Compounds > androstane-3-17-diol-glucuronide

androstane-3-17-diol-glucuronide and Disease-Models--Animal

androstane-3-17-diol-glucuronide has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for androstane-3-17-diol-glucuronide and Disease-Models--Animal

Article	Year
The effects of N,N-diethyl-4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carboxamide, a 5 alpha-reductase inhibitor and antiandrogen, on the development of baldness in the stumptail macaque. The Journal of clinical endocrinology and metabolism, 1987, Volume: 65, Issue:1 We used a primate model of male-pattern baldness to test the efficacy of a topically applied 5 alpha-reductase inhibitor and antiandrogen (4-MA) in the prevention of baldness. Six periadolescent stumptail macaques were given daily topical applications of either 4-MA in dimethylsulfoxide or dimethylsulfoxide alone for 27 months. The three control monkeys developed varying degrees of baldness, while the three 4-MA-treated monkeys retained their juvenile pattern of hair growth. The percentage of actively growing hair follicles in the frontal scalp did not change in the 4-MA-treated group [46 +/- 6 (+/- SE) vs. 48 +/- 4], while a significant decrease occurred in the control group (63 +/- 6 vs. 25 +/- 12; P less than 0.025). Skin 5 alpha-reductase activity was reduced in the scalp of the 4-MA-treated monkeys. We conclude that topical 4-MA can prevent the development of baldness in the stumptail macaque, a primate model of androgen-dependent baldness. Topics: Alopecia; Androgen Antagonists; Androstane-3,17-diol; Animals; Azasteroids; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Disease Models, Animal; Female; Hair; Macaca; Male; Oxidoreductases; Skin; Steroids, Heterocyclic; Testosterone	1987

Article

Year

The effects of N,N-diethyl-4-methyl-3-oxo-4-aza-5 alpha-androstane-17 beta-carboxamide, a 5 alpha-reductase inhibitor and antiandrogen, on the development of baldness in the stumptail macaque.

The Journal of clinical endocrinology and metabolism, 1987, Volume: 65, Issue:1

We used a primate model of male-pattern baldness to test the efficacy of a topically applied 5 alpha-reductase inhibitor and antiandrogen (4-MA) in the prevention of baldness. Six periadolescent stumptail macaques were given daily topical applications of either 4-MA in dimethylsulfoxide or dimethylsulfoxide alone for 27 months. The three control monkeys developed varying degrees of baldness, while the three 4-MA-treated monkeys retained their juvenile pattern of hair growth. The percentage of actively growing hair follicles in the frontal scalp did not change in the 4-MA-treated group [46 +/- 6 (+/- SE) vs. 48 +/- 4], while a significant decrease occurred in the control group (63 +/- 6 vs. 25 +/- 12; P less than 0.025). Skin 5 alpha-reductase activity was reduced in the scalp of the 4-MA-treated monkeys. We conclude that topical 4-MA can prevent the development of baldness in the stumptail macaque, a primate model of androgen-dependent baldness.

Topics: Alopecia; Androgen Antagonists; Androstane-3,17-diol; Animals; Azasteroids; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Disease Models, Animal; Female; Hair; Macaca; Male; Oxidoreductases; Skin; Steroids, Heterocyclic; Testosterone

1987