz, V; Kim, MS; Nguyen, E; Ryabets-Lienhard, A; Tseng, T, 2016)
"The treatment goal in congenital adrenal hyperplasia (CAH) is to replace glucocorticoids while avoiding androgen excess and iatrogenic Cushing's syndrome."1.42Hormonal circadian rhythms in patients with congenital adrenal hyperplasia: identifying optimal monitoring times and novel disease biomarkers. ( Backlund, PS; Crutchfield, CA; Debono, M; Gounden, V; Harrison, RF; Mallappa, A; Merke, DP; Nella, AA; Ross, RJ; Soldin, SJ, 2015)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199027 (67.50)18.7374
1990's1 (2.50)18.2507
2000's1 (2.50)29.6817
2010's11 (27.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kamrath, C3
Wettstaedt, L2
Boettcher, C2
Hartmann, MF3
Wudy, SA3
Auchus, RJ1
Buschur, EO1
Chang, AY1
Hammer, GD1
Ramm, C1
Madrigal, D1
Wang, G1
Gonzalez, M1
Xu, XS1
Smit, JW1
Jiao, J1
Yu, MK1
Debono, M1
Mallappa, A2
Gounden, V2
Nella, AA1
Harrison, RF1
Crutchfield, CA1
Backlund, PS1
Soldin, SJ2
Ross, RJ2
Merke, DP3
Stolze, BR1
Gu, J1
Elliott, EA1
Masika, LS1
Abel, BS1
Skarulis, MC1
Kim, MS1
Dao-Tran, A1
Davidowitz, E1
Tseng, T1
Gilsanz, V1
Ryabets-Lienhard, A1
Nguyen, E1
Geffner, ME1
Jones, CM1
Reisch, N2
Nikolaou, N1
Krone, N2
Hughes, BA2
O'Neil, DM1
Whitaker, MJ1
Tomlinson, JW1
Storbeck, KH1
Arlt, W2
Hochberg, Z1
Remer, T1
Koyama, Y1
Homma, K1
Fukami, M1
Miwa, M1
Ikeda, K1
Ogata, T1
Hasegawa, T1
Murata, M1
Taylor, NF1
Chan, AO1
Idkowiak, J1
Ivison, HE1
Abdul-Rahman, OA1
Hendon, LG1
Olney, AH1
Nielsen, S1
Harrison, R1
Blair, EM1
Dhir, V1
Shackleton, CH1
GOLD, NI1
CRIGLER, JF1
REFORZOMEMBRIVES, J1
DIGNAM, WJ1
PION, RJ1
LAMB, EJ1
SIMMER, HH1
EDWARDS, RW1
MAKIN, HL1
BARRATT, TM1
SORCINI, G1
SCIARRA, F1
CONCOLINO, G1
RASCIO, L1
Shibata, Y1
Mizumoto, T1
Kondo, S1
Yamasaki, S1
Ferrante, L1
Holtzhausen, GH1
Zhukovskiĭ, MA1
Kuznetsova, ES1
Grishina, VP1
Matys, Z1
Gregorová, I2
Tomsová, Z1
Jarosová, M1
Schreiber, V1
Whorwood, CB1
Ueshiba, H1
del Blazo, P1
Dumić, M1
Brkljacić, L1
Mardesić, D1
Plavsić, V1
Lukenda, M1
Kastelan, A1
Rivera, R1
Dorfman, RI1
Forchielli, E1
Rivarola, MA1
Saez, JM1
Migeon, CJ1
Conly, PW1
Sandberg, DH1
Cleveland, WW1
Göbel, P1
Cacciari, E1
Dallera, L1
Tassoni, P1
Cicognani, A1
Miano, A1
Garmendia, F1
Nicolis, GL2
Gabrilove, JL2
Gleispach, H2
Berger, H2
Glatzl, J2
Rössler, H2
Sanghvi, A1
Wight, C1
Serenko, A1
Balachandran, R1
Horký, K1
Kuchel, O1
Stárka, L1
Sohval, AR1
Gillich, KH1
Szamatowicz, M1
Curtius, HC1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 1 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children With Classic 21-Hydroxylase Deficiency[NCT02574910]Phase 136 participants (Anticipated)Interventional2017-08-01Recruiting
A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children With Classic 21-Hydroxylase Deficiency[NCT03548246]Phase 20 participants (Actual)Interventional2023-01-31Withdrawn (stopped due to This study plan has halted and was withdrawn from the IRB.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for androsterone and Adrenal Hyperplasia, Congenital

ArticleYear
[Androsterone].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8

    Topics: Adrenal Hyperplasia, Congenital; Amenorrhea; Androsterone; Biomarkers; Female; Humans; Hyperthyroidi

2005
[Clinical aspects of the anti-androgens].
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Mar-24, Volume: 55, Issue:13

    Topics: 17-Ketosteroids; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Androgen Antagonists; Androgens; An

1979
[Enzyme anomaly in adrenal cortex hormone synthesis].
    Saishin igaku. Modern medicine, 1967, Nov-10, Volume: 22, Issue:11

    Topics: Adrenal Hyperplasia, Congenital; Androsterone; Glucocorticoids; Humans; Hydrocortisone; Hydroxystero

