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amsacrine and Cardiac Diseases

amsacrine has been researched along with Cardiac Diseases in 11 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"Forty-eight patients with acute myelogenous leukemia (AML) not eligible for anthracycline or mitoxantrone treatment, mostly due to cardiac contraindications, were given aggressive therapy using m-amsacrine (AMSA) in combination with conventional or high-dose cytarabine for remission induction."5.07AMSA combination chemotherapy in patients with acute myelogenous leukemia unsuitable for standard antileukemic treatment. ( Heit, W; Maschmeyer, G; Willborn, K, 1992)
"Amsacrine is an antileukemia drug being widely used in North America, Europe, Australia, and New Zealand."5.06Amsacrine-associated cardiotoxicity: an analysis of 82 cases. ( Grillo-López, AJ; Hess, F; Marsoni, S; Posada, JG; Ross, BJ; Weiss, RB, 1986)
"Bacterial or fungal infections (considered life-threatening or fatal) occurred in 17 children with ALL and in 7 with ANLL."2.65Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study. ( Civin, CI; Frankel, LS; Krischer, J; Land, VJ; Mahoney, DH; Ragab, AH, 1984)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's0 (0.00)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Kuron, D1
Pohlmann, A1
Angenendt, L1
Kessler, T2
Mesters, R1
Berdel, WE2
Stelljes, M1
Lenz, G1
Schliemann, C2
Mikesch, JH1
Tan, RM1
Quah, TC1
Aung, L1
Liang, S1
Kirk, RC1
Yeoh, AE1
Mohr, M1
Müller-Tidow, C1
Krug, U1
Brunnberg, U1
Mohr, B1
Sauerland, C1
Serve, H1
Büchner, T1
Mesters, RM1
Krischer, J1
Land, VJ1
Civin, CI1
Ragab, AH1
Mahoney, DH1
Frankel, LS1
Vorobiof, DA1
Iturralde, M1
Falkson, G1
Miller, CF1
Rajdev, N1
Fanucchi, MP1
Arlin, ZA1
Maschmeyer, G1
Willborn, K1
Heit, W1
Dhaliwal, HS1
Shannon, MS1
Barnett, MJ1
Prentice, HG1
Bragman, K1
Malpas, JS1
Lister, TA1
Weiss, RB1
Grillo-López, AJ1
Marsoni, S1
Posada, JG1
Hess, F1
Ross, BJ1
Zittoun, R1

Reviews

1 review available for amsacrine and Cardiac Diseases

ArticleYear
m-AMSA: a review of clinical data.
    European journal of cancer & clinical oncology, 1985, Volume: 21, Issue:6

    Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Drug Evalu

1985

Trials

4 trials available for amsacrine and Cardiac Diseases

ArticleYear
Amsacrine containing induction therapy in elderly AML patients: comparison to standard induction regimens in a matched-pair analysis.
    Leukemia research, 2008, Volume: 32, Issue:3

    Topics: Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Admi

2008
Evaluation of AMSA in children with acute leukemia. A Pediatric Oncology Group study.
    Cancer, 1984, Jul-15, Volume: 54, Issue:2

    Topics: Acute Disease; Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Drug Administrat

1984
AMSA combination chemotherapy in patients with acute myelogenous leukemia unsuitable for standard antileukemic treatment.
    Leukemia & lymphoma, 1992, Volume: 8, Issue:4-5

    Topics: Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Heart Di

1992
Amsacrine-associated cardiotoxicity: an analysis of 82 cases.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1986, Volume: 4, Issue:6

    Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Arrhythmias, Cardiac; Cardiomyopathies

1986

Other Studies

6 other studies available for amsacrine and Cardiac Diseases

ArticleYear
Amsacrine-based induction therapy in AML patients with cardiac comorbidities: a retrospective single-center analysis.
    Annals of hematology, 2023, Volume: 102, Issue:4

    Topics: Amsacrine; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Heart Disease

2023
Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol.
    Pediatric blood & cancer, 2007, Volume: 48, Issue:3

    Topics: Acute Disease; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chemical and

2007
Amsacrine cardiotoxicity: assessment of ventricular function by radionuclide angiography.
    Cancer treatment reports, 1983, Volume: 67, Issue:12

    Topics: Aged; Aminoacridines; Amsacrine; Angiography; Antineoplastic Agents; Dose-Response Relationship, Dru

1983
Acute ECG changes associated with AMSA treatment.
    Cancer treatment reports, 1982, Volume: 66, Issue:8

    Topics: Aminoacridines; Amsacrine; Electrocardiography; Heart Diseases; Humans; Male; Middle Aged

1982
Successful treatment of a patient with acute nonlymphoblastic leukemia (ANLL) and anthracycline cardiomyopathy with 4' (9-acridinylamino) methanesulfon-m-anisidide (AMSA).
    Cancer chemotherapy and pharmacology, 1982, Volume: 10, Issue:1

    Topics: Acute Disease; Adult; Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents;

1982
Treatment of acute leukaemia with m-AMSA in combination with cytosine arabinoside.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:1

    Topics: Aged; Amsacrine; Chemical and Drug Induced Liver Injury; Cytarabine; Female; Gastrointestinal Diseas

1986