amsacrine has been researched along with Carcinoma, Non-Small Cell Lung in 5 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Its hydrochloride salt, 13a·HCl exhibited not only excellent water solubility (1049 μg/mL) but also a high oral bioavailability (57." | 1.37 | Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers. ( Chen, YL; Chen, YW; Liang, CC; Lu, PJ; Tseng, CH; Tzeng, CC; Yang, CN; Yao, YC, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stanslas, J | 1 |
| Hagan, DJ | 1 |
| Ellis, MJ | 1 |
| Turner, C | 1 |
| Carmichael, J | 1 |
| Ward, W | 1 |
| Hammonds, TR | 1 |
| Stevens, MF | 1 |
| Chen, YW | 1 |
| Chen, YL | 1 |
| Tseng, CH | 1 |
| Liang, CC | 1 |
| Yang, CN | 1 |
| Yao, YC | 1 |
| Lu, PJ | 1 |
| Tzeng, CC | 1 |
| Eijdems, EW | 1 |
| de Haas, M | 1 |
| Timmerman, AJ | 1 |
| Van der Schans, GP | 1 |
| Kamst, E | 1 |
| de Nooij, J | 1 |
| Astaldi Ricotti, GC | 1 |
| Borst, P | 1 |
| Baas, F | 1 |
| Bridewell, DJ | 1 |
| Finlay, GJ | 1 |
| Baguley, BC | 2 |
| Harvey, VJ | 1 |
| Hardy, JR | 1 |
| Smith, S | 1 |
| Grove, W | 1 |
5 other studies available for amsacrine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Topics: Acridines; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Drug Resistance, | 2000 |
Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers.
Topics: Administration, Oral; Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-S | 2011 |
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.
Topics: Amsacrine; Carcinoma, Non-Small-Cell Lung; Cell Nucleus; DNA Damage; DNA Topoisomerases, Type II; Dr | 1995 |
Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; | 1999 |
Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.
Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Fema | 1991 |