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amsacrine and Leukemia, Lymphocytic

amsacrine has been researched along with Leukemia, Lymphocytic in 41 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"Amsacrine and high-dose cytarabine (HiDAc), when administered as single agents, are effective treatment of acute leukemia."9.06A new regimen of amsacrine with high-dose cytarabine is safe and effective therapy for acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Feldman, E; Mehta, R; Mittelman, A; Rieber, E; Sullivan, P; Weinstein, P, 1987)
"Twenty-six adults with refractory leukemia were treated with amsacrine gluconate, a new formulation."7.66Phase II study of amsacrine gluconate in refractory leukemia. ( Grillo-Lopez, AJ; Omura, GA; Vogler, WR; Winton, EF; Zuckerman, KS, 1983)
" In acute myelogenous leukemia, amsacrine is as effective as the two most active drugs, cytarabine and daunorubicin and can produce complete remissions in patients refractory to these drugs."6.15Amsacrine: a review. ( Cassileth, PA; Gale, RP, 1986)
"Amsacrine and high-dose cytarabine (HiDAc), when administered as single agents, are effective treatment of acute leukemia."5.06A new regimen of amsacrine with high-dose cytarabine is safe and effective therapy for acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Feldman, E; Mehta, R; Mittelman, A; Rieber, E; Sullivan, P; Weinstein, P, 1987)
"The ECG effect of amsacrine (m-AMSA) was evaluated in 12 consecutive patients with leukemia."3.67Acute electrocardiographic changes induced by amsacrine. ( Hasin, Y; Shinar, E, 1984)
" The overall complete remission rate was 27/78 (35%) in acute myelogenous leukemia and 5/9 (56%) in acute lymphocytic leukemia or acute undifferentiated leukemia for cytosine arabinoside combined with either anthracyclines (rubidazone or Adriamycin [doxorubicin]) or m-AMSA (amsacrine)."3.67Intensive treatment of acute leukemia in adults 70 years of age and older. ( Estey, EH; Freireich, EJ; Kantarjian, HM; Keating, MJ; McCredie, KB; Walters, RS, 1987)
"Twenty-six adults with refractory leukemia were treated with amsacrine gluconate, a new formulation."3.66Phase II study of amsacrine gluconate in refractory leukemia. ( Grillo-Lopez, AJ; Omura, GA; Vogler, WR; Winton, EF; Zuckerman, KS, 1983)
"Bacterial or fungal infections (considered life-threatening or fatal) occurred in 17 children with ALL and in 7 with ANLL."2.65Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study. ( Civin, CI; Frankel, LS; Krischer, J; Land, VJ; Mahoney, DH; Ragab, AH, 1984)
"HDARAC is also active in acute lymphocytic leukemia."2.37High dose cytarabine: a review. ( Bolwell, BJ; Cassileth, PA; Gale, RP, 1988)
" Dosage was 75 mg/m2, iv, day 1-7, all 3-5 weeks."1.27[Phase II study of AMSA in adults with acute therapy-refractory leukemias]. ( Engelhardt, R; Fiebig, HH; Henss, H; Hoelzer, D; Link, H; Pralle, H; Schmitz, R, 1983)
