amsacrine has been researched along with Leukemia, Lymphocytic in 41 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amsacrine and high-dose cytarabine (HiDAc), when administered as single agents, are effective treatment of acute leukemia." | 9.06 | A new regimen of amsacrine with high-dose cytarabine is safe and effective therapy for acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Feldman, E; Mehta, R; Mittelman, A; Rieber, E; Sullivan, P; Weinstein, P, 1987) |
| "Twenty-six adults with refractory leukemia were treated with amsacrine gluconate, a new formulation." | 7.66 | Phase II study of amsacrine gluconate in refractory leukemia. ( Grillo-Lopez, AJ; Omura, GA; Vogler, WR; Winton, EF; Zuckerman, KS, 1983) |
| " In acute myelogenous leukemia, amsacrine is as effective as the two most active drugs, cytarabine and daunorubicin and can produce complete remissions in patients refractory to these drugs." | 6.15 | Amsacrine: a review. ( Cassileth, PA; Gale, RP, 1986) |
| "Amsacrine and high-dose cytarabine (HiDAc), when administered as single agents, are effective treatment of acute leukemia." | 5.06 | A new regimen of amsacrine with high-dose cytarabine is safe and effective therapy for acute leukemia. ( Ahmed, T; Arlin, ZA; Baskind, P; Feldman, E; Mehta, R; Mittelman, A; Rieber, E; Sullivan, P; Weinstein, P, 1987) |
| "The ECG effect of amsacrine (m-AMSA) was evaluated in 12 consecutive patients with leukemia." | 3.67 | Acute electrocardiographic changes induced by amsacrine. ( Hasin, Y; Shinar, E, 1984) |
| " The overall complete remission rate was 27/78 (35%) in acute myelogenous leukemia and 5/9 (56%) in acute lymphocytic leukemia or acute undifferentiated leukemia for cytosine arabinoside combined with either anthracyclines (rubidazone or Adriamycin [doxorubicin]) or m-AMSA (amsacrine)." | 3.67 | Intensive treatment of acute leukemia in adults 70 years of age and older. ( Estey, EH; Freireich, EJ; Kantarjian, HM; Keating, MJ; McCredie, KB; Walters, RS, 1987) |
| "Twenty-six adults with refractory leukemia were treated with amsacrine gluconate, a new formulation." | 3.66 | Phase II study of amsacrine gluconate in refractory leukemia. ( Grillo-Lopez, AJ; Omura, GA; Vogler, WR; Winton, EF; Zuckerman, KS, 1983) |
| "Bacterial or fungal infections (considered life-threatening or fatal) occurred in 17 children with ALL and in 7 with ANLL." | 2.65 | Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study. ( Civin, CI; Frankel, LS; Krischer, J; Land, VJ; Mahoney, DH; Ragab, AH, 1984) |
| "HDARAC is also active in acute lymphocytic leukemia." | 2.37 | High dose cytarabine: a review. ( Bolwell, BJ; Cassileth, PA; Gale, RP, 1988) |
| " Dosage was 75 mg/m2, iv, day 1-7, all 3-5 weeks." | 1.27 | [Phase II study of AMSA in adults with acute therapy-refractory leukemias]. ( Engelhardt, R; Fiebig, HH; Henss, H; Hoelzer, D; Link, H; Pralle, H; Schmitz, R, 1983) |
| "Amsacrine, 90 mg/m2, was given daily for 5-8 days to 45 patients with acute myeloblastic leukemia, 15 patients with acute lymphoblastic leukemia, and six patients with blastic transformation of chronic granulocytic leukemia." | 1.27 | Amsacrine in refractory adult acute leukemia: a pilot study of the Southeastern Cancer Study Group. ( Hearn, EB; Johnson, L; Logan, T; Raney, M; Vogler, WR; Winton, EF, 1983) |
