amsacrine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 28 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated." | 7.68 | Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Chun, HG; Cook, P; Feldman, EJ; Marboe, C; Mehta, R; Mittelman, A; Puccio, C, 1991) |
| "The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated." | 3.68 | Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Chun, HG; Cook, P; Feldman, EJ; Marboe, C; Mehta, R; Mittelman, A; Puccio, C, 1991) |
| "In all, 625 patients with acute lymphoblastic leukemia (ALL) entered the Leucémie Aiguë Lymphoblastique de l'Adulte-94 trial from June 1994 to June 1999, and received a 4-week induction therapy followed either by chemotherapy alone or stem cell transplantation (SCT)." | 2.71 | Rescue therapy combining intermediate-dose cytarabine with amsacrine and etoposide in relapsed adult acute lymphoblastic leukemia. ( Boiron, JM; Buzyn, A; Delannoy, A; Fegueux, N; Fière, D; Gardin, C; Georges, M; Hacini, M; Huguet, F; Kuentz, M; Lhéritier, V; Micléa, JM; Reman, O; Stamatoullas, A; Thomas, X; Vernant, JP, 2004) |
| "Twenty-nine patients with acute myeloid leukemia (AML) received a salvage therapy of amsacrine plus IDAC and etoposide, while 22 patients with acute lymphoblastic leukemia (ALL) received amsacrine plus IDAC." | 2.71 | Phase II trial of amsacrine plus intermediate-dose Ara-C (IDAC) with or without etoposide as salvage therapy for refractory or relapsed acute leukemia. ( Ahn, BM; Baek, JH; Jeon, SB; Kim, DH; Kim, JG; Lee, KB; Moon, JH; Sohn, SK; Sung, WJ, 2005) |
| "5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin has been applied in a treatment protocol for patients with a relapse of acute myeloid or lymphocytic leukemia." | 2.68 | A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893). ( Archimbaud, E; Berneman, Z; Dardenne, M; Dohner, H; Jaksic, B; Jehn, U; Labar, B; Louwagie, EA; Muus, P; Stryckmans, P; Suciu, S; Tjean, M; Wijermans, P; Willemze, R; Zittoun, R, 1997) |
| "Treatment with voriconazole in association with transfusions of leukocytes led to clinical and microbiological cure." | 1.33 | [Disseminated cutaneous and visceral fusariosis in an aplastic patient: an unusual digestive entry]. ( Berthou, C; Eveillard, JR; Ianoto, JC; Karam, A; Le Flohic, AM; Le Roy, JP; Misery, L; Quinio, D, 2005) |
| "The load of minimal residual disease prior to transplantation appears to be predictive for outcome in this very poor-prognosis subgroup of ALL." | 1.33 | Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children. ( Escherich, G; Hassenpflug, WA; Horstmann, MA; Janka, G; Kabisch, H; zur Stadt, U, 2005) |
| "The prognosis for DS acute myeloid leukemia (AML) is better than for non-DS AML, but the clinical outcome of DS acute lymphoblastic leukemia (ALL) is equal to that of non-DS ALL." | 1.31 | Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome. ( Creutzig, U; de Vries, E; Hählen, K; Huismans, DR; Janka-Schaub, GE; Jansen, G; Kaspers, GJ; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Zwaan, CM, 2002) |
| "The clinical outlook for adults with acute lymphoblastic leukemia (ALL) has improved with the use of intensive chemotherapy." | 1.29 | Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults. ( Welborn, JL, 1994) |
| "Effects of amsacrine in combination with other anticancer agents at ID80 were evaluated by cell growth assay using a human T-cell leukemia cell line (MOLT-3)." | 1.28 | Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture. ( Akutsu, M; Inoue, Y; Kano, Y; Kasahara, T; Miura, Y; Sakamoto, S, 1991) |
| "Thus, the CR rate for relapsed ANLL patients who received the higher doses of both agents was 40% (13 of 33)." | 1.28 | Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine. ( Dahl, GV; Grier, HE; Kalwinsky, DK; Mason, C; Mirro, J; Murphy, SB; Santana, VM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (21.43) | 18.7374 |
