amsacrine has been researched along with Carcinoma in 7 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cytotoxicity of a class of compounds related to the topoisomerase-II poison amsacrine was investigated against plateau-phase murine Lewis lung carcinoma cells (LLTC), HCT-8 human colon carcinoma cells and other cell lines." | 3.69 | Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells. ( Baguley, BC; Finlay, GJ; Holdaway, KM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atwell, GJ | 1 |
| Rewcastle, GW | 1 |
| Baguley, BC | 3 |
| Denny, WA | 1 |
| Inamasu, M | 1 |
| Oishi, N | 1 |
| Chen, T | 1 |
| Legha, S | 1 |
| McCracken, J | 1 |
| Balcerzak, S | 1 |
| Stephens, R | 1 |
| O'Bryan, R | 1 |
| Rivkin, SE | 1 |
| Costanzi, JJ | 1 |
| Hilgers, RD | 1 |
| Legha, SS | 1 |
| Panettiere, FJ | 1 |
| Alberts, DS | 1 |
| Finlay, GJ | 1 |
| Holdaway, KM | 1 |
| Matsumoto, Y | 2 |
| Takano, H | 2 |
| Kunishio, K | 1 |
| Nagao, S | 2 |
| Fojo, T | 2 |
| Kestell, P | 1 |
| Paxton, JW | 1 |
| Evans, PC | 1 |
| Young, D | 1 |
| Jurlina, JL | 1 |
| Robertson, IG | 1 |
7 other studies available for amsacrine and Carcinoma
| Article | Year |
|---|---|
Potential antitumor agents. 48. 3'-Dimethylamino derivatives of amsacrine: redox chemistry and in vivo solid tumor activity.
Topics: Amsacrine; Animals; Antineoplastic Agents; Carcinoma; Cell Line; Chemical Phenomena; Chemistry; Colo | 1987 |
Phase II trial of amsacrine in pancreatic carcinoma: a Southwest Oncology Group study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Carcinoma; Drug Evaluation; Humans; Middle Aged; Pancreatic | 1984 |
m-AMSA in epithelial carcinoma of the ovary. A Southwest Oncology Group study.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma; Drug Evaluation; Female; Humans; Leukop | 1983 |
Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells.
Topics: Amsacrine; Animals; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Resistance; | 1994 |
Expression of drug resistance genes in VP-16 and mAMSA-selected human carcinoma cells.
Topics: Amsacrine; Anion Transport Proteins; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agent | 2001 |
Altered topoisomerase IIalpha and multidrug resistance-associated protein levels during drug selection: adaptations to increasing drug pressure.
Topics: Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding | 2001 |
Disposition of amsacrine and its analogue 9-([2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921) in plasma, liver, and Lewis lung tumors in mice.
Topics: Amsacrine; Animals; Antineoplastic Agents; Carcinoma; Liver; Lung Neoplasms; Male; Metabolic Clearan | 1990 |