amyloid-beta-peptides and Hypertrophy

In Alzheimer's disease the normal balance of metabolic pathways regulating trophic factors/cytokines is disrupted; local reduction may result in neurons being deprived of neurotrophic factors while an excess may initiate a cascade of interaction between glial cells and beta-amyloid precursor protein metabolism thereby facilitating plaque formation. This paper briefly discusses the findings of our group on aspects ranging from cholinergic humoral and trophic factors to mechanisms underlying amyloidogenesis in Alzheimer's disease.

Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Cells, Cultured; Hypertrophy; Isomerism; Nerve Growth Factors; Nerve Tissue Proteins; Neuroglia; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger