Page last updated: 2024-10-22

amsacrine and Benign Neoplasms

amsacrine has been researched along with Benign Neoplasms in 42 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"Eligible tumor types included cancers of the breast, stomach, pancreas, nonsmall cell lung, small cell lung, colon, head and neck area, and melanoma."2.67A phase II trial of CI-921 in advanced malignancies. ( Benson, L; Doroshow, JH; Grove, WR; Maroun, JA; Mittelman, A; Robert, F; Rosen, PJ; Sklarin, NT; Stewart, JA; Wiernik, PH, 1992)
"m-AMSA is a new drug in the National Cancer Institute Drug Development Program."2.65m-AMSA: an exciting new drug in the National Cancer Institute Drug Development Program. ( Charles, LM; Macdonald, JS; Weiss, RB, 1980)
"Amsacrine is a 9-anilinoacridine derivative that appears to act as an electron donor in ET reactions on DNA, while N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) may act as an electron acceptor."2.42Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress? ( Baguley, BC; Jacintho, JD; Kovacic, P; Wakelin, LP, 2003)
"Etoposide has been most clearly shown to be schedule dependent in clinical studies."2.39Schedule-dependent topoisomerase II-inhibiting drugs. ( Joel, SP; Slevin, ML, 1994)
"Amsacrine was administered as a single i."1.27Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group. ( Alberto, P; Bramwell, V; Cavalli, F; De Jager, R; Hansen, HH; Joss, R; Klepp, O; Renard, J; Rozencweig, M; Siegenthaler, P; van Glabbeke, M, 1983)
"A joint study of advanced gastric cancer was conducted between the Northern California Oncology Group and a Japanese Cooperative Group involving 13 major institutions through the US-Japan Program."1.27[Research project of cancer chemotherapy]. ( Ogawa, M, 1985)
"Seven patients developed clinical congestive heart failure."1.26Cardiac abnormalities after AMSA administration. ( Mangiacasale, D; Miller, DR; Steinherz, LJ; Steinherz, PG; Tan, C, 1982)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199028 (66.67)18.7374
1990's5 (11.90)18.2507
2000's4 (9.52)29.6817
2010's5 (11.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, FS1
Chen, W1
Wang, C1
Tzeng, CC1
Chen, YL1
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Bist, G1
Park, S1
Song, C1
Thapa Magar, TB1
Shrestha, A1
Kwon, Y1
Lee, ES1
Zagotto, G1
Gianoncelli, A1
Sissi, C1
Marzano, C1
Gandin, V1
Pasquale, R1
Capranico, G1
Ribaudo, G1
Palumbo, M1
Afzal, A1
Sarfraz, M1
Wu, Z1
Wang, G1
Sun, J1
Baguley, BC3
Wakelin, LP1
Jacintho, JD1
Kovacic, P1
Bacherikov, VA1
Chou, TC1
Dong, HJ1
Zhang, X1
Chen, CH1
Lin, YW1
Tsai, TJ1
Lee, RZ1
Liu, LF1
Su, TL1
Arrick, BA1
Nathan, CF1
De Jager, R1
Siegenthaler, P1
Cavalli, F1
Klepp, O1
Bramwell, V1
Joss, R1
Alberto, P1
van Glabbeke, M1
Renard, J1
Rozencweig, M2
Hansen, HH1
Guo, ZG1
Savaraj, N1
Feun, LG1
Lu, K1
Stewart, DJ1
Luna, M2
Benjamin, RS2
Loo, TL1
Woodcock, TM1
Schneider, RJ1
Young, CW1
Goldsmith, MA1
Bhardwaj, S1
Ohnuma, T1
Greenspan, EM1
Holland, JF1
Von Hoff, DD3
Legha, SS2
Cysyk, RL1
Muggia, FM1
Mahal, PS1
Valdivieso, M1
Bodey, GP2
Eagan, RT1
Ahmann, FR1
Meyskens, FL1
Moon, TE1
Durie, BG1
Salmon, SE1
Sculier, JP1
Klastersky, J1
Steinherz, LJ1
Steinherz, PG1
Mangiacasale, D1
Tan, C1
Miller, DR1
Goldman, A1
Malpas, JS1
Macdonald, JS2
Marsoni, S1
Bruno, S1
Poster, D1
Weiss, RB1
Charles, LM1
Zander, AR1
Spitzer, G1
Legha, S1
Dicke, DA1
Verma, DS1
Johnston, DA1
Vellekoop, L1
Beran, M1
Schell, F1
Minnhaar, G1
Blumenschein, GR1
Joel, SP1
Slevin, ML1
Matsumoto, Y2
Takano, H2
Nagao, S2
Iglesias, A1
Fojo, T2
Morisaki, K1
Kunishio, K1
Fyfe, D1
Price, C1
Langley, RE1
Pagonis, C1
Houghton, J1
Osborne, L1
Woll, PJ1
Gardner, C1
Carmichael, J1
Sklarin, NT1
Wiernik, PH1
Grove, WR1
Benson, L1
Mittelman, A1
Maroun, JA1
Stewart, JA1
Robert, F1
Doroshow, JH1
Rosen, PJ1
Cunningham, JM1
Francis, GE1
Holland, MJ1
Pirollo, KF1
Chang, EH1
Hanauske, AR2
Hanauske, U1
Hardy, JR1
Harvey, VJ1
Paxton, JW1
Evans, P1
Smith, S1
Grove, W1
Grillo-Lopez, AJ1
Lazarus, HM1
Berger, NA1
Boven, E1
Winograd, B1
Fodstad, O1
Lobbezoo, MW1
Pinedo, HM1
Van Mouwerik, TJ1
Caines, PM1
Ballentine, R1
Robak, T1
Civin, CI1
Krischer, JP1
Land, VJ1
Nitschke, R1
Kamen, B1
Vats, T1
Louie, AC1
Issell, BF1
Zittoun, R1
Marshall, B1
Ralph, RK1
Ogawa, M2

