amsacrine has been researched along with Local Neoplasm Recurrence in 11 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although only a few patients with head and neck cancer have been included in broad phase II studies, several responses have been reported, but detailed data concerning responders are lacking." | 2.68 | A two-step reevaluation of high-dose amsacrine for advanced carcinoma of the upper aerodigestive tract: a pilot phase II study. ( Jelic, S; Jovanovic, V; Kovcin, V; Milanovic, N; Nikolic-Tomasevic, Z; Tomasevic, Z; Vlajic, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pfrepper, C | 1 |
| Klink, A | 1 |
| Behre, G | 1 |
| Schenk, T | 1 |
| Franke, GN | 1 |
| Jentzsch, M | 1 |
| Schwind, S | 1 |
| Al-Ali, HK | 1 |
| Hochhaus, A | 1 |
| Niederwieser, D | 1 |
| Sayer, HG | 1 |
| Friedell, GH | 1 |
| Witherspoon, RP | 1 |
| Legha, SS | 2 |
| Reimer, RR | 1 |
| Talley, RW | 1 |
| Stuckey, WJ | 1 |
| Dixon, DO | 1 |
| McCracken, JD | 1 |
| Stephens, RL | 2 |
| Oishi, N | 1 |
| Hilgers, RD | 1 |
| Boutselis, JG | 1 |
| Hannigan, EV | 1 |
| Tranum, BL | 1 |
| Surwit, E | 1 |
| Arlin, ZA | 1 |
| Flomenberg, N | 1 |
| Gee, TS | 1 |
| Kempin, SJ | 1 |
| Dellaquila, C | 1 |
| Mertelsmann, R | 1 |
| Straus, DJ | 1 |
| Young, CW | 1 |
| Clarkson, BD | 1 |
| Steuber, CP | 1 |
| Krischer, J | 1 |
| Holbrook, T | 1 |
| Camitta, B | 1 |
| Land, V | 1 |
| Sexauer, C | 1 |
| Mahoney, D | 1 |
| Weinstein, H | 1 |
| Jelic, S | 1 |
| Nikolic-Tomasevic, Z | 1 |
| Kovcin, V | 1 |
| Milanovic, N | 1 |
| Tomasevic, Z | 1 |
| Jovanovic, V | 1 |
| Vlajic, M | 1 |
| Meloni, G | 1 |
| Vignetti, M | 1 |
| De Fabritiis, P | 1 |
| Petti, MC | 1 |
| Pinto, MR | 1 |
| Testi, AM | 1 |
| Vegna, ML | 1 |
| Mandelli, F | 1 |
| Marit, G | 1 |
| Cony, P | 1 |
| Duclos, F | 1 |
| Puntous, M | 1 |
| Broustet, A | 1 |
| Reiffers, J | 1 |
| Carter, C | 1 |
| Winfield, DA | 1 |
| Piotti, P | 1 |
| Villani, F | 1 |
| Comazzi, R | 1 |
| Lacaita, G | 1 |
| Guindani, A | 1 |
4 trials available for amsacrine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Bladder cancer chemotherapy studies supported by the National Bladder Cancer Project.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma in Situ; Carcinoma, Papillary; Ci | 1983 |
Therapy of refractory or recurrent childhood acute myeloid leukemia using amsacrine and etoposide with or without azacitidine: a Pediatric Oncology Group randomized phase II study.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Ch | 1996 |
A two-step reevaluation of high-dose amsacrine for advanced carcinoma of the upper aerodigestive tract: a pilot phase II study.
Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease-Free Survival; Dose | 1997 |
BAVC regimen in CR AML patients.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplant | 1991 |
7 other studies available for amsacrine and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Risk factors for outcome in refractory acute myeloid leukemia patients treated with a combination of fludarabine, cytarabine, and amsacrine followed by a reduced-intensity conditioning and allogeneic stem cell transplantation.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; C | 2016 |
Phase II trial of amsacrine in metastatic or locally recurrent squamous cell carcinoma from head and neck primaries: a Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Animals; Carcinoma, Squamous Cell; Dogs; Drug Ev | 1984 |
Amsacrine (m-AMSA) in squamous cell carcinoma of the uterine cervix: a Southwest Oncology Group study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; L | 1984 |
Treatment of acute leukemia in relapse with 4'(9-acridinylamino) methanesulfon-m-anisidide (AMSA) in combination with cytosine arabinoside and thioguanine.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Chemical a | 1981 |
Treatment of relapsed or refractory acute leukemia: comparison of two different regimens.
Topics: Acute Disease; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transpl | 1990 |
Factor X deficiency during treatment of relapsed acute myeloid leukaemia with amsacrine.
Topics: Adult; Amsacrine; Blood Transfusion; Drug Therapy, Combination; Etoposide; Factor IX; Factor X; Fact | 1988 |
Cardiac function evaluation in AMSA-treated patients.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Electrocardiography; | 1985 |