| "Patients with acute leukemia in relapse were given 5'-(9-acridinylamino)methanesulfon-m-anisidide at a dosage of 75 to 200 mg/sq m as a daily bolus infusion of 5 consecutive days." | 1.26 | Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia. ( Arlin, ZA; Clarkson, BD; Gee, TS; Howard, J; Kempin, SJ; Sklaroff, RB; Young, CW, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (97.56) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, LP | 1 |
| Miller, DR | 1 |
| Tan, CT | 1 |
| Gahrton, G | 1 |
| Fiebig, HH | 1 |
| Henss, H | 1 |
| Engelhardt, R | 1 |
| Hoelzer, D | 1 |
| Pralle, H | 1 |
| Link, H | 1 |
| Schmitz, R | 1 |
| Arlin, ZA | 6 |
| Hittelman, WN | 1 |
| Menegaz, SD | 1 |
| McCredie, KB | 5 |
| Keating, MJ | 6 |
| Weiss, RB | 2 |
| Moquin, D | 1 |
| Adams, JD | 1 |
| Griffin, JD | 1 |
| Zimbler, H | 1 |
| Winton, EF | 3 |
| Hearn, EB | 1 |
| Vogler, WR | 3 |
| Johnson, L | 1 |
| Logan, T | 1 |
| Raney, M | 1 |
| Omura, GA | 1 |
| Zuckerman, KS | 1 |
| Grillo-Lopez, AJ | 1 |
| Stewart, DJ | 1 |
| Zhengang, G | 1 |
| Lu, K | 1 |
| Savaraj, N | 1 |
| Feun, LG | 1 |
| Luna, M | 1 |
| Benjamin, RS | 1 |
| Loo, TL | 1 |
| Estey, EH | 2 |
| Smith, TL | 1 |
| Legha, SS | 3 |
| Walters, RS | 2 |
| Bodey, GP | 3 |
| Freireich, EJ | 5 |
| Krischer, J | 1 |
| Land, VJ | 1 |
| Civin, CI | 1 |
| Ragab, AH | 1 |
| Mahoney, DH | 1 |
| Frankel, LS | 1 |
| Case, DC | 1 |
| Shinar, E | 1 |
| Hasin, Y | 1 |
| Morris, JG | 1 |
| Weil, M | 1 |
| Auclerc, MF | 1 |
| Schaison, G | 2 |
| Auclerc, G | 1 |
| Daubrisson, A | 1 |
| Degos, L | 1 |
| Caro, J | 1 |
| Marty, M | 2 |
| Jacquillat, GI | 1 |
| Zander, AR | 1 |
| Sklaroff, RB | 1 |
| Gee, TS | 2 |
| Kempin, SJ | 2 |
| Howard, J | 1 |
| Clarkson, BD | 2 |
| Young, CW | 2 |
| Slevin, ML | 1 |
| Shannon, MS | 2 |
| Prentice, HG | 2 |
| Goldman, AJ | 1 |
| Lister, TA | 2 |
| Hutter, JJ | 1 |
| Meyskens, FL | 1 |
| Fanucchi, MP | 1 |
| Mertelsmann, R | 2 |
| Appelbaum, FR | 1 |
| Shulman, HM | 1 |
| Dupont, JC | 1 |
| Garay, GE | 1 |
| Scaghone, C | 1 |
| Pavlovsky, S | 1 |
| Woodley, PV | 1 |
| Hotz, MA | 1 |
| Del Bino, G | 1 |
| Lassota, P | 1 |
| Traganos, F | 1 |
| Darzynkiewicz, Z | 1 |
| Potmesil, M | 1 |
| Hsiang, YH | 1 |
| Liu, LF | 1 |
| Bank, B | 1 |
| Grossberg, H | 1 |
| Kirschenbaum, S | 1 |
| Forlenza, TJ | 1 |
| Penziner, A | 1 |
| Kanganis, D | 1 |
| Forlenzar, TJ | 1 |
| Perry, DJ | 1 |
| Hoth, DF | 1 |
| Zittoun, R | 2 |
| Rio, B | 1 |
| Marie, JP | 3 |
| Blanc, CM | 1 |
| Feldman, E | 2 |
| Kempin, S | 1 |
| Ahmed, T | 2 |
| Mittelman, A | 2 |
| Savona, S | 1 |
| Ascensao, J | 1 |
| Baskind, P | 2 |
| Sullivan, P | 2 |
| Fuhr, HG | 1 |
| Bolwell, BJ | 1 |
| Cassileth, PA | 2 |
| Gale, RP | 2 |
| Stryckmans, P | 1 |
| De Witte, T | 1 |
| Bitar, N | 1 |
| Suciu, S | 1 |
| Solbu, G | 1 |
| Debusscher, L | 1 |
| Bury, J | 1 |
| Peetermans, M | 1 |
| Andrien, JM | 1 |
| Leverger, G | 1 |
| Bancillon, A | 1 |
| Olive, D | 1 |
| Cornu, G | 1 |
| Griscelli, C | 1 |
| Lemerle, S | 1 |
| Harousseau, JL | 1 |
| Bonnet, M | 1 |
| Dhaliwal, HS | 1 |
| Barnett, MJ | 1 |
| Bragman, K | 1 |
| Malpas, JS | 1 |
