amsacrine has been researched along with Leukemia, Promyelocytic, Acute in 23 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-nine patients with untreated acute promyelocytic leukemia (APL) were randomly allocated to receive rubidazone (zorubicin) 200 mg/m2/d, days 1 to 4 plus cytarabine (Ara C) 200 mg/m2/d, days 1 to 7 (arm A, 21 patients), or amsacrine (Amsa) 150 mg/m2/d, days 1 to 4 plus Ara C 200 mg/m2/d, days 1 to 7 (arm B, 18 patients)." | 9.07 | A randomized trial of amsacrine and rubidazone in 39 patients with acute promyelocytic leukemia. ( Bordessoule, D; Castaigne, S; Colombat, P; Fenaux, P; Guy, H; Le Gall, E; Leblay, R; Leverger, G; Tertian, G; Tilly, H, 1991) |
| "Thirty-nine patients with untreated acute promyelocytic leukemia (APL) were randomly allocated to receive rubidazone (zorubicin) 200 mg/m2/d, days 1 to 4 plus cytarabine (Ara C) 200 mg/m2/d, days 1 to 7 (arm A, 21 patients), or amsacrine (Amsa) 150 mg/m2/d, days 1 to 4 plus Ara C 200 mg/m2/d, days 1 to 7 (arm B, 18 patients)." | 5.07 | A randomized trial of amsacrine and rubidazone in 39 patients with acute promyelocytic leukemia. ( Bordessoule, D; Castaigne, S; Colombat, P; Fenaux, P; Guy, H; Le Gall, E; Leblay, R; Leverger, G; Tertian, G; Tilly, H, 1991) |
| "Fifty-seven adult patients with acute promyelocytic leukemia (APL) were treated between 1974 and 1984 with daunorubicin (DNR) or 4-(9-acridinylamino)methanesulfan-m-anisidide (AMSA) in combination with arabinosylcytosine (Ara-C) and 6-thioguanine (TG); they also received prophylactic heparin." | 5.06 | Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital. ( Clarkson, BD; Cunningham, I; Gee, TS; Kempin, SJ; Naval, AN; Reich, LM, 1989) |
| "Laboratory evidence of disseminated intravascular coagulation (DIC) and/or fibrinolysis is present in the majority of patients with acute promyelocytic leukemia (APL)." | 2.68 | Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid. ( Escudier, SM; Estey, EH; Kantarjian, HM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 15 (65.22) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelgawad, MA | 1 |
| Mohamed, FEA | 1 |
| Lamie, PF | 1 |
| Bukhari, SNA | 1 |
| Al-Sanea, MM | 1 |
| Musa, A | 1 |
| Elmowafy, M | 1 |
| Nayl, AA | 1 |
| Karam Farag, A | 1 |
| Ali, SM | 1 |
| Shaker, ME | 1 |
| Omar, HA | 1 |
| Abdelhameid, MK | 1 |
| Kandeel, MM | 1 |
| Fouillard, L | 1 |
| Labopin, M | 1 |
| Meloni, G | 2 |
| Polge, E | 1 |
| Gorin, NC | 1 |
| Frassoni, F | 1 |
| Capria, S | 1 |
| Latagliata, R | 1 |
| Avvisati, G | 1 |
| Breccia, M | 1 |
| Cimino, G | 1 |
| Diverio, D | 1 |
| Petti, MC | 1 |
| Solary, E | 1 |
| Bertrand, R | 1 |
| Kohn, KW | 1 |
| Pommier, Y | 1 |
| Ganapathi, R | 1 |
| Zwelling, L | 1 |
| Constantinou, A | 2 |
| Ford, J | 1 |
| Grabowski, D | 1 |
| Boege, F | 2 |
| Gieseler, F | 2 |
| Biersack, H | 2 |
| Meyer, P | 2 |
| Ghaddar, HM | 1 |
| Pierce, S | 1 |
| Kantarjian, HM | 2 |
| Freireich, EJ | 1 |
| Keating, MJ | 1 |
| Estey, EH | 2 |
| Escudier, SM | 1 |
| Thomas, X | 1 |
| Fiere, D | 1 |
| Archimbaud, E | 1 |
| Wan, Y | 1 |
| Wu, D | 1 |
| Hotz, MA | 1 |
| Del Bino, G | 1 |
| Lassota, P | 1 |
| Traganos, F | 1 |
| Darzynkiewicz, Z | 1 |
| Kaufmann, SH | 1 |
| Arlin, ZA | 1 |
| Feldman, EJ | 1 |
| Cook, P | 1 |
| Ahmed, T | 1 |
| Mittelman, A | 1 |
| Chun, HG | 1 |
| Puccio, C | 1 |
| Helson, L | 1 |
| Fenaux, P | 1 |
| Tertian, G | 1 |
| Castaigne, S | 1 |
| Tilly, H | 1 |
| Leverger, G | 1 |
| Guy, H | 1 |
| Bordessoule, D | 1 |
| Leblay, R | 1 |
| Le Gall, E | 1 |
| Colombat, P | 1 |
| Zwelling, LA | 3 |
| Mayes, J | 3 |
| Hinds, M | 3 |
| Chan, D | 3 |
| Altschuler, E | 1 |
| Carroll, B | 1 |
| Parker, E | 2 |
| Deisseroth, K | 1 |
| Radcliffe, A | 2 |
| Seligman, M | 1 |
| Gorsky, LD | 1 |
| Morin, MJ | 1 |
| Ling, YH | 1 |
| Andersson, BS | 1 |
| Nelson, JA | 1 |
| Henning-Chubb, C | 1 |
| Huberman, E | 1 |
| Sie, KL | 1 |
| Silberman, L | 1 |
| Beran, M | 1 |
| Blick, M | 2 |
| Mukaiyama, T | 1 |
| Ogawa, M | 1 |
| Horikoshi, N | 1 |
| Inoue, K | 1 |
| Fukutani, H | 1 |
| Tabata, M | 1 |
| Hirano, A | 1 |
| Mizunuma, N | 1 |
| Itami, S | 1 |
| Silberman, LE | 1 |
| Cunningham, I | 1 |
| Gee, TS | 1 |
| Reich, LM | 1 |
| Kempin, SJ | 1 |
| Naval, AN | 1 |
| Clarkson, BD | 1 |
5 trials available for amsacrine and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
BAVC regimen and autologous bone marrow transplantation for APL patients in second molecular remission: updated results.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplant | 2005 |
Amsacrine and continuous-infusion high-dose cytosine arabinoside as induction therapy for patients with newly-diagnosed acute myelogenous leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Co | 1996 |
Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid.
