amsacrine has been researched along with Benign Neoplasms in 42 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
Excerpt | Relevance | Reference |
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"Eligible tumor types included cancers of the breast, stomach, pancreas, nonsmall cell lung, small cell lung, colon, head and neck area, and melanoma." | 2.67 | A phase II trial of CI-921 in advanced malignancies. ( Benson, L; Doroshow, JH; Grove, WR; Maroun, JA; Mittelman, A; Robert, F; Rosen, PJ; Sklarin, NT; Stewart, JA; Wiernik, PH, 1992) |
"m-AMSA is a new drug in the National Cancer Institute Drug Development Program." | 2.65 | m-AMSA: an exciting new drug in the National Cancer Institute Drug Development Program. ( Charles, LM; Macdonald, JS; Weiss, RB, 1980) |
"Amsacrine is a 9-anilinoacridine derivative that appears to act as an electron donor in ET reactions on DNA, while N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) may act as an electron acceptor." | 2.42 | Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress? ( Baguley, BC; Jacintho, JD; Kovacic, P; Wakelin, LP, 2003) |
"Etoposide has been most clearly shown to be schedule dependent in clinical studies." | 2.39 | Schedule-dependent topoisomerase II-inhibiting drugs. ( Joel, SP; Slevin, ML, 1994) |
"Amsacrine was administered as a single i." | 1.27 | Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group. ( Alberto, P; Bramwell, V; Cavalli, F; De Jager, R; Hansen, HH; Joss, R; Klepp, O; Renard, J; Rozencweig, M; Siegenthaler, P; van Glabbeke, M, 1983) |
"A joint study of advanced gastric cancer was conducted between the Northern California Oncology Group and a Japanese Cooperative Group involving 13 major institutions through the US-Japan Program." | 1.27 | [Research project of cancer chemotherapy]. ( Ogawa, M, 1985) |
"Seven patients developed clinical congestive heart failure." | 1.26 | Cardiac abnormalities after AMSA administration. ( Mangiacasale, D; Miller, DR; Steinherz, LJ; Steinherz, PG; Tan, C, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 28 (66.67) | 18.7374 |
1990's | 5 (11.90) | 18.2507 |
2000's | 4 (9.52) | 29.6817 |
2010's | 5 (11.90) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Chang, FS | 1 |
Chen, W | 1 |
Wang, C | 1 |
Tzeng, CC | 1 |
Chen, YL | 1 |
Lin, R | 1 |
Elf, S | 1 |
Shan, C | 1 |
Kang, HB | 1 |
Ji, Q | 1 |
Zhou, L | 1 |
Hitosugi, T | 1 |
Zhang, L | 1 |
Zhang, S | 1 |
Seo, JH | 1 |
Xie, J | 1 |
Tucker, M | 1 |
Gu, TL | 1 |
Sudderth, J | 1 |
Jiang, L | 1 |
Mitsche, M | 1 |
DeBerardinis, RJ | 1 |
Wu, S | 1 |
Li, Y | 1 |
Mao, H | 1 |
Chen, PR | 1 |
Wang, D | 1 |
Chen, GZ | 1 |
Hurwitz, SJ | 1 |
Lonial, S | 1 |
Arellano, ML | 1 |
Khoury, HJ | 1 |
Khuri, FR | 1 |
Lee, BH | 1 |
Lei, Q | 1 |
Brat, DJ | 1 |
Ye, K | 1 |
Boggon, TJ | 1 |
He, C | 1 |
Kang, S | 1 |
Fan, J | 1 |
Chen, J | 1 |
Bist, G | 1 |
Park, S | 1 |
Song, C | 1 |
Thapa Magar, TB | 1 |
Shrestha, A | 1 |
Kwon, Y | 1 |
Lee, ES | 1 |
Zagotto, G | 1 |
Gianoncelli, A | 1 |
Sissi, C | 1 |
Marzano, C | 1 |
Gandin, V | 1 |
Pasquale, R | 1 |
Capranico, G | 1 |
Ribaudo, G | 1 |
Palumbo, M | 1 |
Afzal, A | 1 |
Sarfraz, M | 1 |
Wu, Z | 1 |
Wang, G | 1 |
Sun, J | 1 |
Baguley, BC | 3 |
Wakelin, LP | 1 |
Jacintho, JD | 1 |
Kovacic, P | 1 |
Bacherikov, VA | 1 |
Chou, TC | 1 |
Dong, HJ | 1 |
Zhang, X | 1 |
Chen, CH | 1 |
Lin, YW | 1 |
Tsai, TJ | 1 |
Lee, RZ | 1 |
Liu, LF | 1 |
Su, TL | 1 |
Arrick, BA | 1 |
Nathan, CF | 1 |
De Jager, R | 1 |
