amylopectin and Colonic-Neoplasms

amylopectin has been researched along with Colonic-Neoplasms* in 3 studies

Reviews

1 review(s) available for amylopectin and Colonic-Neoplasms

ArticleYear
Induction of colorectal tumors in rats by sulfated polysaccharides.
    Critical reviews in toxicology, 1987, Volume: 17, Issue:3

    Some sulfated polysaccharides, such as d-CGN, APS, and DSS, have carcinogenicity to the rat colorectum. These materials first induced colitis, secondly squamous metaplasia, and finally tumors at the colorectum. Initially, colitis was located in the columnar epithelium of the rectum and extended proximally thereafter. Squamous metaplasia persisted in almost all experimental rats and progressed irreversibly. The tumors were adenoma, adenocarcinoma, squamous cell papilloma, and squamous cell carcinoma. Macrophages containing these materials were observed in the lamina propria mucosa and submucosa of the colorectum. There were differences in the molecular weight of the substances and their tumor incidences. However, with regard to their carcinogenicity, these sulfated polysaccharides were inferred to be similar to each other in their target organs and process of tumor development. Consequently, these sulfated polysaccharides may be one entity of carcinogenic sulfates.

    Topics: Amylopectin; Animals; Carrageenan; Cocarcinogenesis; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Dextrans; Female; Intestines; Male; Metaplasia; Polysaccharides; Precancerous Conditions; Rats; Rectal Neoplasms

1987

Other Studies

2 other study(ies) available for amylopectin and Colonic-Neoplasms

ArticleYear
Macromolecular design of folic acid functionalized amylopectin-albumin core-shell nanogels for improved physiological stability and colon cancer cell targeted delivery of curcumin.
    Journal of colloid and interface science, 2020, Nov-15, Volume: 580

    Nanogels have potential for encapsulating cancer therapeutics, yet their susceptibility to physiological degradation and lack of cellular specificity hinder their use as effective oral delivery vehicles. Herein, we engineered novel albumin-core with folic acid functionalized hyperbranched amylopectin shell-type nanogels, prepared through a two-step reaction and loaded with curcumin while the proteinaceous core was undergoing thermal gelation. The nanogels had a mean hydrodynamic diameter of ca. 90 nm and ζ-potential of ca. -24 mV. Encapsulation of curcumin within the nanogels was restored, up to ca. 0.05 mg mL

    Topics: Albumins; Amylopectin; Colonic Neoplasms; Curcumin; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Nanogels

2020
Induction of colorectal adenocarcinoma in rats by amylopectin sulfate.
    Cancer letters, 1985, Volume: 26, Issue:3

    The carcinogenicity of orally administered amylopectin sulfate was studied in F344 rats. Amylopectin sulfate induced adenomas and adenocarcinomas in the rat colorectum. The incidences of tumor induction in groups that were given a 5% diet of amylopectin sulfate for 3, 6 and 9 months were 2 out of 20 rats (10%), 9 out of 20 rats (45%) and 12 out of 20 rats (60%), respectively. Squamous metaplasia of the colorectum persisted in all rats and progressed irreversibly. Amylopectin sulfate was deposited in the colorectal lamina propria, submucosa and regional lymph nodes. Amylopectin sulfate induced a lesion similar to that produced by degraded carrageenan in the rat colorectum.

    Topics: Adenocarcinoma; Amylopectin; Animals; Colon; Colonic Neoplasms; Male; Metaplasia; Molecular Weight; Rats; Rats, Inbred F344; Rectal Neoplasms; Rectum

1985