amyloid-beta-peptides and Vitamin-D-Deficiency

amyloid-beta-peptides has been researched along with Vitamin-D-Deficiency* in 1 studies

Trials

1 trial(s) available for amyloid-beta-peptides and Vitamin-D-Deficiency

Article	Year
Vitamin D Supplementation Appears to Increase Plasma Aβ40 in Vitamin D Insufficient Older Adults: A Pilot Randomized Controlled Trial. Journal of Alzheimer's disease : JAD, 2016, 03-31, Volume: 52, Issue:3 Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, +14.9 ± 12.0 and +12.8 ± 12.8 pg/mL (p = 0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was +18.3 ± 33.6 and -3.2 ± 44.5 pg/mL for vitamin (n = 4) and placebo (n = 4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ. Topics: Age Factors; Amyloid beta-Peptides; Biomarkers; Calcifediol; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Pilot Projects; Treatment Outcome; Vitamin D Deficiency	2016

Article

Year

Vitamin D Supplementation Appears to Increase Plasma Aβ40 in Vitamin D Insufficient Older Adults: A Pilot Randomized Controlled Trial.

Journal of Alzheimer's disease : JAD, 2016, 03-31, Volume: 52, Issue:3

Low plasma amyloid-β (Aβ) is linked to Alzheimer's disease. Since vitamin D cleared brain Aβ in vitro, this 8-week trial examined whether vitamin D increased plasma Aβ40. Vitamin D insufficient adults (6/18 M/F; 64.3 ± 10.9 y) were randomized to placebo or vitamin (50,000 IU/week) treatments. The vitamin group experienced greater plasma Aβ40 change than controls, +14.9 ± 12.0 and +12.8 ± 12.8 pg/mL (p = 0.045; effect size, 0.228). Change in Aβ40 for older participants (≥60 y) was +18.3 ± 33.6 and -3.2 ± 44.5 pg/mL for vitamin (n = 4) and placebo (n = 4) groups (effect size, 0.295). Thus, vitamin D may increase plasma Aβ, particularly in older adults, suggesting decreased brain Aβ.

Topics: Age Factors; Amyloid beta-Peptides; Biomarkers; Calcifediol; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Pilot Projects; Treatment Outcome; Vitamin D Deficiency

2016