"Amsacrine, 90 mg/m2, was given daily for 5-8 days to 45 patients with acute myeloblastic leukemia, 15 patients with acute lymphoblastic leukemia, and six patients with blastic transformation of chronic granulocytic leukemia."1.27Amsacrine in refractory adult acute leukemia: a pilot study of the Southeastern Cancer Study Group. ( Hearn, EB; Johnson, L; Logan, T; Raney, M; Vogler, WR; Winton, EF, 1983)
"Patients with acute leukemia in relapse were given 5'-(9-acridinylamino)methanesulfon-m-anisidide at a dosage of 75 to 200 mg/sq m as a daily bolus infusion of 5 consecutive days."1.26Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia. ( Arlin, ZA; Clarkson, BD; Gee, TS; Howard, J; Kempin, SJ; Sklaroff, RB; Young, CW, 1980)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199040 (97.56)18.7374
1990's1 (2.44)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miller, LP1
Miller, DR1
Tan, CT1
Gahrton, G1
Fiebig, HH1
Henss, H1
Engelhardt, R1
Hoelzer, D1
Pralle, H1
Link, H1
Schmitz, R1
Arlin, ZA6
Hittelman, WN1
Menegaz, SD1
McCredie, KB5
Keating, MJ6
Weiss, RB2
Moquin, D1
Adams, JD1
Griffin, JD1
Zimbler, H1
Winton, EF3
Hearn, EB1
Vogler, WR3
Johnson, L1
Logan, T1
Raney, M1
Omura, GA1
Zuckerman, KS1
Grillo-Lopez, AJ1
Stewart, DJ1
Zhengang, G1
Lu, K1
Savaraj, N1
Feun, LG1
Luna, M1
Benjamin, RS1
Loo, TL1
Estey, EH2
Smith, TL1
Legha, SS3
Walters, RS2
Bodey, GP3
Freireich, EJ5
Krischer, J1
Land, VJ1
Civin, CI1
Ragab, AH1
Mahoney, DH1
Frankel, LS1
Case, DC1
Shinar, E1
Hasin, Y1
Morris, JG1
Weil, M1
Auclerc, MF1
Schaison, G2
Auclerc, G1
Daubrisson, A1
Degos, L1
Caro, J1
Marty, M2
Jacquillat, GI1
Zander, AR1
Sklaroff, RB1
Gee, TS2
Kempin, SJ2
Howard, J1
Clarkson, BD2
Young, CW2
Slevin, ML1
Shannon, MS2
Prentice, HG2
Goldman, AJ1
Lister, TA2
Hutter, JJ1
Meyskens, FL1
Fanucchi, MP1
Mertelsmann, R2
Appelbaum, FR1
Shulman, HM1
Dupont, JC1
Garay, GE1
Scaghone, C1
Pavlovsky, S1
Woodley, PV1
Hotz, MA1
Del Bino, G1
Lassota, P1
Traganos, F1
Darzynkiewicz, Z1
Potmesil, M1
Hsiang, YH1
Liu, LF1
Bank, B1
Grossberg, H1
Kirschenbaum, S1
Forlenza, TJ1
Penziner, A1
Kanganis, D1
Forlenzar, TJ1
Perry, DJ1
Hoth, DF1
Zittoun, R2
Rio, B1
Marie, JP3
Blanc, CM1
Feldman, E2
Kempin, S1
Ahmed, T2
Mittelman, A2
Savona, S1
Ascensao, J1
Baskind, P2
Sullivan, P2
Fuhr, HG1
Bolwell, BJ1
Cassileth, PA2
Gale, RP2
Stryckmans, P1
De Witte, T1
Bitar, N1
Suciu, S1
Solbu, G1
Debusscher, L1
Bury, J1
Peetermans, M1
Andrien, JM1
Leverger, G1
Bancillon, A1
Olive, D1
Cornu, G1
Griscelli, C1
Lemerle, S1
Harousseau, JL1
Bonnet, M1
Dhaliwal, HS1
Barnett, MJ1
Bragman, K1
Malpas, JS1
Willemze, R3
Peters, WG3
Colly, LP2
Kantarjian, HM1
Tham, RT1
de Bruïne, FT1
Mehta, R1
Weinstein, P1
Rieber, E1
Zittoun, J1
Marquet, J1
Haanen, C1