| 1990's | 13 (46.43) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CH | 1 |
| Lin, YW | 1 |
| Zhang, X | 1 |
| Chou, TC | 1 |
| Tsai, TJ | 1 |
| Kapuriya, N | 1 |
| Kakadiya, R | 1 |
| Su, TL | 1 |
| Zohren, F | 1 |
| Czibere, A | 1 |
| Bruns, I | 1 |
| Fenk, R | 1 |
| Schroeder, T | 1 |
| Gräf, T | 1 |
| Haas, R | 1 |
| Kobbe, G | 1 |
| Wernstedt, P | 1 |
| Brune, M | 1 |
| Andersson, PO | 1 |
| Gustavsson, B | 1 |
| Stockelberg, D | 1 |
| Wadenvik, H | 1 |
| Frost, BM | 1 |
| Nygren, P | 1 |
| Gustafsson, G | 1 |
| Forestier, E | 1 |
| Jonsson, OG | 1 |
| Kanerva, J | 1 |
| Nygaard, R | 1 |
| Schmiegelow, K | 1 |
| Larsson, R | 1 |
| Lönnerholm, G | 1 |
| Reman, O | 1 |
| Buzyn, A | 1 |
| Lhéritier, V | 1 |
| Huguet, F | 1 |
| Kuentz, M | 1 |
| Stamatoullas, A | 1 |
| Delannoy, A | 1 |
| Fegueux, N | 1 |
| Micléa, JM | 1 |
| Boiron, JM | 2 |
| Vernant, JP | 1 |
| Gardin, C | 1 |
| Hacini, M | 1 |
| Georges, M | 1 |
| Fière, D | 3 |
| Thomas, X | 3 |
| Karam, A | 1 |
| Eveillard, JR | 1 |
| Ianoto, JC | 1 |
| Quinio, D | 1 |
| Le Flohic, AM | 1 |
| Le Roy, JP | 1 |
| Misery, L | 1 |
| Berthou, C | 1 |
| Sung, WJ | 1 |
| Kim, DH | 1 |
| Sohn, SK | 1 |
| Kim, JG | 1 |
| Baek, JH | 1 |
| Jeon, SB | 1 |
| Moon, JH | 1 |
| Ahn, BM | 1 |
| Lee, KB | 1 |
| Horstmann, MA | 1 |
| Hassenpflug, WA | 1 |
| zur Stadt, U | 1 |
| Escherich, G | 1 |
| Janka, G | 1 |
| Kabisch, H | 1 |
| Archimbaud, E | 4 |
| Charrin, C | 1 |
| Magaud, JP | 1 |
| Cortes, J | 1 |
| O'Brien, SM | 1 |
| Pierce, S | 1 |
| Keating, MJ | 1 |
| Freireich, EJ | 1 |
| Kantarjian, HM | 1 |
| Willemze, R | 4 |
| Muus, P | 2 |
| Zijlmans, JM | 1 |
| den Ottolander, GJ | 1 |
| Kluin-Nelemans, JC | 1 |
| Falkenburg, JH | 1 |
| Starrenburg, CW | 1 |
| van der Burgh, JF | 1 |
| Fibbe, WE | 1 |
| Welborn, JL | 1 |
| Jehn, U | 2 |
| Heinemann, V | 1 |
| Dekker, AW | 1 |
| van't Veer, MB | 1 |
| Sizoo, W | 1 |
| Haak, HL | 1 |
| van der Lelie, J | 1 |
| Ossenkoppele, G | 1 |
| Huijgens, PC | 1 |
| Schouten, HC | 1 |
| Sonneveld, P | 1 |
| Verdonck, LF | 1 |
| van Putten, WL | 1 |
| Löwenberg, B | 1 |
| Suciu, S | 1 |
| Stryckmans, P | 1 |
| Louwagie, EA | 1 |
| Berneman, Z | 1 |
| Tjean, M | 1 |
| Wijermans, P | 1 |
| Dohner, H | 1 |
| Labar, B | 1 |
| Jaksic, B | 1 |
| Dardenne, M | 1 |
| Zittoun, R | 1 |
| Zwaan, CM | 1 |
| Kaspers, GJ | 1 |
| Pieters, R | 1 |
| Hählen, K | 1 |
| Janka-Schaub, GE | 1 |
| van Zantwijk, CH | 1 |
| Huismans, DR | 1 |
| de Vries, E | 1 |
| Rots, MG | 1 |
| Peters, GJ | 1 |
| Jansen, G | 1 |
| Creutzig, U | 1 |
| Veerman, AJ | 1 |
| Bernasconi, C | 1 |
| Lazzarino, M | 1 |
| Morra, E | 1 |
| Alessandrino, EP | 1 |
| Pagnucco, G | 1 |
| Resegotti, L | 1 |
| Locatelli, F | 1 |
| Ficarra, F | 1 |
| Bacigalupo, A | 1 |
| Carella, AM | 1 |
| Arlin, ZA | 3 |
| Feldman, EJ | 1 |
| Mittelman, A | 1 |
| Ahmed, T | 1 |
| Puccio, C | 1 |
| Chun, HG | 1 |
| Cook, P | 1 |
| Baskind, P | 1 |
| Marboe, C | 1 |
| Mehta, R | 1 |
| Kano, Y | 1 |
| Sakamoto, S | 1 |
| Kasahara, T | 1 |
| Akutsu, M | 1 |
| Inoue, Y | 1 |
| Miura, Y | 1 |
| Danks, MK | 1 |
| Schmidt, CA | 1 |
| Deneka, DA | 1 |
| Beck, WT | 1 |
| Reiffers, J | 1 |
| Marit, G | 1 |
| Rice, A | 1 |
| Bernard, P | 1 |
| Vezon, G | 1 |
| Weers-Pothoff, G | 1 |
| Novakova, IR | 1 |
| Donnelly, JP | 1 |
| Muytjens, HL | 1 |
| Mirro, J | 1 |
| Kalwinsky, DK | 1 |
| Grier, HE | 1 |
| Santana, VM | 1 |
| Mason, C | 1 |
| Murphy, SB | 1 |
| Dahl, GV | 1 |
1 review available for amsacrine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Mitoxantrone and amsacrine: two important agents for the treatment of acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL).
