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anastrozole and Puberty, Precocious

anastrozole has been researched along with Puberty, Precocious in 19 studies

Puberty, Precocious: Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.

Research Excerpts

ExcerptRelevanceReference
"We report a long-term follow-up on the use of anastrozole in the treatment of peripheral precocious puberty (PP) in McCune-Albright syndrome (MAS)."7.78Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome. ( Alves, C; Silva, SF, 2012)
"McCune-Albright Syndrome (MAS) is a congenital endocrine disorder due to mosaic tissutal hyper-function."5.38Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome. ( Fiore, L; Lala, R; Matarazzo, P; Mussa, A; Tessaris, D; Tuli, G; Verna, F, 2012)
"No difference in vaginal bleeding (mean number of days per year) was noted."5.35The aromatase inhibitor anastrozole is ineffective in the treatment of precocious puberty in girls with McCune-Albright syndrome. ( Eugster, EA; Lowe, ES; Mieszczak, J; Plourde, P, 2008)
" The potent estrogen suppressive action and simple dosage regimen of anastrozole suggest it may be advantageous compared to other aromatase inhibitors such as testolactone or anti-estrogens."5.31Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. ( Albers, N; Freiberg, C; Roth, C; Zappel, H, 2002)
"We report a long-term follow-up on the use of anastrozole in the treatment of peripheral precocious puberty (PP) in McCune-Albright syndrome (MAS)."3.78Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome. ( Alves, C; Silva, SF, 2012)
"Treatment of testotoxicosis with bicalutamide plus anastrozole resulted in slower growth rate."2.75Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT). ( Amrhein, J; Armstrong, J; De Luca, F; Kulshreshtha, B; Mauras, N; McCormick, K; Melezinkova, H; O'Brien, S; Reiter, EO, 2010)
"A phase II study in testotoxicosis is currently underway,exploring the combination of a highly selective anti-androgen, bicalutamide, and the potent aromatase inhibitor, anastrozole."2.43Testotoxicosis: current viewpoint. ( Norjavaara, E; Reiter, EO, 2005)
"Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males."1.42Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene. ( Büyükünal, C; Ceylaner, S; Ercan, O; Evliyaoğlu, O; Özcabı, B; Özcan, R; Tahmiscioğlu Bucak, F; Tüysüz, B, 2015)
"McCune-Albright Syndrome (MAS) is a congenital endocrine disorder due to mosaic tissutal hyper-function."1.38Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome. ( Fiore, L; Lala, R; Matarazzo, P; Mussa, A; Tessaris, D; Tuli, G; Verna, F, 2012)
"Testotoxicosis is a rare form of precocious puberty caused by a constitutively activating mutation in the luteinizing hormone receptor (LHR) gene."1.35Effectiveness of anastrozole and cyproterone acetate in two brothers with familial male precocious puberty. ( Eyssette-Guerreau, S; Le Merrer, M; Pinto, G; Polak, M; Sultan, A; Sultan, C, 2008)
"Anastrozole is a safe and tolerable drug especially used to suppress estrogen action."1.35Treatment of autonomous ovarian follicular cyst with long-term anastrozole therapy. ( Berberoglu, M; Bilir, P; Engiz, O; Ocal, G; Siklar, Z, 2009)
"No difference in vaginal bleeding (mean number of days per year) was noted."1.35The aromatase inhibitor anastrozole is ineffective in the treatment of precocious puberty in girls with McCune-Albright syndrome. ( Eugster, EA; Lowe, ES; Mieszczak, J; Plourde, P, 2008)
" The potent estrogen suppressive action and simple dosage regimen of anastrozole suggest it may be advantageous compared to other aromatase inhibitors such as testolactone or anti-estrogens."1.31Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. ( Albers, N; Freiberg, C; Roth, C; Zappel, H, 2002)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (47.37)29.6817
2010's10 (52.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Leschek, EW1
Flor, AC1
Bryant, JC1
Jones, JV1
Barnes, KM1
Cutler, GB1
Arya, VB1
Davies, JH1
Senniappan, S1
Wood, D1
Hakeem, V1
Stoneham, S1
Freeman, A1
Dattani, M1
Klein, KO1
Papadimitriou, DT1
Dermitzaki, E1
Papagianni, M1
Papaioannou, G1
Papaevangelou, V1
Papadimitriou, A1
Özcabı, B1
Tahmiscioğlu Bucak, F1
Ceylaner, S1
Özcan, R1
Büyükünal, C1
Ercan, O1
Tüysüz, B1
Evliyaoğlu, O1
Eyssette-Guerreau, S1
Pinto, G1
Sultan, A1
Le Merrer, M1
Sultan, C1
Polak, M1
Engiz, O1
Berberoglu, M1
Siklar, Z1
Bilir, P1
Ocal, G1
Mitre, N1
Lteif, A1
Lenz, AM1
Shulman, D1
Eugster, EA2
Rahhal, S1
Fuqua, JS1
Pescovitz, OH2
Lewis, KA1
Reiter, EO2
Mauras, N1
McCormick, K1
Kulshreshtha, B1
Amrhein, J1
De Luca, F1
O'Brien, S1
Armstrong, J1
Melezinkova, H1
Tessaris, D1
Matarazzo, P1
Mussa, A1
Tuli, G1
Verna, F1
Fiore, L1
Lala, R1
Alves, C1
Silva, SF1
Roth, C1
Freiberg, C1
Zappel, H1
Albers, N1
Norjavaara, E1
Nakagawa, Y1
Ohzeki, T1
Kreher, NC1
Delameter, P1
Tiulpakov, A1
Hochberg, Z1
Mieszczak, J1
Lowe, ES1
Plourde, P1
Faglia, G1
Arosio, M1
Porretti, S1

