amsacrine has been researched along with Retinoblastoma in 4 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the apoptotic effect induced in human retinoblastoma Y79 cells by camptothecin, etoposide, and amsacrine, to examine the effect of these drugs on the expression of many apoptosis-related modulators, and to test the antiapoptotic effect exerted by insulin-like growth factor-I (IGF-I)." | 3.70 | Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors. ( Carabillò, M; Giuliano, M; Lauricella, M; Tesoriere, G; Vassallo, E; Vento, R, 1998) |
| "Camptothecin was found to be the most effective compound." | 1.30 | Increased cyclin E level in retinoblastoma cells during programmed cell death. ( Carabillò, M; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R, 1998) |
| "This suggests that retinoblastoma is a chemosensitive tumour and therefore adjuvant chemotherapy may have a role in children with retinoblastoma who at diagnosis are thought to be at high risk of developing metastatic disease." | 1.27 | Chemotherapy in metastatic retinoblastoma. ( Hungerford, JL; Kingston, JE; Plowman, PN, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giuliano, M | 3 |
| Lauricella, M | 3 |
| Vassallo, E | 1 |
| Carabillò, M | 2 |
| Vento, R | 3 |
| Tesoriere, G | 3 |
| Emanuele, S | 2 |
| Kingston, JE | 1 |
| Hungerford, JL | 1 |
| Plowman, PN | 1 |
4 other studies available for amsacrine and Retinoblastoma
| Article | Year |
|---|---|
Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors.
Topics: Amsacrine; Apoptosis; bcl-2-Associated X Protein; Camptothecin; Cell Survival; Cyclin-Dependent Kina | 1998 |
Apoptotic effects of different drugs on cultured retinoblastoma Y79 cells.
Topics: Amsacrine; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Butyrates; Butyric A | 1998 |
Increased cyclin E level in retinoblastoma cells during programmed cell death.
Topics: Amsacrine; Apoptosis; Camptothecin; Cyclin A; Cyclin E; Enzyme Inhibitors; Etoposide; Humans; Interl | 1998 |
Chemotherapy in metastatic retinoblastoma.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Cyclophosphamide; Eye N | 1987 |