amsacrine has been researched along with Leukocytopenia in 26 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas." | 7.67 | Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986) |
| "Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group." | 7.66 | Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983) |
| "We tested the combination of cisplatin, amsacrine, and mitoguazone as salvage treatment for patients with advanced unfavorable non-Hodgkin's lymphomas." | 3.67 | Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study. ( Coltman, C; Dana, BW; Jones, SE; Stuckey, WJ, 1986) |
| "Amsacrine was administered to 73 evaluable patients with previously treated malignant lymphoma in the Southwest Oncology Group." | 3.66 | Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study. ( Jones, SE; Ryan, DH; Weick, JK, 1983) |
| "Thus, the CR rate for relapsed ANLL patients who received the higher doses of both agents was 40% (13 of 33)." | 1.28 | Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine. ( Dahl, GV; Grier, HE; Kalwinsky, DK; Mason, C; Mirro, J; Murphy, SB; Santana, VM, 1989) |
| "Leukopenia was the dose-limiting toxicity with 7." | 1.27 | The treatment of melanoma with m-AMSA. A Cancer and Leukemia Group B phase II study. ( Amrein, PC; Carey, RW; Coleman, M; Green, MR; Holland, JF; Kennedy, BJ; Poulin, RF; Richards, F; Weil, M; Weinberg, V, 1984) |
| "Amsacrine was administered as a single i." | 1.27 | Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group. ( Alberto, P; Bramwell, V; Cavalli, F; De Jager, R; Hansen, HH; Joss, R; Klepp, O; Renard, J; Rozencweig, M; Siegenthaler, P; van Glabbeke, M, 1983) |
| "The antitumor activity and toxic effect of AMSA were studied in Lewis lung carcinoma (3LL) at various stages of growth." | 1.27 | Influence of scheduling on therapeutic and toxic effect of AMSA in Lewis lung carcinoma. ( Badaracco, G; Greco, C; Zupi, G, 1983) |
| "Leukopenia was found to be dose-limiting; thrombocytopenia and anemia were also observed." | 1.26 | Phase II study of m-AMSA in advances malignant melanoma. ( Arseneau, JC; Kuperminc, M; Probert, JC; Wolter, JM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bukowski, RM | 2 |
| Legha, S | 1 |
| Saiki, J | 1 |
| Eyre, HJ | 1 |
| O'Bryan, R | 1 |
| Cheng, E | 1 |
| Lightdale, C | 1 |
| Young, C | 1 |
| Yagoda, A | 3 |
| Fortner, J | 1 |
| Golbey, R | 1 |
| Leichman, LP | 1 |
| Rivkin, SE | 1 |
| Falkson, G | 1 |
| MacIntyre, JM | 1 |
| Schutt, AJ | 1 |
| Coetzer, B | 1 |
| Johnson, LA | 1 |
| Simson, IW | 1 |
| Douglass, HO | 1 |
| Hilgers, RD | 2 |
| Legha, SS | 3 |
| Boutselis, JG | 1 |
| Hannigan, EV | 1 |
| Stephens, RL | 1 |
| Tranum, BL | 1 |
| Surwit, E | 1 |
| Amrein, PC | 2 |
| Poulin, RF | 2 |
| Coleman, M | 2 |
| Richards, F | 2 |
| Weil, M | 1 |
| Kennedy, BJ | 2 |
| Carey, RW | 1 |
| Green, MR | 1 |
| Holland, JF | 2 |
| Weinberg, V | 1 |
| Bramwell, VH | 1 |
| Holdener, EE | 1 |
| Siegenthaler, P | 3 |
| Ten Bokkel Huinink, W | 1 |
| Bruntsch, U | 1 |
| Renard, J | 2 |
| van Glabbeke, M | 2 |
| De Jager, R | 1 |
| Cavalli, F | 1 |
| Klepp, O | 1 |
| Bramwell, V | 1 |
| Joss, R | 1 |
| Alberto, P | 1 |
| Rozencweig, M | 1 |
| Hansen, HH | 2 |
| Panettiere, FJ | 1 |
| Alberts, DS | 1 |
| Natale, RB | 1 |
| Blumenreich, MS | 1 |
| Watson, RC | 1 |
| Weick, JK | 1 |
| Jones, SE | 2 |
| Ryan, DH | 1 |
| Greco, C | 1 |
| Zupi, G | 1 |
| Badaracco, G | 1 |
| Berkowitz, I | 1 |
| Green, M | 1 |
| Herschkopf, R | 1 |
| Rafla, S | 1 |
| Schneider, RJ | 2 |
| Woodcock, TM | 2 |
| Young, CW | 1 |
| Goldsmith, MA | 1 |
| Bhardwaj, S | 1 |
| Ohnuma, T | 1 |
| Greenspan, EM | 1 |
| Sordillo, PP | 1 |
| Magill, GB | 1 |
| Gralla, RJ | 1 |
| Kelsen, DP | 1 |
| Dombernowsky, P | 1 |
| Somers, R | 1 |
| Buzdar, AU | 1 |
| Hortobagyi, GN | 1 |
| Powell, KC | 1 |
| Blumenschein, GR | 1 |
| Bodey, GP | 1 |
| Arseneau, JC | 1 |
| Wolter, JM | 1 |
| Probert, JC | 1 |
| Kuperminc, M | 1 |
| Drelichman, A | 1 |
| Decker, DA | 1 |
| Al-Sarraf, M | 1 |
| Dhabuwala, CB | 1 |
| Issell, BF | 1 |
| Kearsley, JH | 1 |
| Page, JP | 1 |
| Levi, JA | 1 |
| Woods, RL | 1 |
| Tattersall, MH | 1 |
| Fox, RM | 1 |
| Coates, AS | 1 |
| Mukaiyama, T | 1 |
| Ogawa, M | 1 |
| Horikoshi, N | 1 |
| Inoue, K | 1 |
| Fukutani, H | 1 |
| Tabata, M | 1 |
| Hirano, A | 1 |
| Mizunuma, N | 1 |
| Itami, S | 1 |
| Mirro, J | 1 |
| Kalwinsky, DK | 1 |
| Grier, HE | 1 |
| Santana, VM | 1 |
| Mason, C | 1 |
| Murphy, SB | 1 |
| Dahl, GV | 1 |
| Dana, BW | 1 |
