anandamide has been researched along with AIDS-Dementia-Complex* in 2 studies
1 review(s) available for anandamide and AIDS-Dementia-Complex
| Article | Year |
|---|---|
Druggable targets of the endocannabinoid system: Implications for the treatment of HIV-associated neurocognitive disorder.
HIV-associated neurocognitive disorder (HAND) affects nearly half of all HIV-infected individuals. Synaptodendritic damage correlates with neurocognitive decline in HAND, and many studies have demonstrated that HIV-induced neuronal injury results from excitotoxic and inflammatory mechanisms. The endocannabinoid (eCB) system provides on-demand protection against excitotoxicity and neuroinflammation. Here, we discuss evidence of the neuroprotective and anti-inflammatory properties of the eCB system from in vitro and in vivo studies. We examine the pharmacology of the eCB system and evaluate the therapeutic potential of drugs that modulate eCB signaling to treat HAND. Finally, we provide perspective on the need for additional studies to clarify the role of the eCB system in HIV neurotoxicity and speculate that strategies that enhance eCB signaling might slow cognitive decline in HAND. Topics: AIDS Dementia Complex; Amidohydrolases; Animals; Arachidonic Acids; Endocannabinoids; Glycerides; HIV Infections; HIV-1; Humans; Monoacylglycerol Lipases; Neurocognitive Disorders; Neurons; Polyunsaturated Alkamides; Receptors, Cannabinoid; Signal Transduction | 2019 |
1 other study(ies) available for anandamide and AIDS-Dementia-Complex
| Article | Year |
|---|---|
Do endogenous cannabinoids contribute to HIV-mediated immune failure?
The failure of the immune system to mount a successful attack on the human immunodeficiency virus (HIV) is an old enigma for AIDS research. The high mutational capacity of HIV, which unremittingly confuses the immune system, is a major factor in immune failure. But this alone cannot fully explain the certain and inescapable failure of the immune system, leading to full-blown AIDS. Here, we propose the hypothesis that endogenous cannabinoids, derived mostly from macrophages, might participate in the general failure of the immune system in HIV-infected individuals. Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Animals; Arachidonic Acids; Cannabinoids; Endocannabinoids; Glycerides; HIV Envelope Protein gp120; HIV Envelope Protein gp160; HIV Infections; Humans; Immune Tolerance; Macrophages; Marijuana Smoking; Mice; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction | 1998 |