amsacrine has been researched along with Cancer of Liver in 8 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-seven patients with hepatocellular cancer were treated in a randomised trial comparing adriamycin + VM 26 + 5-Fluorouracil (5-FU) to mAMSA + VM 26 + 5-FU." | 2.66 | Combination chemotherapy of hepatocellular cancer. Comparison of adriamycin + VM 26 + 5-fluorouracil with mAMSA + VM 26 + 5-fluorouracil. ( Bezwoda, WR; Derman, DP; Kew, M; Weaving, A, 1987) |
| " The mean terminal plasma half-life for total 14C ranged from 34 hr in patients with normal organ function to 46 hr in patients with severe liver disease." | 1.27 | Human pharmacokinetics of a new acridine derivative, 4'-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992). ( Benjamin, RS; Friedman, J; Gutterman, JU; Hall, SW; Legha, SS; Loo, TL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bukowski, RM | 1 |
| Legha, S | 1 |
| Saiki, J | 1 |
| Eyre, HJ | 1 |
| O'Bryan, R | 1 |
| Cheng, E | 1 |
| Lightdale, C | 1 |
| Young, C | 1 |
| Yagoda, A | 1 |
| Fortner, J | 1 |
| Golbey, R | 1 |
| Falkson, G | 2 |
| MacIntyre, JM | 1 |
| Schutt, AJ | 1 |
| Coetzer, B | 2 |
| Johnson, LA | 1 |
| Simson, IW | 1 |
| Douglass, HO | 1 |
| Amrein, PC | 1 |
| Richards, F | 1 |
| Coleman, M | 1 |
| Poulin, RF | 1 |
| Holland, JF | 1 |
| Weinberg, V | 1 |
| Perry, M | 1 |
| Hall, SW | 1 |
| Friedman, J | 1 |
| Legha, SS | 1 |
| Benjamin, RS | 1 |
| Gutterman, JU | 1 |
| Loo, TL | 1 |
| Klaassen, DJ | 1 |
| Bezwoda, WR | 1 |
| Weaving, A | 1 |
| Kew, M | 1 |
| Derman, DP | 1 |
| Louie, AC | 1 |
| Issell, BF | 1 |
1 review available for amsacrine and Cancer of Liver
| Article | Year |
|---|---|
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
3 trials available for amsacrine and Cancer of Liver
| Article | Year |
|---|---|
Neocarzinostatin versus m-AMSA or doxorubicin in hepatocellular carcinoma.
Topics: Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Clinical Trials a | 1984 |
Combination chemotherapy of hepatocellular cancer. Comparison of adriamycin + VM 26 + 5-fluorouracil with mAMSA + VM 26 + 5-fluorouracil.
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinica | 1987 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
5 other studies available for amsacrine and Cancer of Liver
| Article | Year |
|---|---|
Phase II trial of m-AMSA in hepatocellular carcinoma: a Southwest Oncology Group Study.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Hepatocellular | 1982 |
Phase II trial of (m-AMSA) 4'-9-(acridinylamino)-methanesulfon-m-aniside in primary liver cancer.
Topics: Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Hepatocellular | 1983 |
Phase II trial of amsacrine in patients with hepatoma: a Cancer and Leukemia Group B study.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Carcinoma, Hepatocellular; Drug Admin | 1984 |
Human pharmacokinetics of a new acridine derivative, 4'-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992).
Topics: Aminoacridines; Amsacrine; Bile; Drug Evaluation; Half-Life; Humans; Kidney Neoplasms; Kinetics; Leu | 1983 |
A phase II study of m-AMSA in patients with primary liver cancer.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Live | 1981 |