Topics: Amsacrine; Daunorubicin; Drug Evaluation; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Precursor | 1989 |
9 trials available for amsacrine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Fludarabine, amsacrine, high-dose cytarabine and 12 Gy total body irradiation followed by allogeneic hematopoietic stem cell transplantation is effective in patients with relapsed or high-risk acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Fr | 2009 |
Rescue therapy combining intermediate-dose cytarabine with amsacrine and etoposide in relapsed adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic | 2004 |
Phase II trial of amsacrine plus intermediate-dose Ara-C (IDAC) with or without etoposide as salvage therapy for refractory or relapsed acute leukemia.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Diar | 2005 |
High-dose Ara-C for remission induction and consolidation of previously untreated adults with ALL or lymphoblastic lymphoma.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplant | 1995 |
[Phase II clinical trial of domestic amsacrine in patients with acute leukemias. Cooperative Group for Treating Acute Leukemias with Domestic m-AMSA].
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relation | 1993 |
Phase-II study of treatment of refractory acute leukemia with intermediate-dose cytosine arabinoside and amsacrine.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug | 1993 |
Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. Dutch Hemato-Oncology Research Group.
Topics: Adolescent; Adult; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; An | 1997 |
A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893).
Topics: Adolescent; Adult; Aged; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemoth | 1997 |
Early intensification followed by allo-BMT or auto-BMT or a second intensification in adult ALL: a randomized multicenter study.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplant | 1992 |
18 other studies available for amsacrine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Synthesis and in vitro cytotoxicity of 9-anilinoacridines bearing N-mustard residue on both anilino and acridine rings.
Topics: Amsacrine; Aniline Compounds; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; M | 2009 |
Favorable outcome with STI571 (imatinib mesylate) and allogeneic stem cell transplantation in a case of Ph+ chemorefractory acute lymphocytic leukaemia.
Topics: Adult; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; | 2002 |
Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyto | 2003 |
[Disseminated cutaneous and visceral fusariosis in an aplastic patient: an unusual digestive entry].
Topics: Adult; Amsacrine; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Die | 2005 |
Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Topics: Adolescent; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Comb | 2005 |
CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Amsacrine; Aneuploidy; Antibiotics, Antineoplastic; Antigens, CD; Antigens, | 1995 |
The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocol | 1995 |
Preliminary results with 5-aza-2'-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group.
Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Agents; Azacitidine; Decitabine; F | 1993 |
Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults.
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Aspartate-Ammonia Ligase; Clinical | 1994 |
Influence of increased body mass index on drug toxicity in patients with acute promyelocytic leukemia.
Topics: Adult; Aged; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; | 1998 |
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.
Topics: Amsacrine; Anthracyclines; Antineoplastic Agents; Busulfan; Cell Survival; Child; Child, Preschool; | 2002 |
Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.
Topics: Amsacrine; Cardiac Output, Low; Cytarabine; Drug Therapy, Combination; Humans; Leukemia; Leukemia, M | 1991 |
Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Dose-Response Relationship | 1991 |
Increased ATP requirement for activity of and complex formation by DNA topoisomerase II from human leukemic CCRF-CEM cells selected for resistance to teniposide.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Amsacrine; Cell Line; Cell Nucleus; DNA Topoisome | 1989 |
The role of peripheral blood stem cells as rescue after myeloablative therapy.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Combined Modality Ther | 1989 |
Bacteraemia caused by Stomatococcus mucilaginosus in a granulocytopenic patient with acute lymphocytic leukaemia.
Topics: Adult; Agranulocytosis; Amsacrine; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Proto | 1989 |
A special role for amsacrine in the treatment of acute leukemia.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Humans; Leukemia, Myeloid, Acute; Precurs | 1989 |
Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; C | 1989 |