Siegenthaler, P | 1 |
Cavalli, F | 1 |
Klepp, O | 1 |
Bramwell, V | 1 |
Joss, R | 1 |
Alberto, P | 1 |
van Glabbeke, M | 1 |
Renard, J | 1 |
Rozencweig, M | 2 |
Hansen, HH | 1 |
Guo, ZG | 1 |
Savaraj, N | 1 |
Feun, LG | 1 |
Lu, K | 1 |
Stewart, DJ | 1 |
Luna, M | 2 |
Benjamin, RS | 2 |
Loo, TL | 1 |
Woodcock, TM | 1 |
Schneider, RJ | 1 |
Young, CW | 1 |
Goldsmith, MA | 1 |
Bhardwaj, S | 1 |
Ohnuma, T | 1 |
Greenspan, EM | 1 |
Holland, JF | 1 |
Von Hoff, DD | 3 |
Legha, SS | 2 |
Cysyk, RL | 1 |
Muggia, FM | 1 |
Mahal, PS | 1 |
Valdivieso, M | 1 |
Bodey, GP | 2 |
Eagan, RT | 1 |
Ahmann, FR | 1 |
Meyskens, FL | 1 |
Moon, TE | 1 |
Durie, BG | 1 |
Salmon, SE | 1 |
Sculier, JP | 1 |
Klastersky, J | 1 |
Steinherz, LJ | 1 |
Steinherz, PG | 1 |
Mangiacasale, D | 1 |
Tan, C | 1 |
Miller, DR | 1 |
Goldman, A | 1 |
Malpas, JS | 1 |
Macdonald, JS | 2 |
Marsoni, S | 1 |
Bruno, S | 1 |
Poster, D | 1 |
Weiss, RB | 1 |
Charles, LM | 1 |
Zander, AR | 1 |
Spitzer, G | 1 |
Legha, S | 1 |
Dicke, DA | 1 |
Verma, DS | 1 |
Johnston, DA | 1 |
Vellekoop, L | 1 |
Beran, M | 1 |
Schell, F | 1 |
Minnhaar, G | 1 |
Blumenschein, GR | 1 |
Joel, SP | 1 |
Slevin, ML | 1 |
Matsumoto, Y | 2 |
Takano, H | 2 |
Nagao, S | 2 |
Iglesias, A | 1 |
Fojo, T | 2 |
Morisaki, K | 1 |
Kunishio, K | 1 |
Fyfe, D | 1 |
Price, C | 1 |
Langley, RE | 1 |
Pagonis, C | 1 |
Houghton, J | 1 |
Osborne, L | 1 |
Woll, PJ | 1 |
Gardner, C | 1 |
Carmichael, J | 1 |
Sklarin, NT | 1 |
Wiernik, PH | 1 |
Grove, WR | 1 |
Benson, L | 1 |
Mittelman, A | 1 |
Maroun, JA | 1 |
Stewart, JA | 1 |
Robert, F | 1 |
Doroshow, JH | 1 |
Rosen, PJ | 1 |
Cunningham, JM | 1 |
Francis, GE | 1 |
Holland, MJ | 1 |
Pirollo, KF | 1 |
Chang, EH | 1 |
Hanauske, AR | 2 |
Hanauske, U | 1 |
Hardy, JR | 1 |
Harvey, VJ | 1 |
Paxton, JW | 1 |
Evans, P | 1 |
Smith, S | 1 |
Grove, W | 1 |
Grillo-Lopez, AJ | 1 |
Lazarus, HM | 1 |
Berger, NA | 1 |
Boven, E | 1 |
Winograd, B | 1 |
Fodstad, O | 1 |
Lobbezoo, MW | 1 |
Pinedo, HM | 1 |
Van Mouwerik, TJ | 1 |
Caines, PM | 1 |
Ballentine, R | 1 |
Robak, T | 1 |
Civin, CI | 1 |
Krischer, JP | 1 |
Land, VJ | 1 |
Nitschke, R | 1 |
Kamen, B | 1 |
Vats, T | 1 |
Louie, AC | 1 |
Issell, BF | 1 |
Zittoun, R | 1 |
Marshall, B | 1 |
Ralph, RK | 1 |
Ogawa, M | 2 |
13 reviews available for amsacrine and Benign Neoplasms
Article | Year |
---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Integrated scientific data bases review on asulacrine and associated toxicity.
Topics: Amsacrine; Animals; Antineoplastic Agents; Humans; Neoplasms; Oxidative Stress; Signal Transduction | 2016 |
Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?
Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; Electron Transport; Humans; Intercalating Agents; | 2003 |
Glutathione metabolism as a determinant of therapeutic efficacy: a review.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Biological Transport; Carmustine; Cycloph | 1984 |
Schedule-dependent topoisomerase II-inhibiting drugs.
Topics: Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle; Clinical Trials, Phase I | 1994 |
DNA topoisomerase II inhibitors.
Topics: Amsacrine; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Etoposide; Evidence-Based Med | 2000 |
The human tumor cloning assay in cancer research and therapy: a review with clinical correlations.
Topics: Aminoacridines; Amsacrine; Animals; Anthracenes; Antineoplastic Agents; Blood Physiological Phenomen | 1985 |
Chemotherapy of malignant disease: an update.
