amsacrine has been researched along with Colonic Neoplasms in 22 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " ER-37328 inhibited topoisomerase II activity at 10 times lower concentration than etoposide in relaxation assay and induced double-strand DNA cleavage within 1 h in murine leukemia P388 cells, in a bell-shaped manner with respect to drug concentration." | 3.71 | Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor. ( Kamata, J; Kitoh, K; Kotake, Y; Koyanagi, N; Nagasu, T; Nakamura, K; Niijima, J; Okada, T; Sugumi, H; Uenaka, T; Yamaguchi, A; Yoshimatsu, K; Yoshino, H, 2002) |
| "The cytotoxicity of a class of compounds related to the topoisomerase-II poison amsacrine was investigated against plateau-phase murine Lewis lung carcinoma cells (LLTC), HCT-8 human colon carcinoma cells and other cell lines." | 3.69 | Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells. ( Baguley, BC; Finlay, GJ; Holdaway, KM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (40.91) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamato, M | 1 |
| Takeuchi, Y | 1 |
| Hashigaki, K | 1 |
| Ikeda, Y | 1 |
| Chang, MR | 1 |
| Takeuchi, K | 1 |
| Matsushima, M | 1 |
| Tsuruo, T | 1 |
| Tashiro, T | 1 |
| Tsukagoshi, S | 1 |
| Atwell, GJ | 4 |
| Rewcastle, GW | 2 |
| Baguley, BC | 9 |
| Denny, WA | 5 |
| Finlay, GJ | 7 |
| Spicer, JA | 2 |
| Gamage, SA | 2 |
| Bu, X | 1 |
| Deady, LW | 1 |
| Lavaggi, ML | 1 |
| Cabrera, M | 1 |
| Aravena, Mde L | 1 |
| Olea-Azar, C | 1 |
| López de Ceráin, A | 1 |
| Monge, A | 1 |
| Pachón, G | 1 |
| Cascante, M | 1 |
| Bruno, AM | 1 |
| Pietrasanta, LI | 1 |
| González, M | 1 |
| Cerecetto, H | 1 |
| Islam, MS | 1 |
| Park, S | 1 |
| Song, C | 1 |
| Kadi, AA | 1 |
| Kwon, Y | 1 |
| Rahman, AF | 1 |
| Nakamura, K | 1 |
| Sugumi, H | 1 |
| Yamaguchi, A | 1 |
| Uenaka, T | 1 |
| Kotake, Y | 1 |
| Okada, T | 1 |
| Kamata, J | 1 |
| Niijima, J | 1 |
| Nagasu, T | 1 |
| Koyanagi, N | 1 |
| Yoshino, H | 1 |
| Kitoh, K | 1 |
| Yoshimatsu, K | 1 |
| Omura, GA | 1 |
| Bartolucci, AA | 1 |
| Lessner, HE | 1 |
| Hill, GJ | 1 |
| Valdivieso, M | 1 |
| Stroehlein, JR | 1 |
| Bedikian, AY | 1 |
| Karlin, DA | 1 |
| Legha, SS | 1 |
| Bennetts, RW | 1 |
| Bodey, GP | 1 |
| Drewinko, B | 1 |
| Yang, LY | 1 |
| Barlogie, B | 1 |
| Inaba, M | 1 |
| Mitsuhashi, J | 1 |
| Kawada, S | 1 |
| Nakano, H | 1 |
| Kirshenbaum, MR | 1 |
| Chen, SF | 1 |
| Behrens, CH | 1 |
| Papp, LM | 1 |
| Stafford, MM | 1 |
| Sun, JH | 1 |
| Behrens, DL | 1 |
| Fredericks, JR | 1 |
| Polkus, ST | 1 |
| Sipple, P | 1 |
| Holdaway, KM | 1 |
| Laurençot, CM | 1 |
| Scheffer, GL | 1 |
| Scheper, RJ | 1 |
| Shoemaker, RH | 1 |
| Lin, H | 1 |
| Liu, XY | 1 |
| Subramanian, B | 1 |
| Nakeff, A | 1 |
| Valeriote, F | 1 |
| Chen, BD | 1 |
| Sohn, TA | 1 |
| Bansal, R | 1 |
| Su, GH | 1 |
| Murphy, KM | 1 |
| Kern, SE | 1 |
| Lathan, B | 1 |
| Von Hoff, DD | 1 |
| Clark, GM | 1 |
| Elslager, EE | 1 |
| Leopold, WR | 1 |
| Corbett, TH | 1 |
| Griswold, DP | 1 |
| Plowman, J | 1 |
| Wilson, WR | 1 |
22 other studies available for amsacrine and Colonic Neoplasms
| Article | Year |
|---|---|
Synthesis and antitumor activity of fused tetracyclic quinoline derivatives. 1.
