anastrozole has been researched along with Sensitivity and Specificity in 17 studies
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The 'Arimidex', Tamoxifen, Alone or in Combination (ATAC) trial is a randomized, double-blind trial comparing anastrozole ('Arimidex'), alone or in combination with tamoxifen, relative to tamoxifen alone as 5 year adjuvant treatment for post-menopausal women with early breast cancer." | 9.11 | The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: baseline endometrial sub-protocol data on the effectiveness of transvaginal ultrasonography and diagnostic hysteroscopy. ( Bianco, AR; Clack, G; Coibion, M; Duffy, S; Jackson, TL; Lansdown, M; Philips, K; Pollard, S; Wells, M, 2005) |
| "This study was undertaken to assess baseline endometrial molecular events in the ATAC (Arimidex, tamoxifen, alone, or in combination) trial of breast cancer adjuvant therapy." | 9.11 | Molecular markers in the endometrium at baseline of postmenopausal patients with early breast cancer in the ATAC (Arimidex, tamoxifen, alone, or in combination) trial. ( Duffy, SR; Taylor, L, 2004) |
| "To conduct an economic analysis comparing tamoxifen and anastrozole (Arimidex) in the adjuvant treatment of hormone receptor-positive (HR+), post-menopausal early breast cancer patients." | 7.73 | Anastrozole is cost-effective vs tamoxifen as initial adjuvant therapy in early breast cancer: Canadian perspectives on the ATAC completed-treatment analysis. ( Rocchi, A; Verma, S, 2006) |
| "The 5-year completed treatment analysis of the Anastrozole and Tamoxifen-Alone or in Combination (ATAC) trial showed the superiority of anastrozole over tamoxifen for reduction of disease progression in patients with hormone receptor-positive (HR+) early breast cancer (EBC)." | 7.73 | Cost-effectiveness of anastrozole compared to tamoxifen in hormone receptor-positive early breast cancer. Analysis based on the ATAC trial. ( Annemans, L; Moeremans, K, 2006) |
| "Thirty-four consecutive patients with advanced breast cancer received anastrozole 1 mg/day." | 7.71 | Biological activity of anastrozole in postmenopausal patients with advanced breast cancer: effects on estrogens and bone metabolism. ( Bajetta, E; Bombardieri, E; Ferrari, L; La Torre, I; Longarini, R; Martinetti, A; Pozzi, P; Salvucci, G; Seregni, E; Zilembo, N, 2002) |
| "Estrone and E(1)S were converted into E(2), and all three estrogen fractions were finally measured by the same highly sensitive and specific radioimmunoassay using estradiol-6-(O-carboxymethyl)-oximino-2-(2--iodo-histamine) as a ligand." | 5.31 | A novel HPLC-RIA method for the simultaneous detection of estrone, estradiol and estrone sulphate levels in breast cancer tissue. ( Berntsen, H; Geisler, J; Lonning, PE, 2000) |
| "The 'Arimidex', Tamoxifen, Alone or in Combination (ATAC) trial is a randomized, double-blind trial comparing anastrozole ('Arimidex'), alone or in combination with tamoxifen, relative to tamoxifen alone as 5 year adjuvant treatment for post-menopausal women with early breast cancer." | 5.11 | The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: baseline endometrial sub-protocol data on the effectiveness of transvaginal ultrasonography and diagnostic hysteroscopy. ( Bianco, AR; Clack, G; Coibion, M; Duffy, S; Jackson, TL; Lansdown, M; Philips, K; Pollard, S; Wells, M, 2005) |
| "This study was undertaken to assess baseline endometrial molecular events in the ATAC (Arimidex, tamoxifen, alone, or in combination) trial of breast cancer adjuvant therapy." | 5.11 | Molecular markers in the endometrium at baseline of postmenopausal patients with early breast cancer in the ATAC (Arimidex, tamoxifen, alone, or in combination) trial. ( Duffy, SR; Taylor, L, 2004) |
| "The third generation aromatase inhibitors anastrozole, exemestane, and letrozole have been compared with tamoxifen and other endocrine therapies in several studies in early and advanced breast cancer." | 4.82 | Aromatase inhibitors in the treatment of early and advanced breast cancer. ( Ejlertsen, B; Joensuu, H; Lønning, PE; Rutqvist, LE, 2005) |
| "To conduct an economic analysis comparing tamoxifen and anastrozole (Arimidex) in the adjuvant treatment of hormone receptor-positive (HR+), post-menopausal early breast cancer patients." | 3.73 | Anastrozole is cost-effective vs tamoxifen as initial adjuvant therapy in early breast cancer: Canadian perspectives on the ATAC completed-treatment analysis. ( Rocchi, A; Verma, S, 2006) |
| "The 5-year completed treatment analysis of the Anastrozole and Tamoxifen-Alone or in Combination (ATAC) trial showed the superiority of anastrozole over tamoxifen for reduction of disease progression in patients with hormone receptor-positive (HR+) early breast cancer (EBC)." | 3.73 | Cost-effectiveness of anastrozole compared to tamoxifen in hormone receptor-positive early breast cancer. Analysis based on the ATAC trial. ( Annemans, L; Moeremans, K, 2006) |
