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amsacrine and Lymphoma

amsacrine has been researched along with Lymphoma in 23 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.

Research Excerpts

ExcerptRelevanceReference
"Thirty adult patients with relapsed or refractory malignant lymphoma underwent a Phase I-II trial of salvage chemotherapy combining methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI protocol)."7.68Salvage therapy with methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI) for recurrent or refractory lymphoma. ( Baume, D; Carde, P; Droz, JP; Gilles, E; Hayat, M; Moran, A; Ostronoff, M; Pico, JL; Zambon, E, 1990)
"We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas."7.67Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986)
"A total of 70 patients with malignant lymphomas refractory to one or more chemotherapeutic regimens were treated with iv amsacrines (m-AMSA and m-AMSA lactate)."7.67Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas. ( Bajetta, E; Bonadonna, G; Buzzoni, R; Gasparini, G; Piotti, P; Villani, F; Viviani, S, 1985)
"Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group."7.66Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983)
" In acute myelogenous leukemia, amsacrine is as effective as the two most active drugs, cytarabine and daunorubicin and can produce complete remissions in patients refractory to these drugs."6.15Amsacrine: a review. ( Cassileth, PA; Gale, RP, 1986)
"Amsacrine is an antileukemia drug being widely used in North America, Europe, Australia, and New Zealand."5.06Amsacrine-associated cardiotoxicity: an analysis of 82 cases. ( Grillo-López, AJ; Hess, F; Marsoni, S; Posada, JG; Ross, BJ; Weiss, RB, 1986)
"The present study was designed to determine and compare the clastogenicity of m-AMSA and camptothecin (CAMP) in vivo in mouse bone marrow and peripheral blood lymphocytes (PBLs), and in vitro in mouse lymphoma L5178Y cells."3.68Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro. ( Allen, JW; Backer, LC; Campbell, JA; DeMarini, DM; Doerr, CL; Harrington-Brock, K; Howard, DR; Kligerman, AD; Moore, MM, 1990)
"Thirty adult patients with relapsed or refractory malignant lymphoma underwent a Phase I-II trial of salvage chemotherapy combining methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI protocol)."3.68Salvage therapy with methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI) for recurrent or refractory lymphoma. ( Baume, D; Carde, P; Droz, JP; Gilles, E; Hayat, M; Moran, A; Ostronoff, M; Pico, JL; Zambon, E, 1990)
"We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas."3.67Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986)
"A total of 70 patients with malignant lymphomas refractory to one or more chemotherapeutic regimens were treated with iv amsacrines (m-AMSA and m-AMSA lactate)."3.67Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas. ( Bajetta, E; Bonadonna, G; Buzzoni, R; Gasparini, G; Piotti, P; Villani, F; Viviani, S, 1985)
"Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group."3.66Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983)
"Thirty previously treated adults with lymphoma received AMSA as single agent therapy."1.26Initial experience with AMSA as single agent treatment against malignant lymphoproliferative disorders. ( Bodey, GP; Cabanillas, F; Freireich, EJ; Legha, SS, 1981)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199020 (86.96)18.7374
1990's2 (8.70)18.2507
2000's1 (4.35)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bramwell, VH1
Holdener, EE1
Siegenthaler, P1
Ten Bokkel Huinink, W1
Bruntsch, U1
Renard, J1
van Glabbeke, M1
Weiss, RB2
Moquin, D1
Adams, JD1
Griffin, JD1
Zimbler, H1
Case, DC1
Warrell, RP1
Weick, JK1
Jones, SE2
Ryan, DH1
Cabanillas, F1
Legha, SS1
Bodey, GP1
Freireich, EJ1
Drewinko, B1
Yang, LY1
Barlogie, B1
Tan, CT1
Hancock, C1
Steinherz, PG1
Steinherz, LJ1
Sorell, M1
Chan, KW1
Mondora, A1
Miller, DR1
Horikoshi, N1
Ogawa, M1
Inagaki, J1
Ezaki, K1
Inoue, K1
Okabe, K1
Nagata, T1
Aiba, K1
Domyo, M1
Wong, KF1
Chan, JK1
Cheung, MM1
So, JC1
Backer, LC1
Allen, JW1
Harrington-Brock, K1
Campbell, JA1
DeMarini, DM1
Doerr, CL1
Howard, DR1
Kligerman, AD1
Moore, MM1
Hayat, M1
Ostronoff, M1
Gilles, E1
Zambon, E1
Baume, D1
Moran, A1
Carde, P1
Droz, JP1
Pico, JL1
Reiffers, J1
Marit, G1
Boiron, JM1
Rice, A1
Bernard, P1
Vezon, G1
Peters, WG1
Willemze, R1
Colly, LP1
Grillo-López, AJ1
Marsoni, S1
Posada, JG1
Hess, F1
Ross, BJ1
Cassileth, PA1
Gale, RP1
Dana, BW1
Coltman, C1
Stuckey, WJ1
McCredie, KB1
Piotti, P2
Villani, F2
Comazzi, R1
Lacaita, G1
Guindani, A1
Bajetta, E1
Buzzoni, R1
Viviani, S1
Gasparini, G1
Bonadonna, G1
Keller, AM1
Tsiatis, AA1
Neiman, RS1
Glick, JH1
Mann, RB1
Louie, AC1
Issell, BF1
Zittoun, R1