1967

Trials

2 trials available for androsterone and Adrenal Hyperplasia, Congenital

ArticleYear
Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:8

    Topics: 17-alpha-Hydroxyprogesterone; Abiraterone Acetate; Adrenal Hyperplasia, Congenital; Adult; Androgen

2014
Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:8

    Topics: 17-alpha-Hydroxyprogesterone; Abiraterone Acetate; Adrenal Hyperplasia, Congenital; Adult; Androgen

2014
Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:8

    Topics: 17-alpha-Hydroxyprogesterone; Abiraterone Acetate; Adrenal Hyperplasia, Congenital; Adult; Androgen

2014
Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:8

    Topics: 17-alpha-Hydroxyprogesterone; Abiraterone Acetate; Adrenal Hyperplasia, Congenital; Adult; Androgen

2014
Effect of aminoglutethimide on urinary steroid excretion in patients with congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency.
    Metabolism: clinical and experimental, 1972, Volume: 21, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenal Hy

1972

Other Studies

35 other studies available for androsterone and Adrenal Hyperplasia, Congenital

ArticleYear
Androgen excess is due to elevated 11-oxygenated androgens in treated children with congenital adrenal hyperplasia.
    The Journal of steroid biochemistry and molecular biology, 2018, Volume: 178

    Topics: Adrenal Hyperplasia, Congenital; Androgens; Androsterone; Biomarkers; Case-Control Studies; Child; C

2018
Hormonal circadian rhythms in patients with congenital adrenal hyperplasia: identifying optimal monitoring times and novel disease biomarkers.
    European journal of endocrinology, 2015, Volume: 173, Issue:6

    Topics: 17-alpha-Hydroxyprogesterone; 5-alpha-Dihydroprogesterone; Adrenal Hyperplasia, Congenital; Adrenoco

2015
An improved micro-method for the measurement of steroid profiles by APPI-LC-MS/MS and its use in assessing diurnal effects on steroid concentrations and optimizing the diagnosis and treatment of adrenal insufficiency and CAH.
    The Journal of steroid biochemistry and molecular biology, 2016, Volume: 162

    Topics: Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Androgens; Androsterone; Chromatography, Liq

2016
Carotid Intima-Media Thickness Is Associated with Increased Androgens in Adolescents and Young Adults with Classical Congenital Adrenal Hyperplasia.
    Hormone research in paediatrics, 2016, Volume: 85, Issue:4

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Hyperplasia, Congenital; Adult; Androsterone; Caro

2016
The urinary steroidome of treated children with classic 21-hydroxylase deficiency.
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 165, Issue:Pt B

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenarche; Androgens; Androsterone; Body Height; Body

2017
Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.
    The Journal of clinical endocrinology and metabolism, 2017, 06-01, Volume: 102, Issue:6

    Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adrenal Hyperplasia, Congenital; Adult; Androgens; Androst

2017
Increased activation of the alternative "backdoor" pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis.
    The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:3

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Androstenedione; Androsterone; Child; Child, Pre

2012
Two-step biochemical differential diagnosis of classic 21-hydroxylase deficiency and cytochrome P450 oxidoreductase deficiency in Japanese infants by GC-MS measurement of urinary pregnanetriolone/ tetrahydroxycortisone ratio and 11β-hydroxyandrosterone.
    Clinical chemistry, 2012, Volume: 58, Issue:4

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Androsterone; Biomarkers; Case-Contro

2012
New strategies for detecting steroid metabolic disorders--paneling vs profiling.
    Clinical chemistry, 2012, Volume: 58, Issue:8

    Topics: Adrenal Hyperplasia, Congenital; Androsterone; Female; Humans; Male; NADPH-Ferrihemoprotein Reductas

2012
Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:3

    Topics: Abnormalities, Multiple; Adrenal Hyperplasia, Congenital; Androsterone; Estriol; Female; Heterozygot

2013
Influence of L-triodothyronine on steroid hormone metabolism: studies in a patient with adrenal hyperplasia (Cushing's syndrome).
    The Journal of clinical endocrinology and metabolism, 1963, Volume: 23

    Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenocortical Hyp

1963
[POLYCYSTIC OVARIES. ENDOCRINE ASPECTS].
    Prensa medica argentina, 1963, May-31, Volume: 50

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenogenital Syndro

1963
PLASMA ANDROGENS IN WOMEN. II. PATIENTS WITH POLYCYSTIC OVARIES AND HIRSUTISM.
    Acta endocrinologica, 1964, Volume: 45

    Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Androgens; Androsterone; Blood Chemical Ana

1964
THE STEROID 11-OXYGENATION INDEX; A RAPID METHOD FOR USE IN THE DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA.
    The Journal of endocrinology, 1964, Volume: 30

    Topics: Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Androsterone; Chem

1964
[ADRENOGENITAL SYNDROME CAUSED BY CONGENITAL HYPERPLASIA OF THE ADRENAL CORTEX: PATHOGENETIC IMPORTANCE OF TESTOSTERONE].
    Folia endocrinologica, 1964, Volume: 17