Topics: Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; DNA; DNA Topois | 1989 |
Potential antitumor agents. 48. 3'-Dimethylamino derivatives of amsacrine: redox chemistry and in vivo solid tumor activity.
Topics: Amsacrine; Animals; Antineoplastic Agents; Carcinoma; Cell Line; Chemical Phenomena; Chemistry; Colo | 1987 |
Potential antitumor agents. 47. 3'-Methylamino analogues of amsacrine with in vivo solid tumor activity.
Topics: Acridines; Aminoacridines; Amsacrine; Animals; Cell Line; Chemical Phenomena; Chemistry; Colonic Neo | 1986 |
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
Topics: Acridines; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Enzyme Inhibitors; Leuk | 1997 |
Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
Topics: Acridines; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screen | 1999 |
Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
Topics: Animals; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Doxorubicin; Drug Design; Drug Res | 2001 |
Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation.
Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Hypoxia; Cell Line; Colonic Neoplasms; Cricetinae | 2010 |
Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells.
Topics: Animals; Antigens, Neoplasm; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, | 2017 |
Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.
Topics: Amsacrine; Animals; Antineoplastic Agents; Carbazoles; Colonic Neoplasms; Cross-Linking Reagents; DN | 2002 |
Phase II evaluation of amsacrine in colorectal, gastric, and pancreatic carcinomas: a Southeastern Cancer Study Group trial.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Female; Gastro | 1984 |
Phase II clinical evaluation of intravenous 4'-(9-acridinylamino)methanesulfon-m-anisidide in colorectal cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Bone Marrow; Colonic Neoplasms; Drug | 1983 |
Lethal activity and kinetic response of cultured human cells to 4'-(9-acridinylamino)methanesulfon-m-anisidine.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Line; Cell Surviva | 1982 |
Different modes of cell-killing action between DNA topoisomerase I and II inhibitors revealed by kinetic analysis.
Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carbazoles; Cell Cycle; Colonic Neoplasms; Diterpene | 1994 |
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic | 1994 |
Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells.
Topics: Amsacrine; Animals; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance; | 1994 |
Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines.
Topics: Amsacrine; Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Nucleus; Cisplatin; Coloni | 1997 |
Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination.
Topics: Amsacrine; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle; Cell Division; Colonic Neoplasms; | 2002 |
High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter.
Topics: Amsacrine; Anticarcinogenic Agents; Antineoplastic Agents; Cell Survival; Colonic Neoplasms; Gene Ex | 2002 |
Potentiation by phenylbisbenzimidazoles of cytotoxicity of anticancer drugs directed against topoisomerase II.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Benzimidazoles; Bisbenzimidazole; Colonic Neop | 1990 |
Evaluation of an amsacrine analog in a human tumor cloning system.
Topics: Amsacrine; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Resistance; Humans; Lung | 1989 |
Experimental antitumor activity of the amsacrine analogue CI-921.
Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Line; Colonic Neoplasms; Disease Models, Animal; Dru | 1987 |
Comparison of in vitro activity of cytotoxic drugs towards human carcinoma and leukaemia cell lines.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Count; Cell Line; Cell Survival; Colonic Neop | 1986 |