amsacrine has been researched along with Metastase in 17 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve patients with recurrent and metastatic breast cancer were treated with a combination of adriamycin and amsacrine (m-AMSA) to evaluate its efficacy and toxicity." | 7.67 | Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer. ( Camacho, FJ; Chang, AY; Kaplan, BH; Solan, A; Taylor, SG; Vogl, SE, 1988) |
| "A randomized phase II study of AMSA (amsacrine) alone and AMSA combined with DTIC (dacarbazine) was carried out in 31 and 39 patients with metastatic melanoma respectively." | 5.06 | Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma. ( Benjamin, RS; Bodey, GP; Burgess, AM; Legha, SS; Polyzos, A, 1988) |
| "Twelve patients with recurrent and metastatic breast cancer were treated with a combination of adriamycin and amsacrine (m-AMSA) to evaluate its efficacy and toxicity." | 3.67 | Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer. ( Camacho, FJ; Chang, AY; Kaplan, BH; Solan, A; Taylor, SG; Vogl, SE, 1988) |
| "Leukopenia was found to be dose-limiting; thrombocytopenia and anemia were also observed." | 1.26 | Phase II study of m-AMSA in advances malignant melanoma. ( Arseneau, JC; Kuperminc, M; Probert, JC; Wolter, JM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tannir, N | 1 |
| Spitzer, G | 1 |
| Schell, F | 1 |
| Legha, S | 1 |
| Zander, A | 1 |
| Blumenschein, G | 1 |
| Williams, SD | 1 |
| Duncan, P | 1 |
| Einhorn, LH | 1 |
| Natale, RB | 1 |
| Yagoda, A | 2 |
| Blumenreich, MS | 1 |
| Watson, RC | 1 |
| Sternberg, CN | 1 |
| Magill, GB | 1 |
| Sordillo, PP | 1 |
| Cheng, E | 1 |
| Currie, VE | 2 |
| Trump, DL | 1 |
| Loening, S | 1 |
| Ahmed, SW | 1 |
| Wajsman, Z | 1 |
| Schneider, RJ | 2 |
| Woodcock, TM | 2 |
| Legha, SS | 3 |
| Hall, SW | 1 |
| Powell, KC | 2 |
| Burgess, MA | 1 |
| Benjamin, RS | 2 |
| Gutterman, JU | 1 |
| Bodey, GP | 4 |
| Nichols, WC | 1 |
| Eagan, RT | 1 |
| Frytak, S | 1 |
| Ingle, JN | 1 |
| Creagan, ET | 1 |
| Kvols, LK | 1 |
| Howard, J | 1 |
| Wittes, R | 1 |
| Amrein, PC | 1 |
| Coleman, M | 1 |
| Richards, F | 1 |
| Poulin, RF | 1 |
| Bernhardt, B | 1 |
| Ginsberg, SJ | 1 |
| Green, MR | 1 |
| Morrison, A | 1 |
| Cortes, E | 1 |
| Kiang, D | 1 |
| Weinberg, V | 1 |
| Wood, WC | 1 |
| Howerd, J | 1 |
| Ochoa, M | 1 |
| Buzdar, AU | 2 |
| Hortobagyi, GN | 2 |
| Blumenschein, GR | 2 |
| Arseneau, JC | 1 |
| Wolter, JM | 1 |
| Probert, JC | 1 |
| Kuperminc, M | 1 |
| Drelichman, A | 1 |
| Decker, DA | 1 |
| Al-Sarraf, M | 1 |
| Dhabuwala, CB | 1 |
| Chang, AY | 1 |
| Solan, A | 1 |
| Kaplan, BH | 1 |
| Vogl, SE | 1 |
| Camacho, FJ | 1 |
| Taylor, SG | 1 |
| Polyzos, A | 1 |
| Burgess, AM | 1 |
| Casimir, MT | 1 |
1 trial available for amsacrine and Metastase
| Article | Year |
|---|---|
Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Evaluation | 1988 |
16 other studies available for amsacrine and Metastase
| Article | Year |
|---|---|
Phase II study of high-dose amsacrine (AMSA) and autologous bone marrow transplantation in patients with refractory metastatic breast cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marrow Transplantation; Breast N | 1983 |
Phase II study of AMSA in refractory testicular cancer.
Topics: Adult; Aminoacridines; Amsacrine; Cisplatin; Drug Administration Schedule; Drug Evaluation; Drug The | 1983 |
Phase II trial of amsacrine (AMSA) in urinary bladder cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk | 1983 |
Phase II evaluation of m-AMSA (4'-(9-acridinylamino)-methanesulfon-m-anisidide) in patients with adenocarcinoma of the pancreas.
Topics: Adenocarcinoma; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Hum | 1983 |
Phase II study of amsacrine (AMSA) in previously treated patients with advanced transitional cell carcinoma of the urothelium: a National Bladder Cancer Collaborative Group A study.
Topics: Aminoacridines; Amsacrine; Carcinoma, Transitional Cell; Drug Evaluation; Epithelium; Humans; Kidney | 1983 |
Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Kidney Neop | 1980 |
Phase II study of 4'-(9-acridinylamino) methanesulfon-m- anisidide (AMSA) in metastatic melanoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Administration Schedule; Drug Ev | 1980 |
Phase II evaluation of AMSA in patients with metastatic lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C | 1980 |
A phase II evaluation of m-AMSA, 4'-(9-acridinylamino) methanesulfon-m-anisidide, in patients with breast cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe | 1981 |
Phase II study of AMSA in patients with metastatic breast cancer: a Cancer and Leukemia Group B study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe | 1982 |
Phase II trial of AMSA in previously treated patients with stage III and IV ovarian cancer.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Follow-Up Studies; Humans | 1982 |
AMSA and peptichemio in the treatment of advances metastatic breast cancer: a phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Dr | 1982 |
Phase II study of m-AMSA in advances malignant melanoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Leukopenia; Male; Melanoma; | 1982 |
M-AMSA in disseminated prostatic carcinoma: a phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Humans; Leukopenia; | 1982 |
Pilot study of adriamycin and amsacrine (m-AMSA) in patients with advanced breast cancer.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Breast Neo | 1988 |
Phase II study of AMSA and doxorubicin to treat metastatic breast cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Breast Neopl | 1986 |