andrographolide has been researched along with Leukemia* in 1 studies
1 other study(ies) available for andrographolide and Leukemia
| Article | Year |
|---|---|
Synthesis, cytotoxicity, and structure-activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent.
A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14 hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure-activity relationship (SAR) revealed that the α-alkylidene-γ-butyrolactone moiety of andrographolide played a major role in the activity profile. The structures of the analogues were established through spectroscopic and analytical data. Topics: 4-Butyrolactone; Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Drug Screening Assays, Antitumor; Humans; Leukemia; Molecular Structure; Spectrum Analysis; Structure-Activity Relationship | 2010 |