amsacrine has been researched along with Coagulation, Disseminated Intravascular in 3 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Laboratory evidence of disseminated intravascular coagulation (DIC) and/or fibrinolysis is present in the majority of patients with acute promyelocytic leukemia (APL)." | 2.68 | Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid. ( Escudier, SM; Estey, EH; Kantarjian, HM, 1996) |
| "Amsacrine is an effective replacement for daunorubicin in the treatment of APL, and its use does not compromise the favorable remission duration characteristic of APL." | 2.65 | Primary therapy of acute promyelocytic leukemia: results of amsacrine- and daunorubicin-based therapy. ( Arlin, Z; Chaganti, RS; Clarkson, B; Gee, T; Higgins, C; Jhanwar, S; Kempin, S; Mertelsmann, R, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arlin, Z | 1 |
| Kempin, S | 1 |
| Mertelsmann, R | 1 |
| Gee, T | 1 |
| Higgins, C | 1 |
| Jhanwar, S | 1 |
| Chaganti, RS | 1 |
| Clarkson, B | 1 |
| Escudier, SM | 1 |
| Kantarjian, HM | 2 |
| Estey, EH | 2 |
| Keating, MJ | 1 |
| Walters, RS | 1 |
| McCredie, KB | 1 |
| Smith, TL | 1 |
| Dalton, WT | 1 |
| Cork, A | 1 |
| Trujillo, JM | 1 |
| Freireich, EJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center Phase 2 Study of Daratumumab With Pomalidomide and Dexamethasone in Combination With All-Transretinoic Acid in Patients With Multiple Myeloma Previously Exposed to Daratumumab-Based Regimens[NCT04700176] | Phase 2 | 43 participants (Anticipated) | Interventional | 2022-05-02 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for amsacrine and Coagulation, Disseminated Intravascular
| Article | Year |
|---|---|
Primary therapy of acute promyelocytic leukemia: results of amsacrine- and daunorubicin-based therapy.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Combined Chemoth | 1984 |
Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid.
Topics: Adult; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemot | 1996 |
1 other study available for amsacrine and Coagulation, Disseminated Intravascular
| Article | Year |
|---|---|
Acute promyelocytic leukemia. M.D. Anderson Hospital experience.
Topics: Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Cytara | 1986 |