amsacrine has been researched along with Mast-Cell Sarcoma in 12 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Mast-Cell Sarcoma: A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil was shown to increase growth inhibition and decrease viability of PY815 mastocytoma cells treated with the anti-cancer drug mAMSA 4'-(9-acridinylamino)methanesulphon-m-anisidide (mAMSA) or its normally inactive congener, 4'-(9-acridinylamino)methanesulphon-o-anisidide (oAMSA)." | 1.27 | Potentiation of 4'-(9-acridinylamino)methanesulphon-m-anisidine) action by verapamil. ( Darkin, S; Ralph, RK, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marshall, B | 4 |
| Ralph, RK | 12 |
| Hancock, R | 1 |
| Darkin, S | 4 |
| McQuillan, J | 1 |
| Collett, AG | 1 |
| Darkin-Rattray, SJ | 1 |
| Darkin, SJ | 2 |
| Schneider, E | 1 |
| Hutchins, AM | 1 |
| Lawson, PA | 1 |
12 other studies available for amsacrine and Mast-Cell Sarcoma
| Article | Year |
|---|---|
The nature of DNA breakage by 4'-[(9-acridinyl)amino]methane-sulphone-m-anisidide.
Topics: Aminoacridines; Amsacrine; Animals; Binding Sites; Cells, Cultured; DNA Topoisomerases, Type I; DNA, | 1982 |
Blocked 5'-termini in the fragments of chromosomal DNA produced in cells exposed to the antitumor drug 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide (mAMSA).
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Base Sequence; DNA; Escherichia coli; Exo | 1983 |
Evidence that mAMSA induces topoisomerase action.
Topics: Aminoacridines; Aminocoumarins; Amsacrine; Animals; Cell Line; Cell Nucleus; Coumarins; DNA Topoisom | 1983 |
Chlorpromazine: a potential anticancer agent?
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cell Line; Chlorpromazine; DNA; Mast-Cell | 1984 |
On the mechanism of action of 4'-[(9-acridinyl)-amino] methanesulphon-m-anisidide.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cells, Cultured; Centrifugation, Density | 1980 |
A reassessment of the mechanism of action of 4'-[(9-acridinyl)-amino]methanesulphon-m-anisidide.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Cells, Cultured; Centrifugation, Density | 1982 |
Regulation of topoisomerase II by murine mastocytoma cells.
Topics: Amsacrine; Animals; Blood; Cell Division; Culture Media; Culture Media, Serum-Free; DNA; DNA Topoiso | 1992 |
Evidence that a protein kinase enhances amsacrine mediated formation of topoisomerase II-DNA complexes in murine mastocytoma cell nuclei.
Topics: Amsacrine; Animals; Casein Kinases; Cell Line; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Neopl | 1991 |
A protein factor that enhances amsacrine-mediated formation of topoisomerase II-DNA complexes in murine mastocytoma cell nuclei.
Topics: Amsacrine; Animals; Cell Nucleus; Cell-Free System; Cytoplasm; DNA, Neoplasm; Hot Temperature; Macro | 1989 |
Relationship between sensitivity to 4'-(9-acridinylamino)methanesulfon-m-anisidide and DNA topoisomerase II in a cold-sensitive cell-cycle mutant of a murine mastocytoma cell line.
Topics: Amsacrine; Animals; Cell Cycle; Cell Division; Cell Survival; Cold Temperature; DNA; DNA Damage; DNA | 1988 |
Potentiation of 4'-(9-acridinylamino)methanesulphon-m-anisidine) action by verapamil.
Topics: Aminoacridines; Amsacrine; Animals; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug | 1986 |
Transport of AMSA drugs into cells.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Biological Transport; Cell Line; DNA, Neo | 1985 |