amsacrine has been researched along with Burkitt Lymphoma in 3 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A human Burkitt's lymphoma cell line (Raji-HN2) made resistant to nitrogen mustard, a bifunctional alkylating agent, was used to study the mechanism of resistance to nitrogen mustard." | 1.27 | Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells. ( Boyce, RA; Hertzberg, RP; Mattern, MR; Schein, PS; Tan, KB, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, PG | 1 |
| Beerman, TA | 1 |
| Thomas, X | 1 |
| Archimbaud, E | 1 |
| Charrin, C | 1 |
| Magaud, JP | 1 |
| Fiere, D | 1 |
| Tan, KB | 1 |
| Mattern, MR | 1 |
| Boyce, RA | 1 |
| Hertzberg, RP | 1 |
| Schein, PS | 1 |
3 other studies available for amsacrine and Burkitt Lymphoma
| Article | Year |
|---|---|
Damage induced in episomal EBV DNA in Raji cells by antitumor drugs as measured by pulsed field gel electrophoresis.
Topics: Amsacrine; Antineoplastic Agents; Bleomycin; Burkitt Lymphoma; Centrifugation, Density Gradient; DNA | 1994 |
CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Amsacrine; Aneuploidy; Antibiotics, Antineoplastic; Antigens, CD; Antigens, | 1995 |
Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells.
Topics: Amsacrine; Burkitt Lymphoma; Cell Line; Cell Survival; Chromatin; DNA Topoisomerases, Type II; Drug | 1987 |