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amsacrine and Chromosomal Translocation

amsacrine has been researched along with Chromosomal Translocation in 4 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"Among the aprt mutations induced in confluence-arrested Chinese hamster ovary D422 cells by the topoisomerase II poison amsacrine, there was a reciprocal exchange between the aprt gene and an unrelated sequence, accompanied by a chromosomal translocation at the aprt locus."3.69A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells. ( Jackson-Cook, CK; Povirk, LF; Wang, P; Zhou, RH; Zou, Y, 1997)
"Treatment-related acute myeloid leukemia (t-AML) following successful therapy of a primary malignancy has been recognized with increasing frequency among cancer survivors over the past several years."1.30Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus. ( Aplan, PD; Chervinsky, DS; Stanulla, M; Wang, J, 1997)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ghaddar, HM1
Plunkett, W1
Kantarjian, HM1
Pierce, S1
Freireich, EJ1
Keating, MJ1
Estey, EH1
Stanulla, M1
Wang, J1
Chervinsky, DS1
Aplan, PD1
Zhou, RH1
Wang, P1
Zou, Y1
Jackson-Cook, CK1
Povirk, LF1
Mosesso, P1
Darroudi, F1
van den Berg, M1
Vermeulen, S1
Palitti, F1
Natarajan, AT1

Trials

1 trial available for amsacrine and Chromosomal Translocation

ArticleYear
Long-term results following treatment of newly-diagnosed acute myelogenous leukemia with continuous-infusion high-dose cytosine arabinoside.
    Leukemia, 1994, Volume: 8, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocol

1994

Other Studies

3 other studies available for amsacrine and Chromosomal Translocation

ArticleYear
Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus.
    Leukemia, 1997, Volume: 11, Issue:4

    Topics: Amsacrine; Antineoplastic Agents; Base Sequence; Cell Line; Dactinomycin; DNA Damage; DNA, Neoplasm;

1997
A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells.
    Cancer research, 1997, Nov-01, Volume: 57, Issue:21

    Topics: Adenine Phosphoribosyltransferase; Amsacrine; Animals; Antineoplastic Agents; Base Sequence; CHO Cel

1997
Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques.
    Mutagenesis, 1998, Volume: 13, Issue:1

    Topics: Amsacrine; Azure Stains; Chromosome Aberrations; Chromosome Banding; Etoposide; Humans; Male; Staini

1998