amsacrine has been researched along with Lymphoma in 23 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty adult patients with relapsed or refractory malignant lymphoma underwent a Phase I-II trial of salvage chemotherapy combining methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI protocol)." | 7.68 | Salvage therapy with methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI) for recurrent or refractory lymphoma. ( Baume, D; Carde, P; Droz, JP; Gilles, E; Hayat, M; Moran, A; Ostronoff, M; Pico, JL; Zambon, E, 1990) |
| "We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas." | 7.67 | Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986) |
| "A total of 70 patients with malignant lymphomas refractory to one or more chemotherapeutic regimens were treated with iv amsacrines (m-AMSA and m-AMSA lactate)." | 7.67 | Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas. ( Bajetta, E; Bonadonna, G; Buzzoni, R; Gasparini, G; Piotti, P; Villani, F; Viviani, S, 1985) |
| "Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group." | 7.66 | Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983) |
| " In acute myelogenous leukemia, amsacrine is as effective as the two most active drugs, cytarabine and daunorubicin and can produce complete remissions in patients refractory to these drugs." | 6.15 | Amsacrine: a review. ( Cassileth, PA; Gale, RP, 1986) |
| "Amsacrine is an antileukemia drug being widely used in North America, Europe, Australia, and New Zealand." | 5.06 | Amsacrine-associated cardiotoxicity: an analysis of 82 cases. ( Grillo-López, AJ; Hess, F; Marsoni, S; Posada, JG; Ross, BJ; Weiss, RB, 1986) |
| "The present study was designed to determine and compare the clastogenicity of m-AMSA and camptothecin (CAMP) in vivo in mouse bone marrow and peripheral blood lymphocytes (PBLs), and in vitro in mouse lymphoma L5178Y cells." | 3.68 | Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro. ( Allen, JW; Backer, LC; Campbell, JA; DeMarini, DM; Doerr, CL; Harrington-Brock, K; Howard, DR; Kligerman, AD; Moore, MM, 1990) |
| "Thirty adult patients with relapsed or refractory malignant lymphoma underwent a Phase I-II trial of salvage chemotherapy combining methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI protocol)." | 3.68 | Salvage therapy with methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI) for recurrent or refractory lymphoma. ( Baume, D; Carde, P; Droz, JP; Gilles, E; Hayat, M; Moran, A; Ostronoff, M; Pico, JL; Zambon, E, 1990) |
| "We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas." | 3.67 | Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986) |
| "A total of 70 patients with malignant lymphomas refractory to one or more chemotherapeutic regimens were treated with iv amsacrines (m-AMSA and m-AMSA lactate)." | 3.67 | Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas. ( Bajetta, E; Bonadonna, G; Buzzoni, R; Gasparini, G; Piotti, P; Villani, F; Viviani, S, 1985) |
| "Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group." | 3.66 | Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983) |
| "Thirty previously treated adults with lymphoma received AMSA as single agent therapy." | 1.26 | Initial experience with AMSA as single agent treatment against malignant lymphoproliferative disorders. ( Bodey, GP; Cabanillas, F; Freireich, EJ; Legha, SS, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (86.96) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bramwell, VH | 1 |
| Holdener, EE | 1 |
| Siegenthaler, P | 1 |
| Ten Bokkel Huinink, W | 1 |
| Bruntsch, U | 1 |
| Renard, J | 1 |
| van Glabbeke, M | 1 |
| Weiss, RB | 2 |
| Moquin, D | 1 |
| Adams, JD | 1 |
| Griffin, JD | 1 |
| Zimbler, H | 1 |
| Case, DC | 1 |
| Warrell, RP | 1 |
| Weick, JK | 1 |
| Jones, SE | 2 |
| Ryan, DH | 1 |
| Cabanillas, F | 1 |
| Legha, SS | 1 |
| Bodey, GP | 1 |
| Freireich, EJ | 1 |
| Drewinko, B | 1 |
| Yang, LY | 1 |
| Barlogie, B | 1 |
| Tan, CT | 1 |
| Hancock, C | 1 |
| Steinherz, PG | 1 |
| Steinherz, LJ | 1 |
| Sorell, M | 1 |
| Chan, KW | 1 |
| Mondora, A | 1 |
| Miller, DR | 1 |
| Horikoshi, N | 1 |
| Ogawa, M | 1 |
| Inagaki, J | 1 |
| Ezaki, K | 1 |
| Inoue, K | 1 |
| Okabe, K | 1 |
| Nagata, T | 1 |
| Aiba, K | 1 |
| Domyo, M | 1 |
| Wong, KF | 1 |
| Chan, JK | 1 |
| Cheung, MM | 1 |
| So, JC | 1 |
| Backer, LC | 1 |
| Allen, JW | 1 |
| Harrington-Brock, K | 1 |
| Campbell, JA | 1 |
| DeMarini, DM | 1 |
| Doerr, CL | 1 |
| Howard, DR | 1 |
| Kligerman, AD | 1 |
| Moore, MM | 1 |
| Hayat, M | 1 |
| Ostronoff, M | 1 |
| Gilles, E | 1 |
| Zambon, E | 1 |
| Baume, D | 1 |
| Moran, A | 1 |
| Carde, P | 1 |
