amsacrine has been researched along with Cardiac Diseases in 11 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-eight patients with acute myelogenous leukemia (AML) not eligible for anthracycline or mitoxantrone treatment, mostly due to cardiac contraindications, were given aggressive therapy using m-amsacrine (AMSA) in combination with conventional or high-dose cytarabine for remission induction." | 5.07 | AMSA combination chemotherapy in patients with acute myelogenous leukemia unsuitable for standard antileukemic treatment. ( Heit, W; Maschmeyer, G; Willborn, K, 1992) |
| "Amsacrine is an antileukemia drug being widely used in North America, Europe, Australia, and New Zealand." | 5.06 | Amsacrine-associated cardiotoxicity: an analysis of 82 cases. ( Grillo-López, AJ; Hess, F; Marsoni, S; Posada, JG; Ross, BJ; Weiss, RB, 1986) |
| "Bacterial or fungal infections (considered life-threatening or fatal) occurred in 17 children with ALL and in 7 with ANLL." | 2.65 | Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study. ( Civin, CI; Frankel, LS; Krischer, J; Land, VJ; Mahoney, DH; Ragab, AH, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Kuron, D | 1 |
| Pohlmann, A | 1 |
| Angenendt, L | 1 |
| Kessler, T | 2 |
| Mesters, R | 1 |
| Berdel, WE | 2 |
| Stelljes, M | 1 |
| Lenz, G | 1 |
| Schliemann, C | 2 |
| Mikesch, JH | 1 |
| Tan, RM | 1 |
| Quah, TC | 1 |
| Aung, L | 1 |
| Liang, S | 1 |
| Kirk, RC | 1 |
| Yeoh, AE | 1 |
| Mohr, M | 1 |
| Müller-Tidow, C | 1 |
| Krug, U | 1 |
| Brunnberg, U | 1 |
| Mohr, B | 1 |
| Sauerland, C | 1 |
| Serve, H | 1 |
| Büchner, T | 1 |
| Mesters, RM | 1 |
| Krischer, J | 1 |
| Land, VJ | 1 |
| Civin, CI | 1 |
| Ragab, AH | 1 |
| Mahoney, DH | 1 |
| Frankel, LS | 1 |
| Vorobiof, DA | 1 |
| Iturralde, M | 1 |
| Falkson, G | 1 |
| Miller, CF | 1 |
| Rajdev, N | 1 |
| Fanucchi, MP | 1 |
| Arlin, ZA | 1 |
| Maschmeyer, G | 1 |
| Willborn, K | 1 |
| Heit, W | 1 |
| Dhaliwal, HS | 1 |
| Shannon, MS | 1 |
| Barnett, MJ | 1 |
| Prentice, HG | 1 |
| Bragman, K | 1 |
| Malpas, JS | 1 |
| Lister, TA | 1 |
| Weiss, RB | 1 |
| Grillo-López, AJ | 1 |
| Marsoni, S | 1 |
| Posada, JG | 1 |
| Hess, F | 1 |
| Ross, BJ | 1 |
| Zittoun, R | 1 |
1 review available for amsacrine and Cardiac Diseases
| Article | Year |
|---|---|
m-AMSA: a review of clinical data.
Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Drug Evalu | 1985 |
4 trials available for amsacrine and Cardiac Diseases
| Article | Year |
|---|---|
Amsacrine containing induction therapy in elderly AML patients: comparison to standard induction regimens in a matched-pair analysis.
Topics: Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Admi | 2008 |
Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study.
Topics: Acute Disease; Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Drug Administrat | 1984 |
AMSA combination chemotherapy in patients with acute myelogenous leukemia unsuitable for standard antileukemic treatment.
Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Heart Di | 1992 |
Amsacrine-associated cardiotoxicity: an analysis of 82 cases.
Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Arrhythmias, Cardiac; Cardiomyopathies | 1986 |
6 other studies available for amsacrine and Cardiac Diseases
| Article | Year |
|---|---|
Amsacrine-based induction therapy in AML patients with cardiac comorbidities: a retrospective single-center analysis.
Topics: Amsacrine; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Heart Disease | 2023 |
Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.
Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chemical and | 2007 |
Amsacrine cardiotoxicity: assessment of ventricular function by radionuclide angiography.
Topics: Aged; Aminoacridines; Amsacrine; Angiography; Antineoplastic Agents; Dose-Response Relationship, Dru | 1983 |
Acute ECG changes associated with AMSA treatment.
Topics: Aminoacridines; Amsacrine; Electrocardiography; Heart Diseases; Humans; Male; Middle Aged | 1982 |
Successful treatment of a patient with acute nonlymphoblastic leukemia (ANLL) and anthracycline cardiomyopathy with 4' (9-acridinylamino) methanesulfon-m-anisidide (AMSA).
Topics: Acute Disease; Adult; Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; | 1982 |
Treatment of acute leukaemia with m-AMSA in combination with cytosine arabinoside.
Topics: Aged; Amsacrine; Chemical and Drug Induced Liver Injury; Cytarabine; Female; Gastrointestinal Diseas | 1986 |