amsacrine has been researched along with Myelodysplastic Syndromes in 9 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Strategies to reduce recurrence are urgently required." | 3.01 | Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia. ( Andrew, G; Byrne, J; Craddock, C; Crawley, C; Dillon, R; Freeman, SD; Gilleece, M; Hodgkinson, A; Hunter, A; Jackson, A; Khan, N; Loke, J; Malladi, R; Mason, J; McCarthy, N; Nagra, S; Parker, A; Pavlu, J; Peniket, A; Potter, V; Protheroe, R; Salim, R; Siddique, S; Tholouli, E; Vyas, P; Wheatley, K; Wilson, K, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Craddock, C | 1 |
| Jackson, A | 1 |
| Loke, J | 1 |
| Siddique, S | 1 |
| Hodgkinson, A | 1 |
| Mason, J | 1 |
| Andrew, G | 1 |
| Nagra, S | 1 |
| Malladi, R | 1 |
| Peniket, A | 1 |
| Gilleece, M | 1 |
| Salim, R | 1 |
| Tholouli, E | 1 |
| Potter, V | 1 |
| Crawley, C | 1 |
| Wheatley, K | 1 |
| Protheroe, R | 1 |
| Vyas, P | 1 |
| Hunter, A | 1 |
| Parker, A | 1 |
| Wilson, K | 1 |
| Pavlu, J | 1 |
| Byrne, J | 1 |
| Dillon, R | 1 |
| Khan, N | 1 |
| McCarthy, N | 1 |
| Freeman, SD | 1 |
| Saure, C | 1 |
| Schroeder, T | 1 |
| Zohren, F | 1 |
| Groten, A | 1 |
| Bruns, I | 1 |
| Czibere, A | 1 |
| Galonska, L | 1 |
| Kondakci, M | 1 |
| Weigelt, C | 1 |
| Fenk, R | 1 |
| Germing, U | 1 |
| Haas, R | 1 |
| Kobbe, G | 1 |
| Hofmann, WK | 1 |
| Heil, G | 1 |
| Zander, C | 1 |
| Wiebe, S | 1 |
| Ottmann, OG | 1 |
| Bergmann, L | 1 |
| Hoeffken, K | 1 |
| Fischer, JT | 1 |
| Knuth, A | 1 |
| Kolbe, K | 1 |
| Schmoll, HJ | 1 |
| Langer, W | 1 |
| Westerhausen, M | 1 |
| Koelbel, CB | 1 |
| Hoelzer, D | 1 |
| Ganser, A | 1 |
| Schmid, C | 1 |
| Schleuning, M | 1 |
| Ledderose, G | 1 |
| Tischer, J | 1 |
| Kolb, HJ | 1 |
| Fukushima, T | 1 |
| Kuriyama, K | 1 |
| Yoshida, S | 1 |
| Nagai, K | 1 |
| Miyazaki, Y | 1 |
| Moriuti, Y | 1 |
| Tomonaga, M | 1 |
| Keating, MJ | 1 |
| Estey, E | 1 |
| Kantarjian, H | 1 |
| Plunkett, W | 1 |
| O'Brien, S | 1 |
| Koller, C | 1 |
| Beran, M | 1 |
| Freireich, EJ | 2 |
| Estienne, MH | 1 |
| Fenaux, P | 1 |
| Preudhomme, C | 1 |
| Lai, JL | 1 |
| Zandecki, M | 1 |
| Lepelley, P | 1 |
| Cosson, A | 1 |
| De Witte, T | 1 |
| Muus, P | 1 |
| De Pauw, B | 1 |
| Haanen, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reduced Intensity Conditioning With Fludarabine and Busulfan Versus Fludarabine and Melphalan Before Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Randomised, Single-Center, Phase III Study[NCT05674539] | Phase 3 | 200 participants (Anticipated) | Interventional | 2022-12-28 | Recruiting | ||
| Early Tapering of Immunosuppressive Agents After Allogeneic Hematopoietic Stem Cell Transplantation Can Improve the Survival of Patients With Advanced Acute Myeloid Leukemia.[NCT03150134] | Phase 4 | 100 participants (Anticipated) | Interventional | 2010-01-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for amsacrine and Myelodysplastic Syndromes
| Article | Year |
|---|---|
Evolution of treatment for acute myelogenous leukemia and myelodysplastic syndrome at M.D. Anderson Cancer Center 1985-1991.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Administra | 1992 |
New strategies in the management of acute leukemias.
Topics: Acute Disease; Amsacrine; Aneuploidy; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Pr | 1987 |
3 trials available for amsacrine and Myelodysplastic Syndromes
| Article | Year |
|---|---|
Augmented Reduced-Intensity Regimen Does Not Improve Postallogeneic Transplant Outcomes in Acute Myeloid Leukemia.
Topics: Adult; Aged; Amsacrine; Busulfan; Cytarabine; Female; Graft vs Host Disease; Humans; Immunosuppressi | 2021 |
Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or secondary acute myeloid leukemia using a FLAMSA-based high-dose sequential conditioning regimen.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cyclophosphamide; | 2012 |
Intensive chemotherapy with idarubicin, cytarabine, etoposide, and G-CSF priming in patients with advanced myelodysplastic syndrome and high-risk acute myeloid leukemia.
Topics: Acute Disease; Adult; Aged; Amsacrine; Anemia, Refractory, with Excess of Blasts; Antineoplastic Com | 2004 |
4 other studies available for amsacrine and Myelodysplastic Syndromes
| Article | Year |
|---|---|
Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Chi-Square Distr | 2005 |
[Allogeneic bone marrow transplantation for two patients with acute myeloid leukemia with trilineage myelodysplasia (T-MDS)].
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combi | 1994 |
Prognostic value of dysmyelopoietic features in de novo acute myeloid leukaemia: a report on 132 patients.
Topics: Adolescent; Adult; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Prot | 1990 |
Intensive antileukemic treatment of patients younger than 65 years with myelodysplastic syndromes and secondary acute myelogenous leukemia.
Topics: Adult; Age Factors; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Pro | 1990 |