amsacrine has been researched along with Fibrosarcoma in 4 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To better understand the molecular basis for the cytotoxic effects of suramin, we have developed suramin-resistant DC-3F/SU 1000 cells by continuous exposure of fibrosarcoma cells to increasing concentrations of suramin." | 7.69 | Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells. ( Benchokroun, Y; Larsen, AK; Lelièvre, S, 1995) |
| "To better understand the molecular basis for the cytotoxic effects of suramin, we have developed suramin-resistant DC-3F/SU 1000 cells by continuous exposure of fibrosarcoma cells to increasing concentrations of suramin." | 3.69 | Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells. ( Benchokroun, Y; Larsen, AK; Lelièvre, S, 1995) |
| "HT1080/DR4 (DR4) is a doxorubicin-resistant human fibrosarcoma line that exhibits 150-fold cross-resistance to etoposide but does not overexpress P-glycoprotein (one mechanism of multiple drug resistance)." | 3.68 | HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II. ( Chan, D; Doroshow, JH; Hinds, M; Mayes, J; Meltzer, PS; Parker, E; Sie, KL; Slovak, ML; Trent, JM; Zwelling, LA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamato, M | 1 |
| Takeuchi, Y | 1 |
| Hashigaki, K | 1 |
| Ikeda, Y | 1 |
| Chang, MR | 1 |
| Takeuchi, K | 1 |
| Matsushima, M | 1 |
| Tsuruo, T | 1 |
| Tashiro, T | 1 |
| Tsukagoshi, S | 1 |
| Lelièvre, S | 2 |
| Benchokroun, Y | 1 |
| Larsen, AK | 2 |
| Bojanowski, K | 1 |
| Markovits, J | 1 |
| Couprie, J | 1 |
| Jacquemin-Sablon, A | 1 |
| Zwelling, LA | 1 |
| Slovak, ML | 1 |
| Doroshow, JH | 1 |
| Hinds, M | 1 |
| Chan, D | 1 |
| Parker, E | 1 |
| Mayes, J | 1 |
| Sie, KL | 1 |
| Meltzer, PS | 1 |
| Trent, JM | 1 |
4 other studies available for amsacrine and Fibrosarcoma
| Article | Year |
|---|---|
Synthesis and antitumor activity of fused tetracyclic quinoline derivatives. 1.
Topics: Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; DNA; DNA Topois | 1989 |
Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells.
Topics: Amsacrine; Animals; Camptothecin; Cell Nucleus; Cricetinae; Cricetulus; DNA Topoisomerases, Type I; | 1995 |
Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.
Topics: Amsacrine; Animals; Cell Compartmentation; Cell Division; Cricetinae; Cricetulus; DNA Damage; Fibros | 1992 |
HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.
Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catalase; Cell Line; Cell Nucleu | 1990 |