Reviews

3 reviews available for amsacrine and Lymphoma

ArticleYear
Amsacrine: a review.
    Leukemia research, 1986, Volume: 10, Issue:11

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical

1986
Amsacrine (AMSA)--a clinical review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4

    Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

1985
m-AMSA: a review of clinical data.
    European journal of cancer & clinical oncology, 1985, Volume: 21, Issue:6

    Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Drug Evalu

1985

Trials

4 trials available for amsacrine and Lymphoma

ArticleYear
Results of induction and consolidation treatment with intermediate and high-dose ara-C and m-AMSA containing regimens in patients with primarily failed or relapsed acute leukemia and non-Hodgkin's lymphoma.
    Scandinavian journal of haematology. Supplementum, 1986, Volume: 44

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemoth

1986
Amsacrine-associated cardiotoxicity: an analysis of 82 cases.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:6

    Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Arrhythmias, Cardiac; Cardiomyopathies

1986
Amsacrine: a review.
    Leukemia research, 1986, Volume: 10, Issue:11

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical

1986
Amsacrine (AMSA)--a clinical review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4

    Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

1985

Other Studies

18 other studies available for amsacrine and Lymphoma

ArticleYear
Phase II study of amsacrine in refractory lymphomas. A report of the EORTC Early Clinical Trials Group.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female;

1984
Electrocardiogram abnormalities induced by amsacrine.
    Cancer chemotherapy and pharmacology, 1983, Volume: 10, Issue:2

    Topics: Aminoacridines; Amsacrine; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Leukemia, Lymp

1983
m-AMSA: phase II trial in advanced lymphoma and leukemia.
    American journal of clinical oncology, 1984, Volume: 7, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marro

1984
Amsacrine (AMSA) in the treatment of lymphoma.
    Cancer treatment reports, 1983, Volume: 67, Issue:3

    Topics: Aminoacridines; Amsacrine; Drug Evaluation; Humans; Lymphoma

1983
Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study.
    Cancer treatment reports, 1983, Volume: 67, Issue:5

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Hodgkin

1983
Initial experience with AMSA as single agent treatment against malignant lymphoproliferative disorders.
    Blood, 1981, Volume: 57, Issue:3

    Topics: Aminoacridines; Amsacrine; Doxorubicin; Humans; Lymphoma; Remission, Spontaneous

1981
Lethal activity and kinetic response of cultured human cells to 4'-(9-acridinylamino)methanesulfon-m-anisidine.
    Cancer research, 1982, Volume: 42, Issue:1

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Line; Cell Surviva

1982
Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992) in children with acute leukemia and lymphoma.
    Cancer research, 1982, Volume: 42, Issue:4

    Topics: Acute Disease; Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool

1982
[Phase I-II studies of a new antineoplastic agent, 4'-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1982, Volume: 9, Issue:2

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe

1982
Bone marrow involvement by nasal NK cell lymphoma at diagnosis is uncommon.
    American journal of clinical pathology, 2001, Volume: 115, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bleomycin

2001
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
    Mutagenesis, 1990, Volume: 5, Issue:6

    Topics: Amsacrine; Animals; Bone Marrow; Bone Marrow Cells; Camptothecin; Cell Line; Chromatids; Chromosome

1990
Salvage therapy with methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI) for recurrent or refractory lymphoma.
    Cancer investigation, 1990, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dose-Respo

1990
The role of peripheral blood stem cells as rescue after myeloablative therapy.
    Bone marrow transplantation, 1989, Volume: 4 Suppl 1

    Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Combined Modality Ther

1989
Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:2

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; D

1986
Amsacrine: a new drug for hematological malignancies.
    European journal of cancer & clinical oncology, 1985, Volume: 21, Issue:1

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Humans; Intercalating Agents; Leukemia; Lymphoma

1985
Cardiac function evaluation in AMSA-treated patients.
    Tumori, 1985, Feb-28, Volume: 71, Issue:1

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Electrocardiography;

1985
Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas.
    Cancer treatment reports, 1985, Volume: 69, Issue:9

    Topics: Adult; Aminoacridines; Amsacrine; Drug Evaluation; Female; Hematologic Diseases; Hodgkin Disease; Hu

1985
m-AMSA in refractory lymphoma. A phase II trial of the Eastern Cooperative Oncology Group.
    American journal of clinical oncology, 1985, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Hodgkin

1985