Page last updated: 2024-10-22

anastrozole and Cancer of Endometrium

anastrozole has been researched along with Cancer of Endometrium in 28 studies

Research Excerpts

ExcerptRelevanceReference
"To investigate whether there may be a role for aromatase inhibitors (AIs) in the treatment of endometrial hyperplasia (EH) and endometrial adenocarcinoma (EA) in postmenopausal women, a retrospective study on the effect of aromatase inhibitors (anastrozole or letrozole) was conducted for 16 patients who were not amenable to surgical treatment."7.75Sustained effect of the aromatase inhibitors anastrozole and letrozole on endometrial thickness in patients with endometrial hyperplasia and endometrial carcinoma. ( Barker, LC; Brand, IR; Crawford, SM, 2009)
"Tamoxifen treatment results in a doubling of the risk of endometrial cancer after 1-2 years of treatment and a quadrupling after 5 years."6.72The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: first results of the endometrial sub-protocol following 2 years of treatment. ( Bianco, AR; Clack, G; Coibion, M; Duffy, S; Jackson, TL; Lansdown, M; Philips, K; Pollard, S; Wells, M, 2006)
"Anastrozole (Arimidex) is an oral nonsteroidal aromatase inhibitor which is active in recurrent breast cancer."6.69A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study. ( Bell, J; Brunetto, VL; Lee, RB; Rose, PG; VanLe, L; Walker, JL, 2000)
"Fulvestrant is a new type of oestrogen receptor antagonist with no agonist effects."6.43Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents. ( Abram, P; Vergote, I, 2006)
"To investigate whether there may be a role for aromatase inhibitors (AIs) in the treatment of endometrial hyperplasia (EH) and endometrial adenocarcinoma (EA) in postmenopausal women, a retrospective study on the effect of aromatase inhibitors (anastrozole or letrozole) was conducted for 16 patients who were not amenable to surgical treatment."3.75Sustained effect of the aromatase inhibitors anastrozole and letrozole on endometrial thickness in patients with endometrial hyperplasia and endometrial carcinoma. ( Barker, LC; Brand, IR; Crawford, SM, 2009)
"This multicenter, open-label, phase 1/2 randomized clinical trial demonstrated that adding vistusertib to anastrozole improved 8wk-PFR, overall response rate, and PFS for patients with endometrial cancer and had manageable adverse events."3.11Safety and Efficacy of the mTOR Inhibitor, Vistusertib, Combined With Anastrozole in Patients With Hormone Receptor-Positive Recurrent or Metastatic Endometrial Cancer: The VICTORIA Multicenter, Open-label, Phase 1/2 Randomized Clinical Trial. ( Abdeddaim, C; Arnaud, A; Augereau, P; Bazan, F; Chakiba, C; Chevalier-Place, A; Dalban, C; Diaz, JJ; Fabbro, M; Frenel, JS; Garin, G; Heudel, P; Joly, F; Lancry-Lecomte, L; Marcel, V; Pautier, P; Pérol, D; Ray-Coquard, I; Treilleux, I; You, B, 2022)
"Patients with endometrial cancer who consented to participate in the study were randomised to receive anastrozole or placebo for a minimum of 14 days prior to definitive surgery."2.78Neoadjuvant treatment of endometrial cancer using anastrozole: a randomised pilot study. ( Duffy, SR; Hewitt, MJ; Quinton, ND; Thangavelu, A, 2013)
"Tamoxifen treatment results in a doubling of the risk of endometrial cancer after 1-2 years of treatment and a quadrupling after 5 years."2.72The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: first results of the endometrial sub-protocol following 2 years of treatment. ( Bianco, AR; Clack, G; Coibion, M; Duffy, S; Jackson, TL; Lansdown, M; Philips, K; Pollard, S; Wells, M, 2006)
"Anastrozole (Arimidex) is an oral nonsteroidal aromatase inhibitor which is active in recurrent breast cancer."2.69A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study. ( Bell, J; Brunetto, VL; Lee, RB; Rose, PG; VanLe, L; Walker, JL, 2000)
"Type I endometrial cancer is a common tumor of the female genital tract."2.53Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma. ( Babilonti, L; Bogliolo, S; Cassani, C; De Silvestri, A; Dominoni, M; Gaggero, CR; Gardella, B; Musacchi, V; Spinillo, A; Zanellini, F, 2016)
