amylopectin and Stomach-Ulcer

Topics: Amylopectin; Carbenoxolone; Cholestyramine Resin; Cimetidine; Gastrointestinal Agents; Gefarnate; Humans; Parasympatholytics; Stomach Ulcer; Trimipramine

Topics: Amylopectin; Antacids; Bismuth; Carbenoxolone; Cholestyramine Resin; Duodenal Ulcer; Estrogens; Fatty Acids, Unsaturated; Glycyrrhiza; Histamine H2 Antagonists; Humans; Imidazoles; Metoclopramide; Parasympatholytics; Plants, Medicinal; Prostaglandins, Synthetic; Recurrence; Stomach Ulcer; Zinc

Topics: Aluminum Hydroxide; Amylopectin; Animals; Anti-Ulcer Agents; Atropine; Chlorpromazine; Hexamethonium Compounds; Indomethacin; Magnesium Oxide; Male; Phentolamine; Propranolol; Rats; Reserpine; Stomach Ulcer; Vagotomy

Water-immersion stress for 7, 14, or 20 hr consistently induced linear or punctate stress ulcers (mucosal erosions) in the corpus of the stomach in intact rats. When the pylorus of the stomach had been ligated prior to stressing, the stress ulcers changed their morphological feature (mainly punctate and in one place elongated) and location (both in corpus and antrum). Histologically, the stress ulcer developed in the proximal antrum of pylorus ligated rats and penetrated into the muscularis mucosa. Sodium bicarbonate, chlorpromazine, hexamethonium, atropine, metiamide, and bilateral vagotomy markedly inhibited the stress ulcers which developed in the pylorus-ligated rats. Phentolamine and propranolol hardly affected the development of stress ulcers. Amylopectine evoked a new type of stress ulcer in the corpus when it was given to the pylorus-ligated rats.

Topics: Amylopectin; Animals; Atropine; Bicarbonates; Chlorpromazine; Disease Models, Animal; Gastric Mucosa; Hexamethonium Compounds; Immersion; Ligation; Male; Metiamide; Phentolamine; Propranolol; Pylorus; Rats; Stomach Ulcer; Stress, Physiological; Time Factors

Topics: Amylopectin; Animals; Gastric Mucosa; Immersion; Male; Pylorus; Rats; Stomach Ulcer; Stress, Physiological

Topics: Amylopectin; Animals; Aspirin; Atropine; Bicarbonates; Drug Interactions; Gastric Mucosa; Glutamine; Ligation; Male; Pyloric Antrum; Pylorus; Rats; Stomach Ulcer; Time Factors

Topics: Amylopectin; Animals; Caseins; Chymotrypsin; Cold Temperature; Electrophoresis; Gastric Juice; Hemoglobins; Ligation; Male; Pepsin A; Pylorus; Rats; Stomach Ulcer; Stress, Physiological; Trypsin Inhibitors

Topics: Amylopectin; Bentonite; Duodenal Ulcer; Gastric Juice; Glycopeptides; Humans; Hydrogen-Ion Concentration; Pepsin A; Stomach Ulcer

Topics: Acrylates; Acrylic Resins; Amylopectin; Animals; Blood Coagulation; Gastric Juice; Gastric Mucosa; Male; Pepsin A; Polymers; Rats; Reserpine; Stomach; Stomach Ulcer; Stress, Physiological

After the application in vitro of (14)C amylopectin sulphate solution to frozen sections of human ulcer-bearing stomach, autoradiography demonstrates localization of amylopectin sulphate to the gastric surface. The affinity of amylopectin sulphate macromolecule for the gastric luminal surface would provide a substrate-bound pepsin inhibitor with a molecular sieve-like action to exclude proteolytic enzymes from the mucosal surface. This protective coating action may mimic the hypothetical role of endogenous gastric mucous substances and account for the action of amylopectin sulphate in human peptic ulcer.

Topics: Amylopectin; Autoradiography; Carbon Radioisotopes; Gastric Mucosa; Humans; Pepsin A; Stomach Ulcer; Sulfates

Topics: Amylopectin; Animals; Bile; Dogs; Gastric Mucosa; Membrane Potentials; Sodium; Stomach Ulcer