| Willemze, R | 3 |
| Peters, WG | 3 |
| Colly, LP | 2 |
| Kantarjian, HM | 1 |
| Tham, RT | 1 |
| de Bruïne, FT | 1 |
| Mehta, R | 1 |
| Weinstein, P | 1 |
| Rieber, E | 1 |
| Zittoun, J | 1 |
| Marquet, J | 1 |
| Haanen, C | 1 |
5 reviews available for amsacrine and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation.
Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinone | 1983 |
Current status of amsacrine (AMSA) combination chemotherapy programs in acute leukemia.
Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Clinical T | 1983 |
New strategies in the management of acute leukemias.
Topics: Acute Disease; Amsacrine; Aneuploidy; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Pr | 1987 |
High dose cytarabine: a review.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Daunorubicin; H | 1988 |
Amsacrine: a review.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical | 1986 |
9 trials available for amsacrine and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Current status of amsacrine (AMSA) combination chemotherapy programs in acute leukemia.
Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Clinical T | 1983 |
Premature chromosome condensation studies in human leukemia: 5. Prediction of early relapse.
Topics: Aminoacridines; Amsacrine; Animals; Cell Fusion; Chromosomes; Clinical Trials as Topic; Cricetinae; | 1984 |
Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study.
Topics: Acute Disease; Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Drug Administrat | 1984 |
[Clinical activity of m-Amsa and the combination of m-Amsa with cytosine arabinoside].
Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Clinical Trials as Topic | 1982 |
Trial of AMSA in acute leukemia.
Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Clinical Trials as Topic | 1982 |
Intermediate-risk childhood acute lymphoblastic leukemias: amsacrine + cytosine arabinoside versus intermediate-dose methotrexate for consolidation, and 6-mercaptopurine + methotrexate + vincristine versus monthly pulses for maintenance.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Cytarabi | 1987 |
Results of induction and consolidation treatment with intermediate and high-dose ara-C and m-AMSA containing regimens in patients with primarily failed or relapsed acute leukemia and non-Hodgkin's lymphoma.
Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemoth | 1986 |
Amsacrine: a review.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical | 1986 |
A new regimen of amsacrine with high-dose cytarabine is safe and effective therapy for acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; B | 1987 |
29 other studies available for amsacrine and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Combination chemotherapy with amsacrine (AMSA) and cyclocytidine in refractory childhood leukemia: preliminary observations of a phase II study.
Topics: Adolescent; Aminoacridines; Amsacrine; Ancitabine; Antineoplastic Agents; Child; Child, Preschool; C | 1983 |
[Phase II study of AMSA in adults with acute therapy-refractory leukemias].
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Humans; | 1983 |
Electrocardiogram abnormalities induced by amsacrine.
