Page last updated: 2024-10-22

amsacrine and Neutropenia

amsacrine has been researched along with Neutropenia in 9 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
"Patients with acute leukemia in relapse were given 5'-(9-acridinylamino)methanesulfon-m-anisidide at a dosage of 75 to 200 mg/sq m as a daily bolus infusion of 5 consecutive days."1.26Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia. ( Arlin, ZA; Clarkson, BD; Gee, TS; Howard, J; Kempin, SJ; Sklaroff, RB; Young, CW, 1980)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's5 (55.56)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arlin, ZA1
Sklaroff, RB1
Gee, TS1
Kempin, SJ1
Howard, J1
Clarkson, BD1
Young, CW1
Ong, ST1
Kueh, YK1
Möllgård, L1
Tidefelt, U1
Sundman-Engberg, B1
Löfgren, C1
Lehman, S1
Paul, C1
Harousseau, JL2
Witz, B1
Lioure, B1
Hunault-Berger, M1
Desablens, B2
Delain, M1
Guilhot, F1
Le Prise, PY2
Abgrall, JF1
Deconinck, E1
Guyotat, D1
Vilque, JP1
Casassus, P2
Tournilhac, O1
Audhuy, B1
Solary, E1
Dreyfus, F1
Leblond, V1
Belanger, C1
Gabarre, J1
Sutton, L1
Boccaccio, C1
Quarre, MC1
Ribrag, V1
Goy, A1
Harvey, VJ1
Hardy, JR1
Smith, S1
Grove, W1
Baguley, BC1
Milpied, N1
Briere, J1
Ifrah, N1
Gandhour, C1
Dhaliwal, HS1
Shannon, MS1
Barnett, MJ1
Prentice, HG1
Bragman, K1
Malpas, JS1
Lister, TA1
Civin, CI1
Krischer, JP1
Land, VJ1
Nitschke, R1
Kamen, B1
Vats, T1

Trials

2 trials available for amsacrine and Neutropenia

ArticleYear
High single dose of mitoxantrone and cytarabine in acute non-lymphocytic leukemia: a pharmacokinetic and clinical study.
    Therapeutic drug monitoring, 1998, Volume: 20, Issue:6

    Topics: Adult; Aged; Amsacrine; Chromatography, High Pressure Liquid; Cytarabine; Drug Administration Schedu

1998
Granulocyte colony-stimulating factor after intensive consolidation chemotherapy in acute myeloid leukemia: results of a randomized trial of the Groupe Ouest-Est Leucémies Aigues Myeloblastiques.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Amsacrine; Anti-Bacterial Agents; Antimetabolites, Antineoplastic;

2000

Other Studies

7 other studies available for amsacrine and Neutropenia

ArticleYear
Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia.
    Cancer research, 1980, Volume: 40, Issue:9

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Drug Administration Schedule; Drug Evaluation; Humans;

1980
Hepatic candidiasis: persistent pyrexia in a patient with acute myeloid leukaemia after recovery from consolidation therapy-induced neutropenia.
    Annals of the Academy of Medicine, Singapore, 1993, Volume: 22, Issue:2

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Candidiasis; Cytosine; Eto

1993
Peripheral blood stem cell collection and autografting in high risk lymphomas.
    Bone marrow transplantation, 1992, Volume: 10, Issue:5

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Component Removal; Blood Tra

1992
Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:12

    Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Fema

1991
Double intensive consolidation chemotherapy (ICC) for acute myeloid leukemia.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmu

1990
Treatment of acute leukaemia with m-AMSA in combination with cytosine arabinoside.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:1

    Topics: Aged; Amsacrine; Chemical and Drug Induced Liver Injury; Cytarabine; Female; Gastrointestinal Diseas

1986
Pediatric oncology group phase II trial of amsacrine in children with solid tumors.
    Cancer treatment reports, 1985, Volume: 69, Issue:3

    Topics: Age Factors; Aminoacridines; Amsacrine; Arrhythmias, Cardiac; Child; Child, Preschool; Drug Evaluati

1985