"The only alternative to breast cancer screening available in France is surgical prevention by prophylactic mastectomy."2.53[Hormonotherapy for breast cancer prevention: What about women with genetic predisposition to breast cancer?]. ( Callet, N; Fourme, E; Noguès, C; Reyal, F; Sénéchal, C; Stoppa-Lyonnet, D; This, P, 2016)
"Fulvestrant is a new type of oestrogen receptor antagonist with no agonist effects."2.43Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents. ( Abram, P; Vergote, I, 2006)
" This study provides RiBi-based markers relevant for a better selection of patients with advanced endometrial carcinoma by predicting the response of endocrine therapy combined with mTOR inhibitor."1.91Ribosome biogenesis-based predictive biomarkers in endocrine therapy (Anastrozole) combined with mTOR inhibitor (Vistusertib) in endometrial cancer: translational study from the VICTORIA trial in collaboration with the GINECO group. ( Abadie-Lacourtoisie, S; Bazan, F; Chabaud, S; Colombe-Vermorel, A; Coquan, E; Dalban, C; Diaz, JJ; Fabbro, M; Frenel, JS; Garin, G; Heudel, PE; Marcel, V; Martinez, S; Mourksi, NE; Odeyer, L; Pérol, D; Ray-Coquard, I; Simioni, V; Tabone-Eglinger, S; Treilleux, I, 2023)
"Anastrozole was administered 1 mg daily orally after performing an accurate clinical and radiological staging."1.62Palliative treatment of endometrial cancer: what is the role of anastrozole in elderly women? ( Bogliolo, S; Carletti, GV; Cassani, C; De Silvestri, A; Dominoni, M; Gardella, B; Spinillo, A, 2021)
"Low-grade endometrial stromal sarcoma is very rare and difficult to diagnose in the early stage."1.42Long-term survival in low-grade endometrial stromal sarcoma with childbirth and multidisciplinary treatment: a case report. ( Horio, M; Ichihara, S; Inoue, T; Ishihara, Y; Ito, M; Kondo, I; Maeda, O; Matsumura, Y; Moritani, S; Sugiyama, K; Yamamoto, S, 2015)
"Anastrozole was effective to recurrent low-grade ESS even after being refractory to progestin therapy."1.37Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report. ( Ikeda, Y; Kawana, K; Kozuma, S; Nakagawa, S; Oda, K; Shoji, K; Takazawa, Y; Taketani, Y; Yasugi, T, 2011)
"We compared the efficacy of endometrial cancer neoadjuvant treatment in 38 patients receiving nonsteroid (letrozol, anastrozol) or steroid (ekzemestan) aromatase inhibitors and 12 patients receiving metformin."1.37[Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer]. ( Bershteĭn, LM; Boiarkina, MP; Danilova, MA; Gershfel'd, ÉD; Khadzhimba, AS; Kovalevskiĭ, AIu; Maksimov, SIa; Meshkova, IE; Turkevich, EA, 2011)
"Patients with metastatic endometrial carcinoma may respond to hormonal therapy with progestins."1.33Durable response of metastatic endometrial carcinoma to treatment with fulvestrant (Faslodex) after prior progestin and anastrozole therapy. ( Hoffman, MA; Khan, A, 2006)
"This is the first report of breast carcinoma metastatic to the endometrium in a patient on adjuvant anastrozole therapy."1.33Lobular carcinoma of the breast metastatic to the uterus in a patient under adjuvant anastrozole therapy. ( Bolat, F; Erkanli, S; Haberal, A; Kayaselcuk, F; Kuscu, E; Sakalli, H, 2006)
"Hormonal therapy for endometrial cancer is occasionally warranted in the premenopausal woman who is interested in maintaining fertility."1.32Anastrozole, an aromatase inhibitor, and medroxyprogesterone acetate therapy in premenopausal obese women with endometrial cancer: a report of two cases successfully treated without hysterectomy. ( Amezcua, C; Bahador, A; Burnett, AF, 2004)
"Letrozole was found to be a highly potent inhibitor of tumor proliferation and more effective than tamoxifen."1.30Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer. ( Brodie, A; Liu, Y; Long, B; Lu, Q; Wang, JP; Yue, W, 1998)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.57)18.2507
2000's12 (42.86)29.6817
2010's10 (35.71)24.3611
2020's5 (17.86)2.80