Topics: Adult; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemot | 1996 |
A randomized trial of amsacrine and rubidazone in 39 patients with acute promyelocytic leukemia.
Topics: Adolescent; Adult; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Prot | 1991 |
Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun | 1989 |
18 other studies available for amsacrine and Leukemia, Promyelocytic, Acute
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells.
Topics: Amsacrine; Antineoplastic Agents; Apoptosis; Cell Proliferation; DNA Topoisomerases, Type II; fms-Li | 2022 |
Comparison of BAVC to BuCy regimens in autologous stem cell transplantation for adult patients with acute myeloid leukemia.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Carmus | 2004 |
Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors.
Topics: Amsacrine; Apoptosis; Camptothecin; Cell Differentiation; DNA; DNA Damage; Etoposide; Humans; Leukem | 1993 |
Altered phosphorylation, biosynthesis and degradation of the 170 kDa isoform of topoisomerase II in amsacrine-resistant human leukemia cells.
Topics: Amsacrine; Autoradiography; DNA Topoisomerases, Type II; Drug Resistance; Electrophoresis, Polyacryl | 1993 |
Different functional states of topoisomerase II can be discriminated by orthovanadate sensitivity in multi-drug resistant human leukemic cells.
Topics: Adenosine Triphosphate; Allosteric Site; Amsacrine; Chromatography, Ion Exchange; Clone Cells; DNA T | 1993 |
Influence of increased body mass index on drug toxicity in patients with acute promyelocytic leukemia.
Topics: Adult; Aged; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; | 1998 |
[Studies on programmed cell death induced by amsacrine and expression of bcl-2 in leukemia cell lines].
Topics: Amsacrine; Antineoplastic Agents; Apoptosis; Gene Expression; Genes, bcl-2; HL-60 Cells; Humans; Leu | 1997 |
The measurement of nuclear topoisomerase II inhibition in vitro: a possible tool for detecting resistance on a subcellular level in haematopoietic malignancies.
Topics: Amsacrine; Antineoplastic Agents; Cell Nucleus; Drug Resistance; Etoposide; Humans; In Vitro Techniq | 1992 |
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
Topics: Alkenes; Amsacrine; Antibiotics, Antineoplastic; Cell Cycle; DNA, Neoplasm; Humans; Leukemia, Lympho | 1992 |
Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.
Topics: Amsacrine; Aphidicolin; Blotting, Western; Camptothecin; Colony-Forming Units Assay; Cycloheximide; | 1991 |
Amsacrine retains a special role supporting Food and Drug Administration approval.
Topics: Amsacrine; Humans; Leukemia, Promyelocytic, Acute; United States; United States Food and Drug Admini | 1992 |
Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions.
Topics: Amsacrine; Antineoplastic Agents; Cell Line; Cell Nucleus; Cell Survival; DNA Topoisomerases, Type I | 1991 |
Microsomal activation and increased production of 4'-(9-acridinylamino)-3-methanesulfon-m-anisidide (m-AMSA)-dependent, topoisomerase-associated DNA lesions in nuclei from human HL-60 leukemia cells.
Topics: Amsacrine; Cell Nucleus; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Humans; Leukemia, P | 1990 |
DNA topoisomerase I as a site of action for 10-hydroxycamptothecin in human promyelocytic leukemia cells.
Topics: Amsacrine; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Division; DNA Damage; DNA Topoisome | 1990 |
Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity.
Topics: Amsacrine; Cell Differentiation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Le | 1989 |
Characterization of an amsacrine-resistant line of human leukemia cells. Evidence for a drug-resistant form of topoisomerase II.
Topics: Adenosine Triphosphate; Amsacrine; Blotting, Northern; Blotting, Southern; Cell Line; Cell Nucleus; | 1989 |
[4'-(9-acridinylamino)-methanesulfon-m-aniside (AMSA) combination salvage therapy in refractory acute non-lymphocytic leukemia in adults].
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun | 1989 |
Effect of phorbol ester treatment on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.
Topics: Amsacrine; Chromatin; DNA; DNA Damage; DNA Topoisomerases, Type II; Etoposide; Humans; Leukemia, Pro | 1988 |