amsacrine has been researched along with Carcinoma, Squamous Cell in 10 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although only a few patients with head and neck cancer have been included in broad phase II studies, several responses have been reported, but detailed data concerning responders are lacking." | 2.68 | A two-step reevaluation of high-dose amsacrine for advanced carcinoma of the upper aerodigestive tract: a pilot phase II study. ( Jelic, S; Jovanovic, V; Kovcin, V; Milanovic, N; Nikolic-Tomasevic, Z; Tomasevic, Z; Vlajic, M, 1997) |
| "Using a human head and neck squamous carcinoma cell line 183A, we have investigated the effect of beta-all-trans-retinoic acid (RA), a substance with known antiproliferative effects, on the DNA cleavage and cytotoxic activities of etoposide and 4'-(acridinylamino)methanesulfon-m-anisidide which interact with topoisomerase II." | 1.28 | Effect of retinoic acid on DNA cleavage and cytotoxicity of topoisomerase II-reactive drugs in a human head and neck squamous carcinoma cell line. ( Chan, D; Glisson, BS; Hong, WK; Kim, HK; Sacks, PG; Silberman, L; Zwelling, LA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Witherspoon, RP | 1 |
| Legha, SS | 2 |
| Reimer, RR | 1 |
| Talley, RW | 1 |
| Stuckey, WJ | 1 |
| Dixon, DO | 1 |
| McCracken, JD | 1 |
| Stephens, RL | 2 |
| Oishi, N | 1 |
| Hilgers, RD | 1 |
| Boutselis, JG | 1 |
| Hannigan, EV | 1 |
| Tranum, BL | 1 |
| Surwit, E | 1 |
| Bonomi, P | 1 |
| Blessing, JA | 1 |
| Sedlacek, TV | 1 |
| Homesley, HD | 1 |
| DiSaia, PJ | 1 |
| Nichols, WC | 1 |
| Eagan, RT | 1 |
| Frytak, S | 1 |
| Ingle, JN | 1 |
| Creagan, ET | 1 |
| Kvols, LK | 1 |
| Forastiere, AA | 1 |
| Young, CW | 1 |
| Wittes, RE | 1 |
| Ratanatharathorn, V | 1 |
| Drelichman, A | 1 |
| Sexon-Porte, M | 1 |
| Al-Sarraf, M | 1 |
| Brenner, DE | 1 |
| Garbino, C | 1 |
| Kasdorf, H | 1 |
| Villasanta, U | 1 |
| Polcaro, R | 1 |
| Yovarone, J | 1 |
| Aisner, J | 1 |
| Schiffer, CA | 1 |
| Wiernik, PH | 1 |
| Jelic, S | 1 |
| Nikolic-Tomasevic, Z | 1 |
| Kovcin, V | 1 |
| Milanovic, N | 1 |
| Tomasevic, Z | 1 |
| Jovanovic, V | 1 |
| Vlajic, M | 1 |
| Kim, HK | 1 |
| Zwelling, LA | 1 |
| Sacks, PG | 1 |
| Hong, WK | 1 |
| Chan, D | 1 |
| Silberman, L | 1 |
| Glisson, BS | 1 |
| Perry, DJ | 1 |
| Weiss, RB | 1 |
| Hoth, DF | 1 |
1 trial available for amsacrine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
A two-step reevaluation of high-dose amsacrine for advanced carcinoma of the upper aerodigestive tract: a pilot phase II study.
Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease-Free Survival; Dose | 1997 |
9 other studies available for amsacrine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Phase II trial of amsacrine in metastatic or locally recurrent squamous cell carcinoma from head and neck primaries: a Southwest Oncology Group study.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Animals; Carcinoma, Squamous Cell; Dogs; Drug Ev | 1984 |
Amsacrine (m-AMSA) in squamous cell carcinoma of the uterine cervix: a Southwest Oncology Group study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; L | 1984 |
Phase II trial of AMSA in patients with advanced or recurrent squamous cell carcinoma of the cervix: a gynecologic oncology group study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evalua | 1983 |
Phase II evaluation of AMSA in patients with metastatic lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C | 1980 |
A phase II trial of m-AMSA in head and neck cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evalua | 1981 |
Phase II evaluation of 4'-(9-acridinylamino)-methanesulfon-m--anisidine (AMSA) in patients with advanced head and neck cancers.
Topics: Adenocarcinoma; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous C | 1982 |
A phase II trial of m-AMSA in the treatment of advanced gynecologic malignancies.
Topics: Adenocarcinoma; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Eva | 1982 |
Effect of retinoic acid on DNA cleavage and cytotoxicity of topoisomerase II-reactive drugs in a human head and neck squamous carcinoma cell line.
Topics: Amsacrine; Carcinoma, Squamous Cell; Cell Survival; DNA Damage; DNA Topoisomerases, Type II; Etoposi | 1989 |
Hypersensitivity reactions to amsacrine.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Squamous Cell; | 1985 |