| Coltman, C | 1 |
| Stuckey, WJ | 1 |
1 trial available for amsacrine and Leukocytopenia
| Article | Year |
|---|---|
Neocarzinostatin versus m-AMSA or doxorubicin in hepatocellular carcinoma.
Topics: Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Clinical Trials a | 1984 |
25 other studies available for amsacrine and Leukocytopenia
| Article | Year |
|---|---|
Phase II trial of m-AMSA in hepatocellular carcinoma: a Southwest Oncology Group Study.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Hepatocellular | 1982 |
Phase II trial of (m-AMSA) 4'-9-(acridinylamino)-methanesulfon-m-aniside in primary liver cancer.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Hepatocellular | 1983 |
Phase II trial of m-AMSA in gallbladder and cholangiocarcinoma: a Southwest Oncology Group Study.
Topics: Adenoma, Bile Duct; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bile Duct Neoplas | 1983 |
Amsacrine (m-AMSA) in squamous cell carcinoma of the uterine cervix: a Southwest Oncology Group study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; L | 1984 |
The treatment of melanoma with m-AMSA. A Cancer and Leukemia Group B phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk | 1984 |
Phase II study of amsacrine in refractory lymphomas. A report of the EORTC Early Clinical Trials Group.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; | 1984 |
Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Blood Cell Count; Drug Administration | 1983 |
m-AMSA in epithelial carcinoma of the ovary. A Southwest Oncology Group study.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma; Drug Evaluation; Female; Humans; Leukop | 1983 |
Phase II trial of amsacrine (AMSA) in urinary bladder cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk | 1983 |
Phase II study of amsacrine (m-AMSA) in advanced lymphomas: a Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Hodgkin | 1983 |
Influence of scheduling on therapeutic and toxic effect of AMSA in Lewis lung carcinoma.
Topics: Aminoacridines; Amsacrine; Animals; Drug Administration Schedule; Female; Hematopoiesis; Leukopenia; | 1983 |
Phase II study of amsacrine in metastatic renal cell carcinoma: a Cancer and Leukemia Group B study.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Bone Marrow; Drug Evaluation; Female; Humans | 1983 |
Phase II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) in patients with metastatic hypernephroma.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Kidney Neop | 1980 |
Phase I evaluation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) by a weekly iv dose schedule.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Dru | 1980 |
Phase I study of m-AMSA in patients with solid tumors and leukemias.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Chemical and Drug Induced Liver I | 1980 |
Phase II evaluation of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-AMSA) in patients with gastric adenocarcinoma.
Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Anemia; Antineoplastic Agents; Drug Evaluation; Humans; L | 1982 |
Phase II trial of amsacrine (m-AMSA) in advanced ovarian carcinoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leuk | 1982 |
AMSA and peptichemio in the treatment of advances metastatic breast cancer: a phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Dr | 1982 |
Phase II study of m-AMSA in advances malignant melanoma.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Humans; Leukopenia; Male; Melanoma; | 1982 |
M-AMSA in disseminated prostatic carcinoma: a phase II study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Humans; Leukopenia; | 1982 |
Amsacrine (AMSA).
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Dogs; Dose-Response Rel | 1980 |
Meta AMSA (m-AMSA) in patients with advanced ovarian carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Fema | 1982 |
[4'-(9-acridinylamino)-methanesulfon-m-aniside (AMSA) combination salvage therapy in refractory acute non-lymphocytic leukemia in adults].
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun | 1989 |
Effective reinduction therapy for childhood acute nonlymphoid leukemia using simultaneous continuous infusions of teniposide and amsacrine.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; C | 1989 |
Salvage treatment of unfavorable non-Hodgkin's lymphoma with cisplatin, amsacrine, and mitoguazone: a Southwest Oncology Group Pilot Study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; D | 1986 |