amsacrine has been researched along with Head and Neck Neoplasms in 8 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although only a few patients with head and neck cancer have been included in broad phase II studies, several responses have been reported, but detailed data concerning responders are lacking." | 2.68 | A two-step reevaluation of high-dose amsacrine for advanced carcinoma of the upper aerodigestive tract: a pilot phase II study. ( Jelic, S; Jovanovic, V; Kovcin, V; Milanovic, N; Nikolic-Tomasevic, Z; Tomasevic, Z; Vlajic, M, 1997) |
| "Using a human head and neck squamous carcinoma cell line 183A, we have investigated the effect of beta-all-trans-retinoic acid (RA), a substance with known antiproliferative effects, on the DNA cleavage and cytotoxic activities of etoposide and 4'-(acridinylamino)methanesulfon-m-anisidide which interact with topoisomerase II." | 1.28 | Effect of retinoic acid on DNA cleavage and cytotoxicity of topoisomerase II-reactive drugs in a human head and neck squamous carcinoma cell line. ( Chan, D; Glisson, BS; Hong, WK; Kim, HK; Sacks, PG; Silberman, L; Zwelling, LA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Witherspoon, RP | 1 |
| Legha, SS | 1 |
| Reimer, RR | 1 |
| Talley, RW | 1 |
| Stuckey, WJ | 1 |
| Dixon, DO | 1 |
| McCracken, JD | 1 |
| Stephens, RL | 1 |
| Oishi, N | 1 |
| Forastiere, AA | 1 |
| Young, CW | 1 |
| Wittes, RE | 1 |
| Ratanatharathorn, V | 1 |
| Drelichman, A | 1 |
| Sexon-Porte, M | 1 |
| Al-Sarraf, M | 1 |
| Jelic, S | 1 |
| Nikolic-Tomasevic, Z | 1 |
| Kovcin, V | 1 |
| Milanovic, N | 1 |
| Tomasevic, Z | 1 |
| Jovanovic, V | 1 |
| Vlajic, M | 1 |
| Hanauske, AR | 2 |
| Hanauske, U | 1 |
| Von Hoff, DD | 2 |
| Kim, HK | 1 |
| Zwelling, LA | 1 |
| Sacks, PG | 1 |
| Hong, WK | 1 |
| Chan, D | 1 |
| Silberman, L | 1 |
| Glisson, BS | 1 |
| Crivellari, D | 1 |
| Tirelli, U | 1 |
| Frustaci, S | 1 |
| Veronesi, A | 1 |
| Galligioni, E | 1 |
| Tumolo, S | 1 |
| Grigoletto, E | 1 |
2 reviews available for amsacrine and Head and Neck Neoplasms
| Article | Year |
|---|---|
The human tumor cloning assay in cancer research and therapy: a review with clinical correlations.
Topics: Aminoacridines; Amsacrine; Animals; Anthracenes; Antineoplastic Agents; Blood Physiological Phenomen | 1985 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul | 1985 |
2 trials available for amsacrine and Head and Neck Neoplasms
| Article | Year |
|---|---|
A two-step reevaluation of high-dose amsacrine for advanced carcinoma of the upper aerodigestive tract: a pilot phase II study.
Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease-Free Survival; Dose | 1997 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul | 1985 |
5 other studies available for amsacrine and Head and Neck Neoplasms
| Article | Year |
|---|---|
Phase II trial of amsacrine in metastatic or locally recurrent squamous cell carcinoma from head and neck primaries: a Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Animals; Carcinoma, Squamous Cell; Dogs; Drug Ev | 1984 |
A phase II trial of m-AMSA in head and neck cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evalua | 1981 |
Phase II evaluation of 4'-(9-acridinylamino)-methanesulfon-m--anisidine (AMSA) in patients with advanced head and neck cancers.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C | 1982 |
Effect of retinoic acid on DNA cleavage and cytotoxicity of topoisomerase II-reactive drugs in a human head and neck squamous carcinoma cell line.
Topics: Amsacrine; Carcinoma, Squamous Cell; Cell Survival; DNA Damage; DNA Topoisomerases, Type II; Etoposi | 1989 |
A phase II study of AMSA in head and neck cancer.
Topics: Adult; Aged; Amsacrine; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged | 1987 |