Page last updated: 2024-10-22

anastrozole and Hypertension, Pulmonary

anastrozole has been researched along with Hypertension, Pulmonary in 3 studies

Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Research Excerpts

ExcerptRelevanceReference
"The aromatase inhibitor anastrozole blocks the conversion of androgens to estrogen and blunts pulmonary hypertension in animals, but its efficacy in treating patients with pulmonary arterial hypertension (PAH) is unknown."5.24Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial. ( Archer-Chicko, CL; DeMichele, A; Fritz, JS; Kawut, SM; Klinger, JR; Ky, B; Palevsky, HI; Palmisciano, AJ; Patel, M; Pinder, D; Propert, KJ; Smith, KA; Stanczyk, F; Tracy, R; Vaidya, A; Ventetuolo, CE; Whittenhall, ME, 2017)
"Anastrozole treatment reversed the impaired bone morphogenetic protein receptor 2 pathway in females."1.40Sex-dependent influence of endogenous estrogen in pulmonary hypertension. ( Duggan, N; Fullerton, J; Hussey, MJ; Loughlin, L; MacLean, MR; Mair, KM; Nilsen, M; Roberts, S; Rowlands, DJ; Thomas, M; Wright, AF, 2014)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, X1
Austin, ED1
Talati, M1
Fessel, JP1
Farber-Eger, EH1
Brittain, EL1
Hemnes, AR1
Loyd, JE1
West, J1
Mair, KM1
Wright, AF1
Duggan, N1
Rowlands, DJ1
Hussey, MJ1
Roberts, S1
Fullerton, J1
Nilsen, M1
Loughlin, L1
Thomas, M1
MacLean, MR1
Kawut, SM1
Archer-Chicko, CL1
DeMichele, A1
Fritz, JS1
Klinger, JR1
Ky, B1
Palevsky, HI1
Palmisciano, AJ1
Patel, M1
Pinder, D1
Propert, KJ1
Smith, KA1
Stanczyk, F1
Tracy, R1
Vaidya, A1
Whittenhall, ME1
Ventetuolo, CE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-blind, Placebo-controlled Phase II Study of Anastrozole in Patients With Pulmonary Arterial Hypertension[NCT01545336]Phase 218 participants (Actual)Interventional2012-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Plasma Estradiol (E2) Level

(NCT01545336)
Timeframe: Baseline, 3 months

Intervention% change from baseline (Median)
Anastrozole-40
Placebo-4

Six Minute Walk Distance

(NCT01545336)
Timeframe: Baseline, 3 months

Intervention% change from baseline (Median)
Anastrozole8
Placebo-2

Tricuspid Annular Plane Systolic Excursion (TAPSE)

(NCT01545336)
Timeframe: Baseline, 3 months

Intervention% change from baseline (Median)
Anastrozole7
Placebo10

Trials

1 trial available for anastrozole and Hypertension, Pulmonary

ArticleYear
Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial.
    American journal of respiratory and critical care medicine, 2017, 02-01, Volume: 195, Issue:3

    Topics: Anastrozole; Aromatase Inhibitors; Biomarkers; Double-Blind Method; Estradiol; Estrone; Female; Gona

2017

Other Studies

2 other studies available for anastrozole and Hypertension, Pulmonary

ArticleYear
Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.
    The European respiratory journal, 2017, Volume: 50, Issue:2

    Topics: Anastrozole; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Echocar

2017
Sex-dependent influence of endogenous estrogen in pulmonary hypertension.
    American journal of respiratory and critical care medicine, 2014, Aug-15, Volume: 190, Issue:4

    Topics: Anastrozole; Animals; Aromatase Inhibitors; Blotting, Western; Disease Models, Animal; Enzyme-Linked

2014
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