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amsacrine and Fibrosarcoma

amsacrine has been researched along with Fibrosarcoma in 4 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"To better understand the molecular basis for the cytotoxic effects of suramin, we have developed suramin-resistant DC-3F/SU 1000 cells by continuous exposure of fibrosarcoma cells to increasing concentrations of suramin."7.69Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells. ( Benchokroun, Y; Larsen, AK; Lelièvre, S, 1995)
"To better understand the molecular basis for the cytotoxic effects of suramin, we have developed suramin-resistant DC-3F/SU 1000 cells by continuous exposure of fibrosarcoma cells to increasing concentrations of suramin."3.69Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells. ( Benchokroun, Y; Larsen, AK; Lelièvre, S, 1995)
"HT1080/DR4 (DR4) is a doxorubicin-resistant human fibrosarcoma line that exhibits 150-fold cross-resistance to etoposide but does not overexpress P-glycoprotein (one mechanism of multiple drug resistance)."3.68HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II. ( Chan, D; Doroshow, JH; Hinds, M; Mayes, J; Meltzer, PS; Parker, E; Sie, KL; Slovak, ML; Trent, JM; Zwelling, LA, 1990)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yamato, M1
Takeuchi, Y1
Hashigaki, K1
Ikeda, Y1
Chang, MR1
Takeuchi, K1
Matsushima, M1
Tsuruo, T1
Tashiro, T1
Tsukagoshi, S1
Lelièvre, S2
Benchokroun, Y1
Larsen, AK2
Bojanowski, K1
Markovits, J1
Couprie, J1
Jacquemin-Sablon, A1
Zwelling, LA1
Slovak, ML1
Doroshow, JH1
Hinds, M1
Chan, D1
Parker, E1
Mayes, J1
Sie, KL1
Meltzer, PS1
Trent, JM1

Other Studies

4 other studies available for amsacrine and Fibrosarcoma

ArticleYear
Synthesis and antitumor activity of fused tetracyclic quinoline derivatives. 1.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; DNA; DNA Topois

1989
Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells.
    Molecular pharmacology, 1995, Volume: 47, Issue:5

    Topics: Amsacrine; Animals; Camptothecin; Cell Nucleus; Cricetinae; Cricetulus; DNA Topoisomerases, Type I;

1995
Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Apr-01, Volume: 89, Issue:7

    Topics: Amsacrine; Animals; Cell Compartmentation; Cell Division; Cricetinae; Cricetulus; DNA Damage; Fibros

1992
HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.
    Journal of the National Cancer Institute, 1990, Oct-03, Volume: 82, Issue:19

    Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catalase; Cell Line; Cell Nucleu

1990