amsacrine has been researched along with Melanoma in 21 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a phase II study 20 patients with measurable metastatic melanoma were treated with amsacrine 120 mg/m2 every 3 weeks." | 7.67 | Chemotherapy in metastatic melanoma: phase II studies of amsacrine, mitoxantrone and bisantrene. ( Bishop, J; Coates, AS; Mann, GJ; Raghavan, D, 1986) |
| "A randomized phase II study of AMSA (amsacrine) alone and AMSA combined with DTIC (dacarbazine) was carried out in 31 and 39 patients with metastatic melanoma respectively." | 5.06 | Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma. ( Benjamin, RS; Bodey, GP; Burgess, AM; Legha, SS; Polyzos, A, 1988) |
| "In a phase II study 20 patients with measurable metastatic melanoma were treated with amsacrine 120 mg/m2 every 3 weeks." | 3.67 | Chemotherapy in metastatic melanoma: phase II studies of amsacrine, mitoxantrone and bisantrene. ( Bishop, J; Coates, AS; Mann, GJ; Raghavan, D, 1986) |
| "Laboratory evidence of disseminated intravascular coagulation (DIC) and/or fibrinolysis is present in the majority of patients with acute promyelocytic leukemia (APL)." | 2.68 | Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid. ( Escudier, SM; Estey, EH; Kantarjian, HM, 1996) |
| "Leukopenia was the dose-limiting toxicity with 7." | 1.27 | The treatment of melanoma with m-AMSA. A Cancer and Leukemia Group B phase II study. ( Amrein, PC; Carey, RW; Coleman, M; Green, MR; Holland, JF; Kennedy, BJ; Poulin, RF; Richards, F; Weil, M; Weinberg, V, 1984) |
| "Leukopenia was found to be dose-limiting; thrombocytopenia and anemia were also observed." | 1.26 | Phase II study of m-AMSA in advances malignant melanoma. ( Arseneau, JC; Kuperminc, M; Probert, JC; Wolter, JM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (85.71) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamato, M | 1 |
| Takeuchi, Y | 1 |
| Hashigaki, K | 1 |
| Ikeda, Y | 1 |
| Chang, MR | 1 |
| Takeuchi, K | 1 |
| Matsushima, M | 1 |
| Tsuruo, T | 1 |
| Tashiro, T | 1 |
| Tsukagoshi, S | 1 |
| Amrein, PC | 1 |
| Poulin, RF | 1 |
| Coleman, M | 1 |
| Richards, F | 1 |
| Weil, M | 1 |
| Kennedy, BJ | 1 |
| Carey, RW | 1 |
| Green, MR | 1 |
| Holland, JF | 1 |
| Weinberg, V | 1 |
| Stewart, DJ | 1 |
| Zhengang, G | 1 |
| Lu, K | 1 |
| Savaraj, N | 1 |
| Feun, LG | 1 |
| Luna, M | 1 |
| Benjamin, RS | 3 |
| Keating, MJ | 1 |
| Loo, TL | 1 |
| Legha, SS | 2 |
| Hall, SW | 1 |
| Powell, KC | 1 |
| Burgess, MA | 1 |
| Gutterman, JU | 1 |
| Bodey, GP | 2 |
| Dumont, P | 1 |
| Atassi, G | 1 |
| Tagnon, HJ | 1 |
| Stephens, TC | 1 |
| Peacock, JH | 1 |
| Arseneau, JC | 1 |
| Wolter, JM | 1 |
| Probert, JC | 1 |
| Kuperminc, M | 1 |
| Ahmann, FR | 1 |
| Meyskens, FL | 1 |
| Moon, TE | 1 |
| Durie, BG | 1 |
| Salmon, SE | 1 |
| Horikoshi, N | 1 |
| Ogawa, M | 1 |
| Inagaki, J | 1 |
| Ezaki, K | 1 |
| Inoue, K | 1 |
| Okabe, K | 1 |
| Nagata, T | 1 |
| Aiba, K | 1 |
| Domyo, M | 1 |
| Issell, BF | 2 |
| Kirshenbaum, MR | 1 |
| Chen, SF | 1 |
| Behrens, CH | 1 |
| Papp, LM | 1 |
| Stafford, MM | 1 |
| Sun, JH | 1 |
| Behrens, DL | 1 |
| Fredericks, JR | 1 |
| Polkus, ST | 1 |
| Sipple, P | 1 |
| Escudier, SM | 1 |
| Kantarjian, HM | 1 |
| Estey, EH | 1 |
| Johnson, RK | 1 |
| Wodinsky, I | 1 |
| Swiniarski, J | 1 |
| Meaney, KF | 1 |
| Clement, JJ | 1 |
| Finlay, GJ | 1 |
| Baguley, BC | 1 |
| Hanauske, AR | 2 |
| Hanauske, U | 1 |
| Von Hoff, DD | 2 |
| West, CM | 1 |
| Stratford, IJ | 1 |
| Perry, DJ | 1 |
| Weiss, RB | 1 |
| Hoth, DF | 1 |
| Polyzos, A | 1 |
| Burgess, AM | 1 |
| Coates, AS | 1 |
| Bishop, J | 1 |
| Mann, GJ | 1 |
| Raghavan, D | 1 |
| Louie, AC | 1 |
3 reviews available for amsacrine and Melanoma
| Article | Year |
|---|---|
The human tumor cloning assay in cancer research and therapy: a review with clinical correlations.