| "Thirty-four consecutive patients with advanced breast cancer received anastrozole 1 mg/day." | 3.71 | Biological activity of anastrozole in postmenopausal patients with advanced breast cancer: effects on estrogens and bone metabolism. ( Bajetta, E; Bombardieri, E; Ferrari, L; La Torre, I; Longarini, R; Martinetti, A; Pozzi, P; Salvucci, G; Seregni, E; Zilembo, N, 2002) |
| "Anastrozole was quantified by comparing its peak area to that of an internal standard." | 2.68 | Validated assay for the quantification of anastrozole in human plasma by capillary gas chromatography-63Ni electron capture detection. ( Bara, I; Bock, MJ; Dyroff, M; LeDonne, N; Martz, A, 1997) |
| " The present method was applied successfully to the pharmacokinetic study of anastrozole after oral administration of 1 mg anastrozole tablet to healthy male volunteers." | 1.38 | Hydrophilic interaction chromatography-electrospray ionization tandem mass spectrometric analysis of anastrozole in human plasma and its application to a pharmacokinetic study. ( Ji, HY; Lee, HS; Sohn, JH, 2012) |
| "A fast, selective and sensitive ultraperformance liquid chromatography-tandem mass spectrometry method was developed for determination and pharmacokinetic study of anastrozole in human plasma." | 1.37 | An ultraperformance liquid chromatography-tandem mass spectrometry method for determination of anastrozole in human plasma and its application to a pharmacokinetic study. ( He, J; Li, F; Qin, F; Xiong, Z; Yu, J; Zhang, Y, 2011) |
| "The majority of breast cancer patients who have estrogen receptor positive (ER(+)) tumors whose proliferation is reduced after estrogen deprivation by aromatase inhibitors (AI)." | 1.37 | Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer. ( Anderson, H; Buffa, FM; Detre, S; Dexter, T; Dowsett, M; Dunbier, AK; Ghazoui, Z; Harris, AL; Salter, J; Smith, IE, 2011) |
| "Anastrozole was used as internal standard." | 1.37 | Development and validation of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of exemestane in human plasma. ( Buś-Kwaśnik, K; Ksycińska, H; Rudzki, PJ; Szlagowska, A, 2011) |
| " This HPLC-MS-MS procedure was used to assess pharmacokinetic studies." | 1.34 | Anastrozole quantification in human plasma by high-performance liquid chromatography coupled to photospray tandem mass spectrometry applied to pharmacokinetic studies. ( De Nucci, G; Hamamoto, D; Ilha, J; Mendes, GD; Pereira, Ados S, 2007) |
| " This method has been applied to the oral pharmacokinetic study of anastrozole in healthy Chinese male volunteers." | 1.31 | Rapid determination of anastrozole in plasma by gas chromatography with electron capture detection and its application to an oral pharmacokinetic study in healthy volunteers. ( Duan, G; Liang, J; Zuo, M, 2002) |
| "Estrone and E(1)S were converted into E(2), and all three estrogen fractions were finally measured by the same highly sensitive and specific radioimmunoassay using estradiol-6-(O-carboxymethyl)-oximino-2-(2--iodo-histamine) as a ligand." | 1.31 | A novel HPLC-RIA method for the simultaneous detection of estrone, estradiol and estrone sulphate levels in breast cancer tissue. ( Berntsen, H; Geisler, J; Lonning, PE, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, L | 1 |
| Qiu, S | 1 |
| Liu, Z | 1 |
| Ning, M | 1 |
| Klein, KO | 1 |
| Apostolou, C | 1 |
| Dotsikas, Y | 1 |
| Kousoulos, C | 1 |
| Loukas, YL | 1 |
| Yu, J | 1 |
| He, J | 1 |
| Zhang, Y | 1 |
| Qin, F | 1 |
| Xiong, Z | 1 |
| Li, F | 1 |
| Ghazoui, Z | 1 |
| Buffa, FM | 1 |
| Dunbier, AK | 1 |
| Anderson, H | 1 |
| Dexter, T | 1 |
| Detre, S | 1 |
| Salter, J | 1 |
| Smith, IE | 1 |
| Harris, AL | 1 |
| Dowsett, M | 1 |
| Ksycińska, H | 1 |
| Buś-Kwaśnik, K | 1 |
| Szlagowska, A | 1 |
| Rudzki, PJ | 1 |
| Ji, HY | 1 |
| Sohn, JH | 1 |
| Lee, HS | 1 |
| Bajetta, E | 1 |
| Martinetti, A | 1 |
| Zilembo, N | 1 |
| Pozzi, P | 1 |
| La Torre, I | 1 |
| Ferrari, L | 1 |
| Seregni, E | 1 |
| Longarini, R | 1 |
| Salvucci, G | 1 |
| Bombardieri, E | 1 |
| Duan, G | 1 |
| Liang, J | 1 |
| Zuo, M | 1 |
| Duffy, S | 1 |
| Jackson, TL | 1 |
| Lansdown, M | 1 |
| Philips, K | 1 |
| Wells, M | 1 |
| Pollard, S | 1 |
| Clack, G | 1 |
| Coibion, M | 1 |
| Bianco, AR | 1 |
| Duffy, SR | 1 |
| Taylor, L | 1 |
| Joensuu, H | 1 |
| Ejlertsen, B | 1 |
| Lønning, PE | 1 |
| Rutqvist, LE | 1 |
| Rocchi, A | 1 |
| Verma, S | 1 |
| Moeremans, K | 1 |
| Annemans, L | 1 |
| Mendes, GD | 1 |
| Hamamoto, D | 1 |
| Ilha, J | 1 |
| Pereira, Ados S | 1 |
| De Nucci, G | 1 |
| Bock, MJ | 1 |
| Bara, I | 1 |
| LeDonne, N | 1 |
| Martz, A | 1 |
| Dyroff, M | 1 |
| Geisler, J | 1 |
| Berntsen, H | 1 |
| Lonning, PE | 1 |
2 reviews available for anastrozole and Sensitivity and Specificity
| Article | Year |
|---|---|
Is there a role for estrogen activity assays? Recombinant cell bioassay for estrogen: Development and applications.