| Droz, JP | 1 |
| Pico, JL | 1 |
| Reiffers, J | 1 |
| Marit, G | 1 |
| Boiron, JM | 1 |
| Rice, A | 1 |
| Bernard, P | 1 |
| Vezon, G | 1 |
| Peters, WG | 1 |
| Willemze, R | 1 |
| Colly, LP | 1 |
| Grillo-López, AJ | 1 |
| Marsoni, S | 1 |
| Posada, JG | 1 |
| Hess, F | 1 |
| Ross, BJ | 1 |
| Cassileth, PA | 1 |
| Gale, RP | 1 |
| Dana, BW | 1 |
| Coltman, C | 1 |
| Stuckey, WJ | 1 |
| McCredie, KB | 1 |
| Piotti, P | 2 |
| Villani, F | 2 |
| Comazzi, R | 1 |
| Lacaita, G | 1 |
| Guindani, A | 1 |
| Bajetta, E | 1 |
| Buzzoni, R | 1 |
| Viviani, S | 1 |
| Gasparini, G | 1 |
| Bonadonna, G | 1 |
| Keller, AM | 1 |
| Tsiatis, AA | 1 |
| Neiman, RS | 1 |
| Glick, JH | 1 |
| Mann, RB | 1 |
| Louie, AC | 1 |
| Issell, BF | 1 |
| Zittoun, R | 1 |
3 reviews available for amsacrine and Lymphoma
| Article | Year |
|---|---|
Amsacrine: a review.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical | 1986 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
m-AMSA: a review of clinical data.
Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Drug Evalu | 1985 |
4 trials available for amsacrine and Lymphoma
| Article | Year |
|---|---|
Results of induction and consolidation treatment with intermediate and high-dose ara-C and m-AMSA containing regimens in patients with primarily failed or relapsed acute leukemia and non-Hodgkin's lymphoma.
Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemoth | 1986 |
Amsacrine-associated cardiotoxicity: an analysis of 82 cases.
Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Arrhythmias, Cardiac; Cardiomyopathies | 1986 |
Amsacrine: a review.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical | 1986 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
18 other studies available for amsacrine and Lymphoma
| Article | Year |
|---|---|
Phase II study of amsacrine in refractory lymphomas. A report of the EORTC Early Clinical Trials Group.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; | 1984 |
Electrocardiogram abnormalities induced by amsacrine.
Topics: Aminoacridines; Amsacrine; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Leukemia, Lymp | 1983 |
m-AMSA: phase II trial in advanced lymphoma and leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marro | 1984 |
Amsacrine (AMSA) in the treatment of lymphoma.
Topics: Aminoacridines; Amsacrine; Drug Evaluation; Humans; Lymphoma | 1983 |
Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Hodgkin | 1983 |
Initial experience with AMSA as single agent treatment against malignant lymphoproliferative disorders.
Topics: Aminoacridines; Amsacrine; Doxorubicin; Humans; Lymphoma; Remission, Spontaneous | 1981 |
Lethal activity and kinetic response of cultured human cells to 4'-(9-acridinylamino)methanesulfon-m-anisidine.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Line; Cell Surviva | 1982 |
Phase II study of 4'-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992) in children with acute leukemia and lymphoma.
Topics: Acute Disease; Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool | 1982 |
[Phase I-II studies of a new antineoplastic agent, 4'-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA)].
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Fe | 1982 |
Bone marrow involvement by nasal NK cell lymphoma at diagnosis is uncommon.
Topics: Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bleomycin | 2001 |
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
Topics: Amsacrine; Animals; Bone Marrow; Bone Marrow Cells; Camptothecin; Cell Line; Chromatids; Chromosome | 1990 |
Salvage therapy with methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide (MAMI) for recurrent or refractory lymphoma.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dose-Respo | 1990 |
The role of peripheral blood stem cells as rescue after myeloablative therapy.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Combined Modality Ther | 1989 |
Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; D | 1986 |
Amsacrine: a new drug for hematological malignancies.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Humans; Intercalating Agents; Leukemia; Lymphoma | 1985 |
Cardiac function evaluation in AMSA-treated patients.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Electrocardiography; | 1985 |
Phase II study with amsacrines (m-AMSA and m-AMSA lactate) in refractory lymphomas.
Topics: Adult; Aminoacridines; Amsacrine; Drug Evaluation; Female; Hematologic Diseases; Hodgkin Disease; Hu | 1985 |
m-AMSA in refractory lymphoma. A phase II trial of the Eastern Cooperative Oncology Group.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Hodgkin | 1985 |