Reviews

5 reviews available for amsacrine and Leukemia, Lymphocytic

ArticleYear
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation.
    Advances in cancer research, 1983, Volume: 40

    Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinone

1983
Current status of amsacrine (AMSA) combination chemotherapy programs in acute leukemia.
    Cancer treatment reports, 1983, Volume: 67, Issue:11

    Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Clinical T

1983
New strategies in the management of acute leukemias.
    Acta haematologica, 1987, Volume: 78 Suppl 1

    Topics: Acute Disease; Amsacrine; Aneuploidy; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Pr

1987
High dose cytarabine: a review.
    Leukemia, 1988, Volume: 2, Issue:5

    Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Daunorubicin; H

1988
Amsacrine: a review.
    Leukemia research, 1986, Volume: 10, Issue:11

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical

1986

Trials

9 trials available for amsacrine and Leukemia, Lymphocytic

ArticleYear
Current status of amsacrine (AMSA) combination chemotherapy programs in acute leukemia.
    Cancer treatment reports, 1983, Volume: 67, Issue:11

    Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Clinical T

1983
Premature chromosome condensation studies in human leukemia: 5. Prediction of early relapse.
    Blood, 1984, Volume: 64, Issue:5

    Topics: Aminoacridines; Amsacrine; Animals; Cell Fusion; Chromosomes; Clinical Trials as Topic; Cricetinae;

1984
Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study.
    Cancer, 1984, Jul-15, Volume: 54, Issue:2

    Topics: Acute Disease; Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Drug Administrat

1984
[Clinical activity of m-Amsa and the combination of m-Amsa with cytosine arabinoside].
    La Nouvelle presse medicale, 1982, Oct-09, Volume: 11, Issue:39

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Clinical Trials as Topic

1982
Trial of AMSA in acute leukemia.
    Cancer treatment reports, 1982, Volume: 66, Issue:7

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Clinical Trials as Topic

1982
Intermediate-risk childhood acute lymphoblastic leukemias: amsacrine + cytosine arabinoside versus intermediate-dose methotrexate for consolidation, and 6-mercaptopurine + methotrexate + vincristine versus monthly pulses for maintenance.
    Haematology and blood transfusion, 1987, Volume: 30

    Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Cytarabi

1987
Results of induction and consolidation treatment with intermediate and high-dose ara-C and m-AMSA containing regimens in patients with primarily failed or relapsed acute leukemia and non-Hodgkin's lymphoma.
    Scandinavian journal of haematology. Supplementum, 1986, Volume: 44

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemoth

1986
Amsacrine: a review.
    Leukemia research, 1986, Volume: 10, Issue:11

    Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical

1986
A new regimen of amsacrine with high-dose cytarabine is safe and effective therapy for acute leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1987, Volume: 5, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; B

1987

Other Studies

29 other studies available for amsacrine and Leukemia, Lymphocytic

ArticleYear
Combination chemotherapy with amsacrine (AMSA) and cyclocytidine in refractory childhood leukemia: preliminary observations of a phase II study.
    Cancer treatment reports, 1983, Volume: 67, Issue:5

    Topics: Adolescent; Aminoacridines; Amsacrine; Ancitabine; Antineoplastic Agents; Child; Child, Preschool; C

1983
[Phase II study of AMSA in adults with acute therapy-refractory leukemias].
    Onkologie, 1983, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Humans;

1983
Electrocardiogram abnormalities induced by amsacrine.
    Cancer chemotherapy and pharmacology, 1983, Volume: 10, Issue:2

    Topics: Aminoacridines; Amsacrine; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Leukemia, Lymp

1983
Amsacrine in refractory adult acute leukemia: a pilot study of the Southeastern Cancer Study Group.
    Cancer treatment reports, 1983, Volume: 67, Issue:11

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Bone Marrow; Drug Evaluation; Female; Humans; Hy

1983
Phase II study of amsacrine gluconate in refractory leukemia.
    Cancer treatment reports, 1983, Volume: 67, Issue:12

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Gluconates; Humans; Lactates; Leuke

1983
Human tissue distribution of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (NSC 141549, AMSA).
    Cancer chemotherapy and pharmacology, 1984, Volume: 12, Issue:2

    Topics: Adult; Aminoacridines; Amsacrine; Chromatography, High Pressure Liquid; Female; Humans; Leukemia, Ly

1984
Prediction of complete remission in patients with refractory acute leukemia treated with AMSA.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:2

    Topics: Acute Disease; Adult; Aminoacridines; Amsacrine; Female; Humans; Leukemia; Leukemia, Lymphoid; Leuke

1984
m-AMSA: phase II trial in advanced lymphoma and leukemia.
    American journal of clinical oncology, 1984, Volume: 7, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marro