Topics: Aminoacridines; Amsacrine; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Leukemia, Lymp | 1983 |
Amsacrine in refractory adult acute leukemia: a pilot study of the Southeastern Cancer Study Group.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Bone Marrow; Drug Evaluation; Female; Humans; Hy | 1983 |
Phase II study of amsacrine gluconate in refractory leukemia.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Drug Evaluation; Female; Gluconates; Humans; Lactates; Leuke | 1983 |
Human tissue distribution of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (NSC 141549, AMSA).
Topics: Adult; Aminoacridines; Amsacrine; Chromatography, High Pressure Liquid; Female; Humans; Leukemia, Ly | 1984 |
Prediction of complete remission in patients with refractory acute leukemia treated with AMSA.
Topics: Acute Disease; Adult; Aminoacridines; Amsacrine; Female; Humans; Leukemia; Leukemia, Lymphoid; Leuke | 1984 |
m-AMSA: phase II trial in advanced lymphoma and leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marro | 1984 |
Acute electrocardiographic changes induced by amsacrine.
Topics: Acute Disease; Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic C | 1984 |
Acute tumor lysis in T-cell leukemia induced by amsacrine.
Topics: Adolescent; Aminoacridines; Amsacrine; Bone Marrow; Humans; Hyperkalemia; Leukemia, Lymphoid; Male; | 1983 |
4'-(9-Acridinylamino) methanesulfon-m-anisidide (AMSA): a new drug effective in the treatment of adult acute leukemia.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Bone Marrow; Dose-Response Relationship, Drug; D | 1980 |
Phase I and II trial of 4'-(9-acridinylamino)methanesulfon-m-anisidide in patients with acute leukemia.
Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Drug Administration Schedule; Drug Evaluation; Humans; | 1980 |
A phase I and II study of m-AMSA in acute leukaemia.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool; | 1981 |
AMSA therapy for children with lymphoblastic malignancy.
Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool; Humans; Leuke | 1982 |
Evaluation of AMSA in previously treated patients with acute leukemia: results of therapy in 109 adults.
Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; H | 1982 |
Treatment of refractory adult lymphoblastic leukemia (ALL) with 4'(9-acridinylamino) methanesulfon-M-anisidide (AMSA).
Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Female; Humans; Infusions, Pare | 1982 |
Fatal hepatotoxicity associated with AMSA therapy.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Female; Hepatic Encephalopathy; Humans; Leukemia, | 1982 |
Cytostatic and cytotoxic effects of fostriecin on human promyelocytic HL-60 and lymphocytic MOLT-4 leukemic cells.
Topics: Alkenes; Amsacrine; Antibiotics, Antineoplastic; Cell Cycle; DNA, Neoplasm; Humans; Leukemia, Lympho | 1992 |
Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.
Topics: Amsacrine; DNA; DNA Damage; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Etoposide; Fl | 1988 |
Hypersensitivity reactions to amsacrine.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; | 1985 |
[Combination of AMSA-high dose cytosine arabinoside in acute leukemia].
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; | 1985 |
Amsacrine with high-dose cytarabine is highly effective therapy for refractory and relapsed acute lymphoblastic leukemia in adults.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fema | 1988 |
Cytosine arabinoside for induction, salvage, and consolidation therapy of adult acute lymphoblastic leukemia.
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmu | 1987 |
Treatment of acute leukaemia with m-AMSA in combination with cytosine arabinoside.
Topics: Aged; Amsacrine; Chemical and Drug Induced Liver Injury; Cytarabine; Female; Gastrointestinal Diseas | 1986 |
High-dose cytosine arabinoside with amsacrine for treatment of acute lymphoblastic leukemia.
Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Leukem | 1986 |
Short-term high-dose treatment in bad-risk ALL and lymphoblastic NHL.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Leukemia, Lymphoid; L | 1987 |
Intensive treatment of acute leukemia in adults 70 years of age and older.
Topics: Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun | 1987 |
Pulmonary complications of cytosine-arabinoside therapy: radiographic findings.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Humans; Leukemia, | 1987 |
Modulation of cytosine arabinoside (ara-C) and high-dose ara-C in acute leukemia.
Topics: Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Resistan | 1985 |