Topics: Anastrozole; Aromatase Inhibitors; Biological Assay; Breast Neoplasms; Child; Estradiol; Female; Hum | 2015 |
Aromatase inhibitors in the treatment of early and advanced breast cancer.
Topics: Adult; Aged; Anastrozole; Aromatase Inhibitors; Biopsy, Needle; Breast Neoplasms; Chemotherapy, Adju | 2005 |
3 trials available for anastrozole and Sensitivity and Specificity
| Article | Year |
|---|---|
The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: baseline endometrial sub-protocol data on the effectiveness of transvaginal ultrasonography and diagnostic hysteroscopy.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Pro | 2005 |
Molecular markers in the endometrium at baseline of postmenopausal patients with early breast cancer in the ATAC (Arimidex, tamoxifen, alone, or in combination) trial.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomar | 2004 |
Validated assay for the quantification of anastrozole in human plasma by capillary gas chromatography-63Ni electron capture detection.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Chromatography, Gas; Drug Stability; Female; Humans; N | 1997 |
12 other studies available for anastrozole and Sensitivity and Specificity
| Article | Year |
|---|---|
Preparation and in vitro/in vivo evaluation of anastrozole reservoir-type intravaginal ring.
Topics: Anastrozole; Animals; Chromatography, High Pressure Liquid; Contraceptive Devices, Female; Dogs; Fem | 2019 |
Development and validation of an improved high-throughput method for the determination of anastrozole in human plasma by LC-MS/MS and atmospheric pressure chemical ionization.
Topics: Acetonitriles; Anastrozole; Area Under Curve; Aromatase Inhibitors; Atmospheric Pressure; Chromatogr | 2008 |
An ultraperformance liquid chromatography-tandem mass spectrometry method for determination of anastrozole in human plasma and its application to a pharmacokinetic study.
Topics: Administration, Oral; Anastrozole; Chromatography, High Pressure Liquid; Humans; Least-Squares Analy | 2011 |
Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Cel | 2011 |
Development and validation of a sensitive liquid chromatography/tandem mass spectrometry method for the determination of exemestane in human plasma.
Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Chromatography, Liquid; Humans; Linear Models; N | 2011 |
Hydrophilic interaction chromatography-electrospray ionization tandem mass spectrometric analysis of anastrozole in human plasma and its application to a pharmacokinetic study.
Topics: Anastrozole; Chromatography, Liquid; Humans; Hydrophobic and Hydrophilic Interactions; Linear Models | 2012 |
Biological activity of anastrozole in postmenopausal patients with advanced breast cancer: effects on estrogens and bone metabolism.
Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androgens; Biological Availability; Biomarkers; Biopsy, | 2002 |
Rapid determination of anastrozole in plasma by gas chromatography with electron capture detection and its application to an oral pharmacokinetic study in healthy volunteers.
Topics: Administration, Oral; Adult; Anastrozole; Area Under Curve; Aromatase Inhibitors; Chromatography, Ga | 2002 |
Anastrozole is cost-effective vs tamoxifen as initial adjuvant therapy in early breast cancer: Canadian perspectives on the ATAC completed-treatment analysis.
Topics: Analysis of Variance; Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemothe | 2006 |
Cost-effectiveness of anastrozole compared to tamoxifen in hormone receptor-positive early breast cancer. Analysis based on the ATAC trial.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Cost | 2006 |
Anastrozole quantification in human plasma by high-performance liquid chromatography coupled to photospray tandem mass spectrometry applied to pharmacokinetic studies.
Topics: Anastrozole; Aromatase Inhibitors; Calibration; Chromatography, High Pressure Liquid; Humans; Nitril | 2007 |
A novel HPLC-RIA method for the simultaneous detection of estrone, estradiol and estrone sulphate levels in breast cancer tissue.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chromatography, High Pressure Liquid | 2000 |