Page last updated: 2024-10-22

anastrozole and Aging

anastrozole has been researched along with Aging in 6 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Roelfsema, F1
Yang, RJ1
Takahashi, PY1
Erickson, D1
Bowers, CY1
Veldhuis, JD1
Dias, JP1
Melvin, D1
Simonsick, EM1
Carlson, O1
Shardell, MD1
Ferrucci, L1
Chia, CW1
Basaria, S1
Egan, JM1
Burnett-Bowie, SA1
McKay, EA1
Lee, H1
Leder, BZ2
Rohrer, JL1
Rubin, SD1
Gallo, J1
Longcope, C1
Cherrier, MM1
Matsumoto, AM1
Amory, JK1
Ahmed, S1
Bremner, W1
Peskind, ER1
Raskind, MA1
Johnson, M1
Craft, S1
Lea, CK1
Flanagan, AM1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Anastrozole Administration in Elderly Hypogonadal Men[NCT00136695]Phase 288 participants (Actual)Interventional2004-10-31Completed
Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals)[NCT00146146]Phase 315 participants (Actual)Interventional2005-05-31Completed
Testosterone Supplementation in Men With MCI[NCT00539305]Phase 322 participants (Actual)Interventional2009-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Lean Body Mass

(NCT00136695)
Timeframe: Baseline and 1 year

Interventiongrams (Mean)
Anastrozole-2000
Placebo-1500

Behavioral & Mood Measure: Profile of Mood States (POMS)

Values represent self evaluation of vigor-activity. The scale compares t-scores of participants to published norms (range 0-100), and higher scores indicate elevated emotion in subscale. Higher t-scores in vigor-activity subscale are considered favorable. Month 3 and Month 6 values display change from baseline. (NCT00539305)
Timeframe: Baseline, 3 and 6 months

,
Interventionunits on a scale (Mean)
BaselineMonth 3 (Change from Baseline)Month 6 (Change from Baseline)
Placebo Group55.5-0.1-0.5
Treatment Group57.7-4.51.9

Cognitive Changes Measured by Neuropsychological Tests: Rey Auditory Verbal Learning Test

Values represent total score in Long Delay Word List Recall. Higher score indicates higher level of functioning (range 0-15). Month 3 and Month 6 indicate change from baseline. (NCT00539305)
Timeframe: Baseline, 3 and 6 months

,
Interventionunits on a scale (Mean)
BaselineMonth 3 (Change from Baseline)Month 6 (Change from Baseline)
Placebo Group4.90.01.5
Treatment Group6.22.30.9

Geriatric Depression Scale (GDS)

Values represent self evaluation of depression (range 0-30). Higher scores indicate a more depressed mood. Month 3 and Month 6 indicate change from baseline. (NCT00539305)
Timeframe: Baseline, Month 3, Month 6

,
Interventionunits on a scale (Mean)
BaselineMonth 3 (Change from Baseline)Month 6 (Change from Baseline)
Placebo Group4.12.32.7
Treatment Group7.20.7-2.8

Short-Form Health Survey (SF-36)

Self assessment of Physical Functioning in Health Survey. Higher scores indicate a higher level of functioning (range 0-100). Month 3 and 6 values represent change from baseline in subscale. (NCT00539305)
Timeframe: Baseline, Month 3, Month 6

,
Interventionunits on a scale (Mean)
BaselineMonth 3 (Change from Baseline)Month 6 (Change from Baseline)
Placebo Group85.6-3.8-5.4
Treatment Group70.715.06.4

Trials

5 trials available for anastrozole and Aging

ArticleYear
Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in Testosterone-Replaced Older Hypogonadal Men.
    The Journal of clinical endocrinology and metabolism, 2018, 12-01, Volume: 103, Issue:12

    Topics: Administration, Cutaneous; Adult; Aged; Aging; Anastrozole; Aromatase; Aromatase Inhibitors; Circadi

2018
Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial.
    Andrology, 2016, Volume: 4, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Anastrozole; Aromatase; Aromatase Inhibitors; Body Composition; Bone

2016
Effects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levels.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:12

    Topics: Aged; Aging; Anastrozole; Aromatase Inhibitors; Biomarkers; Bone and Bones; Bone Density; Double-Bli

2009
Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:3

    Topics: Aged; Aging; Anastrozole; Aromatase Inhibitors; Enzyme Inhibitors; Estrogens; Humans; Hypogonadism;

2004
The role of aromatization in testosterone supplementation: effects on cognition in older men.
    Neurology, 2005, Jan-25, Volume: 64, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Anastrozole; Aromatase; Aromatase Inhibitors; Double-Blind Method; E

2005
The role of aromatization in testosterone supplementation: effects on cognition in older men.
    Neurology, 2005, Jan-25, Volume: 64, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Anastrozole; Aromatase; Aromatase Inhibitors; Double-Blind Method; E

2005
The role of aromatization in testosterone supplementation: effects on cognition in older men.
    Neurology, 2005, Jan-25, Volume: 64, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Anastrozole; Aromatase; Aromatase Inhibitors; Double-Blind Method; E

2005
The role of aromatization in testosterone supplementation: effects on cognition in older men.
    Neurology, 2005, Jan-25, Volume: 64, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Anastrozole; Aromatase; Aromatase Inhibitors; Double-Blind Method; E

2005

Other Studies

1 other study available for anastrozole and Aging

ArticleYear
Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat.
    The American journal of physiology, 1998, Volume: 274, Issue:2

    Topics: Aging; Anastrozole; Androgen Antagonists; Androstenedione; Anilides; Animals; Body Weight; Bone Reso

1998