anandamide has been researched along with Mastocytosis* in 1 studies
1 other study(ies) available for anandamide and Mastocytosis
| Article | Year |
|---|---|
Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and
Mastocytosis is a condition characterized by the expansion and accumulation of mast cells (MCs) in various organs. The symptoms are related to the increased release of MC-derived mediators that exert local and distant effects. MCs are a source and target of phospholipase enzymes (PLs), which catalyze the cleavage of membrane phospholipids releasing lipid mediators (e.g., diacylglycerols (DAGs) and the endocannabinoid (EC) 2-arachidonoylglycerol (2-AG)). To date, there are no data on the role of these lipid mediators in mastocytosis. Here, we analyzed plasma levels of PLA. In 23 patients with mastocytosis and 23 healthy individuals, we measured plasma PLA. Plasma PLA. PLs and some lipid mediators are altered in patients with mastocytosis. Our results may pave the way for investigating the functions of these mediators in the pathophysiology of mastocytosis and provide new potential biomarkers and therapeutic targets. Topics: Adult; Aged; Arachidonic Acids; Biomarkers; Diglycerides; Endocannabinoids; Ethanolamines; Female; Humans; Male; Mastocytosis; Middle Aged; Phospholipases A2; Polyunsaturated Alkamides; Tryptases; Type C Phospholipases | 2019 |