Authors

AuthorsStudies
Heudel, P1
Frenel, JS2
Dalban, C2
Bazan, F2
Joly, F1
Arnaud, A1
Abdeddaim, C1
Chevalier-Place, A1
Augereau, P1
Pautier, P1
Chakiba, C1
You, B1
Lancry-Lecomte, L1
Garin, G2
Marcel, V2
Diaz, JJ2
Treilleux, I2
Pérol, D2
Fabbro, M2
Ray-Coquard, I2
Mourksi, NE1
Colombe-Vermorel, A1
Odeyer, L1
Simioni, V1
Abadie-Lacourtoisie, S1
Coquan, E1
Martinez, S1
Tabone-Eglinger, S1
Chabaud, S1
Heudel, PE1
Gardella, B2
Dominoni, M2
Bogliolo, S2
Cassani, C2
Carletti, GV1
De Silvestri, A2
Spinillo, A2
Friedlander, M2
Benson, C1
O'Connell, RL2
Reed, N1
Clamp, A2
Lord, R2
Millan, D2
Nottley, S2
Amant, F2
Steer, C1
Anand, A1
Mileshkin, L2
Beale, P2
Banerjee, S1
Bradshaw, N1
Kelly, C1
Carty, K2
Divers, L1
Alexander, L2
Edmondson, R2
Yanase, T1
Kikuchi, A1
Sasagawa, M1
Honma, S1
Sjoquist, KM1
Andrews, J1
Jyothirmayi, R1
Bonaventura, T1
Goh, J1
Hall, M1
Green, J1
Paul, J1
Scurry, J1
Boccardo, F1
Guglielmini, P1
Bordonaro, R1
Fini, A1
Massidda, B1
Porpiglia, M1
Roagna, R1
Serra, P1
Orzalesi, L1
Ucci, G1
Rubagotti, A1
Thangavelu, A1
Hewitt, MJ1
Quinton, ND1
Duffy, SR1
Maeda, O1
Moritani, S1
Ichihara, S1
Inoue, T1
Ishihara, Y1
Yamamoto, S1
Ito, M1
Matsumura, Y1
Sugiyama, K1
Horio, M1
Kondo, I1
Musacchi, V1
Zanellini, F1
Gaggero, CR1
Babilonti, L1
Sénéchal, C1
Reyal, F1
Callet, N1
This, P1
Noguès, C1
Stoppa-Lyonnet, D1
Fourme, E1
Bellone, S1
Shah, HR1
McKenney, JK1
Stone, PJ1
Santin, AD1
Barker, LC1
Brand, IR1
Crawford, SM1
Bershteĭn, LM2
Danilova, MA2
Kovalevskiĭ, AIu2
Gershfel'd, ED2
Poroshina, TE1
Tsyrlina, TE1
Meshkova, IE2
Turkevich, EA2
Maksimov, SIa2
Shoji, K1
Oda, K1
Nakagawa, S1
Kawana, K1
Yasugi, T1
Ikeda, Y1
Takazawa, Y1
Kozuma, S1
Taketani, Y1
Lisianskaia, AS1
Manikhas, GM1
Fadeeva, EP1
Fedosenko, KV1
Tapil'skaia, NI1
Boiarkina, MP1
Khadzhimba, AS1
Leiser, AL1
Hamid, AM1
Blanchard, R1
Burnett, AF1
Bahador, A1
Amezcua, C1
Hiura, M1
Oshita, T1
Nogawa, T1
Yokoyama, T1
Duffy, S1
Jackson, TL1
Lansdown, M1
Philips, K1
Wells, M1
Pollard, S1
Clack, G1
Coibion, M1
Bianco, AR1
Vergote, I1
Abram, P1
Hoffman, MA1
Khan, A1
Erkanli, S1
Kayaselcuk, F1
Kuscu, E1
Bolat, F1
Sakalli, H1
Haberal, A1
Alkasi, O1
Meinhold-Heerlein, I1
Zaki, R1
Fasching, P1
Maass, N1
Jonat, W1
Beckmann, MW1
Brodie, A1
Lu, Q1
Liu, Y1
Long, B1
Wang, JP1
Yue, W1
Rose, PG1
Brunetto, VL1
VanLe, L1
Bell, J1
Walker, JL1
Lee, RB1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicentric, Randomized, Non Comparative, Open-label Phase I/II Evaluating AZD2014 (Dual Mammalian Target of Rapamycin Complex 1/2 (mTORC1/mTORC2) Inhibitor) in Combination With Anastrozole Versus Anastrozole Alone in the Treatment of Metastatic Hormon[NCT02730923]Phase 1/Phase 272 participants (Anticipated)Interventional2016-04-30Active, not recruiting
Gonadotropin-releasing Hormone Agonist Combined With Letrozole Compared With Megestrol Acetate or Medroxyprogesterone Acetate Alone as Fertility-sparing Treatment in Early Endometrial Cancer[NCT05247268]Phase 2104 participants (Anticipated)Interventional2022-03-11Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for anastrozole and Cancer of Endometrium

