amsacrine has been researched along with Metastase in 17 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Excerpt | Relevance | Reference |
---|---|---|
"Twelve patients with recurrent and metastatic breast cancer were treated with a combination of adriamycin and amsacrine (m-AMSA) to evaluate its efficacy and toxicity." | 7.67 | Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer. ( Camacho, FJ; Chang, AY; Kaplan, BH; Solan, A; Taylor, SG; Vogl, SE, 1988) |
"A randomized phase II study of AMSA (amsacrine) alone and AMSA combined with DTIC (dacarbazine) was carried out in 31 and 39 patients with metastatic melanoma respectively." | 5.06 | Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma. ( Benjamin, RS; Bodey, GP; Burgess, AM; Legha, SS; Polyzos, A, 1988) |
"Twelve patients with recurrent and metastatic breast cancer were treated with a combination of adriamycin and amsacrine (m-AMSA) to evaluate its efficacy and toxicity." | 3.67 | Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer. ( Camacho, FJ; Chang, AY; Kaplan, BH; Solan, A; Taylor, SG; Vogl, SE, 1988) |
"Leukopenia was found to be dose-limiting; thrombocytopenia and anemia were also observed." | 1.26 | Phase II study of m-AMSA in advances malignant melanoma. ( Arseneau, JC; Kuperminc, M; Probert, JC; Wolter, JM, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 17 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Tannir, N | 1 |
Spitzer, G | 1 |
Schell, F | 1 |
Legha, S | 1 |
Zander, A | 1 |
Blumenschein, G | 1 |
Williams, SD | 1 |
Duncan, P | 1 |
Einhorn, LH | 1 |
Natale, RB | 1 |
Yagoda, A | 2 |
Blumenreich, MS | 1 |
Watson, RC | 1 |
Sternberg, CN | 1 |
Magill, GB | 1 |
Sordillo, PP | 1 |
Cheng, E | 1 |
Currie, VE | 2 |
Trump, DL | 1 |
Loening, S | 1 |
Ahmed, SW | 1 |
Wajsman, Z | 1 |
Schneider, RJ | 2 |
Woodcock, TM | 2 |
Legha, SS | 3 |
Hall, SW | 1 |
Powell, KC | 2 |
Burgess, MA | 1 |
Benjamin, RS | 2 |
Gutterman, JU | 1 |
Bodey, GP | 4 |
Nichols, WC | 1 |
Eagan, RT | 1 |
Frytak, S | 1 |
Ingle, JN | 1 |
Creagan, ET | 1 |
Kvols, LK | 1 |
Howard, J | 1 |
Wittes, R | 1 |
Amrein, PC | 1 |
Coleman, M | 1 |
Richards, F | 1 |
Poulin, RF | 1 |
Bernhardt, B | 1 |
Ginsberg, SJ | 1 |
Green, MR | 1 |
Morrison, A | 1 |
Cortes, E | 1 |
Kiang, D | 1 |
Weinberg, V | 1 |
Wood, WC | 1 |
Howerd, J | 1 |
Ochoa, M | 1 |
Buzdar, AU | 2 |
Hortobagyi, GN | 2 |
Blumenschein, GR | 2 |
Arseneau, JC | 1 |
Wolter, JM | 1 |
Probert, JC | 1 |
Kuperminc, M | 1 |
Drelichman, A | 1 |
Decker, DA | 1 |
Al-Sarraf, M | 1 |
Dhabuwala, CB | 1 |
Chang, AY | 1 |
Solan, A | 1 |
Kaplan, BH | 1 |
Vogl, SE | 1 |
Camacho, FJ | 1 |
Taylor, SG | 1 |
Polyzos, A | 1 |
Burgess, AM | 1 |
Casimir, MT | 1 |
1 trial available for amsacrine and Metastase
Article | Year |
---|---|
Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Evaluation | 1988 |
16 other studies available for amsacrine and Metastase
Article | Year |
---|---|
Phase II study of high-dose amsacrine (AMSA) and autologous bone marrow transplantation in patients with refractory metastatic breast cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marrow Transplantation; Breast N | 1983 |
Phase II study of AMSA in refractory testicular cancer.
Topics: Adult; Aminoacridines; Amsacrine; Cisplatin; Drug Administration Schedule; Drug Evaluation; Drug The | 1983 |
Phase II trial of amsacrine (AMSA) in urinary bladder cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk | 1983 |
Phase II evaluation of m-AMSA (4'-(9-acridinylamino)-methanesulfon-m-anisidide) in patients with adenocarcinoma of the pancreas.
Topics: Adenocarcinoma; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Hum | 1983 |
Phase II study of amsacrine (AMSA) in previously treated patients with advanced transitional cell carcinoma of the urothelium: a National Bladder Cancer Collaborative Group A study.
Topics: Aminoacridines; Amsacrine; Carcinoma, Transitional Cell; Drug Evaluation; Epithelium; Humans; Kidney | 1983 |
Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Kidney Neop | 1980 |
Phase II study of 4'-(9-acridinylamino) methanesulfon-m- anisidide (AMSA) in metastatic melanoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Administration Schedule; Drug Ev | 1980 |
Phase II evaluation of AMSA in patients with metastatic lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C | 1980 |
A phase II evaluation of m-AMSA, 4'-(9-acridinylamino) methanesulfon-m-anisidide, in patients with breast cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe | 1981 |
Phase II study of AMSA in patients with metastatic breast cancer: a Cancer and Leukemia Group B study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe | 1982 |
Phase II trial of AMSA in previously treated patients with stage III and IV ovarian cancer.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Follow-Up Studies; Humans | 1982 |
AMSA and peptichemio in the treatment of advances metastatic breast cancer: a phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Dr | 1982 |
Phase II study of m-AMSA in advances malignant melanoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Leukopenia; Male; Melanoma; | 1982 |
M-AMSA in disseminated prostatic carcinoma: a phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Humans; Leukopenia; | 1982 |
Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Breast Neo | 1988 |
Phase II study of AMSA and doxorubicin to treat metastatic breast cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl | 1986 |