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amsacrine and Leukocytopenia

amsacrine has been researched along with Leukocytopenia in 26 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas."7.67Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986)
"Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group."7.66Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983)
"We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas."3.67Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986)
"Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group."3.66Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983)
"Thus, the CR rate for relapsed ANLL patients who received the higher doses of both agents was 40% (13 of 33)."1.28Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine. ( Dahl, GV; Grier, HE; Kalwinsky, DK; Mason, C; Mirro, J; Murphy, SB; Santana, VM, 1989)
"Leukopenia was the dose-limiting toxicity with 7."1.27The treatment of melanoma with m-AMSA. A Cancer and Leukemia Group B phase II study. ( Amrein, PC; Carey, RW; Coleman, M; Green, MR; Holland, JF; Kennedy, BJ; Poulin, RF; Richards, F; Weil, M; Weinberg, V, 1984)
"Amsacrine was administered as a single i."1.27Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group. ( Alberto, P; Bramwell, V; Cavalli, F; De Jager, R; Hansen, HH; Joss, R; Klepp, O; Renard, J; Rozencweig, M; Siegenthaler, P; van Glabbeke, M, 1983)
"The antitumor activity and toxic effect of AMSA were studied in Lewis lung carcinoma (3LL) at various stages of growth."1.27Influence of scheduling on therapeutic and toxic effect of AMSA in Lewis lung carcinoma. ( Badaracco, G; Greco, C; Zupi, G, 1983)
"Leukopenia was found to be dose-limiting; thrombocytopenia and anemia were also observed."1.26Phase II study of m-AMSA in advances malignant melanoma. ( Arseneau, JC; Kuperminc, M; Probert, JC; Wolter, JM, 1982)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199026 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bukowski, RM2
Legha, S1
Saiki, J1
Eyre, HJ1
O'Bryan, R1
Cheng, E1
Lightdale, C1
Young, C1
Yagoda, A3
Fortner, J1
Golbey, R1
Leichman, LP1
Rivkin, SE1
Falkson, G1
MacIntyre, JM1
Schutt, AJ1
Coetzer, B1
Johnson, LA1
Simson, IW1
Douglass, HO1
Hilgers, RD2
Legha, SS3
Boutselis, JG1
Hannigan, EV1
Stephens, RL1
Tranum, BL1
Surwit, E1
Amrein, PC2
Poulin, RF2
Coleman, M2
Richards, F2
Weil, M1
Kennedy, BJ2
Carey, RW1
Green, MR1
Holland, JF2
Weinberg, V1
Bramwell, VH1
Holdener, EE1
Siegenthaler, P3
Ten Bokkel Huinink, W1
Bruntsch, U1
Renard, J2
van Glabbeke, M2
De Jager, R1
Cavalli, F1
Klepp, O1
Bramwell, V1
Joss, R1
Alberto, P1
Rozencweig, M1
Hansen, HH2
Panettiere, FJ1
Alberts, DS1
Natale, RB1
Blumenreich, MS1
Watson, RC1
Weick, JK1
Jones, SE2
Ryan, DH1
Greco, C1
Zupi, G1
Badaracco, G1
Berkowitz, I1
Green, M1
Herschkopf, R1
Rafla, S1
Schneider, RJ2
Woodcock, TM2
Young, CW1
Goldsmith, MA1
Bhardwaj, S1
Ohnuma, T1
Greenspan, EM1
Sordillo, PP1
Magill, GB1
Gralla, RJ1
Kelsen, DP1
Dombernowsky, P1
Somers, R1
Buzdar, AU1
Hortobagyi, GN1
Powell, KC1
Blumenschein, GR1
Bodey, GP1
Arseneau, JC1
Wolter, JM1
Probert, JC1
Kuperminc, M1
Drelichman, A1
Decker, DA1
Al-Sarraf, M1
Dhabuwala, CB1
Issell, BF1
Kearsley, JH1
Page, JP1
Levi, JA1
Woods, RL1
Tattersall, MH1
Fox, RM1
Coates, AS1
Mukaiyama, T1
Ogawa, M1
Horikoshi, N1
Inoue, K1
Fukutani, H1
Tabata, M1
Hirano, A1
Mizunuma, N1
Itami, S1
Mirro, J1
Kalwinsky, DK1
Grier, HE1
Santana, VM1
Mason, C1
Murphy, SB1
Dahl, GV1
Dana, BW1
Coltman, C1
Stuckey, WJ1