Topics: Amsacrine; Antineoplastic Agents; Cisplatin; Coformycin; Etoposide; Female; Humans; Ifosfamide; Male | 1988 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
m-AMSA: a review of clinical data.
Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Drug Evalu | 1985 |
The mechanism of action of mAMSA.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Survival; DNA, Neo | 1985 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul | 1985 |
[Current status of clinical results of new antitumor drugs].
Topics: Aminoacridines; Amsacrine; Anthracyclines; Anthraquinones; Antibiotics, Antineoplastic; Antineoplast | 1985 |
6 trials available for amsacrine and Benign Neoplasms
Article | Year |
---|---|
m-AMSA: an exciting new drug in the National Cancer Institute Drug Development Program.
Topics: Acute Disease; Aminoacridines; Amsacrine; Breast Neoplasms; Clinical Trials as Topic; Dose-Response | 1980 |
A phase I trial of amsalog (CI-921) administered by intravenous infusion using a 5-day schedule.
Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Area Under Curve; Bone Marrow Diseases; Dose-Response | 2001 |
A phase II trial of CI-921 in advanced malignancies.
Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Male; M | 1992 |
Amsacrine evaluation.
Topics: Adult; Amsacrine; Child; Clinical Trials as Topic; Humans; Kinetics; Leukemia; Neoplasms | 1987 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
Clinical correlations with the human tumor cloning assay.
Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul | 1985 |
25 other studies available for amsacrine and Benign Neoplasms
Article | Year |
---|---|
Synthesis and antiproliferative evaluations of certain 2-phenylvinylquinoline (2-styrylquinoline) and 2-furanylvinylquinoline derivatives.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antit | 2010 |
Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, | 2017 |
Novel ametantrone-amsacrine related hybrids as topoisomerase IIβ poisons and cytotoxic agents.
Topics: Amsacrine; Cell Proliferation; Cell Survival; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins | 2014 |
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity.
Topics: Alkylating Agents; Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Do | 2005 |
Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Blood Cell Count; Drug Administration | 1983 |
Tumor penetration of AMSA in man.
Topics: Aged; Aminoacridines; Amsacrine; Female; Humans; Male; Middle Aged; Neoplasms; Tissue Distribution | 1983 |
Phase I evaluation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) by a weekly iv dose schedule.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Dru | 1980 |
Phase I study of m-AMSA in patients with solid tumors and leukemias.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Chemical and Drug Induced Liver I | 1980 |
m-AMSA: a new anticancer agent.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Drug Evaluation; Humans; Neoplasms | 1980 |
AMSA toxicity in patients with abnormal liver function.
Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Hum | 1981 |
Pilot studies of various combinations of dibromodulcitol, VP-16, and AMSA.
Topics: Aged; Aminoacridines; Amsacrine; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Huma | 1982 |
In vitro chemosensitivities of human tumor stem cells to the Phase II drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and prospective in vivo correlations.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cells, Cultured; Drug Evaluation; Female; Genital | 1982 |
[Prospects of new chemotherapies].
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Drug Evaluation; Drug Therapy, Combinat | 1982 |
Cardiac abnormalities after AMSA administration.
Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Ch | 1982 |
Phase I and II study of AMSA in childhood tumours.
Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool; Drug Administ | 1982 |
Current status of clinical trials of m-AMSA, dihydroxyanthracenedione, and deoxycoformycin.
Topics: Adenosine Deaminase Inhibitors; Aminoacridines; Amsacrine; Anthracenes; Antineoplastic Agents; Cofor | 1982 |
High-dose AMSA and bone marrow rescue in patients with solid tumors.
Topics: Aminoacridines; Amsacrine; Bone Marrow; Bone Marrow Transplantation; Humans; Neoplasms | 1982 |
[Expression of DNA topoisomerases (I, II alpha, II beta) mRNA in etoposide- and mAMSA-resistant cell lines].
Topics: Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, N | 1997 |
[Incidence of mutation and deletion in topoisomerase II mRNA of etoposide and m-AMSA resistant cell lines].
Topics: Amsacrine; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; DNA Topoisomerases, Type II; Dr | 1998 |
Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.
Topics: Amsacrine; Ataxia Telangiectasia; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cytarabi | 1991 |
Phase I trial of the amsacrine analogue 9-[( 2-methoxy-4-[(methylsulfonyl)amino]-phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921).
Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Male; Middle Aged; N | 1988 |
Preclinical phase II studies in human tumor lines: a European multicenter study.
Topics: Amsacrine; Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Line; Doxorubicin; Drug Evaluati | 1988 |
[Clinical pharmacology of amsacrine].
Topics: Amsacrine; Humans; Kinetics; Neoplasms | 1986 |
Pediatric oncology group phase II trial of amsacrine in children with solid tumors.
Topics: Age Factors; Aminoacridines; Amsacrine; Arrhythmias, Cardiac; Child; Child, Preschool; Drug Evaluati | 1985 |
[Research project of cancer chemotherapy].
Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Dacarbazine; Etoposide; Hu | 1985 |