Page last updated: 2024-10-22

amsacrine and Metastase

amsacrine has been researched along with Metastase in 17 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"Twelve patients with recurrent and metastatic breast cancer were treated with a combination of adriamycin and amsacrine (m-AMSA) to evaluate its efficacy and toxicity."7.67Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer. ( Camacho, FJ; Chang, AY; Kaplan, BH; Solan, A; Taylor, SG; Vogl, SE, 1988)
"A randomized phase II study of AMSA (amsacrine) alone and AMSA combined with DTIC (dacarbazine) was carried out in 31 and 39 patients with metastatic melanoma respectively."5.06Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma. ( Benjamin, RS; Bodey, GP; Burgess, AM; Legha, SS; Polyzos, A, 1988)
"Twelve patients with recurrent and metastatic breast cancer were treated with a combination of adriamycin and amsacrine (m-AMSA) to evaluate its efficacy and toxicity."3.67Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer. ( Camacho, FJ; Chang, AY; Kaplan, BH; Solan, A; Taylor, SG; Vogl, SE, 1988)
"Leukopenia was found to be dose-limiting; thrombocytopenia and anemia were also observed."1.26Phase II study of m-AMSA in advances malignant melanoma. ( Arseneau, JC; Kuperminc, M; Probert, JC; Wolter, JM, 1982)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199017 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tannir, N1
Spitzer, G1
Schell, F1
Legha, S1
Zander, A1
Blumenschein, G1
Williams, SD1
Duncan, P1
Einhorn, LH1
Natale, RB1
Yagoda, A2
Blumenreich, MS1
Watson, RC1
Sternberg, CN1
Magill, GB1
Sordillo, PP1
Cheng, E1
Currie, VE2
Trump, DL1
Loening, S1
Ahmed, SW1
Wajsman, Z1
Schneider, RJ2
Woodcock, TM2
Legha, SS3
Hall, SW1
Powell, KC2
Burgess, MA1
Benjamin, RS2
Gutterman, JU1
Bodey, GP4
Nichols, WC1
Eagan, RT1
Frytak, S1
Ingle, JN1
Creagan, ET1
Kvols, LK1
Howard, J1
Wittes, R1
Amrein, PC1
Coleman, M1
Richards, F1
Poulin, RF1
Bernhardt, B1
Ginsberg, SJ1
Green, MR1
Morrison, A1
Cortes, E1
Kiang, D1
Weinberg, V1
Wood, WC1
Howerd, J1
Ochoa, M1
Buzdar, AU2
Hortobagyi, GN2
Blumenschein, GR2
Arseneau, JC1
Wolter, JM1
Probert, JC1
Kuperminc, M1
Drelichman, A1
Decker, DA1
Al-Sarraf, M1
Dhabuwala, CB1
Chang, AY1
Solan, A1
Kaplan, BH1
Vogl, SE1
Camacho, FJ1
Taylor, SG1
Polyzos, A1
Burgess, AM1
Casimir, MT1

Trials

1 trial available for amsacrine and Metastase

ArticleYear
Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma.
    Investigational new drugs, 1988, Volume: 6, Issue:1

    Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Evaluation

1988

Other Studies

16 other studies available for amsacrine and Metastase

ArticleYear
Phase II study of high-dose amsacrine (AMSA) and autologous bone marrow transplantation in patients with refractory metastatic breast cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:6

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marrow Transplantation; Breast N

1983
Phase II study of AMSA in refractory testicular cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:3

    Topics: Adult; Aminoacridines; Amsacrine; Cisplatin; Drug Administration Schedule; Drug Evaluation; Drug The

1983
Phase II trial of amsacrine (AMSA) in urinary bladder cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:4

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk

1983
Phase II evaluation of m-AMSA (4'-(9-acridinylamino)-methanesulfon-m-anisidide) in patients with adenocarcinoma of the pancreas.
    American journal of clinical oncology, 1983, Volume: 6, Issue:4

    Topics: Adenocarcinoma; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Hum

1983
Phase II study of amsacrine (AMSA) in previously treated patients with advanced transitional cell carcinoma of the urothelium: a National Bladder Cancer Collaborative Group A study.
    Cancer treatment reports, 1983, Volume: 67, Issue:9

    Topics: Aminoacridines; Amsacrine; Carcinoma, Transitional Cell; Drug Evaluation; Epithelium; Humans; Kidney

1983
Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.
    Cancer treatment reports, 1980, Volume: 64, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Kidney Neop

1980
Phase II study of 4'-(9-acridinylamino) methanesulfon-m- anisidide (AMSA) in metastatic melanoma.
    Cancer clinical trials, 1980,Summer, Volume: 3, Issue:2

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Administration Schedule; Drug Ev

1980
Phase II evaluation of AMSA in patients with metastatic lung cancer.
    Cancer treatment reports, 1980, Volume: 64, Issue:12

    Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C

1980
A phase II evaluation of m-AMSA, 4'-(9-acridinylamino) methanesulfon-m-anisidide, in patients with breast cancer.
    Cancer clinical trials, 1981,Fall, Volume: 4, Issue:3

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe

1981
Phase II study of AMSA in patients with metastatic breast cancer: a Cancer and Leukemia Group B study.
    Cancer treatment reports, 1982, Volume: 66, Issue:5

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe

1982
Phase II trial of AMSA in previously treated patients with stage III and IV ovarian cancer.
    Cancer treatment reports, 1982, Volume: 66, Issue:7

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Follow-Up Studies; Humans

1982
AMSA and peptichemio in the treatment of advances metastatic breast cancer: a phase II study.
    American journal of clinical oncology, 1982, Volume: 5, Issue:4

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Dr

1982
Phase II study of m-AMSA in advances malignant melanoma.
    American journal of clinical oncology, 1982, Volume: 5, Issue:4

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Leukopenia; Male; Melanoma;

1982
M-AMSA in disseminated prostatic carcinoma: a phase II study.
    Cancer treatment reports, 1982, Volume: 66, Issue:11

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Humans; Leukopenia;

1982
Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer.
    American journal of clinical oncology, 1988, Volume: 11, Issue:5

    Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Breast Neo

1988
Phase II study of AMSA and doxorubicin to treat metastatic breast cancer.
    Oncology, 1986, Volume: 43, Issue:4

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl

1986