Trials

1 trial available for amsacrine and Leukocytopenia

ArticleYear
Neocarzinostatin versus m-AMSA or doxorubicin in hepatocellular carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:6

    Topics: Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Clinical Trials a

1984

Other Studies

25 other studies available for amsacrine and Leukocytopenia

ArticleYear
Phase II trial of m-AMSA in hepatocellular carcinoma: a Southwest Oncology Group Study.
    Cancer treatment reports, 1982, Volume: 66, Issue:8

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Hepatocellular

1982
Phase II trial of (m-AMSA) 4'-9-(acridinylamino)-methanesulfon-m-aniside in primary liver cancer.
    American journal of clinical oncology, 1983, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Hepatocellular

1983
Phase II trial of m-AMSA in gallbladder and cholangiocarcinoma: a Southwest Oncology Group Study.
    European journal of cancer & clinical oncology, 1983, Volume: 19, Issue:6

    Topics: Adenoma, Bile Duct; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bile Duct Neoplas

1983
Amsacrine (m-AMSA) in squamous cell carcinoma of the uterine cervix: a Southwest Oncology Group study.
    Cancer treatment reports, 1984, Volume: 68, Issue:2

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; L

1984
The treatment of melanoma with m-AMSA. A Cancer and Leukemia Group B phase II study.
    American journal of clinical oncology, 1984, Volume: 7, Issue:3

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk

1984
Phase II study of amsacrine in refractory lymphomas. A report of the EORTC Early Clinical Trials Group.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female;

1984
Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group.
    European journal of cancer & clinical oncology, 1983, Volume: 19, Issue:2

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Blood Cell Count; Drug Administration

1983
m-AMSA in epithelial carcinoma of the ovary. A Southwest Oncology Group study.
    American journal of clinical oncology, 1983, Volume: 6, Issue:3

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma; Drug Evaluation; Female; Humans; Leukop

1983
Phase II trial of amsacrine (AMSA) in urinary bladder cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:4

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk

1983
Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study.
    Cancer treatment reports, 1983, Volume: 67, Issue:5

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Hodgkin

1983
Influence of scheduling on therapeutic and toxic effect of AMSA in Lewis lung carcinoma.
    Cancer chemotherapy and pharmacology, 1983, Volume: 11, Issue:1

    Topics: Aminoacridines; Amsacrine; Animals; Drug Administration Schedule; Female; Hematopoiesis; Leukopenia;

1983
Phase II study of amsacrine in metastatic renal cell carcinoma: a Cancer and Leukemia Group B study.
    Cancer treatment reports, 1983, Volume: 67, Issue:11

    Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Bone Marrow; Drug Evaluation; Female; Humans

1983
Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.
    Cancer treatment reports, 1980, Volume: 64, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Kidney Neop

1980
Phase I evaluation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) by a weekly iv dose schedule.
    Cancer treatment reports, 1980, Volume: 64, Issue:1

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Dru

1980
Phase I study of m-AMSA in patients with solid tumors and leukemias.
    Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Chemical and Drug Induced Liver I

1980
Phase II evaluation of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-AMSA) in patients with gastric adenocarcinoma.
    American journal of clinical oncology, 1982, Volume: 5, Issue:3

    Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Anemia; Antineoplastic Agents; Drug Evaluation; Humans; L

1982
Phase II trial of amsacrine (m-AMSA) in advanced ovarian carcinoma.
    European journal of cancer & clinical oncology, 1982, Volume: 18, Issue:1

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk

1982
AMSA and peptichemio in the treatment of advances metastatic breast cancer: a phase II study.
    American journal of clinical oncology, 1982, Volume: 5, Issue:4

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Dr

1982
Phase II study of m-AMSA in advances malignant melanoma.
    American journal of clinical oncology, 1982, Volume: 5, Issue:4

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Leukopenia; Male; Melanoma;

1982
M-AMSA in disseminated prostatic carcinoma: a phase II study.
    Cancer treatment reports, 1982, Volume: 66, Issue:11

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Humans; Leukopenia;

1982
Amsacrine (AMSA).
    Cancer treatment reviews, 1980, Volume: 7, Issue:2

    Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Dogs; Dose-Response Rel

1980
Meta AMSA (m-AMSA) in patients with advanced ovarian carcinoma.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1982, Volume: 22, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Fema

1982
[4'-(9-acridinylamino)-methanesulfon-m-aniside (AMSA) combination salvage therapy in refractory acute non-lymphocytic leukemia in adults].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:5

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun

1989
Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; C

1989
Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:2

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; D

1986