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenal Gland Diseases; Adre

1964
[An analysis and identification of urinary steroids in normal people and patients with 21-hydroxylase deficiency and urinary excretion patterns].
    Nihon Naibunpi Gakkai zasshi, 1984, Feb-20, Volume: 60, Issue:2

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Aged; Androgens; Androsterone; Child; Cortisone;

1984
[Complex biochemical aspects in virilizing adrenal gland syndromes].
    Minerva pediatrica, 1976, Jun-23, Volume: 28, Issue:22

    Topics: Adrenal Hyperplasia, Congenital; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Female; Huma

1976
[Difficulties of differential diagnosis of androsteroma in an 8-year-old girl].
    Pediatriia, 1979, Issue:5

    Topics: Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Androsterone; Child; Diagnosis, Differenti

1979
[Urinary excretion of steroids in congenital adrenogenital syndrome with successful pregnancy (author's transl)].
    Sbornik lekarsky, 1977, Volume: 79, Issue:7-8

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Androsterone; Etiocholanolone; Female; Huma

1977
Plasma levels of C19 steroid glucuronides in pre-menopausal women with non-classical congenital adrenal hyperplasia.
    The Journal of steroid biochemistry and molecular biology, 1992, Volume: 42, Issue:2

    Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Androstane-3,17-diol; Androster

1992
'Cryptic' form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency in the Yugoslav population.
    Acta endocrinologica, 1985, Volume: 109, Issue:3

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; A

1985
A modified method for the analysis of urinary 17-ketosteroids, pregnanediol and pregnanetriol by gas liquid chromatography in normal subjects and subjects with various endocrine disorders.
    Acta endocrinologica, 1967, Volume: 54, Issue:1

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androsterone; Chromatography, Gas; Cushing Syndrom

1967
Studies of androgens in patients with congenital adrenal hyperplasia.
    The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:5

    Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult; Androsterone; Carbon Isotopes; C

1967
Steroid metabolism in premature pubarche and virilizing adrenal hyperplasia.
    The Journal of pediatrics, 1967, Volume: 71, Issue:4

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Androgens;

1967
[Adrenal hirsutism (3-beta-hydroxysteroid dehydrogenase deficiency). Studies using chromatographic separation of the urinary 17-ketosteroid fraction. 3. On the differential diagnosis of adrenal hirsutism (M. Cushing, congenital adrenogenital syndrome)].
    Endokrinologie, 1968, Volume: 52, Issue:5

    Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre

1968
[Various aspects of steroidogenesis in congenital adrenogenital syndrome with or without salt loss (determination of the urinary excretion of aldosterone, androsterone, etiocholanolone, dehydroisoandrosterone, 17-hydroxy-11-desoxycorticosterone, pregnaned
    Minerva pediatrica, 1969, May-26, Volume: 21, Issue:21

    Topics: Adrenal Hyperplasia, Congenital; Aldosterone; Androgens; Androsterone; Child; Child, Preschool; Dehy

1969
The determination of urinary pregnanetriol and the neutral 17-ketosteroids by gas-liquid chromatography.
    Steroids, 1971, Volume: 18, Issue:2

    Topics: 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adre

1971
[Congenital adrenal hyperplasia; 21-hydroxylase-deficiency combined with 17-desmolase-deficiency (author's transl)].
    Padiatrie und Padologie, 1974, Volume: 9, Issue:3

    Topics: Adrenal Hyperplasia, Congenital; Androsterone; Chemical Phenomena; Chemistry; Dehydroepiandrosterone

1974
Gas-liquid chromatography of underivatized steroids: simultaneous determination of urinary 17-ketosteroids, pregnanediol, pregnanetriol, and pregnanetriolone.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Oct-15, Volume: 56, Issue:1

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Androsterone; Chromatography, Gas; Computers; Dehy

1974
[Pregnanetriolone excretion after stimulation with ACTH as a test on presumably heterozygous carriers of a 21-hydroxylase-deficiency (author's transl)].
    Padiatrie und Padologie, 1974, Volume: 9, Issue:3

    Topics: 17-Hydroxycorticosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Andr

1974
Non-tumorous feminizing adrenogenital syndrome in the male subject.
    The Journal of urology, 1973, Volume: 110, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorti

1973
[Evaluation of neutral urinary steroid analysis by gas liquid chromatography using OV-210].
    Horumon to rinsho. Clinical endocrinology, 1971, Volume: 19, Issue:11

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrena

1971
[Postpuberal adrenogenital syndrome and gravidity].
    Medizinische Klinik, 1968, Jul-26, Volume: 63, Issue:30

    Topics: 17-Ketosteroids; Abortion, Spontaneous; Adolescent; Adrenal Hyperplasia, Congenital; Age Factors; An

1968
[Diagnosis and therapeutic results in cases of hirsutism in women].
    Ginekologia polska, 1969, Volume: 40, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adult; Androsterone; Cu

1969
[Gas chromatography determination of pregnanediol, pregnanetriol and pregnanetriolone in urine].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1966, Volume: 4, Issue:3

    Topics: Adrenal Hyperplasia, Congenital; Androsterone; Chemistry, Clinical; Chromatography, Gas; Glucuronida

1966