Reviews

13 reviews available for amsacrine and Benign Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Integrated scientific data bases review on asulacrine and associated toxicity.
    Critical reviews in oncology/hematology, 2016, Volume: 104

    Topics: Amsacrine; Animals; Antineoplastic Agents; Humans; Neoplasms; Oxidative Stress; Signal Transduction

2016
Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?
    Current medicinal chemistry, 2003, Volume: 10, Issue:24

    Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; Electron Transport; Humans; Intercalating Agents;

2003
Glutathione metabolism as a determinant of therapeutic efficacy: a review.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Biological Transport; Carmustine; Cycloph

1984
Schedule-dependent topoisomerase II-inhibiting drugs.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34 Suppl

    Topics: Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle; Clinical Trials, Phase I

1994
DNA topoisomerase II inhibitors.
    IARC monographs on the evaluation of carcinogenic risks to humans, 2000, Volume: 76

    Topics: Amsacrine; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Etoposide; Evidence-Based Med

2000
The human tumor cloning assay in cancer research and therapy: a review with clinical correlations.
    Current problems in cancer, 1985, Volume: 9, Issue:12

    Topics: Aminoacridines; Amsacrine; Animals; Anthracenes; Antineoplastic Agents; Blood Physiological Phenomen

1985
Chemotherapy of malignant disease: an update.
    Comprehensive therapy, 1988, Volume: 14, Issue:5

    Topics: Amsacrine; Antineoplastic Agents; Cisplatin; Coformycin; Etoposide; Female; Humans; Ifosfamide; Male

1988
Amsacrine (AMSA)--a clinical review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4

    Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

1985
m-AMSA: a review of clinical data.
    European journal of cancer & clinical oncology, 1985, Volume: 21, Issue:6

    Topics: Acute Disease; Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Drug Evalu

1985
The mechanism of action of mAMSA.
    Advances in cancer research, 1985, Volume: 44

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Survival; DNA, Neo

1985
Clinical correlations with the human tumor cloning assay.
    Cancer investigation, 1985, Volume: 3, Issue:6

    Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul

1985
[Current status of clinical results of new antitumor drugs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2

    Topics: Aminoacridines; Amsacrine; Anthracyclines; Anthraquinones; Antibiotics, Antineoplastic; Antineoplast

1985

Trials

6 trials available for amsacrine and Benign Neoplasms

ArticleYear
m-AMSA: an exciting new drug in the National Cancer Institute Drug Development Program.
    Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3

    Topics: Acute Disease; Aminoacridines; Amsacrine; Breast Neoplasms; Clinical Trials as Topic; Dose-Response

1980
A phase I trial of amsalog (CI-921) administered by intravenous infusion using a 5-day schedule.
    Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:4

    Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Area Under Curve; Bone Marrow Diseases; Dose-Response

2001
A phase II trial of CI-921 in advanced malignancies.
    Investigational new drugs, 1992, Volume: 10, Issue:4

    Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Male; M

1992
Amsacrine evaluation.
    Drug intelligence & clinical pharmacy, 1987, Volume: 21, Issue:4

    Topics: Adult; Amsacrine; Child; Clinical Trials as Topic; Humans; Kinetics; Leukemia; Neoplasms

1987
Amsacrine (AMSA)--a clinical review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4

    Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

1985
Clinical correlations with the human tumor cloning assay.
    Cancer investigation, 1985, Volume: 3, Issue:6

    Topics: Aminoacridines; Amsacrine; Anthracenes; Breast Neoplasms; Clinical Trials as Topic; Clone Cells; Cul

1985

Other Studies

25 other studies available for amsacrine and Benign Neoplasms

ArticleYear
Synthesis and antiproliferative evaluations of certain 2-phenylvinylquinoline (2-styrylquinoline) and 2-furanylvinylquinoline derivatives.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antit

2010
Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.
    European journal of medicinal chemistry, 2017, Jun-16, Volume: 133

    Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases,

2017
Novel ametantrone-amsacrine related hybrids as topoisomerase IIβ poisons and cytotoxic agents.
    Archiv der Pharmazie, 2014, Volume: 347, Issue:10

    Topics: Amsacrine; Cell Proliferation; Cell Survival; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins

2014
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity.
    Bioorganic & medicinal chemistry, 2005, Jun-02, Volume: 13, Issue:12

    Topics: Alkylating Agents; Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Do

2005
Phase II study of amsacrine in solid tumors: a report of the EORTC Early Clinical Trial-Group.
    European journal of cancer & clinical oncology, 1983, Volume: 19, Issue:2

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Blood Cell Count; Drug Administration

1983
Tumor penetration of AMSA in man.
    Cancer investigation, 1983, Volume: 1, Issue:6

    Topics: Aged; Aminoacridines; Amsacrine; Female; Humans; Male; Middle Aged; Neoplasms; Tissue Distribution

1983
Phase I evaluation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA) by a weekly iv dose schedule.
    Cancer treatment reports, 1980, Volume: 64, Issue:1

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Dru

1980
Phase I study of m-AMSA in patients with solid tumors and leukemias.
    Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Chemical and Drug Induced Liver I

1980
m-AMSA: a new anticancer agent.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 74

    Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; Drug Evaluation; Humans; Neoplasms

1980
AMSA toxicity in patients with abnormal liver function.
    European journal of cancer & clinical oncology, 1981, Volume: 17, Issue:12

    Topics: Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Dose-Response Relationship, Drug; Hum

1981
Pilot studies of various combinations of dibromodulcitol, VP-16, and AMSA.
    Oncology, 1982, Volume: 39, Issue:5

    Topics: Aged; Aminoacridines; Amsacrine; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Huma

1982
In vitro chemosensitivities of human tumor stem cells to the Phase II drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and prospective in vivo correlations.
    Cancer research, 1982, Volume: 42, Issue:11

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cells, Cultured; Drug Evaluation; Female; Genital

1982
[Prospects of new chemotherapies].
    Revue medicale de Bruxelles, 1982, Volume: 3, Issue:8

    Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Drug Evaluation; Drug Therapy, Combinat

1982
Cardiac abnormalities after AMSA administration.
    Cancer treatment reports, 1982, Volume: 66, Issue:3

    Topics: Adolescent; Adult; Aminoacridines; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Ch

1982
Phase I and II study of AMSA in childhood tumours.
    Cancer chemotherapy and pharmacology, 1982, Volume: 9, Issue:1

    Topics: Adolescent; Aminoacridines; Amsacrine; Antineoplastic Agents; Child; Child, Preschool; Drug Administ

1982
Current status of clinical trials of m-AMSA, dihydroxyanthracenedione, and deoxycoformycin.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1982, Volume: 80

    Topics: Adenosine Deaminase Inhibitors; Aminoacridines; Amsacrine; Anthracenes; Antineoplastic Agents; Cofor

1982
High-dose AMSA and bone marrow rescue in patients with solid tumors.
    Cancer treatment reports, 1982, Volume: 66, Issue:2

    Topics: Aminoacridines; Amsacrine; Bone Marrow; Bone Marrow Transplantation; Humans; Neoplasms

1982
[Expression of DNA topoisomerases (I, II alpha, II beta) mRNA in etoposide- and mAMSA-resistant cell lines].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:15

    Topics: Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, N

1997
[Incidence of mutation and deletion in topoisomerase II mRNA of etoposide and m-AMSA resistant cell lines].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:8

    Topics: Amsacrine; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; DNA Topoisomerases, Type II; Dr

1998
Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.
    British journal of cancer, 1991, Volume: 63, Issue:1

    Topics: Amsacrine; Ataxia Telangiectasia; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cytarabi

1991
Phase I trial of the amsacrine analogue 9-[( 2-methoxy-4-[(methylsulfonyl)amino]-phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921).
    Cancer research, 1988, Nov-15, Volume: 48, Issue:22

    Topics: Adult; Aged; Amsacrine; Antineoplastic Agents; Drug Evaluation; Female; Humans; Male; Middle Aged; N

1988
Preclinical phase II studies in human tumor lines: a European multicenter study.
    European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:3

    Topics: Amsacrine; Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Line; Doxorubicin; Drug Evaluati

1988
[Clinical pharmacology of amsacrine].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1986, Oct-27, Volume: 41, Issue:43

    Topics: Amsacrine; Humans; Kinetics; Neoplasms

1986
Pediatric oncology group phase II trial of amsacrine in children with solid tumors.
    Cancer treatment reports, 1985, Volume: 69, Issue:3

    Topics: Age Factors; Aminoacridines; Amsacrine; Arrhythmias, Cardiac; Child; Child, Preschool; Drug Evaluati

1985
[Research project of cancer chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:3 Pt 2

    Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Dacarbazine; Etoposide; Hu

1985