ArticleYear
Effectiveness of aromatase inhibitors in the treatment of advanced endometrial adenocarcinoma.
    Archives of gynecology and obstetrics, 2016, Volume: 293, Issue:4

    Topics: Adenocarcinoma; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Endometria

2016
[Hormonotherapy for breast cancer prevention: What about women with genetic predisposition to breast cancer?].
    Bulletin du cancer, 2016, Volume: 103, Issue:3

    Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Endometrial Neoplasms; Female;

2016
[Postoperative hormone (endocrine) therapy in endometrial carcinoma].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 10

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Chemotherapy, Adjuvant; Drug The

2004
Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:2

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms

2006

Trials

7 trials available for anastrozole and Cancer of Endometrium

ArticleYear
Safety and Efficacy of the mTOR Inhibitor, Vistusertib, Combined With Anastrozole in Patients With Hormone Receptor-Positive Recurrent or Metastatic Endometrial Cancer: The VICTORIA Multicenter, Open-label, Phase 1/2 Randomized Clinical Trial.
    JAMA oncology, 2022, 07-01, Volume: 8, Issue:7

    Topics: Aged; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Breast Neoplasms; End

2022
Phase 2 study of anastrozole in patients with estrogen receptor/progesterone receptor positive recurrent low-grade endometrial stromal sarcomas: The PARAGON trial (ANZGOG 0903).
    Gynecologic oncology, 2021, Volume: 161, Issue:1

    Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Endometrial Neoplasms; End

2021
Phase 2 study of anastrozole in recurrent estrogen (ER)/progesterone (PR) positive endometrial cancer: The PARAGON trial - ANZGOG 0903.
    Gynecologic oncology, 2019, Volume: 154, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Endometrial Neoplasms; Female; Humans; Immunohistochemi

2019
Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: long term results of the Italian Tamoxifen Anastrozole trial.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:7

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival;

2013
Neoadjuvant treatment of endometrial cancer using anastrozole: a randomised pilot study.
    Gynecologic oncology, 2013, Volume: 131, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors;

2013
The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: first results of the endometrial sub-protocol following 2 years of treatment.
    Human reproduction (Oxford, England), 2006, Volume: 21, Issue:2

    Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan

2006
A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study.
    Gynecologic oncology, 2000, Volume: 78, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Carcino

2000

Other Studies

17 other studies available for anastrozole and Cancer of Endometrium

ArticleYear
Combination Vistusertib and Anastrozole Shows Benefit in Endometrial Cancer.
    Cancer discovery, 2022, 07-06, Volume: 12, Issue:7

