anastrozole and Hypertension, Pulmonary
anastrozole has been researched along with Hypertension, Pulmonary in 3 studies
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"The aromatase inhibitor anastrozole blocks the conversion of androgens to estrogen and blunts pulmonary hypertension in animals, but its efficacy in treating patients with pulmonary arterial hypertension (PAH) is unknown." | 5.24 | Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial. ( Archer-Chicko, CL; DeMichele, A; Fritz, JS; Kawut, SM; Klinger, JR; Ky, B; Palevsky, HI; Palmisciano, AJ; Patel, M; Pinder, D; Propert, KJ; Smith, KA; Stanczyk, F; Tracy, R; Vaidya, A; Ventetuolo, CE; Whittenhall, ME, 2017) |
"Anastrozole treatment reversed the impaired bone morphogenetic protein receptor 2 pathway in females." | 1.40 | Sex-dependent influence of endogenous estrogen in pulmonary hypertension. ( Duggan, N; Fullerton, J; Hussey, MJ; Loughlin, L; MacLean, MR; Mair, KM; Nilsen, M; Roberts, S; Rowlands, DJ; Thomas, M; Wright, AF, 2014) |
Research
Studies (3)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Chen, X | 1 |
Austin, ED | 1 |
Talati, M | 1 |
Fessel, JP | 1 |
Farber-Eger, EH | 1 |
Brittain, EL | 1 |
Hemnes, AR | 1 |
Loyd, JE | 1 |
West, J | 1 |
Mair, KM | 1 |
Wright, AF | 1 |
Duggan, N | 1 |
Rowlands, DJ | 1 |
Hussey, MJ | 1 |
Roberts, S | 1 |
Fullerton, J | 1 |
Nilsen, M | 1 |
Loughlin, L | 1 |
Thomas, M | 1 |
MacLean, MR | 1 |
Kawut, SM | 1 |
Archer-Chicko, CL | 1 |
DeMichele, A | 1 |
Fritz, JS | 1 |
Klinger, JR | 1 |
Ky, B | 1 |
Palevsky, HI | 1 |
Palmisciano, AJ | 1 |
Patel, M | 1 |
Pinder, D | 1 |
Propert, KJ | 1 |
Smith, KA | 1 |
Stanczyk, F | 1 |
Tracy, R | 1 |
Vaidya, A | 1 |
Whittenhall, ME | 1 |
Ventetuolo, CE | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Double-blind, Placebo-controlled Phase II Study of Anastrozole in Patients With Pulmonary Arterial Hypertension[NCT01545336] | Phase 2 | 18 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Plasma Estradiol (E2) Level
(NCT01545336)
Timeframe: Baseline, 3 months
Intervention | % change from baseline (Median) |
---|---|
Anastrozole | -40 |
Placebo | -4 |
Six Minute Walk Distance
(NCT01545336)
Timeframe: Baseline, 3 months
Intervention | % change from baseline (Median) |
---|---|
Anastrozole | 8 |
Placebo | -2 |
Tricuspid Annular Plane Systolic Excursion (TAPSE)
(NCT01545336)
Timeframe: Baseline, 3 months
Intervention | % change from baseline (Median) |
---|---|
Anastrozole | 7 |
Placebo | 10 |
Trials
1 trial available for anastrozole and Hypertension, Pulmonary
Article | Year |
---|---|
Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial.
Topics: Anastrozole; Aromatase Inhibitors; Biomarkers; Double-Blind Method; Estradiol; Estrone; Female; Gona | 2017 |
Other Studies
2 other studies available for anastrozole and Hypertension, Pulmonary
Article | Year |
---|---|
Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.
Topics: Anastrozole; Animals; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Echocar | 2017 |
Sex-dependent influence of endogenous estrogen in pulmonary hypertension.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Blotting, Western; Disease Models, Animal; Enzyme-Linked | 2014 |