1984
Acute electrocardiographic changes induced by amsacrine.
    Cancer treatment reports, 1984, Volume: 68, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic C

1984
Acute tumor lysis in T-cell leukemia induced by amsacrine.
    Archives of internal medicine, 1983, Volume: 143, Issue:1

    Topics: Adolescent; Aminoacridines; Amsacrine; Bone Marrow; Humans; Hyperkalemia; Leukemia, Lymphoid; Male;

1983
4'-(9-Acridinylamino) methanesulfon-m-anisidide (AMSA): a new drug effective in the treatment of adult acute leukemia.
    Annals of internal medicine, 1980, Volume: 93, Issue:1

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Bone Marrow; Dose-Response Relationship, Drug; D

1980
Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia.
    Cancer research, 1980, Volume: 40, Issue:9

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Drug Administration Schedule; Drug Evaluation; Humans;

1980
A phase I and II study of m-AMSA in acute leukaemia.
    Cancer chemotherapy and pharmacology, 1981, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool;

1981
AMSA therapy for children with lymphoblastic malignancy.
    Cancer treatment reports, 1982, Volume: 66, Issue:3

    Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool; Humans; Leuke

1982
Evaluation of AMSA in previously treated patients with acute leukemia: results of therapy in 109 adults.
    Blood, 1982, Volume: 60, Issue:2

    Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; H

1982
Treatment of refractory adult lymphoblastic leukemia (ALL) with 4'(9-acridinylamino) methanesulfon-M-anisidide (AMSA).
    Blood, 1982, Volume: 60, Issue:5

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Female; Humans; Infusions, Pare

1982
Fatal hepatotoxicity associated with AMSA therapy.
    Cancer treatment reports, 1982, Volume: 66, Issue:10

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Female; Hepatic Encephalopathy; Humans; Leukemia,

1982
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
    Cancer research, 1992, Mar-15, Volume: 52, Issue:6

    Topics: Alkenes; Amsacrine; Antibiotics, Antineoplastic; Cell Cycle; DNA, Neoplasm; Humans; Leukemia, Lympho

1992
Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.
    Cancer research, 1988, Jun-15, Volume: 48, Issue:12

    Topics: Amsacrine; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Fl

1988
Hypersensitivity reactions to amsacrine.
    Cancer treatment reports, 1985, Volume: 69, Issue:2

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell;

1985
[Combination of AMSA-high dose cytosine arabinoside in acute leukemia].
    Presse medicale (Paris, France : 1983), 1985, Jun-29, Volume: 14, Issue:26

    Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols;

1985
Amsacrine with high-dose cytarabine is highly effective therapy for refractory and relapsed acute lymphoblastic leukemia in adults.
    Blood, 1988, Volume: 72, Issue:2

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fema

1988
Cytosine arabinoside for induction, salvage, and consolidation therapy of adult acute lymphoblastic leukemia.
    Seminars in oncology, 1987, Volume: 14, Issue:2 Suppl 1

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmu

1987
Treatment of acute leukaemia with m-AMSA in combination with cytosine arabinoside.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:1

    Topics: Aged; Amsacrine; Chemical and Drug Induced Liver Injury; Cytarabine; Female; Gastrointestinal Diseas

1986
High-dose cytosine arabinoside with amsacrine for treatment of acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:12

    Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Leukem

1986
Short-term high-dose treatment in bad-risk ALL and lymphoblastic NHL.
    British journal of haematology, 1987, Volume: 65, Issue:4

    Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Leukemia, Lymphoid; L

1987
Intensive treatment of acute leukemia in adults 70 years of age and older.
    Cancer, 1987, Jul-15, Volume: 60, Issue:2

    Topics: Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun

1987
Pulmonary complications of cytosine-arabinoside therapy: radiographic findings.
    AJR. American journal of roentgenology, 1987, Volume: 149, Issue:1

    Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Humans; Leukemia,

1987
Modulation of cytosine arabinoside (ara-C) and high-dose ara-C in acute leukemia.
    Seminars in oncology, 1985, Volume: 12, Issue:2 Suppl 3

    Topics: Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Resistan

1985