Reviews

3 reviews available for anastrozole and Puberty, Precocious

ArticleYear
Is there a role for estrogen activity assays? Recombinant cell bioassay for estrogen: Development and applications.
    Steroids, 2015, Volume: 99, Issue:Pt A

    Topics: Anastrozole; Aromatase Inhibitors; Biological Assay; Breast Neoplasms; Child; Estradiol; Female; Hum

2015
Testotoxicosis: current viewpoint.
    Pediatric endocrinology reviews : PER, 2005, Volume: 3, Issue:2

    Topics: Anastrozole; Androgen Antagonists; Anilides; Aromatase Inhibitors; Body Height; Child; Clinical Tria

2005
[Precocious puberty].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 4

    Topics: Anastrozole; Aromatase Inhibitors; Female; Fibrous Dysplasia, Polyostotic; Gonadotropins, Pituitary;

2006

Trials

3 trials available for anastrozole and Puberty, Precocious

ArticleYear
Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty.
    The Journal of pediatrics, 2017, Volume: 190

    Topics: Adult; Anastrozole; Androgen Antagonists; Aromatase Inhibitors; Body Height; Child; Child, Preschool

2017
Anastrozole plus leuprorelin in early maturing girls with compromised growth: the "GAIL" study.
    Journal of endocrinological investigation, 2016, Volume: 39, Issue:4

    Topics: Anastrozole; Aromatase Inhibitors; Body Height; Bone Density; Case-Control Studies; Child; Female; F

2016
Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT).
    Journal of pediatric endocrinology & metabolism : JPEM, 2010, Volume: 23, Issue:10

    Topics: Anastrozole; Anilides; Bone Development; Child; Child, Preschool; Drug Therapy, Combination; Gonadot

2010

Other Studies

13 other studies available for anastrozole and Puberty, Precocious

ArticleYear
Idiopathic gonadotropin-independent precocious puberty - is regular surveillance required?
    Journal of pediatric endocrinology & metabolism : JPEM, 2019, Apr-24, Volume: 32, Issue:4

    Topics: Anastrozole; Anilides; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Chorionic Gonad

2019
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma.
    Hormone research in paediatrics, 2014, Volume: 82, Issue:4

    Topics: Adolescent; Anastrozole; Androgens; Antineoplastic Agents, Hormonal; Carcinoma, Embryonal; Child; Ch

2014
Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene.
    Journal of clinical research in pediatric endocrinology, 2015, Volume: 7, Issue:3

    Topics: Anastrozole; Androgen Antagonists; Anilides; Aromatase Inhibitors; Cytochrome P-450 CYP3A Inhibitors

2015
Effectiveness of anastrozole and cyproterone acetate in two brothers with familial male precocious puberty.
    Journal of pediatric endocrinology & metabolism : JPEM, 2008, Volume: 21, Issue:10

    Topics: Anastrozole; Androgen Antagonists; Aromatase Inhibitors; Body Height; Child, Preschool; Cyproterone

2008
Treatment of autonomous ovarian follicular cyst with long-term anastrozole therapy.
    Indian journal of pediatrics, 2009, Volume: 76, Issue:9

    Topics: Anastrozole; Aromatase Inhibitors; Child; Female; Humans; Nitriles; Ovarian Cysts; Puberty, Precocio

2009
Treatment of familial male-limited precocious puberty (testotoxicosis) with anastrozole and bicalutamide in a boy with a novel mutation in the luteinizing hormone receptor.
    Journal of pediatric endocrinology & metabolism : JPEM, 2009, Volume: 22, Issue:12

    Topics: Anastrozole; Androgen Antagonists; Anilides; Aromatase Inhibitors; Body Height; Body Weight; Child D

2009
Bicalutamide and third-generation aromatase inhibitors in testotoxicosis.
    Pediatrics, 2010, Volume: 126, Issue:3

    Topics: Anastrozole; Androgen Antagonists; Anilides; Aromatase Inhibitors; Child, Preschool; Humans; Letrozo

2010
Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome.
    Endocrine journal, 2012, Volume: 59, Issue:2

    Topics: Anastrozole; Androgen Antagonists; Anilides; Aromatase Inhibitors; Child Development; Child, Prescho

2012
Partial benefit of anastrozole in the long-term treatment of precocious puberty in McCune-Albright syndrome.
    Journal of pediatric endocrinology & metabolism : JPEM, 2012, Volume: 25, Issue:3-4

    Topics: Age Determination by Skeleton; Anastrozole; Aromatase Inhibitors; Cafe-au-Lait Spots; Child, Prescho

2012
Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome.
    Journal of pediatric endocrinology & metabolism : JPEM, 2002, Volume: 15 Suppl 3

    Topics: Anastrozole; Aromatase Inhibitors; Child; Enzyme Inhibitors; Estrogen Antagonists; Female; Fibrous D

2002
Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole.
    The Journal of pediatrics, 2006, Volume: 149, Issue:3

    Topics: Anastrozole; Androgen Antagonists; Anilides; Aromatase Inhibitors; Child; Child, Preschool; Humans;

2006
The aromatase inhibitor anastrozole is ineffective in the treatment of precocious puberty in girls with McCune-Albright syndrome.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:7

    Topics: Anastrozole; Aromatase Inhibitors; Child; Child, Preschool; Female; Fibrous Dysplasia, Polyostotic;

2008
Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole. Would it help short children grow up?
    Journal of endocrinological investigation, 2000, Volume: 23, Issue:11

    Topics: Anastrozole; Aromatase Inhibitors; Body Height; Bone Development; Child, Preschool; Enzyme Inhibitor

2000