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Benzamides; Breast Neoplasms; Endometrial Neoplasms; F

2022
Ribosome biogenesis-based predictive biomarkers in endocrine therapy (Anastrozole) combined with mTOR inhibitor (Vistusertib) in endometrial cancer: translational study from the VICTORIA trial in collaboration with the GINECO group.
    Molecular oncology, 2023, Volume: 17, Issue:1

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Breast Neoplasms; En

2023
Palliative treatment of endometrial cancer: what is the role of anastrozole in elderly women?
    BMC palliative care, 2021, Feb-05, Volume: 20, Issue:1

    Topics: Aged; Aged, 80 and over; Anastrozole; Endometrial Neoplasms; Female; Humans; Nitriles; Palliative Ca

2021
Two cases of endometrial cancer arising from adenomyosis during aromatase inhibitors therapy after mastectomy.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2017, Volume: 37, Issue:7

    Topics: Adenocarcinoma; Adenomyosis; Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Endometrial Neopla

2017
Long-term survival in low-grade endometrial stromal sarcoma with childbirth and multidisciplinary treatment: a case report.
    Journal of medical case reports, 2015, Oct-20, Volume: 9

    Topics: Adult; Anastrozole; Antineoplastic Agents, Hormonal; Biopsy; Endometrial Neoplasms; Female; Humans;

2015
Recurrent endometrial carcinoma regression with the use of the aromatase inhibitor anastrozole.
    American journal of obstetrics and gynecology, 2008, Volume: 199, Issue:3

    Topics: Adenocarcinoma; Anastrozole; Aromatase Inhibitors; Endometrial Neoplasms; Female; Humans; Immunohist

2008
Sustained effect of the aromatase inhibitors anastrozole and letrozole on endometrial thickness in patients with endometrial hyperplasia and endometrial carcinoma.
    Current medical research and opinion, 2009, Volume: 25, Issue:5

    Topics: Aged; Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Carcinoma; Disease Progression; Endo

2009
[Criteria for evaluating the effectiveness of aromatase inhibitors in the neoadjuvant treatment of patients with endometrial carcinoma].
    Voprosy onkologii, 2009, Volume: 55, Issue:3

    Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Bi

2009
Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report.
    Medical oncology (Northwood, London, England), 2011, Volume: 28, Issue:3

    Topics: Adult; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; En

2011
[Endometrial stromal sarcoma: complete response to therapy with aromatase-inhibitor, anastrozole].
    Voprosy onkologii, 2010, Volume: 56, Issue:1

    Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Endometrial Neoplasms; Fem

2010
[Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer].
    Voprosy onkologii, 2011, Volume: 57, Issue:6

    Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Ar

2011
Recurrence of prolactin-producing endometrial stromal sarcoma with sex-cord stromal component treated with progestin and aromatase inhibitor.
    Gynecologic oncology, 2004, Volume: 94, Issue:2

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromat

2004
Anastrozole, an aromatase inhibitor, and medroxyprogesterone acetate therapy in premenopausal obese women with endometrial cancer: a report of two cases successfully treated without hysterectomy.
    Gynecologic oncology, 2004, Volume: 94, Issue:3

    Topics: Adult; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Endometria

2004
Durable response of metastatic endometrial carcinoma to treatment with fulvestrant (Faslodex) after prior progestin and anastrozole therapy.
    Gynecologic oncology, 2006, Volume: 100, Issue:2

    Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Endometrial Neoplasms; Estradiol; Female; Fulves

2006
Lobular carcinoma of the breast metastatic to the uterus in a patient under adjuvant anastrozole therapy.
    Breast (Edinburgh, Scotland), 2006, Volume: 15, Issue:4

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Duc

2006
Long-term disease-free survival after hormonal therapy of a patient with recurrent low grade endometrial stromal sarcoma: a case report.
    Archives of gynecology and obstetrics, 2009, Volume: 279, Issue:1

    Topics: Adult; Anastrozole; Antineoplastic Agents, Hormonal; Combined Modality Therapy; Disease-Free Surviva

2009
Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:3 Suppl 5

    Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocol

1998