Topics: Aminoacridines; Amsacrine; Animals; Anthracenes; Antineoplastic Agents; Blood Physiological Phenomen | 1985 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul | 1985 |
4 trials available for amsacrine and Melanoma
| Article | Year |
|---|---|
Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid.
Topics: Adult; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemot | 1996 |
Phase II study of AMSA alone and in combination with DTIC in patients with metastatic melanoma.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Drug Evaluation | 1988 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul | 1985 |
16 other studies available for amsacrine and Melanoma
| Article | Year |
|---|---|
Synthesis and antitumor activity of fused tetracyclic quinoline derivatives. 1.
Topics: Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; DNA; DNA Topois | 1989 |
The treatment of melanoma with m-AMSA. A Cancer and Leukemia Group B phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk | 1984 |
Human tissue distribution of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (NSC 141549, AMSA).
Topics: Adult; Aminoacridines; Amsacrine; Chromatography, High Pressure Liquid; Female; Humans; Leukemia, Ly | 1984 |
Phase II study of 4'-(9-acridinylamino) methanesulfon-m- anisidide (AMSA) in metastatic melanoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Administration Schedule; Drug Ev | 1980 |
Combination chemotherapy with AMSA on L1210 leukaemia and B16 melanoma.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Carmustine; Dacarbazine; Drug Therapy, Co | 1981 |
Clonal variation in the sensitivity of B16 melanoma to m-AMSA.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Survival; Clone Cells; Lung Neoplasm | 1982 |
Phase II study of m-AMSA in advances malignant melanoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Leukopenia; Male; Melanoma; | 1982 |
In vitro chemosensitivities of human tumor stem cells to the Phase II drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and prospective in vivo correlations.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cells, Cultured; Drug Evaluation; Female; Genital | 1982 |
[Phase I-II studies of a new antineoplastic agent, 4'-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA)].
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe | 1982 |
Amsacrine (AMSA).
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Dogs; Dose-Response Rel | 1980 |
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic | 1994 |
Interaction of gamma-irradiation with two new antineoplastic agents, aziridinylbenzoquinone (AZQ) and 4'- (acridinylamino)methanesulfon-m-anisidide (AMSA), in murine tumors in vivo.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Aziridines; Azirines; Benzoquinones; Cell | 1979 |
Potentiation by phenylbisbenzimidazoles of cytotoxicity of anticancer drugs directed against topoisomerase II.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Benzimidazoles; Bisbenzimidazole; Colonic Neop | 1990 |
A comparison of adriamycin and mAMSA. II. Studies with V79 and human tumour multicellular spheroids.
Topics: Amsacrine; Animals; Carcinoma, Small Cell; Cell Survival; Cricetinae; Cricetulus; Dose-Response Rela | 1987 |
Hypersensitivity reactions to amsacrine.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; | 1985 |
Chemotherapy in metastatic melanoma: phase II studies of amsacrine, mitoxantrone and bisantrene.
Topics: Aminoacridines; Amsacrine; Anthracenes; Anthraquinones; Antineoplastic Agents; Drug Evaluation; Fema | 1986 |