amsacrine has been researched along with Chromosomal Translocation in 4 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among the aprt mutations induced in confluence-arrested Chinese hamster ovary D422 cells by the topoisomerase II poison amsacrine, there was a reciprocal exchange between the aprt gene and an unrelated sequence, accompanied by a chromosomal translocation at the aprt locus." | 3.69 | A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells. ( Jackson-Cook, CK; Povirk, LF; Wang, P; Zhou, RH; Zou, Y, 1997) |
| "Treatment-related acute myeloid leukemia (t-AML) following successful therapy of a primary malignancy has been recognized with increasing frequency among cancer survivors over the past several years." | 1.30 | Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus. ( Aplan, PD; Chervinsky, DS; Stanulla, M; Wang, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghaddar, HM | 1 |
| Plunkett, W | 1 |
| Kantarjian, HM | 1 |
| Pierce, S | 1 |
| Freireich, EJ | 1 |
| Keating, MJ | 1 |
| Estey, EH | 1 |
| Stanulla, M | 1 |
| Wang, J | 1 |
| Chervinsky, DS | 1 |
| Aplan, PD | 1 |
| Zhou, RH | 1 |
| Wang, P | 1 |
| Zou, Y | 1 |
| Jackson-Cook, CK | 1 |
| Povirk, LF | 1 |
| Mosesso, P | 1 |
| Darroudi, F | 1 |
| van den Berg, M | 1 |
| Vermeulen, S | 1 |
| Palitti, F | 1 |
| Natarajan, AT | 1 |
1 trial available for amsacrine and Chromosomal Translocation
| Article | Year |
|---|---|
Long-term results following treatment of newly-diagnosed acute myelogenous leukemia with continuous-infusion high-dose cytosine arabinoside.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocol | 1994 |
3 other studies available for amsacrine and Chromosomal Translocation
| Article | Year |
|---|---|
Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus.
Topics: Amsacrine; Antineoplastic Agents; Base Sequence; Cell Line; Dactinomycin; DNA Damage; DNA, Neoplasm; | 1997 |
A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells.
Topics: Adenine Phosphoribosyltransferase; Amsacrine; Animals; Antineoplastic Agents; Base Sequence; CHO Cel | 1997 |
Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques.
Topics: Amsacrine; Azure Stains; Chromosome Aberrations; Chromosome Banding; Etoposide; Humans; Male; Staini | 1998 |