amsacrine has been researched along with Fibrosarcoma in 4 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Excerpt | Relevance | Reference |
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"To better understand the molecular basis for the cytotoxic effects of suramin, we have developed suramin-resistant DC-3F/SU 1000 cells by continuous exposure of fibrosarcoma cells to increasing concentrations of suramin." | 7.69 | Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells. ( Benchokroun, Y; Larsen, AK; Lelièvre, S, 1995) |
"To better understand the molecular basis for the cytotoxic effects of suramin, we have developed suramin-resistant DC-3F/SU 1000 cells by continuous exposure of fibrosarcoma cells to increasing concentrations of suramin." | 3.69 | Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells. ( Benchokroun, Y; Larsen, AK; Lelièvre, S, 1995) |
"HT1080/DR4 (DR4) is a doxorubicin-resistant human fibrosarcoma line that exhibits 150-fold cross-resistance to etoposide but does not overexpress P-glycoprotein (one mechanism of multiple drug resistance)." | 3.68 | HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II. ( Chan, D; Doroshow, JH; Hinds, M; Mayes, J; Meltzer, PS; Parker, E; Sie, KL; Slovak, ML; Trent, JM; Zwelling, LA, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (25.00) | 18.7374 |
1990's | 3 (75.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Yamato, M | 1 |
Takeuchi, Y | 1 |
Hashigaki, K | 1 |
Ikeda, Y | 1 |
Chang, MR | 1 |
Takeuchi, K | 1 |
Matsushima, M | 1 |
Tsuruo, T | 1 |
Tashiro, T | 1 |
Tsukagoshi, S | 1 |
Lelièvre, S | 2 |
Benchokroun, Y | 1 |
Larsen, AK | 2 |
Bojanowski, K | 1 |
Markovits, J | 1 |
Couprie, J | 1 |
Jacquemin-Sablon, A | 1 |
Zwelling, LA | 1 |
Slovak, ML | 1 |
Doroshow, JH | 1 |
Hinds, M | 1 |
Chan, D | 1 |
Parker, E | 1 |
Mayes, J | 1 |
Sie, KL | 1 |
Meltzer, PS | 1 |
Trent, JM | 1 |
4 other studies available for amsacrine and Fibrosarcoma
Article | Year |
---|---|
Synthesis and antitumor activity of fused tetracyclic quinoline derivatives. 1.
Topics: Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; DNA; DNA Topois | 1989 |
Altered topoisomerase I and II activities in suramin-resistant lung fibrosarcoma cells.
Topics: Amsacrine; Animals; Camptothecin; Cell Nucleus; Cricetinae; Cricetulus; DNA Topoisomerases, Type I; | 1995 |
Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.
Topics: Amsacrine; Animals; Cell Compartmentation; Cell Division; Cricetinae; Cricetulus; DNA Damage; Fibros | 1992 |
HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.
Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catalase; Cell Line; Cell Nucleu | 1990 |