anandamide and Nociceptive-Pain

anandamide has been researched along with Nociceptive-Pain* in 2 studies

Other Studies

2 other study(ies) available for anandamide and Nociceptive-Pain

Article	Year
Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons. The Journal of comparative neurology, 2017, Jun-01, Volume: 525, Issue:8 Elevation of intracellular Ca Topics: Animals; Arachidonic Acids; Axotomy; Blotting, Western; Disease Models, Animal; Endocannabinoids; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Hybridization, Fluorescence; Inflammation; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nociception; Nociceptive Pain; Phospholipase D; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Signal Transduction; Spinal Nerves	2017
Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy. Neuropharmacology, 2016, Volume: 107 The involvement of transient receptor vanilloid type-1 (TRPV1) channels in pain modulation by the brain remains understudied. The rostroventromedial medulla (RVM) plays a key role in conveying to the spinal cord pain modulatory influences triggered in higher brain centres, with co-existence of inhibitory (antinociceptive) and facilitatory (pronociceptive) effects. In spite of some reports of TRPV1 expression in the RVM, it remains unknown if endovanilloid signalling plays a direct role in local pain modulation. Here we used a model of diabetic neuropathy, the streptozotocin (STZ)-diabetic rat, to study the role of endovanilloid signalling in RVM-mediated pain modulation during chronic pain. Four weeks after diabetes induction, the levels of TRPV1 mRNA and fatty acid amide hydrolase (FAAH), a crucial enzyme for endovanilloid catabolism, in the RVM of STZ-diabetic rats were higher than control. The RVM of STZ-diabetic rats presented decreased levels of several TRPV1 endogenous ligands, namely anandamide (AEA), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Administration of capsaicin (a TRPV1 agonist) into the RVM decreased nociceptive behavioural responses in the inflammatory phase of the formalin test (phase 2). These findings suggest that diabetic neuropathy induces plastic changes of RVM endovanilloid signalling, indicating that TRPV1 may be a putative target for pain modulation in this chronic pain condition. Topics: Amides; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Capsaicin; Chronic Pain; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endocannabinoids; Ethanolamines; Formaldehyde; Male; Medulla Oblongata; Nociceptive Pain; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; RNA, Messenger; TRPV Cation Channels	2016

Article

Year

Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons.

The Journal of comparative neurology, 2017, Jun-01, Volume: 525, Issue:8

Elevation of intracellular Ca

Topics: Animals; Arachidonic Acids; Axotomy; Blotting, Western; Disease Models, Animal; Endocannabinoids; Image Processing, Computer-Assisted; Immunohistochemistry; In Situ Hybridization, Fluorescence; Inflammation; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nociception; Nociceptive Pain; Phospholipase D; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Signal Transduction; Spinal Nerves

2017

Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy.

Neuropharmacology, 2016, Volume: 107

The involvement of transient receptor vanilloid type-1 (TRPV1) channels in pain modulation by the brain remains understudied. The rostroventromedial medulla (RVM) plays a key role in conveying to the spinal cord pain modulatory influences triggered in higher brain centres, with co-existence of inhibitory (antinociceptive) and facilitatory (pronociceptive) effects. In spite of some reports of TRPV1 expression in the RVM, it remains unknown if endovanilloid signalling plays a direct role in local pain modulation. Here we used a model of diabetic neuropathy, the streptozotocin (STZ)-diabetic rat, to study the role of endovanilloid signalling in RVM-mediated pain modulation during chronic pain. Four weeks after diabetes induction, the levels of TRPV1 mRNA and fatty acid amide hydrolase (FAAH), a crucial enzyme for endovanilloid catabolism, in the RVM of STZ-diabetic rats were higher than control. The RVM of STZ-diabetic rats presented decreased levels of several TRPV1 endogenous ligands, namely anandamide (AEA), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Administration of capsaicin (a TRPV1 agonist) into the RVM decreased nociceptive behavioural responses in the inflammatory phase of the formalin test (phase 2). These findings suggest that diabetic neuropathy induces plastic changes of RVM endovanilloid signalling, indicating that TRPV1 may be a putative target for pain modulation in this chronic pain condition.

Topics: Amides; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Capsaicin; Chronic Pain; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endocannabinoids; Ethanolamines; Formaldehyde; Male; Medulla Oblongata; Nociceptive Pain; Oleic Acids; Palmitic Acids; Polyunsaturated Alkamides; Rats, Wistar; RNA, Messenger; TRPV Cation Channels

2016