amsacrine has been researched along with Carcinoma, Oat Cell in 20 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with paclitaxel or vinblastine, but not navelbine, sensitized the subline to cisplatin and chlorambucil (P < 0." | 1.31 | Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle. ( Davey, M; Davey, R; Locke, V, 2001) |
| "We describe a patient with acute renal failure resulting from bilateral infiltration of the kidneys by metastases secondary to small cell lung cancer." | 1.31 | Small cell lung cancer as a cause of acute renal failure secondary to bilateral renal infiltration. ( Smith, IE; Stebbing, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (35.00) | 18.7374 |
| 1990's | 10 (50.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creech, RH | 2 |
| Tritchler, D | 1 |
| Ettinger, DS | 2 |
| Ferraro, JA | 2 |
| Ruckdeschel, JC | 2 |
| Vogl, SE | 2 |
| Woll, J | 1 |
| Dady, PJ | 1 |
| Sappino, AP | 1 |
| Rudd, A | 1 |
| Smith, IE | 2 |
| Natale, RB | 1 |
| Gralla, RJ | 1 |
| Wittes, RE | 1 |
| Day, R | 1 |
| Woll, JE | 1 |
| Gromova, II | 1 |
| Thomsen, B | 1 |
| Razin, SV | 1 |
| Prost, S | 1 |
| Riou, G | 2 |
| Jensen, PB | 3 |
| Sørensen, BS | 2 |
| Sehested, M | 3 |
| Grue, P | 1 |
| Demant, EJ | 2 |
| Hansen, HH | 2 |
| de Jong, S | 2 |
| Kooistra, AJ | 1 |
| de Vries, EG | 3 |
| Mulder, NH | 3 |
| Zijlstra, JG | 2 |
| Withoff, S | 1 |
| Keith, WN | 1 |
| Nienhuis, EF | 1 |
| van der Graaf, WT | 1 |
| Uges, DR | 1 |
| Maurer, LH | 1 |
| Herndon, JE | 1 |
| Hollis, DR | 1 |
| Aisner, J | 1 |
| Carey, RW | 1 |
| Skarin, AT | 1 |
| Perry, MC | 1 |
| Eaton, WL | 1 |
| Zacharski, LL | 1 |
| Hammond, S | 1 |
| Green, MR | 1 |
| Wessel, I | 1 |
| Jensen, LH | 1 |
| Falck, J | 1 |
| Rose, A | 1 |
| Roerth, M | 1 |
| Nitiss, JL | 1 |
| Qian, W | 1 |
| Parmar, MK | 1 |
| Sambrook, RJ | 1 |
| Fayers, PM | 1 |
| Girling, DJ | 1 |
| Stephens, RJ | 1 |
| Locke, V | 1 |
| Davey, R | 1 |
| Davey, M | 1 |
| Stebbing, J | 1 |
| Pommier, Y | 1 |
| Orr, A | 1 |
| Kohn, KW | 1 |
| Riou, JF | 2 |
| Jensen, PS | 1 |
| Vindeløv, L | 1 |
| Multon, E | 1 |
| LeFevre, D | 1 |
| Ahomadegbe, JC | 1 |
| West, CM | 1 |
| Stratford, IJ | 1 |
| Kramer, BS | 1 |
| Birch, R | 1 |
| Einhorn, L | 1 |
| Greco, A | 1 |
4 trials available for amsacrine and Carcinoma, Oat Cell
| Article | Year |
|---|---|
Phase II study of PALA, amsacrine, teniposide, and zinostatin in small cell lung carcinoma (EST 2579).
Topics: Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Carcin | 1984 |
A randomized phase II study of m-AMSA (NSC 249992) and neocarzinostatin (NSC 157365) in non-small cell bronchogenic carcinoma. An Eastern Cooperative Group Study.
Topics: Aged; Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Bron | 1983 |
Randomized trial of chemotherapy and radiation therapy with or without warfarin for limited-stage small-cell lung cancer: a Cancer and Leukemia Group B study.
Topics: Adult; Aged; Amsacrine; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, S | 1997 |
Analysis of messy longitudinal data from a randomized clinical trial. MRC Lung Cancer Working Party.
Topics: Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cytarabine; Data I | 2000 |
16 other studies available for amsacrine and Carcinoma, Oat Cell
| Article | Year |
|---|---|
A phase II clinical study of mAMSA in small cell carcinoma of the lung.
Topics: Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Small Cell; Drug Evaluation; Fema | 1981 |
A phase II trial of m-AMSA in patients with small-cell lung cancer.
Topics: Aged; Aminoacridines; Amsacrine; Bone Marrow; Carcinoma, Small Cell; Dose-Response Relationship, Dru | 1981 |
Different topoisomerase II antitumor drugs direct similar specific long-range fragmentation of an amplified c-MYC gene locus in living cells and in high-salt-extracted nuclei.
Topics: Amsacrine; Antineoplastic Agents; Carcinoma, Small Cell; Cell Fractionation; Cell Line; Cell Nucleus | 1995 |
A human small cell lung carcinoma cell line, resistant to 4'-(9-acridinylamino)-methanesulfon-m-anisidide and cross-resistant to camptothecin with a high level of topoisomerase I.
Topics: Amsacrine; Base Sequence; Camptothecin; Carcinoma, Small Cell; DNA Primers; DNA Topoisomerases, Type | 1994 |
Targeting the cytotoxicity of topoisomerase II-directed epipodophyllotoxins to tumor cells in acidic environments.
Topics: Amsacrine; Animals; Carcinoma, Small Cell; Chloroquine; DNA Damage; DNA Topoisomerases, Type II; DNA | 1994 |
Topoisomerase II as a target of VM-26 and 4'-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells.
Topics: Amsacrine; Carcinoma, Small Cell; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug | 1993 |
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Topics: Amsacrine; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding | 1996 |
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Amino Acid Substitution; Amsacrine; Animals; Antineopla | 1999 |
Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.
Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carcinoma, Small Cell; Cell Cycle; Cell Survival; Ch | 2001 |
Small cell lung cancer as a cause of acute renal failure secondary to bilateral renal infiltration.
Topics: Acute Kidney Injury; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cel | 2000 |
Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.
Topics: Amsacrine; Animals; Base Sequence; Binding Sites; Carcinoma, Small Cell; Cell Line; DNA Damage; DNA | 1992 |
Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.
Topics: Amsacrine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Cycl | 1990 |
Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4'-(9-acridinylamino)methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage.
Topics: Aclarubicin; Amsacrine; Carcinoma, Small Cell; Cell Survival; DNA Damage; DNA, Neoplasm; Doxorubicin | 1990 |
Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
Topics: Alkaloids; Amsacrine; Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Cell Line; DNA; D | 1989 |
A comparison of adriamycin and mAMSA. II. Studies with V79 and human tumour multicellular spheroids.
Topics: Amsacrine; Animals; Carcinoma, Small Cell; Cell Survival; Cricetinae; Cricetulus; Dose-Response Rela | 1987 |
Phase II evaluation of amsacrine in small cell lung cancer: a Southeastern Cancer Study Group trial.
Topics: Aminoacridines; Amsacrine; Carcinoma, Small Cell; Drug Evaluation; Humans; Leukocyte Count; Lung Neo | 1985 |